Clinical trials: Injections
Macular Degeneration, Diabetic Retinopathy
Ocular Discomfort Assessment After Intravitreal Injections
In this study, ocular discomfort following intravitreal injection in naïve patients will be studied, as well as the efficacy of wetting agent (Optive eyewash) to prevent ocular discomfort.
- Conditions
- Macular Degeneration, Diabetic Retinopathy, Retinal Artery Occlusion, Myopia, Degenerative
- Trial name
- EVAGO (NCT02806830)
- Testing
- Optive
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Advanced Malignant Solid Tumor
A Study of MHB042C in Patients With Advanced Solid Tumors
This is a first-in-human, open-label, multicenter Phase I/II study of MHB042C in patients with advanced solid tumors. The study was designed to evaluate the safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of…
- Trial name
- NCT07192107
- Testing
- MHB042C for Injection
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Minghui Pharmaceutical (Hangzhou) Ltd
Acute Respiratory Infection
Meditation and Exercise for Prevention of Acute Respiratory Infection
The overarching goal of this project is to determine whether mind-body practices such as meditation or exercise can reduce the public health burden of acute respiratory infection.
- Trial name
- MEPARI (NCT01057771)
- Testing
- Meditation, Exercise
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
in Vitro Fertilization
ICSI Using Pentoxifylline to Identify Viable Spermatozoa in Absolute Asthenozoospermia Patients
Absolute asthenozoospermia is a rare condition in men with an occurrence frequency of 1/5000 and greatly affects fertility product. Previous studies have shown that the ovum can be fertilized with live but immotile sperm.
- Trial name
- NCT05943353
- Testing
- Pentoxifylline
- Where
- Vietnam
- Volunteers
- 10 people
- Sponsor
- Mỹ Đức Hospital
Diabetic Macular Edema
Additional Effect of Subthreshold Micropulse Laser to Intravitreous Injection of Bevacizumab on Diabetic Macular Edema
In this study, all eyes with diabetic macular edema who meet the inclusion criteria and do not meet the exclusion criteria will be included.
- Trial name
- NCT05582577
- Testing
- Intravitreal bevacizumab injection with subthreshold micropulse laser, Intravitreal bevacizumab injection alone
- Where
- Iran
- Volunteers
- 30 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Cesarean Section
Wound Infiltration With Bupivacaine/Adrenalin During Cesarean Section and Postoperative Pain.
Thus study evaluates the advantage of infiltration of the surgical wound by local anesthetics in cesarean section on post operative pain relief.
- Trial name
- NCT03395912
- Testing
- Intervention
- Where
- Israel
- Volunteers
- 288 people
- Sponsor
- HaEmek Medical Center, Israel
Hypertension, Hypertension,Essential
Renal Artery Denervation Assessment Without Antihypertensive Medication Regimen (RADAR)
To obtain an assessment of the efficacy and safety of renal denervation by dehydrated alcohol injection, USP administered via the Peregrine System™ Infusion Catheter in hypertensive subjects in the absence of antihypertensive…
- Trial name
- RADAR (NCT07083765)
- Testing
- Dehydrated Alcohol Injection, USP
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Ablative Solutions, Inc.
Age-Related Macular Degeneration
Macugen (Pegaptanib Sodium) Alone, Versus Macugen in Combination With PDT (Photodynamic Therapy) With Visudyne (Verteporfin) in Patients With Age-Related Macular Degeneration (AMD)
The purpose of the trial is to compare whether Macugen (pegaptanib sodium) in combination with PDT with Visudyne (verteporfin) is safe and effective in slowing down the leakage of fluid within the eye and thereby stabilizing or…
- Trial name
- NCT00134667
- Testing
- Photodynamic Therapy (PDT) with Visudyne (verteporfin), Macugen (pegaptanib sodium)
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Eyetech Pharmaceuticals
Hip Osteoarthritis
Efficacy of a Combination of Ultrasound-guided Intra-articular Injections of Hyaluronic Acid, High-power Laser Therapy and Rehabilitation on Functioning in Patients Affected by Hip Osteoarthritis.
High-power laser therapy (HPLT) is effective in treating musculoskeletal conditions, reducing pain and improving joint functionality.
- Trial name
- NCT07108400
- Testing
- ultrasound-guided injections of hyaluronic acid plus high-power laser therapy
- Where
- 2 sites in Italy
- Volunteers
- 57 people
- Sponsor
- De Sire Alessandro
Safety, Tolerability
A Clinical Study of GenSci134 in Healthy Adults and Adult Growth Hormone Deficiency(AGHD)
To check how safe and well-tolerated a single subcutaneous injection of GenSc134 is in healthy male volunteers， a multiple-doses subcutaneous injection of GenSc134 is in healthy volunteers，a single subcutaneous injection of…
- Conditions
- Safety, Tolerability, Adult Growth Hormone Deficiency
- Trial name
- NCT07016802
- Testing
- GenSci134, Recombinant Human Growth Hormone Injection (Norditropin®)
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Antibiotic Stewardship, Overactive Bladder
Antibiotic Usage Prior to OnabotulinumtoxinA Injection
Intradetrusor injection of onabotulinumtoxinA, which is performed through a cystoscopic procedure, has been demonstrated to be efficacious in the treatment of both neurogenic and non-neurogenic overactive bladder (OAB), and is…
- Conditions
- Antibiotic Stewardship, Overactive Bladder, Onabotulinumtoxin A, UTI
- Trial name
- NCT04754737
- Testing
- No antibiotic, Prophylactic antibiotic, cystoscopic injection of onabotulinumtoxinA
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benaroya Research Institute
Healthy Volunteer
A Single-volunteer Study of Immune Response Following OTS-412 Vaccinia Virus Systemic Injection(Self-experiment)
Following oncolytic virus (OV) administration, the host immune response is initiated immediately and evolves dynamically. However, in clinical OV therapy, it is virtually impossible to capture these immune events in real time.
- Trial name
- NCT07302945
- Testing
- OTS-412
- Where
- South Korea
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bionoxx Inc.
Pain, Postoperative
Block and Periarticular Injection Study
The purpose of the study is to compare two types of perioperative analgesic modalities, adductor canal block plus interspace between popliteal artery and capsule of the knee (IPACK) block and periarticular injection versus…
- Trial name
- NCT06410612
- Testing
- regional anesthesia and PAI, PAI
- Where
- United States
- Volunteers
- 174 people
- Sponsor
- Washington University School of Medicine
Urinary Incontinence, Urinary Incontinence, Urge
Prophylactic Analgesia for Bladder Botox Injections
The goal of this clinical trial is to learn more about using phenazopyridine (Pyridium) for pain control during bladder onabotulinumtoxinA ("botox") injections for surgical management of overactive bladder (OAB) for patients at…
- Conditions
- Urinary Incontinence, Urinary Incontinence, Urge, Overactive Bladder
- Trial name
- NCT06514430
- Testing
- Phenazopyridine, 1% lidocaine with sodium bicarbonate
- Where
- United States
- Sponsor
- Montefiore Medical Center
Solid Tumors
A Study of BL-ARC002 in Patients With Locally Advanced or Metastatic Solid Tumors
This study is an open-label, multicenter, dose-escalation and expansion, non-randomized Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics, and preliminary efficacy of BL-ARC002 for…
- Trial name
- NCT07591155
- Testing
- BL-ARC002
- Where
- China
- Volunteers
- 22 people
- Sponsor
- Sichuan Baili Pharmaceutical Co., Ltd.
Healthy Volunteer Study
Study of Intranasal Octreotide (DP1038) in Healthy Adult Volunteers
The purpose of the study is to investigate the drug octreotide acetate in a new intranasal formulation and compare it to the FDA-approved subcutaneous (SC) injection formulation.
- Trial name
- NCT03031535
- Testing
- Intranasal octreotide acetate, Subcutaneous octreotide acetate, Growth hormone-releasing hormone
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Dauntless Pharmaceuticals
Complications; Cesarean Section, Hypotension
Extra Sitting Time After Spinal Anesthesia for Cesarean Section and Fetal Well-being
After injection of the spinal anesthetic drug, women will be allowed to lie down immediately (0-30 sec) or after three minutes (180 sec) of sitting.
- Trial name
- NCT02893696
- Testing
- Various sitting time
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Olfactory Dysfunction, Anosmia
Topical Versus Injection PRP for Olfactory Dysfunction
The goal of this clinical trial is to determine whether two different delivery methods of autologous platelet-rich plasma (PRP) can improve olfactory function in adults with persistent olfactory dysfunction lasting more than…
- Conditions
- Olfactory Dysfunction, Anosmia, Hyposmia
- Trial name
- TOP-IN (NCT07151703)
- Testing
- Intranasal Injection of Autologous PRP, Carrier-Assisted Topical Application of Autologous PRP, platelet-rich plasma
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Medication Overuse Headache
Pilot Study of DFN-11 Injection in Medication Overuse Headache
Efficacy and Safety Pilot Study of DFN-11 Injection in Medication Overuse Headache
- Trial name
- NCT02583425
- Testing
- DFN-11 Injection
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Safety
Single and Multiple Dose Escalation Trial of an Intravenous Antibiotic RC-01
A Phase 1 study of the safety, tolerability and pharmacokinetics of a new antibiotic (RC-01). In Part 1 cohorts of healthy adults will participate in a single dose escalation study of increasing intravenous doses of RC-01.
- Trial name
- NCT03832517
- Testing
- Single intravenous doses of RC-01, Multiple intravenous doses of RC-01
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Recida Therapeutics, Inc.
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