Clinical trials: Injuries, Knee
Anterior Cruciate Ligament Injury
Anterior Cruciate Ligament Reconstruction: Residual Rotational Laxity for Single Versus Double Bundle Techniques
The main objective of this study is to compare, using MRI measures with a specialized splint, the persistent rotatory laxity after anterior cruciate ligament reconstruction using single bundle and double bundle surgical…
- Trial name
- LCA IRM (NCT01377129)
- Testing
- Single bundle anterior cruciate ligament reconstruction, Double bundle anterior cruciate ligament reconstruction
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Knee Injuries
Comparison Between the Use of the Tensioner and Standard Surgical Technique for Ligament Balancing of Total Knee Prostheses
the objective of the present study is to compare the post-operative laxity using stress radiographs and clinical scores in two groups of patients undergoing primary PS TKA with identical prosthetic model performed in two…
- Trial name
- NCT06770153
- Testing
- Tensor, standard
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Ortopedico Rizzoli
Anterior Cruciate Ligament Injury, Knee Injuries
Sensory Deficit Following ACL Reconstruction: PRF Pilot Study
Pilot, single-center, non-randomized, parallel-group clinical study designed to assess whether intraoperative application of autologous platelet-rich fibrin (PRF) at the bone-patellar tendon-bone (BPTB) donor site reduces…
- Conditions
- Anterior Cruciate Ligament Injury, Knee Injuries, Sensory Disorders, Bone-Patellar Tendon-Bone Autograft
- Trial name
- PRF-ACL (NCT07257666)
- Testing
- Platelet-rich fibrin (PRF), Standard Closure (Control)
- Where
- Serbia
- Volunteers
- 53 people
- Sponsor
- University of Belgrade
Tibial Plateau Fracture
Comparison of Functional Outcome Between Locking Plate Technique Versus Hybrid Ilizarov Technique in Patients With Schatzker Type V and VI Tibial Plateau Fractures
This comparative clinical study will evaluate and compare the functional outcomes of patients with Schatzker type V and VI tibial plateau fractures treated using either the locking plate technique or the hybrid Ilizarov…
- Trial name
- TPF (NCT07773402)
- Testing
- Hybrid Ilizarov Fixation, Locking Plate Fixation
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Prof. Sajjad Hussain Goraya
ACL Injury
Molecular Imaging Assessment of ACL Viability
The objective of this study is to answer the following questions: 1. Does the appearance of the reconstructed anterior cruciate ligament (ACL) vary in appearance on PET/MRI depending on graft type and time after surgery? 2.
- Trial name
- NCT03491046
- Testing
- PET scan, MRI scan
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of Cincinnati
Osteoarthritis (OA) of the Knee, Fracture
LinkSymphoKnee (LSK) Total Knee Replacement System Study - Ultra-congruent (UC)
To collect information about implant performance and patient clinical outcomes in patients undergoing primary total knee arthroplasty with the LinkSymphoKnee total knee replacement system with ultra-congruent tibial bearing…
- Conditions
- Osteoarthritis (OA) of the Knee, Fracture, Rheumatoid Arthritis
- Trial name
- NCT06670651
- Testing
- total knee arthroplasty device
- Where
- 2 sites in United States
- Volunteers
- 600 people
- Sponsor
- LinkBio Corp.
Cartilage Defects of the Knee
Long-term Safety and Efficacy of CartiFill After Microfracture Surgery in Knee Cartilage Defects
The purpose of this clinical trial is to evaluate the safety and efficacy of CartiFill implanted at the site of knee joint cartilage defect in a 6-year, long-term, follow-up investigation.
- Trial name
- NCT07621172
- Testing
- CartiFill, Microfracture
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Cellontech Co., Ltd.
Knee Ligament Injury
Comparison of ACL Reconstruction With Stump Preservation and Stump Resection
To assess the clinical outcome in patients who had ACL reconstruction with preservation of the remnant and compare it with patients in whom the stump was resected
- Trial name
- NCT05364398
- Testing
- ACL reconstruction
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Cairo University
ACL Injury, MRI
Evaluation of Anterior Cruciate Ligament Tears Using Diffusion Tractography
Knees injuries commonly affect the ACL. French current methodology is based on MRI focused on the knee with morphological sequences (T1, DP fat sat) allowing the study of ACL as follows: No lesion / Partial tear / Complete tear.
- Conditions
- ACL Injury, MRI, Tractography
- Trial name
- TRACTOLCA (NCT05806034)
- Testing
- tractography MRI sequence protocol
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Post-traumatic Osteoarthritis
A Biologic Joint Replacement Strategy to Treat Patients With Severe Knee Trauma and Post-Traumatic Knee Osteoarthritis
With IRB approval and informed consent, patients (n=10) (18-50 years old) with post-traumatic knee OA and requiring a tibial plateau and meniscus arthroplasty plus a femoral condyle arthroplasty will be enrolled in the study.
- Trial name
- NCT03257371
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- James Stannard
Surgical Site Infection
One Stage Versus Two Stage For Periprosthetic Hip And Knee Infection
The purpose of this study is to compare the outcomes of two different treatment options commonly used to manage periprosthetic joint infection (PJI), an infection around the artificial knee or hip.
- Trial name
- NCT02734134
- Testing
- One-stage exchange joint replacement surgery, Two-stage exchange joint replacement surgery
- Where
- 5 sites in United States
- Volunteers
- 343 people
- Sponsor
- OrthoCarolina Research Institute, Inc.
Stroke, Parkinson Disease
C-STAR Movement Database
The purpose of this study is to develop a database that contains movement and rehabilitation-related data collected through the use of wearable sensors and video.
- Conditions
- Stroke, Parkinson Disease, Lower Limb Amputation Above Knee (Injury), Lower Limb Amputation Below Knee (Injury)
- Trial name
- NCT05471375
- Testing
- Database Entry
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Shirley Ryan AbilityLab
Patellar Tendinopathy, Patellar Tendinitis
Continued Activity During Rehabilitation in Patients With Patellar Tendinopathy
This pilot study will evaluate the feasibility of pain-guided activity modification during rehabilitation for patellar tendinopathy.
- Conditions
- Patellar Tendinopathy, Patellar Tendinitis, Patellar Tendon Pain, Patellar Tendinosis
- Trial name
- NCT03694730
- Testing
- Exercise Treatment, Pain- Guided Activity Modification
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Delaware
ACL - Anterior Cruciate Ligament Rupture
Prospective Evaluation of Osseous Integration in ACL Reconstruction Comparing Tightrope vs Interference Screw Fixation
The purpose of our study was to compare osseous integration of the bone block in Achilles tendon allograft ACL reconstruction using a cortical button versus biocomposite interference screw fixation.
- Trial name
- NCT03841500
- Testing
- Biocomposite intereference screw femoral tunnel fixation, Endobutton (Tightrope) femoral tunnel fixation
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Kelsey-Seybold Clinic
Defect of Articular Cartilage, Articular Cartilage Disorder of Knee
the Safety and Efficacy Evaluation of Chondron Compared With Mircrofracture of Knee
The purpose of this study is to evaluate safety and efficacy of Chondron(autologous cultured Chondrocyte) by comparing between Chondron implantation and Microfracture.
- Conditions
- Defect of Articular Cartilage, Articular Cartilage Disorder of Knee, Degeneration; Articular Cartilage, Knee
- Trial name
- NCT02524509
- Where
- South Korea
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cellontech Co., Ltd.
Total Knee Arthroplasty, Post Operative Analgesia
Comparing Postoperative Functional Recovery and Analgesic Efficacy of a Single Shot Sciatic Nerve Block Versus Posterior Capsule/Fat Pad Infiltration of Local Anesthetic for Total Knee Arthroplasty
Many methods of pain relief have been implemented in an attempt to provide safe and effective analgesia for patients following total knee arthroplasty.
- Trial name
- NCT00677261
- Testing
- Sciatic Nerve Block, Posterior capsule infiltration with local anesthetic
- Where
- Canada
- Volunteers
- 104 people
- Sponsor
- Sunnybrook Health Sciences Centre
ACL Tear
Effects of Blood Flow Restriction Rehabilitation After Anterior Cruciate Ligament Reconstruction
The study is a prospective randomized control trial consisting of subjects requiring ACL reconstruction with BTB autograft. Subjects were randomly divided into two groups following their inclusion in the study.
- Trial name
- NCT04484961
- Testing
- Blood flow restriction (BFR)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The Methodist Hospital Research Institute
Anterior Cruciate Ligament Injuries
Comparison of Remnant-Preserving Anterior Cruciate Ligament Reconstruction With Healthy Controls
Anterior cruciate ligament reconstruction stabilizes the knee joint biomechanically and returns the patients back to the sportive activities.
- Trial name
- NCT05245461
- Testing
- Assessments
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Acibadem University
Tibial Plateau Fracture, Pain, Postoperative
Duloxetine Tibial Plateau
The purpose of this study is to determine if Duloxetine provides effective pain management for adult patients (18 or older) undergoing tibial plateau surgery.
- Trial name
- NCT04639011
- Testing
- Duloxetine, Standard of care (SOC) for tibial plateau surgery
- Where
- 2 sites in United States
- Sponsor
- Boston Medical Center
Osteoarthritis, Arthritis
Multicenter Orthopaedic Outcomes Network (MOON) ACL Reconstruction (ACLR): 10 Year Onsite Follow-up
In this study the investigators will examine patients who have undergone unilateral ACL reconstruction surgery to determine which structural and functional characteristics of the knee two and ten years post reconstruction…
- Conditions
- Osteoarthritis, Arthritis, Joint Diseases, Musculoskeletal Diseases
- Trial name
- NCT02717559
- Volunteers
- 225 people
- Sponsor
- Vanderbilt University Medical Center
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