Clinical trials: Injuries, Acute Brain
Stroke, Cerebral Venous System
Study of Cerebral Venous System in Acute Ischemic Stroke Patients Receiving Reperfusion Therapy
The VAST study is a single-center prospective observational study that enrolled individuals with acute ischemic stroke (AIS) within 24 hours onset.
- Conditions
- Stroke, Cerebral Venous System, Reperfusion Injury
- Trial name
- VAST (NCT03838289)
- Testing
- multimodal magnetic resonance imaging or computed tomography
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Traumatic Brain Injury With Brief Loss of Consciousness
Multidisciplinary Treatment in Patients With Mild Traumatic Brain Injury
The aim of the study is to compare a multidisciplinary examination and follow up by rehabilitation program with a multidisciplinary examination, good advice and follow up by the family doctor.
- Trial name
- NCT00869154
- Testing
- primary care follow up, Multidisciplinary follow up
- Where
- 2 sites in Norway
- Volunteers
- 151 people
- Sponsor
- Haukeland University Hospital
Extracorporeal Membrane Oxygenation Complication, Acute Brain Injury
Assessing Brain Injury Using Portable Magnetic Resonance Imaging (MRI)
This study aims to assess the feasibility of assessing acute brain injury using a portable low field MRI in patients on ECMO.
- Trial name
- SAFE MRI (NCT05469139)
- Testing
- Portable MRI acquisition
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Johns Hopkins University
Aneurysm, Dissection
PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches
The purpose of this registry is to collect safety and performance data on all commercially available Terumo Aortic knitted and woven grafts, and cardiovascular patches in standard clinical practice.
- Conditions
- Aneurysm, Dissection, Aortic Root Aneurysm, Aortic Root Dissection
- Trial name
- PANTHER (NCT04545502)
- Testing
- Gelsoft Plus Vascular Graft, Vascular Bypass Graft, Cardiovascular Patch
- Where
- 30 sites in United States, Belgium and 4 more
- Volunteers
- 2,000 people
- Sponsor
- Vascutek Ltd.
Brain Injury, Head Injury
S100 Biomarker in the Acute Management of Mild Head Injuries
A prospective validation study of the "Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults".
- Trial name
- S100 (NCT02650765)
- Testing
- Indications for head CT imaging after acute head injury
- Where
- Finland
- Volunteers
- 295 people
- Sponsor
- Tampere University Hospital
Acute Ischemic Stroke, Reperfusion Injury
Wet and Dry Biomarkers to Predict Secondary Injury in Stroke: From Bench to Bedside - The NIMBLE Study
Infarct growth (IG), Hemorrhagic Transformation (HT) and Cerebral Edema (CE) can be considered pivotal phenomena of clinical deterioration following an acute ischemic stroke.
- Conditions
- Acute Ischemic Stroke, Reperfusion Injury, Cerebral Edema, Hemorrhagic Transformation Due to Acute Stroke
- Trial name
- NIMBLE (NCT07422636)
- Where
- Italy
- Volunteers
- 213 people
- Sponsor
- University of Florence
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Traumatic Brain Injury
Cerebrovascular Reactivity Assessed With fNIRS as a Biomarker of TCVI After Acute Traumatic Brain Injury in Military
The study includes people who have recently had a traumatic brain injury (TBI) and healthy controls who have not had a TBI and is designed to measure brain blood flow serially after a TBI.
- Trial name
- NCT04058132
- Testing
- Sildenafil Citrate 50Mg Tab, functional Near-infrared Spectroscopy (fNIRS), Carbon Dioxide (CO2) 5%
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Traumatic Brain Injury
Doxycycline in Acute Traumatic Brain Injury
evaluate the impact of Doxycycline on both clinical outcome and blood levels of NSE in patients with TBI.
- Trial name
- NCT04239755
- Testing
- Doxycycline 100 MG Oral Tablet
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Damanhour University
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Acute Subdural Hematoma
Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia in Acute Subdural Hematoma Patients
Consent will be taken from the relatives and the patient will be taken to the operating room. Inside the operation theatre patient will be shifted to operating table and standard monitors will be attached.
- Trial name
- NCT03146104
- Testing
- Propofol, Isoflurane
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Jawaharlal Institute of Postgraduate Medical Education & Research
EpiDural Hematoma, Traumatic Brain Injury
Acute EpiDural Hematoma Treated With Middle Meningeal Artery Embolization: a Randomized Trial (AEDH-MT)
A prospective, multicenter, randomized controlled, open-label, blinded endpoint evaluation study.
- Trial name
- AEDH-MT (NCT06292585)
- Testing
- MMA embolization plus medical therapy, Medical therapy alone
- Where
- China
- Volunteers
- 194 people
- Sponsor
- Changhai Hospital
Acute Ischemic Stroke, Stroke
MRI-SWI as a Predictor of Functional Outcome in Acute Ischemic Stroke
The purpose of the study is to use diffusion tensor imaging (DTI) derived axial diffusivity and susceptibility weighted imaging (SWI) to evaluate the severity of acute ischemic stroke and to predict its functional outcome.
- Conditions
- Acute Ischemic Stroke, Stroke, Cerebral Stroke, Cerebrovascular Accident
- Trial name
- NCT00696306
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Stroke, Acute, Traumatic Brain Injury
Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage.
- Trial name
- Navomuss (NCT06718608)
- Testing
- imaging
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Spinal Cord Injuries, Cardiovascular Abnormalities
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls…
- Conditions
- Spinal Cord Injuries, Cardiovascular Abnormalities, Cerebrovascular Disease; Sequelae, Cognitive Impairment
- Trial name
- NCT05542238
- Testing
- One bout of moderate-intensity sub-maximal aerobic exercise
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Brain Injury, Acute
Non-Invasive Monitoring Methods in Patients With Acute Brain Injury
Life-threatening mass effect (LTME) arises when brain swelling displaces or compresses crucial midline structures subsequent to acute brain injuries (ABIs) like traumatic brain injury (TBI), ischemic stroke (IS), and…
- Trial name
- NIMABI (NCT06504238)
- Where
- United States
- Volunteers
- 720 people
- Sponsor
- Boston Medical Center
Acute Brain Injuries
Building Resiliency in Patients Admitted to the Neuroscience Intensive Care Unit and Their Caregivers
The investigators will compare a dyadic intervention (Recovering Together) with an attention placebo educational control in dyads of patients with acute neurological illnesses and their caregivers at risk for chronic emotional…
- Trial name
- NCT03694678
- Testing
- Recovering Together
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Massachusetts General Hospital
Traumatic Brain Injury
Serum Neuroglobin and Nogo-A Concentrations in Acute Traumatic Brain Injury
Neuroglobin has been described as a marker of traumatic brain injury. Nogo-A plays an important role in mediating neuroanatomical plasticity and functional recovery following traumatic brain injury.
- Trial name
- NCT02229643
- Where
- China
- Volunteers
- 34 people
- Sponsor
- Shanghai 6th People's Hospital
Acute Brain Injuries, Consciousness Disorders
CONNECT-ME: Consciousness in Neurocritical Care Cohort Study Using fMRI and EEG
Detecting preserved consciousness in brain-injured patients by traditional clinical means requires presence of motor function. Otherwise, patients may be erroneously classified as being in a vegetative state.
- Trial name
- CONNECT-ME (NCT02644265)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Brain Injury, Neuropsychological Deficits
Cognitive Functions in Severe Acquired Brain Injury After Cranioplasty
Cranioplasty is the main reconstructive neurosurgical procedure, performed in approximately 80% of patients who have previously undergone demolitive surgeries in an emergency setting, particularly in the case of decompressive…
- Conditions
- Brain Injury, Neuropsychological Deficits, Cranioplasty, Cognitive Deficit Following Brain Lesions
- Trial name
- NeC (NCT06895109)
- Testing
- improvement of cognitive functions and psychological aspects
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS