Clinical trials: Injuries, Acute Brain
Concussion, Mild
Multimodal Approach to Testing the Acute Effects of Mild Traumatic Brain Injury (mTBI)
The objective of the study is to determine the relative roles for various testing modalities in the diagnosis and prognosis of mild traumatic brain injury.
- Trial name
- NCT02069613
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Huntington Medical Research Institutes
Mild Traumatic Brain Injury
OPTIMA-TBI Pilot Study
This is a double-blind, randomized controlled trial comparing the effect of omega-3 fatty acid versus placebo on blood biomarkers of brain injury, inflammation and neurogenesis.
- Trial name
- OPTIMA (NCT03345550)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- University of Michigan
Acute Ischemic Stroke
ATILA Project: Aspirin Versus Tirofiban in Endovascular Treatment for Patients With Acute Ischemic Stroke Due to Tandem Lesion
Patients with tandem lesions (TL) are defined as patients with an acute ischemic stroke (AIS) with occlusion of an intracranial vessel of the anterior circulation and an occlusion or severe stenosis (70-99%) of the origin of the…
- Trial name
- ATILA (NCT05225961)
- Testing
- Tirofiban, Acetylsalicylic acid
- Where
- 13 sites in Spain
- Volunteers
- 240 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Intracerebral Hemorrhage
Short-term And Longer-term Cognitive Impact Of Neurochecks
The proposed research plan seeks to understand the impact of sleep disruption in the Neurological Intensive Care Unit (ICU) on older patients with acute brain injury (ABI).
- Trial name
- NCT06219889
- Testing
- Frequency of neurochecks
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Self-management, Feasibility Studies
Self-management Program for Patients in the Sub-acute Phase After Traumatic Injury - a Feasibility Study
The goal of this descriptive non-randomized feasibility study is to assess aspects of feasibility of the intervention arm in a planned full-scale randomized controlled trial testing the effectiveness of a self-management program…
- Conditions
- Self-management, Feasibility Studies, Spinal Cord Injuries, Brain Injuries
- Trial name
- SMS_trauma (NCT06093074)
- Testing
- self-management program after traumatic injuries
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Oslo University Hospital
Traumatic Brain Injury
Micronutrient Supplement Effects on Cognitive Outcomes in Post-Acute TBI
Traumatic brain injury (TBI) refers to neuronal damage occurring as the result of an external force being applied to brain tissue.
- Trial name
- NCT03032302
- Testing
- Swisse Womens 50+ Ultivite Multivitamin, Holland and Barrett Triple Strength Omega-3 Fish Oil
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Sheffield Hallam University
Traumatic Brain Injury, Ischemic Stroke
Shared Decision Making to Improve Goals-of-Care Decisions for Families of Severe Acute Brain Injury Patients
Severe acute brain injury (SABI), including large artery acute ischemic stroke, intracerebral hemorrhage, and severe traumatic brain injury continue to be the leading cause of death and disability in adults in the U.S.
- Conditions
- Traumatic Brain Injury, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT03833375
- Testing
- Decision Aid
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- University of Massachusetts, Worcester
Concussion, Brain
Oculomotor Function Testing in Acute Concussion
This is a prospective longitudinal study which aims to compare oculomotor function and visual scanning behaviour (VSB) of participants who suffered concussion with healthy controls with no concussion.
- Trial name
- NCT03892356
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Paroxysmal Sympathetic Hyperactivity
Percutaneous Neurostimulation to Treat Paroxysmal Sympathetic Hyperactivity in Children
Survivors of severe brain injury, such as lack of oxygen or severe traumatic brain injury, frequently experience Paroxysmal Sympathetic Hyperactivity (PSH).
- Trial name
- NCT05343988
- Testing
- Percutaneous Electrical Nerve Field Stimulation (PENFS) device application
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Medical College of Wisconsin
Concussion, Mild, Autonomic Nervous System
Acute Nerve Stimulation For Enhancing Human and Cognitive Performance
The goal of this clinical trial is to test a wearable device's effect on performance in tactical populations with a history of concussion.
- Conditions
- Concussion, Mild, Autonomic Nervous System, Cognitive
- Trial name
- NCT05675956
- Testing
- Experimental group with 100% intensity setting on Apollo Neuro device, Active Comparator group with 10% intensity setting on the Apollo Neuro device
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill
Traumatic Brain Injury, Intracranial Hemorrhages
Efficacy and Feasibility Trial of a Portable Near Infra-Red Hematoma Imager (NIRD-HI)
Traumatic Brain Injury (TBI) is a leading cause of death and disability among military personnel, Veterans, and civilians. One of the most dangerous complications of moderate-to-severe TBI is intracranial hemorrhage (ICH).
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Combat Casualty Care, Point of Care
- Trial name
- NIRD-HI (NCT07338383)
- Testing
- NIRD-HI scan at the time of enrollment, Secondary NIRD-HI scan when a planned repeat CT is performed
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Geneva Foundation
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
Ischemic Stroke, Acute, Ischemia-reperfusion Injury
Clinical Significance of DKK2 Protein in Cerebral Ischemia-reperfusion Injury
The study is a two-center prospective cohort clinical trial. The primary purpose of this trial is to identify the pattern of DKK2 serum levels in ischemic stroke patients after revascularization therapy and determine the…
- Conditions
- Ischemic Stroke, Acute, Ischemia-reperfusion Injury, Cerebral Edema
- Trial name
- NCT05585255
- Testing
- enzyme-linked immunosorbent assay(ELISA)
- Where
- 2 sites in China
- Volunteers
- 108 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy
PK and Safety of Caffeine in Neonates With Hypoxic Ischemic Encephalopathy Receiving Therapeutic Hypothermia
A phase 1 study investigating the tolerability and pharmacokinetics of caffeine citrate in neonates with hypoxic ischemic encephalopathy receiving therapeutic hypothermia.
- Conditions
- Acute Kidney Injury, Hypoxic-Ischemic Encephalopathy, Caffeine
- Trial name
- NCT05295784
- Testing
- Caffeine citrate
- Where
- 2 sites in United States
- Sponsor
- University of Arkansas
Sport-related Concussion
Sub-acute Exercise Following Sport-Related Concussion
Determine the safety and efficacy of sub-maximal aerobic exercise during the subacute phase of recovery following sport-related concussion.
- Trial name
- NCT03575455
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Acute Ischemic Stroke
Rapid Local Ischemic Postconditioning on Stroke After Thrombectomy
The main goal of this study is to find out if a new, quick "brain rescue" procedure can help people recover better from a severe stroke caused by a large vessel occlusion.
- Trial name
- RAPIDIMPROVE (NCT07598799)
- Testing
- High-dose RL-IPostC, Low-dose RL-IPostC
- Where
- China
- Volunteers
- 448 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Magnetic Resonance Imaging, Neuronal Activity
Acute Pain Memory Among Former Burned: Exploration of fMRI.
Pain is complex phenomenon misunderstood in spite of medical progress and neurosciences. That's why the relief of chronic pain is only partial for a lot of infection as arthrosis, chronic back pain, headaches or neuropathic pain.
- Trial name
- EXPLO-DMA (NCT03224975)
- Testing
- fMRI
- Where
- France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Stroke, Stroke, Acute
Study of Allogeneic Umbilical Cord Blood Infusion for Adults With Ischemic Stroke
The primary objective of this study is to determine the efficacy of a single intravenous infusion of unrelated donor umbilical cord blood (UCB) for improving functional outcomes in patients with ischemic stroke.
- Conditions
- Stroke, Stroke, Acute, Brain Injury, Acute
- Trial name
- CoBIS 2 (NCT03004976)
- Testing
- Umbilical Cord Blood
- Where
- 6 sites in United States
- Volunteers
- 79 people
- Sponsor
- Joanne Kurtzberg, MD
Cerebral Injuries, Acute Respiratory Distress Syndrome (ARDS)
Alveolar Recruitment Maneuvers, Intracerebral Hemodynamic and Oxygenation
This study aims to compare 2 alveolar recruitment maneuvers (ARM) in patients with cerebral injuries and acute respiratory distress syndrome (ARDS) in term of efficacy and tolerance.
- Trial name
- M'RHICO (NCT02574169)
- Testing
- alveolar recruitment maneuvers group 1, alveolar recruitment maneuvers group 2
- Where
- 5 sites in France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Toulouse