Clinical trials: Insufficiency, Pulmonary
ARDS, Human, COVID
Senicapoc in COVID-19 Patients With Severe Respiratory Insufficiency
SARS-CoV-2, one of a family of human coronaviruses, was initially identified in December 2019 in Wuhan city. This new coronavirus causes a disease that has now been named COVID-19.
- Trial name
- COVIPOC (NCT04594668)
- Testing
- Senicapoc
- Where
- 4 sites in Denmark
- Volunteers
- 46 people
- Sponsor
- University of Aarhus
COPD, Lung Function Decreased
Permian Health Women's Lung Health Study
The goal of this cross-sectional observational study is to estimate the prevalence of lung function impairment as measured by spirometry in a population of Gambian women aged 15 and older.
- Conditions
- COPD, Lung Function Decreased, Alpha 1-Antitrypsin
- Trial name
- WLHS (NCT06029543)
- Where
- The Gambia
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Permian Health Lung Institute
Pulmonary Disease, Chronic Obstructive, Noninvasive Ventilation
NIV for COPD: Hospital to Home
This is a pilot study to evaluate the impact of providing patients admitted with acute exacerbations of COPD (AECOPD) with non-invasive ventilation (NIV)home devices prior to discharge on hospital readmission rates and other…
- Trial name
- H2H (NCT04413643)
- Testing
- Noninvasive Ventilation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- San Francisco Veterans Affairs Medical Center
Systemic Sclerosis, Diaphragm Defect
Muscular Respiratory Involvement and Systemic Sclerosis
Dyspnea in systemic sclerosis (ScS) constitute a major factor of functional disability. Intensity of dyspnea is sometimes discordant with objectives data from cardiopulmonary involvements, suggesting unknown additional factors.
- Conditions
- Systemic Sclerosis, Diaphragm Defect, Respiratory Insufficiency, Pulmonary Function Test
- Trial name
- SIROCO (NCT04118725)
- Testing
- Pulmonary function test
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Poitiers University Hospital
Dementia, Diabetes Mellitus
Impact of Lifestyle Modification on the Development of Dementia, Chronic Kidney Disease, Diabetes, Chronic Obstructive Pulmonary Disease, Cancers and Cardiovascular Disease in a Thai General Population
This is a community-based cluster randomized control trial aimed to investigate the impact of lifestyle modification (diet, physical activity, alcohol drinking and smoking) on the development of dementia, diabetes, chronic kidney…
- Conditions
- Dementia, Diabetes Mellitus, Chronic Kidney Disease, Cardiovascular Diseases
- Trial name
- NCT02967406
- Testing
- 4 x 4 lifestyle modification
- Where
- Thailand
- Volunteers
- 3,600 people, healthy volunteers welcome
- Sponsor
- Sanpasitthiprasong Hospital
Acute Kidney Injury, Surgery
Risk Factors for AKI in Patients Undergoing VATS for Pulmonary Resection
This study aims to investigate the potential factors contributing to the development of Acute Kidney Injury (AKI) in patients undergoing pulmonary resection with Video Assisted Thoracoscopic Surgery (VATS) for lung malignancy.
- Conditions
- Acute Kidney Injury, Surgery, Lung Cancer
- Trial name
- NCT06341933
- Testing
- Duration of Surgery, Volume of Fluid in Surgery, Blood Loss
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Mechanical Ventilation Complication, Diaphragm Injury
Respiratory Muscle Structure and Function in Mechanically Ventilated Patients and Long-term Outcomes
Air is normally pumped in and out of the lungs by the muscles that contribute to inhalation and exhalation, called the respiratory muscles.
- Conditions
- Mechanical Ventilation Complication, Diaphragm Injury, Lung Injury, Respiratory Insufficiency
- Trial name
- RESPIRE (NCT05857774)
- Testing
- Sonographic measurements, Physiological measurements, Biological measurements
- Where
- Canada
- Volunteers
- 230 people
- Sponsor
- University Health Network, Toronto
Respiratory Insufficiency
Evaluation of Leak-free Bronchoscope Adapter
Patients who develop respiratory failure require the assistance of mechanical ventilation while recovering from their respiratory injury.
- Trial name
- NCT05288218
- Testing
- Leak-free Bronchoscope Adapter, Standard Bronchoscope Adapter
- Volunteers
- healthy volunteers welcome
- Sponsor
- Columbia University
Adrenal Insufficiency, Inflammatory Lung Diseases
The Significance of Defensin Alpha 4 in the Pathophysiology of the Adrenal Insufficiency in Inflammatory Lung Diseases
The pathophysiology of the adrenal insufficiency of patients with critical diseases remains unclear. In a prior exploratory study investigating patients with exacerbation of chronic obstructive pulmonary disease (COPD), the…
- Trial name
- NCT01703013
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cantonal Hospital of St. Gallen
Infant, Newborn, Respiratory Distress Syndrome
Early Surfactant to Reduce Use of Mechanical Breathing in Low Birth Weight Infants
Mechanical ventilation (MV) of preterm infants with respiratory distress syndrome (RDS) is associated with lung injury and nosocomial infection.
- Conditions
- Infant, Newborn, Respiratory Distress Syndrome, Respiratory Insufficiency
- Trial name
- Surfactant 2 (NCT00005774)
- Testing
- Early surfactant, Standard practice
- Where
- 13 sites in United States
- Volunteers
- 61 people
- Sponsor
- NICHD Neonatal Research Network
COPD, Pre-Lung-Transplantation
Pulmonary Rehabilitation in Patients Before Lung Transplantation (LTx)
The purpose of this study is to study the effects of a complex pulmonary rehabilitation program on mobility measured by 6 minute walking distance (6MWD) and physical activity, measured via Dynaport and Actibelt Aktivitätsmonitor…
- Conditions
- COPD, Pre-Lung-Transplantation, Hypercapnia, Respiratory Insufficiency
- Trial name
- NCT00962078
- Testing
- continuous endurance training, interval training
- Where
- Germany
- Volunteers
- 71 people
- Sponsor
- Schön Klinik Berchtesgadener Land
Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD)
Improving Clinician Communication Skills (ICCS)
This research study is a randomized trial to evaluate a training program that is designed to improve the communication skills of clinicians.
- Conditions
- Advanced Cancer, Chronic Obstructive Pulmonary Disease (COPD), Restrictive Lung Disease, Congestive Heart Failure
- Trial name
- ICCS (NCT00687349)
- Testing
- Training Program Intervention
- Where
- 4 sites in United States
- Volunteers
- 6,086 people
- Sponsor
- University of Washington
Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome)
The Impact of Low Versus High Positive End-expiratory Pressure on Diaphragm Function, Ventilation Efficiency, and Lung Mechanics
The goal of this interventional study is to evaluate the effect of different positive end-expiratory pressures (PEEP) on lung and diaphragm function in patients mechanically ventilated with pressure support ventilation in the…
- Conditions
- Respiratory Failure, ARDS (Acute Respiratory Distress Syndrome), Pneumonia, Respiratory Insufficiency
- Trial name
- INFLATE-ICU (NCT07188038)
- Testing
- Low positive end-expiratory pressure, Medium positive end-expiratory pressure, High positive end-expiratory pressure
- Where
- 2 sites in Sweden
- Volunteers
- 25 people
- Sponsor
- Vastra Gotaland Region
Heart Failure, Chronic Obstructive Pulmonary Disease
Metabolic Changes in Patients With Chronic Cardiopulmonary Disease
This study aims to evaluate prevalence of sarcopenia and cachexia in patients with chronic cardiopulmonary disease. The investigators will also investigate metabolic disorders like glucose metabolism, presence of metabolic…
- Conditions
- Heart Failure, Chronic Obstructive Pulmonary Disease, Malignancy, Chronic Kidney Disease
- Trial name
- NCT02550808
- Where
- Slovenia
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- General and Teaching Hospital Celje
Pulmonary Hypertension, Chronic Kidney Disease
Association Between Biomarkers and Kidney Function Decline in Pulmonary Hypertension
The objective of this study is to examine the association between urinary and plasma biomarkers and change in estimated glomerular filtration rate (eGFR) among patients with pulmonary hypertension (PH).
- Trial name
- NCT06409624
- Testing
- No intervention is planned as part of the study
- Where
- 2 sites in Germany
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Bronchial Asthma, Bronchiectasis
The Use of Entropy to Assess Sleep Disordered Breathing in Chronic Respiratory Disease
Research is being conducted into chronic respiratory diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease, and bronchiectasis.
- Conditions
- Bronchial Asthma, Bronchiectasis, ILD, COPD
- Trial name
- NCT07060079
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University College, London
Vascular Diseases, Embolism and Thrombosis
Epidemiology of Thromboembolism Disease: A Cohort Study
The purpose of this study is to determine different risk factors of thromboembolic disease. Different points will be studied 1. do different types of thromboembolic disease (distal Deep Vein Thrombosis (DVT), proximal DVT…
- Conditions
- Vascular Diseases, Embolism and Thrombosis, Phlebitis, Venous Insufficiency
- Trial name
- OPTIMEV (NCT00670540)
- Testing
- procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosis
- Where
- 231 sites in Belgium, France and 1 more
- Volunteers
- 8,256 people
- Sponsor
- University Hospital, Grenoble
Vitamin D Deficiency, Cystic Fibrosis
Efficacy of Intensive Cholecalciferol Monitoring and Supplementation on Serum vitD Levels in Pediatric Patients With CF
Cystic fibrosis (CF) is an autosomal recessive disease caused by alterations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, characterized by multisystemic alterations, mainly in the lung, intestine…
- Conditions
- Vitamin D Deficiency, Cystic Fibrosis, Bone Density, Low, Inflammation Chronic
- Trial name
- NCT05276960
- Testing
- Cholecalciferol Pill
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Respiratory Muscle Paralysis
Respiratory Muscle Strength and Function in Neuromuscular Disorders and Chronic Obstructive Pulmonary Disease
Using an extensive set of both volitional and non-volitional tests of respiratory muscle function and strength it is the aim of this study to identify disease-specific patterns of respiratory muscle impairment in different NMD…
- Trial name
- NCT03032562
- Testing
- Multimodal measurement of respiratory muscle function and strength
- Where
- 2 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Universität Münster
SARS-CoV 2 Pneumonia
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
Descriptive, retrospective, observational, anonymous, study to evaluate the potential effect of incorporating calcifediol into the therapeutic protocol of patients hospitalized for COVID-19 on mortality and other outcome…
- Trial name
- COVIDIOL (NCT06279910)
- Testing
- Calcifediol
- Where
- Spain
- Volunteers
- 230 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
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