Clinical trials: Innate Inflammatory Response
Neuromuscular Blockade, Innate Inflammatory Response
Impact of Deep Neuromuscular Blockade During Total Hip Replacement Surgery on Postoperative Recovery and Immune Function
Monocenter randomized controlled trial to compare the effect of deep neuromuscular blockade (NMB) versus moderate NMB during total hip replacement surgery on postoperative quality of recovery and innate immune function.
- Conditions
- Neuromuscular Blockade, Innate Inflammatory Response, Quality of Life, Postoperative Complications
- Trial name
- HIPPO (NCT05562999)
- Testing
- Rocuronium Bromide
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Radboud University Medical Center
Pneumonia, Necrotizing Soft Tissue Infection
The Role of Circadian Clock Proteins in Innate and Adaptive Immunity
Our data suggest that modulating the characteristics of light carries the potential to modify the host response to injury and critical illness and thus, improve outcome.
- Conditions
- Pneumonia, Necrotizing Soft Tissue Infection, Intraabdominal Infections, Infection Joint
- Trial name
- NCT03482245
- Testing
- Blue Light
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- Washington University School of Medicine
Sepsis Syndrome
Use of a Live Attenuated Vaccine as an Immune-based Preventive Against COVID-19-associated Sepsis
The objective of this randomized clinical trial is to test whether administration of live attenuated MMR vaccine (measles mumps rubella; Merck) to eligible adults at highest risk for contracting COVID-19 (healthcare workers…
- Trial name
- NCT04475081
- Testing
- MMR vaccine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Prematurity, Neonatal Sepsis
Defects in Opsonophagocytosis in Premature Infants
The purpose of the study is to characterize innate immune function of premature infants, and identify defects that may be responsible for the development of bacterial sepsis.
- Trial name
- NCT00866567
- Where
- Switzerland
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Endotoxemia
Effects of Vasopressors on Immune Response
Noradrenaline is a catecholamine and the cornerstone treatment for the improvement of hemodynamic parameters in septic shock. Catecholamines exert profound immunomodulatory effects.
- Trial name
- NCT02675868
- Testing
- Norepinephrine, Phenylephrine, Vasopressins
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Crohn Disease
The Innate Immune Response and Enteric Nervous System in Crohn's Disease.
The study aims to explore the relationships between inflammation, nerve changes, and the expression of interferon-stimulated proteins in inflamed and non-inflamed bowel areas from patients with Crohn's disease.
- Trial name
- NCT06485193
- Testing
- Immunohistochemistry
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Aalborg University Hospital
COVID-19, Microbial Colonization
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease
Determining whether in the mouth there are differences between the participant groups in the nature and activity of mucosal innate immunity, in immune responses to SARS-COV2 antigens, or in the oral microbiome
- Conditions
- COVID-19, Microbial Colonization, Oral Disease, Periodontal Diseases
- Trial name
- MIMSA (NCT05212766)
- Testing
- COVID infection, COVID vaccination, Oral examination
- Where
- United Kingdom
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- King's College London
Adult Respiratory Distress Syndrome, Pneumonia
Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome
The acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure with a mortality rate of approximately 40%.
- Conditions
- Adult Respiratory Distress Syndrome, Pneumonia, Sepsis
- Trial name
- NCT04079426
- Testing
- Sampling of Blood and bronchoalveolar lavage
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- University of Bonn
Endotoxemia
Anti-inflammatory Effects of Enriched Enteral Nutrition During Human Experimental Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- VIHE (NCT01100996)
- Testing
- control enteral nutrition, enriched enteral feeding
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Sepsis, Pneumonia
Genetic Variation and Immune Responses After Injury
Our overall hypothesis is that genetic variations in innate immunity genes predispose patients to varying responses after injury by altering the systemic and local inflammatory responses.
- Conditions
- Sepsis, Pneumonia, Trauma, Burn
- Trial name
- NCT00294697
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Aspirin-exacerbated Respiratory Disease
Mechanisms of Dupilumab in AERD
Aspirin-Exacerbated Respiratory Disease (AERD), although uncommon in the general population, is an important phenotype of severe asthma and nasal polyposis where it occurs in 15% of severe asthmatics, and up to 30% of those with…
- Trial name
- NCT05031455
- Testing
- Aspirin Challenge
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Scripps Clinic
Quorum Sensing, Prebiotics
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs).
- Conditions
- Quorum Sensing, Prebiotics, Probiotics, Sepsis
- Trial name
- NCT01201577
- Testing
- Bifidobacterium longum BB536, Active hexose correlated compound (AHCC), Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Viral Infection, Sepsis
COMPArative Study of the Consequence on innaTe Immune Response du to Bacterial or Viral Infection in Patients Admitted to Intensive Care Unit
Patient admitted in intensive care unit (ICU) for acute infection whether it be viral or bacterial had major impairment of the immune response.
- Trial name
- COMPACT (NCT05671159)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 38 people
- Sponsor
- University Hospital, Limoges
Vaginal Inflammation, Vaginal Infections
Identification of Novel Biomarkers of Cervicovaginal Mucosal Inflammation
This study investigates the response of vaginal and cervical tissue after exposure to three vaginal products: hydroxyethyl cellulose (HEC) placebo, nonoxynol-9 (N9) and imiquimod (IMQ) cream.
- Trial name
- Biomarkers (NCT01593124)
- Testing
- Imiquimod, Nonoxynol-9
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- CONRAD
Sepsis
The Impact of Zinc Supplementation on Innate Immunity and Patient Safety in Sepsis
Sepsis is the body's response to a life-threatening infection. This study will determine if zinc supplementation is safe to use in patients with severe sepsis or septic shock.
- Trial name
- NCT02130388
- Testing
- Zinc
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Ohio State University
Innate Inflammatory Response, Vaccination
PFAS Exposure and Immune Response to Vaccination in Adults
This clinical trial aims to investigate how exposure to Perfluorononanoic acid (PFNA), a type of per- and polyfluoroalkyl substance (PFAS), affects the immune response to the standard tetanus and diphtheria (Td) vaccine.
- Conditions
- Innate Inflammatory Response, Vaccination, Diphtheria, Tetanus
- Trial name
- NCT06588530
- Testing
- TENIVAC
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Pregnancy Related, Innate Inflammatory Response
Understanding Host-pathogen Interaction in the Respiratory Mucosa During Pregnancy
The clinical presentation of the ongoing coronavirus disease-19 (COVID-19) pandemic in pregnant women is unique with more asymptomatic infection, higher morbidity when symptomatic, yet without a difference in mortality rate.
- Trial name
- NCT04962477
- Testing
- Nasal brush sampling
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Allograft
Feasibility Study of Platelet Activation and Inflammatory Response of Platelets in Hematopoietic Stem Cell Allograft Patients Post-transplant: Spontaneously and After Stimulation by an CMV Antigen
Traditionally known for their role in haemostasis, platelets have also an immune role. Platelets play a key role in immune mediator secretion, and interact with innate and adaptive immune cells, contributing to the fight against…
- Trial name
- FIPALLOC (NCT03009708)
- Testing
- Blood samples
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Institut de Cancérologie de la Loire
Endotoxemia
The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia
During sepsis and septic shock the immune response can be overwhelming leading to excessive tissue damage, organ failure and death.
- Trial name
- NCT01091571
- Testing
- Dipyridamole, LPS
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endotoxemia, Inflammation
In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Excessive inflammation is associated with tissue damage caused by over-activation of the innate immune system. This can range from mild disease to extreme conditions such as multiple organ failure (MOF).
- Conditions
- Endotoxemia, Inflammation, Multi Organ Dysfunction Syndrome
- Trial name
- VECTOR (NCT00785018)
- Testing
- C1-esterase inhibitor, Endotoxin administration
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center