Clinical trials: Injections
Solid Tumor
Technetium [99mTc]-H7ND in Patients With Gastrointestinal Malignancies and Healthy Volunteers
The primary objective of this study is: to evaluate the safety of technetium [99mTc]-H7ND injection in patients with gastrointestinal malignancies and in healthy subjects.
- Trial name
- NCT06443710
- Testing
- Technetium [99mTc]-H7ND injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiaxing Pharmadax Genesis Pharmaceutical Technology Co.,Ltd.
Post-operative Pain
Does a Single Shot Femoral Nerve Block Alone Produce Appropriate Pain Relief?
The aim of this study is to compare the efficacy of the analgesic effect of the preoperative femoral nerve block alone versus combined femoral, sciatic, obturator and lateral femoral cutaneous nerve blocks in patients after TKA…
- Trial name
- NCT01303120
- Testing
- Femoral Nerve Block, Combined nerve blocks, Patient-controlled analgesia
- Where
- Israel
- Volunteers
- 107 people
- Sponsor
- Hillel Yaffe Medical Center
Healthy Adult Volunteers
Study of VSA001 Injection in Chinese Healthy Adult Volunteers
This is a phase 1, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics effects of a single dose of VSA001 injection in Chinese healthy…
- Trial name
- NCT05757596
- Testing
- VSA001 injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Visirna Therapeutics HK Limited
Injection Fear, Injection Pain Prevention
Does Ethyl Chloride Spray Work?
A procedure frequently performed by orthopaedic providers is the administration of corticosteroid injections for the management of various soft tissues and joint-related conditions, such as osteoarthritis, tendinitis, carpal…
- Conditions
- Injection Fear, Injection Pain Prevention, Injection Complication
- Trial name
- NCT06651788
- Testing
- Ethyl Chloride, Cold Saline Spray
- Where
- United States
- Volunteers
- 246 people
- Sponsor
- University of Chicago
Acute Ischemic Stroke
Phase III Clinical Trial of rhTNK-tPA in Treating Acute Ischemic Stroke With Extended Time Window.
This is a multicenter, randomized, double-blind, placebo-controlled Phase III clinical study designed to evaluate the efficacy of recombinant human tissue-type plasminogen activator variant (rhTNK-tPA) (0.25 mg/kg, maximum dose…
- Trial name
- TRACE-LATE (NCT07201688)
- Testing
- rhTNK-tPA
- Where
- China
- Volunteers
- 890 people
- Sponsor
- CSPC Mingfule Pharmaceutical (Guangzhou) Co., Ltd.
Osteoarthritis
Ultrasound (US)-Guided Versus Sham Ultrasound Corticosteroid (CS) Knee Injections
To determine if ultrasound-guided knee steroid injections are more effective than sham ultrasound knee steroid injections for the treatment of osteoarthritis.
- Trial name
- NCT01032720
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VA Connecticut Healthcare System
Knee Osteoarthritis
Homologous PRP vs Placebo in Knee Osteoarthritis in Over 65 Years Old Patients
The aim of the study is to compare the 6 months clinical outcome of the treatment with a single injection of Homologous PRP versus single injection of placebo (saline solution) in the infiltrative treatment of knee osteoarthritis…
- Trial name
- NCT04901273
- Testing
- Homologous PRP injections
- Where
- Italy
- Volunteers
- 204 people
- Sponsor
- Istituto Ortopedico Rizzoli
Herpes Labialis
Botulinum Toxin A for Herpes Labialis
The purpose of this study is to determine the efficacy and safety of Botulinum Toxin Type A as a preventative measure for Herpes Labialis.
- Trial name
- NCT01225341
- Testing
- onabotulinumtoxinA, Bacteriostatic normal saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- DeNova Research
Abdominal Aortic Surgery
The Effect of Intraperitoneal Injection of Magnesium Sulphate Versus Dexmedetomidine as an Adjuvant to Bupivacaine on Postoperative Analgesia in Patients Undergoing Abdominal Aortic Surgery
optimal management of postoperative pain is essentiel for better outcome in abdominal aortic surgery.the study aim to compare between analgesic effect of magnesium sulphate versus dexmedetomidine as an adjuvant to bupivacaine…
- Trial name
- NCT05577260
- Testing
- magnesuim sulphate, Dexmedetomidine, isobaric bupivacaine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mansoura University
Recurrent Human Papillomavirus Type 16 Associated Cancer
TA-CIN Vaccine With Anti-PD-1 Therapy in Recurrent HPV16-associated Cancers
The primary to assess the safety and tolerability of TA-CIN and anti-PD-1 therapy in patients with recurrent HPV16-associated cancers and to assess the feasibility of IT injection of TA-CIN in patients with recurrent…
- Trial name
- NCT05132803
- Testing
- HPV 16 TA-CIN
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Healthy
A Phase I Study of LX22001 for Injection in Healthy Subjects
Study to evaluate the safety and tolerability, pharmacokinetics/pharmacodynamics (PK/PD) parameters of an escalating, single dose/repeat doses of LX22001 for injection in healthy subjects.
- Trial name
- NCT06561542
- Testing
- LX22001 for Injeciton, Tegoprazan tablet, Esomeprazole sodium for injection
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shandong Luoxin Pharmaceutical Group Stock Co., Ltd.
Diabetes Mellitus, Type 2
Variable Bolus Regimen 1-2-3 for Type 2 Diabetes Mellitus
The purpose of this study is to show the non-inferiority of insulin glulisine administered with 1 meal versus 2 meals versus 3 daily meals, as measured by the change in hemoglobin A1c (HbA1c), from baseline to study week 24.
- Trial name
- NCT00135083
- Testing
- insulin glulisine
- Volunteers
- 347 people
- Sponsor
- Sanofi
Injection Pain, Local Anesthesia
Efficacy of Virtual Reality in Reducing Injection Pain and Anxiety During Local Anesthesia in Children
The aim of this study is to determine the efficacy of a virtual reality (VR) device in reducing injection pain and anxiety associated with local anesthesia in pediatric dental patients.
- Trial name
- NCT03772483
- Testing
- Local anesthesia with conventional syringe, Local anesthesia with conventional syringe + VR device
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Classical Hodgkin's Lymphoma
Study of GLS-010 Injection in the Treatment of Classical Hodgkin's Lymphoma
Patients with refractory cHL. Patients will be treated with GLS-010
- Trial name
- NCT03655483
- Testing
- GLS-010
- Where
- 5 sites in China
- Volunteers
- 85 people
- Sponsor
- Guangzhou Gloria Biosciences Co., Ltd.
Osteoarthritis of the Knee
Apitox, Honeybee Venom Treatment for Osteoarthritis Pain and Inflammation
The study will evaluate Apitox, pure honeybee venom as a treatment for pain and inflammation of osteoarthritis of the knee.
- Trial name
- HBV (NCT00949754)
- Testing
- honeybee venom (Apitoxin (Korea) Apitox (USA))
- Where
- 4 sites in United States
- Volunteers
- 40 people
- Sponsor
- Apimeds, Inc.
Soft Tissue Sarcoma, Sarcoma,Soft Tissue
Neoadjuvant Intralesional Injection of Talimogene Laherparepvec
The proposed study is designed to treat locally advanced soft tissue sarcoma (STS) subtypes with neoadjuvant talimogene laherparepvec (TVEC) and preoperative external beam radiation therapy (EBRT).
- Trial name
- NCT06660810
- Testing
- Talimogene Laherparepvec, Neoadjuvant Radiation, Surgery
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- John Rieth
Chronic Hip Pain
Comparison of Femoral and Obturatory Nerve Joint Branches Conventional Radiofrequency Thermocoagulation ,Intraarticular Steroid Injection and Pericapsular Nerve Group (PENG) Block in Chronic Hip Pain
In this study ,the investigators aimed to show the decrease in pain levels and the effect on quality of life of patients who underwent chronic hip painRFT , intraartıcular steroid injection and Peng block.
- Trial name
- NCT05822310
- Testing
- radiofrequency thermocoagulation to the articular branches of the femoral and obturatory nerves, intraairticular steroid injection, pericapsular nerve group (PENG) block
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Aydin Adnan Menderes University
OHSS
Cabergoline and Coasting to Prevent OHSS
The effectiveness of cabergoline to prevent moderate-severe OHSS to coasting.
- Trial name
- OHSS (NCT01984320)
- Testing
- ICSI
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Cairo University
Pulmonary Arterial Hypertension
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAH
This is a multi-center, randomized, double-blind, controlled, Phase 2 study to assess the safety, tolerability, and efficacy of pemziviptadil (PB1046) at the optimally titrated dose after 16 weeks of treatment.
- Trial name
- VIP (NCT03556020)
- Testing
- Pemziviptadil (PB1046)
- Where
- 26 sites in United States
- Volunteers
- 35 people
- Sponsor
- PhaseBio Pharmaceuticals Inc.
SLE - Systemic Lupus Erythematosus, Systemic Sclerosis
CD19/BCMA-Targeted Universal CAR-T Cell Injection for the Treatment of Autoimmune Diseases
This is a single-arm, open-label, investigator-initiated trial (IIT) designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics and efficacy of RD06-05 in patients with autoantibody-mediated autoimmune…
- Conditions
- SLE - Systemic Lupus Erythematosus, Systemic Sclerosis, ANCA Associated Vasculitis, Idiopathic Inflammatory Myopathies
- Trial name
- NCT07596680
- Testing
- RD06-05 CAR-T Cell Injection
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Nanjing Bioheng Biotech Co., Ltd.
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