Clinical trials: Injuries, Acute Brain
Brain Injuries
The Effect of Paracetamol on Brain Temperature
The main objective of this study is to compare the effect of intravenous paracetamol administration on mean brain temperature (measured between H0 and H6) in patients with cerebral hyperthermia versus placebo.
- Trial name
- NEUROTHERM (NCT03648021)
- Testing
- Paracetamol
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischemic Stroke, Acute, Myocardial Injury
Safety and Efficacy of Remote Ischemic Conditioning in Patients With Acute Myocardial Injury Following Acute Ischemic Stroke
Introduction: The management of acute myocardial injury following acute ischemic stroke (AMI-AIS), a frequent complication that severely worsens prognosis, is challenging.
- Trial name
- NCT07531394
- Testing
- Remote Ischemic Conditioning
- Volunteers
- 580 people
- Sponsor
- Capital Medical University
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Delirium, Ischemic Stroke
CTSN Embolic Protection Trial
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
- Conditions
- Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease
- Trial name
- EMPRO (NCT06027788)
- Testing
- CardioGard Embolic Protection Cannula, Standard Aortic Cannula
- Where
- 24 sites in United States, Canada
- Volunteers
- 842 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Brain Injury, Pupillary Reflex Impaired
Outcome pRognostication of Acute Brain Injury With the NeuroloGical Pupil indEx
The use of quantitative, automated, infrared technology for pupillary examination has long been used in ophthalmology and anesthesiology research.
- Trial name
- ORANGE (NCT04490005)
- Testing
- pupillometry
- Where
- 14 sites in United States, Belgium and 6 more
- Volunteers
- 118 people
- Sponsor
- University of Milano Bicocca
Stroke, Ischemic, Stroke Hemorrhagic
Exploring Accessible Beauty for Individuals With Upper Extremity Deficits
The purpose of this study is to investigate the accessibility of beauty products for individuals with upper extremity disabilities.
- Conditions
- Stroke, Ischemic, Stroke Hemorrhagic, Stroke (CVA) or TIA, Stroke, Acute
- Trial name
- NCT05945784
- Testing
- Use of Rare Beauty makeup products
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Acute Brain Injury
Safety and Efficacy of Wendan Decoction in Acute Moderated to Severe Brain Injury
Efficacy and safety of Traditional Chinese Medicine (Wendan decoction) combined with conventional neurologic intensive care in patients with acute moderated to severe brain injury in early stage - A randomized controlled study.
- Trial name
- NCT03851809
- Testing
- Wendan decoction combination in acute brain injury
- Volunteers
- 60 people
- Sponsor
- Taichung Tzu Chi Hospital
Traumatic Brain Injury
Early Digital, Analyte and Neurologic Biomarkers of Acute and Chronic Brain Injury and Recovery in CQT Instructors
Repetitive blast exposure has been shown to lead to more severe neurobehavioral impairments versus a single exposure. Blast-induced Traumatic Brain Injury (TBI) can lead to short- and long-term adverse outcomes Even mild brain…
- Trial name
- NCT05917665
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Acute Coronary Syndrome, Atrial Fibrillation
Short- and Long-term Health Effects of Air Pollution in Poland
The effects of air pollution on the frequency of hospital admissions and mortality due to acute coronary syndromes, atrial fibrillation, and renal disfunction are noted also in areas perceived as pollution-free (due to the lack…
- Conditions
- Acute Coronary Syndrome, Atrial Fibrillation, Kidney Diseases, Particulate Matter Inhalation Injury
- Trial name
- EP-PARTICLES (NCT05198492)
- Testing
- Impact of air pollution
- Where
- Poland
- Volunteers
- 8,300,000 people
- Sponsor
- Medical University of Bialystok
Traumatic Brain Injuries, Intracranial Hypertension
Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema.
- Trial name
- E-SPACE-TBI (NCT06776614)
- Testing
- Decompressive Craniectomy, Expansion Craniotomy
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Traumatic Brain Injury
Magnetic Resonance Elastography in Patients With Acute Closed Traumatic Brain Injury
Traumatic brain injury (TBI) is a major public health issue, and intracranial hypertension in the acute phase remains a critical scientific issue.
- Trial name
- NCT04361578
- Testing
- Magnetic resonance elastography
- Volunteers
- 43 people
- Sponsor
- Xiangya Hospital of Central South University
Sport-related Concussion
Sub-acute Exercise Following Sport-Related Concussion
Determine the safety and efficacy of sub-maximal aerobic exercise during the subacute phase of recovery following sport-related concussion.
- Trial name
- NCT03575455
- Testing
- Exercise
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Florida State University
Stroke, Stroke, Acute
Improving Medication Self-Administration and Health After Brain Injury
The purpose of this research study is to assess medication self-administration (MSA) and the impact of three different interventions on improving medication adherence.
- Conditions
- Stroke, Stroke, Acute, Cognitive Impairment, Brain Injuries, Traumatic
- Trial name
- NCT03885674
- Testing
- Video Call Reminder Condition, Automated Text Message Reminder Condition
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Kessler Foundation
Acute Brain Injuries
Dexmedetomidine-based Sedation in Neurocritical Care Patients
This will be an open, prospective pilot study with pharmacological analysis. This study is designed to assess the efficacity and safety of dexmedetomidine-based sedation in two subgroups of neurocritically ill patients requiring…
- Trial name
- NCT02252523
- Testing
- Dexmedetomidine
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Clermont-Ferrand
Intracranial Hypertension, Acute Brain Injury
Non-Invasive Triage for Intracranial Hypertension in Prehospital Care
This study tests whether two non-invasive tools can help paramedics detect dangerously high pressure inside the skull in patients with a sudden brain injury, such as stroke or head trauma, before they reach the hospital.
- Conditions
- Intracranial Hypertension, Acute Brain Injury, Stroke, Traumatic Brain Injury
- Trial name
- B4C-APH (NCT07747636)
- Testing
- Brain4care non-invasive intracranial pressure monitor, Optic nerve sheath diameter ultrasound
- Volunteers
- 180 people
- Sponsor
- Juliana Caldas
Spinal Cord Injuries, Cardiovascular Abnormalities
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls…
- Conditions
- Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
- Trial name
- NCT05542238
- Testing
- One bout of moderate-intensity sub-maximal aerobic exercise
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Acute Ischemic Stroke, Large Vessel Occlusion
Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion
The goal of this observational study is to describe the local change in interleukin-6 (IL-6) across a blood clot in adults with acute ischemic stroke caused by anterior circulation large vessel occlusion who are undergoing…
- Trial name
- IMPACT-LVO (NCT07754942)
- Testing
- Prospective Mechanical Thrombectomy Cohort
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Hospital Xiamen University
Brain Injuries, Traumatic
Multiomic Analysis of Body Fluid in Acute Traumatic Brain Injury
The goal of this experimental observation study is to figure out differently expressed biomarkers in body fluid in traumatic brain injury patients.
- Trial name
- MOSS-FAST (NCT05778123)
- Testing
- Type of disease
- Where
- China
- Volunteers
- 10 people
- Sponsor
- RenJi Hospital
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Acute Ischemic Stroke, Acute Renal Injury
Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation
The aim of this trial is to assess the safety and efficacy of conestat alfa (Ruconest®, Pharming Technologies B.V.) on renal and cerebral ischemic events in patients undergoing TAVI for severe symptomatic aortic stenosis (AS)…
- Trial name
- PAIR-TAVI (NCT05145283)
- Testing
- Conestat alfa (Ruconest®), NaCl 0.9%)
- Where
- 2 sites in Switzerland
- Volunteers
- 141 people
- Sponsor
- University Hospital, Basel, Switzerland