Clinical trials: Injuries
Colon Cancer, Breast Cancer
SurgicAl Metabolic Phenotyping Longitudinal Evaluation Study
This work will use a new approach to measure how surgery effects human biochemistry and metabolism. It will create a metabolic signature or 'phenotype' for surgical injury that will help clinicians choose the right surgical…
- Conditions
- Colon Cancer, Breast Cancer, Trauma, Inflammatory Bowel Disease
- Trial name
- SaMPLE (NCT01378013)
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Renal Disease, End-Stage, Renal Insufficiency, Chronic
Bosutinib In Subjects With Renal Impairment
This is a two-staged study of a single dose of 200 mg of bosutinib given to subjects with renal impairment and matching healthy volunteers.
- Conditions
- Renal Disease, End-Stage, Renal Insufficiency, Chronic, Renal Insufficiency, Acute
- Trial name
- NCT01233882
- Testing
- Bosutinib
- Where
- 5 sites in United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Pfizer
Tick Bites, Tick-borne Diseases
Tick-borne Illness and Clothing Study of Rhode Island
Lyme and other tick-borne diseases pose a significant health threat to outdoor workers. This study is a double-blind randomized controlled trial of outdoor workers in Rhode Island and the surrounding area that will address the…
- Trial name
- NCT02613585
- Testing
- Permethrin Impregnated Clothing
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Traumatic Brain Injury
Evaluation of Mild TBI in Collegiate Athletes
The purpose of this study is to evaluate blood-based biomarkers before and after sports-induced concussion using neuroimaging and head impact sensor technology.
- Trial name
- AWARE (NCT02189525)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Banyan Biomarkers, Inc
Immune System
Inflammation and the Host Response to Injury (In Healthy Volunteers)
The body's immune response to injury or infection is very complex.Endotoxin is a man-made substance, which causes the body to "mimic" sickness (fever,chills, and achiness)for a few hours.
- Trial name
- Mono (NCT00820989)
- Testing
- Endotoxin, Lipopolysaccharide, LPS
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Rotator Cuff Tear, Pain, Postoperative
Single Shot Liposomal Bupivicaine in Rotator Cuff Surgery
This document is a protocol for a human research study. This study is to be conducted according to United States standards of Good Clinical Practice in accordance with applicable Federal regulations and institutional research…
- Trial name
- NCT03822182
- Testing
- liposomal bupivicaine, Dexamethasone
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy, Traumatic Brain Injury
Investigating Event-Related Potentials and Eye-Tracking Measures in Hockey Players
Traumatic brain injury (TBI) is a health issue impacting athletes and no clinical treatment protocol, other than rest, is yet established.
- Trial name
- NCT03975023
- Testing
- NeuroCatch Platform (NCP)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Frederick Carrick, PhD, FACCN
Spinal Cord Injuries, Neuropathic Pain
Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury
Many adults with spinal cord injury (SCI) suffer from long-term debilitating neuropathic pain. Available treatments, including opioids, are ineffective at eliminating this pain.
- Trial name
- NCT04706208
- Testing
- Cognitive Multisensory Therapy, Usual Care, Clinical Assessment
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Acute Kidney Injury, Exercise-associated Hyponatremia
Non-steroidal Anti-inflammatory Affect on Kidneys in Endurance Distances
The specific aim of this study is to evaluate the safety of non-steroidal anti-inflammatory drugs (NSAIDs) and their impact on renal function and/or contribution to exercise-associated hyponatremia (EAH) during an ultramarathon…
- Conditions
- Acute Kidney Injury, Exercise-associated Hyponatremia, Perceived Exertion
- Trial name
- NAKED (NCT02272725)
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pressure Injuries, Spinal Cord Injuries (SCI)
Electrical Stimulation for Clinical and Psychosocial Outcomes in Chronic Pressure Injuries
Pressure injuries are chronic wounds that frequently occur in immobilized patients and are associated with delayed healing, reduced quality of life, and significant psychological burden.
- Conditions
- Pressure Injuries, Spinal Cord Injuries (SCI), Traumatic Brain Injury
- Trial name
- NCT07493889
- Testing
- High-Voltage Monophasic Pulsed Current Electrical Stimulation, Standard Wound Care
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Basilar Thumb Arthritis, Wrist Fracture
Measurement of Grip and Pinch Forces Needed for Activities of Daily Living, Work and Prehistoric Stone Tool Production
Very little is known about the pinch and grip forces that are critical for activities of daily living (ADL) or work. Human success in evolution is a result of the combination of great brain power and great hand ability to…
- Conditions
- Basilar Thumb Arthritis, Wrist Fracture, Measure Pressure Distribution and Resultant Forces Needed
- Trial name
- NCT03316768
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Shaare Zedek Medical Center
Bullying, School Fear
Enhancing School Safety Officers' Effectiveness Through Online Professional and Job Embedded Coaching
The University of Florida's (UF) Lastinger Center for Learning, in partnership with the UF Psychology Department, have been funded by the National Institute of Justice to advance the skills of School Resource Officers (SROs)…
- Conditions
- Bullying, School Fear, Professional Role
- Trial name
- MiamiSROs (NCT03339648)
- Testing
- Professional Development Enhancement
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- University of Florida
Fear, GAD
Intracranial Neurophysiological Signatures of Fear and Anxiety in Humans
Anxiety disorders such as post-traumatic stress disorder (PTSD) and generalized anxiety disorder (GAD) affect a large number of individuals with a significant portion of patients failing to improve with current treatments.
- Conditions
- Fear, GAD, Emotional Memory, PTSD
- Trial name
- NCT05120635
- Testing
- Deep Brain Stimulation, Virtual and augmented reality tasks
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Concussion, Brain
Neurocognitive Dysfunction After Anesthesia in Patients With Recent Concussion
Researchers are trying to determine if the impact of a concussion on the brain is affected by anesthesia and surgery.
- Trial name
- NCT03952208
- Testing
- Neurocognitive Testing
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Hemorrhoidectomy, Hemorrhoids Third Degree
Comparison Study: Ligasure Versus Conventional Hemorrhoidectomy in III and IV Degree Hemorrhoids.
A comparison study was performed between Ligasure and Milligan morgan hemorrhoidectomy to find out the outcome between these two techniques in 3rd and 4th degree hemorrhoids.This advance vessel sealing device is used to seal the…
- Conditions
- Hemorrhoidectomy, Hemorrhoids Third Degree, Hemorrhoids Fourth Degree, Operative Time
- Trial name
- NCT03848468
- Testing
- Hemorrhoidectomy
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Services Hospital, Lahore
Paraplegia
High-intensity Interval Training for Cardiometabolic Health in Persons With Spinal Cord Injury
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population.
- Trial name
- NCT04397250
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Borderline Personality Disorder
Relationship Between Oxytocin Level, Trust, and Attachment in Individuals With Borderline Personality Disorder
We aim to assess the baseline oxytocin levels in individuals with borderline personality disorder and correlate those levels with social behavior, and compare the results with controls.
- Trial name
- NCT06045650
- Testing
- baseline serum oxytocin levels, Emotional Sensitivity test, Neuro-economical game
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
PTSD
Monoamine Transporters Genotypes: Risk of PTSD and Related Comorbidities
Dr. Wang's merit review is aimed at providing a better understanding of the relationship between SLC6A3/SLC6A4 and the mental health of veterans exposed to high levels of combat stress, specifically focusing on PTSD symptoms…
- Trial name
- MTG (NCT00403455)
- Testing
- Paroxetine
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hyperthermia, Kidney Injury, Acute
Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain
Prolonged, high intensity work in a hot environment results in significant strain on the body, known as heat strain. Heat strain in hot occupational settings such as agriculture, fire suppression, and military work can lead to…
- Trial name
- NCT05710978
- Testing
- Work Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Obstetric; Injury, Injury
Impact of Monitoring Quality Indicators in Maternity Departments on Mother and Infant Health
Hypothesis: Continuously monitor quality indicators with a specific method (CUSUM: Cumulative Sum) will increase the awareness of health care staff in maternity and permit rapid detection of a small dip in performance in order to…
- Trial name
- MATICUS (NCT01459978)
- Testing
- CUmulative SUM (CUSUM) Chart
- Where
- 2 sites in France
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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