Clinical trials: Insulin Dependent Diabetes
Type 1 Diabetes Mellitus
Gene Expression Profiling in Type 1 Diabetes
One of the goals of the Kansas City Diabetes Consortium is to identify and characterize genes and their products that are associated with T1DM.
- Trial name
- NCT00330954
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 2, Food Insecurity
Food Insecurity Reduction & Strategy Team
This study seeks to address the multifaceted challenges posed by food disparities and their negative consequences on health outcomes, via a comprehensive community health intervention program. Study objectives include: 1.
- Conditions
- Diabetes Mellitus, Type 2, Food Insecurity, Diabetes Mellitus, Type 1
- Trial name
- FIRST (NCT06329375)
- Testing
- Nutrition program
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Stanford University
Diabetes Mellitus, Type I, Adjustment of Basal Insulin Flow Rate During Physical Activity
Validation of Algorithms for Basal Insulin Rate Reductions in Type 1 Diabetic Patients Practising Physical Activity in Real Life Conditions
There is no specific recommendations on the adjustments of the insulin treatment in the event of physical activity (PA) in T1D patients treated on insulin pump therapy.
- Conditions
- Diabetes Mellitus, Type I, Adjustment of Basal Insulin Flow Rate During Physical Activity, Adjustment of Prandial Insulin in Case of Physical Activity
- Trial name
- Diabrasport2 (NCT02521675)
- Testing
- Usual algorithm, Diabrasport algorithm, Rest
- Where
- 17 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes
Adherence to Guidelines VAccination in Type 1 DIabetes Mellitus Patients (AVADI-2)
Observational study about adherence to guidelines for Covid-19, Influenza, Pneumococcal and Hepatitis B Vaccination in adult patients with type 1 Diabetes mellitus.
- Trial name
- AVADI-2 (NCT05481801)
- Testing
- Covid-19 vaccination, Influenza vaccination, Pneumococal vaccination
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Castilla-La Mancha Health Service
Type 1 Diabetes Mellitus
Diabetes Autoimmunity Study in the Young
Type 1 diabetes (T1D) affects 1.4 million people in the U.S. and its incidence has doubled over the past 20 years. The Diabetes Autoimmunity in the Young Study (DAISY) will estimate overall burden of T1D and other autoimmune…
- Trial name
- DAISY (NCT03205865)
- Volunteers
- 2,700 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus, Multiple Sclerosis
T and B Cell Responses in Autoimmune Diseases
The study aims to establish whether defects in immune cell function are shared across multiple autoimmune diseases and whether those problems match to similar genes in the cells.
- Conditions
- Type 1 Diabetes Mellitus, Multiple Sclerosis, Arthritis, Rheumatoid, Crohn's Disease
- Trial name
- SRA01 (NCT01947036)
- Where
- 6 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1
Joint Application of Human Insulin and Rapid Insulin Analogue in Control of Postprandial Glycemia
Postprandial glycemic control is essential for diabetes compensation. Insulin pump therapy control blood glucose released in response to both high and low glycemic index carbohydrates in a mixed diet using normal, square and…
- Trial name
- CPIT (NCT01088451)
- Testing
- Combined prandial insulin therapy (CPIT)
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- University Hospital Hradec Kralove
Diabetes, Diabetes Mellitus, Type 1
The HEADWIND Study - Part 4
To analyse driving behavior of individuals with type 1 diabetes in eu- and mild hypoglycaemia while driving in a real car. Based on the in-vehicle variables, the investigators aim at establishing algorithms capable of…
- Trial name
- NCT05308095
- Testing
- Controlled hypoglycaemic state while driving
- Where
- Switzerland
- Volunteers
- 10 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Type 1 Diabetes Mellitus
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Oral Insulin (IN-105) in Type 1 Diabetes Patients
The purpose of this study is to see whether IN-105 (oral insulin) is able to control increase in blood glucose after eating a meal.
- Trial name
- NCT01035801
- Testing
- IN-105, Insulin Lispro Injection
- Where
- 5 sites in India
- Volunteers
- 20 people
- Sponsor
- Biocon Limited
Diabetes
Safety and Efficacy of Single Administration of Oshadi Oral Insulin in Type I Diabetes Patients
The study will be a non-randomized, open label, single dose, single blind, placebo control, single center, single arm study in Type I diabetes patients.
- Trial name
- NCT01120912
- Testing
- Oshadi Oral Insulin
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Oshadi Drug Administration
Diabetes Mellitus, Type 1
Starting Technology in At Risk Type 1 Diabetes Study
Diabetes technology has revolutionized T1D management, disparities in technology access are evident among racial-ethnic minorities, patients with lower socioeconomic status and those with poorly controlled T1D (A1c>8.5%).
- Trial name
- STAR-T1D (NCT06453928)
- Testing
- Hybrid Closed Loop Insulin Pump System
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Los Angeles
Multiple Myeloma
Phase 1 Study of Tremelimumab, Durvalumab, High-dose Chemotherapy, + Autologous Stem Cell Transplant
This was a Phase 1, open-label, multicenter, study of checkpoint inhibitor therapy (tremelimumab ± durvalumab) prior to and following autologous stem cell transplant (ASCT) and high-dose melphalan in subjects with multiple…
- Trial name
- NCT02716805
- Testing
- Tremelimumab, Durvalumab, Prevnar-13
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Ludwig Institute for Cancer Research
Diabetes Mellitus, Type 1
COMPARATIVE ANALYSIS OF THE MORPHO-MECHANICAL PROPERTIES OF RED BLOOD CELLS EXTRACTED FROM DIABETIC PATIENTS WITH AND WITHOUT MICROVASCULAR COMPLICATIONS
The aim of the study is to analyse the biomechanical stiffness of red blood cells extracted from subjects with type I diabetes with and without microvascular complications through a biophysical characterization of red blood cells…
- Trial name
- NCT06068205
- Testing
- Blood test - atomic force microscopy in the force spectroscopy mode
- Volunteers
- 48 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Diabetes Mellitus Type 1
A Monocenter, Open-Label Glucose Clamp Study Examining the Metabolic Effect of Insulin Infusion Intervals for Basal Insulin Infusion in Patients With Type I Diabetes
This crossover, glucose-clamp study will investigate the impact of different basal insulin infusion rates on glucose control employing insulin pumps with different insulin delivery regimen.
- Trial name
- NCT00772356
- Testing
- Accu-Chek Spirit Insulin Pump, Comparator insulin pump
- Where
- Germany
- Volunteers
- 14 people
- Sponsor
- Hoffmann-La Roche
Type 1 Diabetes Mellitus
Clinical Phase II/III Trial of Ustekinumab to Treat Type 1 Diabetes (UST1D2)
In type 1 diabetes (T1D), immune defense cells in the body attack and destroy insulin-producing beta cells leaving affected people with a lifelong need for daily insulin injections.
- Trial name
- UST1D2 (NCT03941132)
- Testing
- Ustekinumab
- Where
- 2 sites in Canada
- Volunteers
- 66 people
- Sponsor
- University of British Columbia
Type 1 Diabetes Mellitus
Ovarian Ageing in Type 1 Diabetes Mellitus
In healthy women, early menopause is an event that is associated with the exacerbation of several risk factors of cardiovascular and skeletal disease.
- Trial name
- OVADIA (NCT01665716)
- Where
- Netherlands
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Type I Diabetes
Clinical Evaluation of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in Adult Subjects With Type 1 Diabetes (CIP347)
The purpose of this study is to evaluate the clinical performance of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in adult patients with Type 1 diabetes mellitus that cannot be controlled with subcutaneous insulin…
- Trial name
- Phoenix CIP347 (NCT06739811)
- Testing
- Implantable Insulin Pump System
- Where
- 11 sites in France, Netherlands
- Volunteers
- 40 people
- Sponsor
- Medtronic MiniMed, Inc.
Diabetes Mellitus, Type 1
EDCR Study - Etanercept Diamyd Combination Regimen -Open Trial to Evaluate Safety in Children With Type 1 Diabetes
The objectives of this study is to: Evaluate the tolerability of a combination therapy with Diamyd, vitamin D and etanercept Evaluate how the above mentioned treatments influence the immune system and endogenous insulin secretion
- Trial name
- NCT02464033
- Testing
- GAD-Alum, Vitamin D, Etanercept
- Where
- 8 sites in Sweden
- Volunteers
- 20 people
- Sponsor
- Johnny Ludvigsson
Type 1 Diabetes (T1D), Type 2 Diabetes
Primary Care Pragmatic, Real World Experience for Automated Insulin Delivery
The goal of this randomized controlled trial is to compare the efficacy and safety of the iLet Bionic Pancreas (BP) System in adults with insulin-treated diabetes (type 1 diabetes or type 2 diabetes) compared to standard of care…
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes, Diabetes, Autoimmune, Diabetes Mellitus
- Trial name
- PREPARE 4 AID (NCT07011147)
- Testing
- Bionic Pancreas, Routine Care
- Where
- 2 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of Colorado, Denver
Hypoglycemia, Diabetes Mellitus, Type 1
Comparison Between Hypoglycemic Counter Regulatory Responses in Type 1 Diabetics vs Control Subjects
This study compares the hypoglycemic counter regulatory response in type 1 diabetics and in healthy control subjects with and without antecedent hypoglycemia
- Trial name
- NCT03034226
- Testing
- Glucose clamp technique
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
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