Clinical trials: Innovative Procedures
Prediabetes
Fiber mHealth Intervention for Prediabetes
This is a single-arm feasibility trial to examine an mHealth intervention that combines high fiber education, home-delivered high fiber foods, and use of continuous glucose monitors.
- Trial name
- GO-FAR (NCT07491653)
- Testing
- GO-FAR
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Oklahoma
Tobacco Use Disorder, Substance Use Disorders
A Digital Smoking Cessation Intervention for Adults With Substance Use Disorder
Adults with substance use disorder (SUD) tend to have started smoking at a younger age and are more likely to be heavy smokers. Due to the many conflicting priorities in this population, smoking cessation is often relegated and…
- Trial name
- NCT04419922
- Testing
- Smartphone Contingency Management Intervention
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- BrightView LLC
Chronic Pain
Acceptance and Commitment Therapy and Cognitive Behavioral Therapy for Chronic Pain
Chronic pain is a long-term condition which is related to a number of negative consequences including reduced productivity at work, increased number of sick leave , depression and emotional difficulties among others.
- Trial name
- ALGEA (NCT02778737)
- Testing
- ACT-based intervention, CBT-based intervention
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Cyprus
Health Knowledge Attitudes and Practice, Breast Feeding
Promotion of Breast Milk Donation in Breastfeeding Mothers Through a Mobile Health Intervention Using Amamantapp
In Peru, 7 out of 10 preterm babies die due to health complications. These newborns often cannot be breastfed by their own mothers and urgently need donated breast milk (BM) to survive.
- Trial name
- NCT07477041
- Testing
- Education on human milk donation via a mobile app Amamantapp, Education via printed leaflets
- Where
- Peru
- Volunteers
- 112 people
- Sponsor
- National University of San Marcos, Peru
HIV-1
Prevention of Mother-to-child Transmission of HIV-1 Using a Responsive Intervention
The second visit of the Expanded Programme of Immunization when the child is 2 months old (EPI-2) represents a unique opportunity to link the EPI and PMTCT programmes and to introduce preventive and therapeutic rescue…
- Trial name
- PROMISE-EPI (NCT03870438)
- Testing
- Lamivudine Oral Solution
- Where
- 6 sites in Burkina Faso, Zambia
- Volunteers
- 1,506 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Asthma
MISSION Severe Asthma Modern Innovative Solutions to Improve Outcomes in Severe Asthma.
MISSION is a new and novel way of delivering highly specialised asthma care and has the potential to change the way asthma care across the United Kingdom (UK) is delivered as well as services for other long term health…
- Trial name
- MISSION (NCT02509130)
- Where
- United Kingdom
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Portsmouth Hospitals NHS Trust
Caregiver Burden, Dementia
Mobile App Intervention for Informal Dementia Caregivers
Informal caregivers of persons with dementia (PWD) usually experience elevated levels of caregiving burden and potential depression.
- Conditions
- Caregiver Burden, Dementia, Digital Health
- Trial name
- NCT05551533
- Testing
- Kampung Care App
- Where
- Singapore
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Institute of Mental Health, Singapore
Normobaric Hypoxia, Hypoventilation
"Living Low - Training High" Methods and Physiological Responses in Well-trained Swimmers
To overcome the lack of knowledge regarding the impact of different "living low, training high" methods on swimming performance, a 4-week intervention will be carried out to determine and compare the effects of three Repeated…
- Conditions
- Normobaric Hypoxia, Hypoventilation, Normoxia
- Trial name
- NCT06253039
- Testing
- Repeated sprint
- Where
- Portugal
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Motor Disorders
Using Telerehabilitation to Support Families of Children With Motor Difficulties Aged 3-8 Years Old
Background: Many children (about 1 child out of 20) have motor delays that are sometimes seen as "minor" and are not immediately explained by a specific diagnosis.
- Trial name
- WeCare (NCT04254302)
- Testing
- WECARE web platform
- Where
- Canada
- Volunteers
- 118 people
- Sponsor
- Université de Sherbrooke
Knee Arthroplasty
Technology Interventions to Improve Outcomes After Knee Replacement
The purpose of this study is to examine the effects of two technology interventions on health outcomes (e.g., physical activity, sedentary behavior, physical function, pain) after knee replacement at 2 and 5 months .
- Trial name
- NCT04482400
- Testing
- NEAT!2, MyKneeGuide
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
MYOPIA
Myopia Adjustment Using Dual-intervention: Red-Light Therapy & Innovative Design in Orthokeratology
This clinical trial investigates the efficacy of combining orthokeratology (OK) lenses with repeated low-level red-light (R.L.R.L.) therapy in slowing the progression of myopia in children classified as ortho-k non-responders.
- Trial name
- MADRID (NCT06899139)
- Testing
- Orthokeratology Lens Wear, Repeated Low-Level Red-Light Therapy Intervention Type: Device Description: Participants in the experimental group will receive repeated low-level red-light (R.L.R.L.) therapy twice daily using a no
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Centro de Miopía Fernández-Velázquez
Esophageal Neoplasms
Innovative MRI Techniques to Improve Treatment Stratification of Patients With Esophageal Cancer
The current standard treatment of resectable esophageal cancer consists of neoadjuvant chemoradiation followed by resection. However, some patients develop recurrent disease despite chemoradiation and additional (systemic)…
- Trial name
- IMPROVE (NCT02253602)
- Testing
- Ferumoxytol
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Heart Failure
An Innovative Mobile Health Intervention to Improve Self-care in Patients With Heart Failure
Heart failure (HF) is associated with high mortality and hospitalization rates. Prior studies show that adherence to routine HF self-care behaviors reduces the risk of all-cause mortality and HF-related hospitalizations, and…
- Trial name
- NCT04262544
- Testing
- iCardia4HF, Usual Care
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- University of Illinois Chicago
Multiple Chronic Conditions, Disability Physical
Behavioral Activation + Occupational Therapy
Approximately 45% of older adults in the U.S. have 2 or more chronic health conditions (e.g., arthritis, hypertension, diabetes) in addition to functional limitations that prevent performance of health self-management activities.
- Trial name
- BA+OT (NCT05600465)
- Testing
- Behavioral Activation + Occupational Therapy, Enhanced Usual Care
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Oklahoma
Overweight and Obesity
Rapid Evaluation of Innovative Intervention Components to Maximize the Health Benefits of Behavioral Obesity Treatment Delivered Online: An Application of Multiphase Optimization Strategy
When delivered online, behavioral obesity treatments have the potential to reach large numbers of individuals with overweight/obesity and produce significant improvements in health and wellbeing.
- Trial name
- NCT04520256
- Testing
- Online Behavioral Weight Loss Program, Virtual Reality for Behavioral Weight Loss Skills Training, Tailored Interactive Video Feedback
- Where
- United States
- Volunteers
- 384 people
- Sponsor
- The Miriam Hospital
Smoking, Pain
Online Automated Self-Hypnosis Program
After developing professional quality materials (audio) for an affordable automated self-hypnosis intervention program for facilitating smoking cessation, stress and pain reduction, researchers aim to gain qualitative reviews of…
- Conditions
- Smoking, Pain, Stress
- Trial name
- NCT03931772
- Testing
- Automated Self-Hypnosis
- Where
- 2 sites in United States
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Stanford University
Parkinson Disease
Tai Chi Intervention by Telerehabilitation
Rational : A lot of people in the province of Quebec suffer from Parkinson's disease and they are mostly vulnerable because they gradually lose their autonomy with the worsening of the disease.
- Trial name
- TeleParkinson (NCT03985631)
- Testing
- Rehabilitation intervention
- Where
- 2 sites in Canada
- Volunteers
- 2 people
- Sponsor
- Université de Sherbrooke
Child Obesity, Nutrition, Healthy
Healthy Start: Family Childcare Providers and Parents
The preschool years are a critical time for shaping food preferences and eating behaviors, which affect dietary behaviors in adults and life-long risks for obesity, diabetes, cardiovascular disease, and other chronic conditions.
- Trial name
- NCT06978270
- Testing
- Healthy Eating: Provider and Parent Components, Healthy Start: Reading Readiness Childcare Proiver and Parent Materials
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Brown University
Newly Diagnosed Multiple Myeloma (NDMM)
Positron Emission Tomography With Innovative Laboratory Techniques for Improved Risk and Disease Assessment in Newly Diagnosed Multiple Myeloma Patients
This study investigates newly diagnosed multiple myeloma patients following standard of care treatment. The primary endpoint of the study is to determine minimal residual disease (MRD) by combining 2 techniques in order to better…
- Trial name
- IMMPROVED (NCT07087964)
- Where
- 4 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Universiteit Antwerpen
Tobacco Cessation
Addressing Tobacco Use Disparities in Rural Older Adults Through an Innovative Mobile Phone Intervention
The purpose of this study is to evaluate the feasibility, acceptability and preliminary efficacy of a Scheduled Gradual Reduction (SGR) intervention via SMS (short message service) text messaging plus SMS Support Messages in…
- Trial name
- NCT02510716
- Testing
- SGR, Support message only
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University