Clinical trials: Injections
Contraception Behavior, Contraceptive Usage
Effects of One-to-one Service on the Continuation and Satisfaction of Contraceptive Use.
This study aims to explore the impact of a mobile based one-to-one service model on improving the continuation and satisfaction of combined injectable contraceptive use, and improve the utilization and acceptability of efficient…
- Trial name
- NCT05362019
- Testing
- Compound Norethisterone Enanthate Injection, One-to-one Service, Family Planning Service
- Where
- 8 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- National Research Institute for Family Planning, China
Breast Cancer Females
Dextrose Hydrodissection for Post-Breast Cancer Chest Wall and Axillary Tightness.
The goal of this clinical trial (prospective case series) is to evaluate the feasibility, safety, and preliminary clinical outcomes of ultrasound-guided dextrose prolotherapy in female breast cancer survivors with persistent…
- Trial name
- NCT07378319
- Testing
- ultrasound guided dextrose prolotherapy
- Where
- Taiwan
- Volunteers
- 15 people
- Sponsor
- Taichung Veterans General Hospital
Growth Hormone Disorders
A Post Marketing Surveillance Program for NutropinAq® in Paediatric Growth Disorders
This study is a multicenter, open label, observational, post marketing surveillance study of NutropinAq® in Austria, France, Germany, Italy, Spain, Romania and United Kingdom to collect long-term safety and effectiveness…
- Trial name
- iNCGS (NCT00455728)
- Where
- United Kingdom
- Volunteers
- 3,690 people
- Sponsor
- Ipsen
Mandibular Prosthesis User
Comparison Between Injection Molded Polyetheretherketone (PEEK) Framework and Cobalt Chromium Framework Removable Partial Dentures Regarding Periodontal Health of Abutment Teeth
This study is aiming to evaluate the periodontal status of the abutment teeth in Polyetheretherketone ( PEEK ) framework partial dentures compared with cobalt-chromium ones in mandibular kennedy class I edentulous cases aiming to…
- Trial name
- NCT03777345
- Testing
- cobalt-chromium framework partial dentures, PEEK framework partial dentures
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Unresectable Locally Recurrent Breast Cancer, Unresectable Locally Metastatic Breast Cancer
A Trial of Trastuzumab Rezetecan in Unresectable Locally Recurrent/Metastatic Breast Cancer
The study is designed to compare the efficacy and safety of different dose groups of Trastuzumab Rezetecan or Trastuzumab Deruxtecan in patients with HR-positive, HER2-low unresectable locally recurrent/metastatic breast cancer.
- Trial name
- NCT07497386
- Testing
- Trastuzumab Rezetecan for Injection, Trastuzumab Deruxtecan for Injection
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Myelodysplastic Syndromes
To Demonstrate Superiority of Decitabine Over Azacitidine in Subjects With Intermediate- or High-risk MDS.
The purpose of this study is to compare the response of patients with Intermediate or High Risk myelodysplastic syndromes (MDS) following treatment with decitabine or azacitidine.
- Trial name
- NCT01011283
- Testing
- decitabine, azacitidine
- Where
- 19 sites in United States
- Volunteers
- 26 people
- Sponsor
- Eisai Inc.
Nocturnal Bruxism
Botulinum Toxin A Injectable Solution in the Management of Bruxism: A Clinical Trial Study
A Clinical Trial Study to investigate the potential performance of BTXA on masseter muscle on patient with nocturnal bruxism and to check the pain scale and share this clinical experience.
- Trial name
- NCT03827122
- Testing
- onabotulinumtoxinA
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Diabetic Macular Edema
A Multicenter Study to Compare Multiple Doses of Intravitreal Microplasmin Versus Sham Injection for Treatment of Patients With Diabetic Macular Edema (DME)
A multicenter study to compare multiple doses of intravitreal microplasmin for non-surgical PVD induction for treatment of patients with DME.
- Trial name
- MIVI-II (NCT00412451)
- Testing
- ocriplasmin
- Where
- 15 sites in Belgium, Germany and 4 more
- Volunteers
- 51 people
- Sponsor
- ThromboGenics
Axial Spondyloarthritis
to Evaluate the Preliminary Efficacy and Safety of GR1501 Injection in Patients With Active Axial Spondyloarthritis
Dosage: 100mg or 200mg or 300mg Administration frequency: Q2W administration in the first 4 weeks (W0, W2, W4), and subsequent Q4W administration (W8, W12) Administration: subcutaneous injection Specifications: 100mg/ 1mL/bottle…
- Trial name
- NCT05162937
- Testing
- IL-17A antibody
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Genrix (Shanghai) Biopharmaceutical Co., Ltd.
Telangiectasia
Injected Ranibizumab to Treat Macular Telangiectasia Without New Blood Vessel Formation
This study will examine whether the drug ranibizumab is an effective treatment for macular telangiectasia, a condition in which existing blood vessels near the macula (the back part of the eye responsible for sharp central…
- Trial name
- NCT00457145
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Macular Edema, Age-Related Macular Degeneration
Effect of Corona Virus on Intravitreal Injections
During pandemic of corona virus, patients compliance may be affected. We aim to study the factors lead to unregulated visits and its implications on the final visual outcome.
- Conditions
- Diabetic Macular Edema, Age-Related Macular Degeneration, Choroidal Neovascularization, Myopic Choroidal Neovascularisation
- Trial name
- NCT05494775
- Testing
- Anti-vascular endothelial growth factors (Anti-VEGFs)
- Where
- Egypt
- Volunteers
- 250 people
- Sponsor
- Benha University
Tumors, Neoplasms
Phase I Study of LB-100 With Docetaxel in Solid Tumors
The purpose of this study is to test the safety of an investigational drug called LB-100 for Injection for treatment of solid tumors, when given with or without docetaxel.
- Conditions
- Tumors, Neoplasms, Cancer
- Trial name
- NCT01837667
- Testing
- LB-100 for Injection, Docetaxel
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Lixte Biotechnology Holdings, Inc.
Immunology, Hematologic Malignancies
A Clinical Study to Evaluate the Safety and Efficacy of Anti-human CD 7 CAR-NK Cell Injection in Subjects With Relapsed and Refractory CD7-positive Hematological Malignancy
This study is a single-arm, open-label, dose-escalation clinical trial to explore the safety, tolerability, pharmacokinetics and pharmacodynamics characteristics of the drug; The efficacy of the study drug in subjects with…
- Conditions
- Immunology, Hematologic Malignancies, CAR-NK
- Trial name
- NCT07117175
- Testing
- Anti-human CD7 CAR-NK cell injection
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Sacro-iliac Joint Pain
Ketorolac Versus Corticosteroid Injections for Sacroiliac Joint Pain
This study will contribute to the current literature that have compared joint injections with steroid versus ketorolac providing evidence for the use of ketorolac for SI joint pain.
- Trial name
- NCT06081101
- Testing
- Methylprednisolone Injection, Ketorolac Injection
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- McMaster University
Advanced Malignant Tumor
Clinical Trial of TQB2868 Injection in Subjects With Advanced Malignant Tumors
The TQB2868 protein in this study targeted programmed cell death protein 1 (PD-1) and transforming growth factor-β (TGF-β). The bifunctional fusion protein targets and neutralizes TGF-β in the tumor microenvironment.
- Trial name
- NCT05198505
- Testing
- TQB2868 Injection
- Where
- 3 sites in China
- Volunteers
- 280 people
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Nanjing Shunxin Pharmaceutical Co., Ltd.
Direct Coracohumeral Ligament Steroid Injection
Efficacy of Corticosteroid Injection Into Coracohumeral Ligament in Patients With Adhesive Capsulitis of the Shoulder
Steroid injections are widely utilized to reduce inflammation and fibrosis in patients with the frozen shoulder. In this study, investigators will compare intra-articular steroid injections with direct coracohumeral ligament…
- Trial name
- NCT03013205
- Testing
- Intraarticular triamcinolone injection, Intraarticular Xylocaine injection, Coracohumeral ligament triamcinolone injection
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Heart Arrest
RCT Study of Levosimendan Improving Prognosis of Cardiac Arrest
This study is intended to use a multicenter, double-blind, superior effect, placebo controlled randomized controlled clinical trial to explore the therapeutic effect of Levosimendan (within 6 hours after the recovery of…
- Trial name
- NCT05956431
- Testing
- Levosimendan Injection, physiological saline
- Volunteers
- 60 people
- Sponsor
- Peking University Third Hospital
HIV Infections
Evolution of HIV Reservoir, Inflammation and Microbiota Footprint of PLWH Switching to Long-acting Injectable Treatment Compared to Patients on Oral Dual or Triple Anti-integrase-based Therapy
In the last 40 years of HIV history, we have managed to attain most of our therapeutic objectives, namely virological suppression of most patients and sufficient immune reconstitution.
- Trial name
- LAMIVIH (NCT05303337)
- Testing
- Stool sampling, Blood plasma collection
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Hôpital Européen Marseille
Age-Related Macular Degeneration, Choroidal Neovascularization
20089 TA+Lucentis Combo Intravitreal Injections for Treatment of Neovascular Age-related Macular Degeneration (AMD)
The primary purpose of this study is to assess the safety \& tolerability of an investigational drug 20089 TA (6.9 mg or 13.8 mg) when used adjunctively with Lucentis 0.5 mg in subjects with sub-foveal neovascular AMD.
- Trial name
- 20089/Combo (NCT01175395)
- Testing
- IBI-20089/Lucentis
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois Chicago
Perianal Fistula
FiLaC and PRGF-Endoret for Multi-recurrent Cryptoglandular Perianal Fistula (PLASMA Pilot Study)
Multi-recurrent cryptoglandular perianal fistula represents a challenging clinical problem with no established surgical solution after repeated failures.
- Trial name
- PLASMA (NCT07810075)
- Testing
- Laser ablation of fistula tract using 1000-µm radial fibre (Biolitec, 1470 nm, 12 W, continuous, 1 mm/s withdrawal). Internal opening closed with Vicryl 2/0 suture in all patients
- Volunteers
- 25 people
- Sponsor
- Complejo Hospitalario Universitario de Santiago
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