Clinical trials: Inoperable Disease
Colorectal Cancer
Endoscopic Treatment of Inoperable Colorectal Cancer With the EndoVe System
A new approach to treating solid tumours (both operable and inoperable) has been carried out by the Cork Cancer Research Centre (CCRC) at the Mercy University Hospital, Cork, Ireland since 2002.
- Trial name
- CCEE EndoVe (NCT01172860)
- Testing
- EndoVe endoscopic electroporation
- Where
- Ireland
- Volunteers
- 10 people
- Sponsor
- Mercy University Hospital, Cork, Ireland
Hepatocellular Carcinoma, Stage I Hepatocellular Carcinoma AJCC v8
Y-90 Versus SBRT for Inoperable HCC
This phase II trial tests whether Y-90 segmentectomy (internal radiation) versus stereotactic body radiation therapy (external radiation) is more optimal in treating inoperable liver cancer.
- Conditions
- Hepatocellular Carcinoma, Stage I Hepatocellular Carcinoma AJCC v8, Stage IA Hepatocellular Carcinoma AJCC v8, Stage IB Hepatocellular Carcinoma AJCC v8
- Trial name
- NCT05157451
- Testing
- Quality of Life, Questionnaire Administration, Stereotactic Body Radiation Therapy
- Sponsor
- OHSU Knight Cancer Institute
Neurofibroma, Plexiform
Observational Study to Evaluate the Effect and Safety of Selumetinib in Pediatric Patients With NF1-PNs
This is a prospective, multicenter, observational study of Chinese pediatric NF1-PN patients treated with selumetinib. The study will be conducted at approximately 12 centers in China and will include approximately 80-100…
- Trial name
- PEDIA (NCT06175637)
- Where
- 25 sites in China
- Volunteers
- 409 people
- Sponsor
- AstraZeneca
Non Small Cell Lung Cancer
131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With Locally-advanced Non Small Cell Lung Cancer (NSCLC)
The aim of this feasibility study is to determine the therapeutic potential of the L19SIP antibody, labeled with the radionuclide 131I in combination with radiochemotherapy, for the treatment of patients with newly diagnosed…
- Trial name
- NCT01124812
- Testing
- 131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiotherapy (EBRT) and Concurrent Chemotherapy
- Where
- 2 sites in Italy
- Volunteers
- 3 people
- Sponsor
- Philogen S.p.A.
Coronary Artery Disease
Endothelial Modulation for Angiogenic Therapy
Coronary artery disease is the single most important killer of Canadians. Despite major advances in therapy, there is still a significant proportion of patients identified with the disease who die of it because current treatment…
- Trial name
- NCT00134433
- Testing
- intramyocardial VEGF angiogenesis (at a dose of 2 mg), oral L-arginine supplementation (at a dose of 6 g/day)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Pancreas Cancer
Sintilimab Combined With Chemotherapy and Radiotherapy in Patients With Inoperable Pancreatic Cancer
Hypothesis: Survival benefits could be found in Sintilimab plus chemotherapy and radiotherapy in patients with inoperable pancreatic cancer.
- Trial name
- NCT06050317
- Testing
- Sintilimab Plus mFFN or NALIRIFOX and Radiation
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Shandong Cancer Hospital and Institute
HPV-unrelated Head and Neck Squamous Cell Carcinoma
Induction PD-1 Inhibitor and Chemotherapy Followed by Chemoradiotherapy in Unresectable or Inoperable HPV-negative LA-HNSCC
The goal of this clinical trial is to evaluate if adding chemotherapy and immunotherapy as induction treatment prior to definitive chemoradiotherapy could improve the outcomes of locally advanced HPV-negative head and neck…
- Trial name
- NCT07776340
- Testing
- Tislelizumab, Paclitaxel, Cisplatin (75 mg/m2)
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Fudan University
Intestinal Obstruction
Study to Assess Efficacy and Safety of Lanreotide Autogel 120 MG in Treatment of Clinical Symptoms Associated With Inoperable Malignant Intestinal Obstruction
To assess the efficacy of Lanreotide Autogel 120 mg for the relief of vomiting due to inoperable malignant intestinal obstruction in patients without nasogastric tube (NGT) and to assess the efficacy of lanreotide Autogel 120 mg…
- Trial name
- IMIO (NCT02275338)
- Testing
- Lanreotide Autogel
- Where
- 17 sites in Belgium
- Volunteers
- 52 people
- Sponsor
- Ipsen
Melanoma
Safety and Efficacy of Combination HDI and Anti-CTLA4 for Recurrent Inoperable Stage III or Stage IV Melanoma
To determine the safety and efficacy of the combination of HDI and anti-CTLA-4 monoclonal antibody for patients with recurrent inoperable stage III or stage IV melanoma.
- Trial name
- NCT00610857
- Testing
- Anti-CTLA4 monoclonal antibody and HDI
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Ahmad Tarhini
Advanced Non Small Cell Lung Cancer, Advanced (Inoperable) Non Small Cell Lung Cancer
AZD9291 First Time In Patients Ascending Dose Study
This study will treat patients with advanced NSCLC who have already received at least one course of specific anti-cancer treatment but the tumour has started to re-grow following that treatment.
- Trial name
- AURA (NCT01802632)
- Testing
- AZD9291
- Where
- 45 sites in United States, Australia and 8 more
- Volunteers
- 603 people
- Sponsor
- AstraZeneca
CNS Cancer, Meningioma
Phase II Trial of Sunitinib (SU011248) in Patients With Recurrent or Inoperable Meningioma
The purpose of this study is to find out what effects, good and/or bad, sunitinib has on patients and their tumors. At this time, no drugs are routinely used to treat meningioma, hemangioblastoma or hemangiopericytoma.
- Conditions
- CNS Cancer, Meningioma, Intracranial Hemangiopericytoma, Hemangioblastoma
- Trial name
- NCT00589784
- Testing
- Sunitinib
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Breast Cancer
A Study to Learn About the Relationship Between Hepatic Impairment and Myelosuppression (Decreased Bone Marrow Function) in Breast Cancer Patients Treated With the Study Medicine Palbociclib (Pal-bow-sai-klib)
The purpose of this study is to evaluate incidence of grade 4 neutropenia in patients who have hepatic impairment and use the study medicine Palbociclib.This study is seeking participants: - treated with the study medicine…
- Trial name
- NCT05912933
- Where
- United States
- Volunteers
- 1,342 people
- Sponsor
- Pfizer
Endometrial Cancer, Cancer of the Endometrium
TSR-042 in Addition to Standard of Care Definitive Radiation for Inoperable Endometrial Cancer
Patients with inoperable endometrial cancer have limited treatment options. PD-L1 expression is common in endometrial cancers and RT induces tumor and systemic changes that induce the immune system.
- Trial name
- NCT03955978
- Testing
- TSR-042, Brachytherapy, Endometrial biopsy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Carcinoma, Non-Small-Cell Lung
The Addition of Metformin to Definitive Radiotherapy in Patients With Stage III NSCLC
Study the effect of metformin when added to definitive locoregional radiotherapy on locoregional control and relapse rate in stage III non-small cell lung cancer patients receiving sequential chemoradiotherapy.
- Trial name
- RADFORMIN (NCT04170959)
- Testing
- Metformin, No metformin
- Where
- Belgium
- Volunteers
- 3 people
- Sponsor
- ethisch.comite@uza.be
Grade 1 Meningioma, Grade 2 Meningioma
Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy
This phase II trial studies how well lutathera works in treating patients with meningioma that cannot be treated with surgery (inoperable) and is growing, spreading, or getting worse (progressive) after external beam radiation…
- Conditions
- Grade 1 Meningioma, Grade 2 Meningioma, Grade 3 Meningioma, Recurrent Meningioma
- Trial name
- NCT04082520
- Testing
- Gallium Ga 68-DOTATATE, Lutetium Lu 177 Dotatate, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Mayo Clinic
Triple Negative Breast Cancer(TNBC)
PM8002 or Placebo Plus Nab-Paclitaxel as First-line Treatment in Inoperable Locally Advanced/Metastatic TNBC
This multicenter, randomized, double-blind study will evaluate the safety and efficacy of PM8002 in combination with Nab-Paclitaxel compared with placebo combined with Nab-Paclitaxel as first-line treatment in inoperable locally…
- Trial name
- NCT06419621
- Testing
- PM8002, Nab-Paclitaxel
- Where
- 70 sites in China
- Volunteers
- 392 people
- Sponsor
- Biotheus Inc.
Non Small Cell Lung Cancer, Immunotherapy
RADICAL-IO: thRee Cycles of immunotherApy Without raDical Therapy In mediCALly InOperable Stage I Non-small Cell Lung Cancer
Traditionally, chemotherapy and/or immunotherapy are combined with surgery or radiotherapy to cure patients with lung cancer. However, some patients treated with immunotherapy appear to be cured before surgery or radiotherapy.
- Trial name
- RADICAL-IO (NCT07808138)
- Testing
- Cemiplimab 350 mg IV
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- The Netherlands Cancer Institute
Pancreatic Cancer
Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas
The prognosis for patients with localized pancreatic adenocarcinoma who are not surgical candidates is poor. Patients characterized as having "borderline resectable" disease treated with preoperative chemo-radiotherapy fair…
- Trial name
- NCT02598349
- Testing
- Proton Radiation, Capecitabine, Surgical resection
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- Proton Collaborative Group
Non-small Cell Lung Cancer (NSCLC), Huaier Granules
Clinical Efficacy and Safety of Microwave Ablation Combined With Huaier Granules in Patients With Inoperable Stage IA Non-Small Cell Lung Cancer: A Prospective, Single-Center, Randomized Controlled Clinical Trial
This prospective, single-center, randomized controlled clinical trial aims to evaluate the efficacy and safety of microwave ablation (MWA) combined with Huaier granules in patients with inoperable stage IA non-small cell lung…
- Conditions
- Non-small Cell Lung Cancer (NSCLC), Huaier Granules, Microwave Ablation
- Trial name
- HAMSTER (NCT07197853)
- Testing
- Huaier Granule
- Volunteers
- 180 people
- Sponsor
- Xin Ye
Mediastinal Tumor
MR-linac Guided Adaptive Radiotherapy for Inoperable Mediastinal Tumor
This Phase II study is to determine the efficacy and safety of MR-Linac Guided Radiotherapy in patients with inoperable mediastinal tumors.
- Trial name
- NCT05163509
- Testing
- Unity-based MR-Linac guided Radiotherapy
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Sun Yat-sen University