Clinical trials: Insulin Dependent Diabetes
Type1diabetes
The Effect of Bolus Speed of Rapid-Acting Insulin Analog Absorption and Action in Individuals With Type 1 Diabetes
Rapid Action Insulin (RAI) absorption and action measured by time to reach maximum insulin concentration and glucose infusion rate.
- Trial name
- NCT03542682
- Testing
- Quick Bolus, Standard Bolus
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Yale University
Advanced Solid Tumor
CTLA-4 and PD-1 Antibodies Expressing Mesothelin-CAR-T Cells for Mesothelin Positive Advanced Solid Tumor
This is a single-arm, open-label, one center clinical study, to determine the safety and efficacy of infusion of autologous T cells engineered to express immune checkpoint antibodies (CTLA-4 and PD-1) and chimeric antigen…
- Trial name
- NCT03182803
- Testing
- CTLA-4/PD-1 antibodies expressing mesoCAR-T
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shanghai Cell Therapy Research Institute
Type 1 Diabetes, Type 2 Diabetes
Autologous Adult Stem Cells to Patients With Type 1 Diabetes and a Successful Renal Transplant
This is a phase I study to assess the safety and tolerability of infusing expanded stem cells into the pancreas of patients with type I diabetes and a successful renal transplant.
- Trial name
- NCT00788827
- Testing
- Autologous CD34+ stem cells
- Where
- United Kingdom
- Volunteers
- 7 people
- Sponsor
- Imperial College London
Diabetes, Diabetes Mellitus, Type 1
Safety of Insulin Detemir Produced by a New Process as Measured by Antibody Formation in Subjects With Type 1 Diabetes
The trial was conducted in Germany, The Republic of Macedonia, Russian Federation, Serbia and South Africa. The aim of this trial was to make a safety comparison of insulin detemir produced by a new production method (NN729) with…
- Trial name
- NCT00447382
- Testing
- insulin detemir, insulin aspart
- Where
- 5 sites in Germany, North Macedonia and 3 more
- Volunteers
- 330 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Efficacy and Safety of Insulin Glulisine in Type 1 Diabetes Mellitus
To evaluate non-inferiority in the efficacy of HMR1964 as compared with Insulin lispro in terms of the change in HbA1C from baseline to endpoint. To compare the safety of HMR1964 with insulin lispro.
- Trial name
- NCT00290979
- Testing
- insulin glulisine
- Where
- Japan
- Volunteers
- 250 people
- Sponsor
- Sanofi
Type 1 Diabetes
Ultrarapid Insulin Administered by a Bihormonal Closed Loop System in Patients With Type 1 Diabetes
The main objective is to determine the efficacy of Lyumjev (insulin) in a bi-hormonal reactive closed loop system for automated glucose regulation (artificial pancreas; AP®) in patients with diabetes mellitus type 1.
- Trial name
- FAST 1 (NCT05508061)
- Testing
- Insulin Lispro Cartridge [Lyumjev], Insulin Lispro Cartridge
- Where
- 3 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- Inreda Diabetic B.V.
Diabetes Mellitus, Type 1
Trial of Otelixizumab for Adults With Newly Diagnosed Type 1 Diabetes Mellitus (Autoimmune): DEFEND-1
The purpose of this study is to find out if an 8-day series of otelixizumab infusions leads to greater improvement in insulin secretion as compared with placebo infusion.
- Trial name
- DEFEND-1 (NCT00678886)
- Testing
- otelixizumab infusion plus physician determined standard of care
- Where
- 109 sites in United States, Canada and 7 more
- Volunteers
- 272 people
- Sponsor
- GlaxoSmithKline
Type 1 Diabetes
The Banana Exercise Type 1 Diabetes Study
Former and current KADET athletes participate in two controlled training sessions: one with a banana 20 minutes pre-exercise and one without.
- Trial name
- NCT06917274
- Testing
- Banana, No banana
- Volunteers
- 20 people
- Sponsor
- University of Aarhus
Type 1 Diabetes
Efficacy of Coordinated Insulin Boluses in Type 1 Diabetic Patients
A recent study suggests that, in Type 1 Diabetes (T1D) patients treated by insulin pumps, a better coordination of meal boluses and post prandial basal rate could reduce the importance of postprandial hyperglycaemias without…
- Trial name
- COBOL (NCT02229097)
- Testing
- Normal bolus, Coordinated bolus
- Where
- 3 sites in France
- Volunteers
- 17 people
- Sponsor
- University Hospital, Toulouse
Diabetes Mellitus
A GLP-1 Receptor PET Imaging Substudy Within the VER-A-T1D Trial Investigating the Effects on Beta Cell Mass
The goal of the trial is to measure pancreatic uptake of 68Ga-NODAGA-exendin by PET/CT for detection of intra-individual differences in beta cell mass before and after treatment with Verapamil.
- Trial name
- Ver-A-image (NCT04615910)
- Testing
- 68Ga-NODAGA-exendin-4 PET/CT
- Where
- 2 sites in Austria, France
- Volunteers
- 30 people
- Sponsor
- Radboud University Medical Center
Insulin Resistance, Type 1 Diabetes
Validation of a 13C Glucose Breath Test Compared With the Euglycaemic Clamp Test
Insulin resistance can be assessed by the euglycaemic clamp technique. To date, this is the golden standard, but it is not suited for clinical practice. A 13C glucose breath test will be tested as a valid alternative.
- Trial name
- BRECLAIR (NCT04623320)
- Testing
- euglycaemic clamp test, 13C glucose breath test
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Hospital, Antwerp
Diabetes Mellitus, Diabetes Mellitus, Type 1
Pharmacokinetics Study of Gamma-aminobutyric Acid
The purpose of this study is to determine upon administering GABA orally to a person how it is absorbed, distributed, as well as the drug's pharmacological effects on the body such as glucose levels, serum C-peptide and/or…
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- GABA-PK (NCT01917760)
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Diabetic Peripheral Neuropathy
Safety and Efficacy of CBX129801 in Patients With Type 1 Diabetes
The purpose of the study is to determine the beneficial effects of CBX129801 (PEGylated synthetic human C-peptide) following weekly subcutaneous administration for 12 months in type 1 diabetes mellitus patients (T1DM) with mild…
- Trial name
- NCT01681290
- Testing
- CBX129801
- Where
- 29 sites in United States, Canada and 1 more
- Volunteers
- 250 people
- Sponsor
- Cebix Incorporated
Type 1 Diabetes
Glucose Variability in Type 1 Diabetes and Its Effect on Factors That Influence New Vessel Formation
The aim of the study is to see how glycaemic control and glycaemic variability affect levels of HIF, VEGF, erythropoietin and cortisol in Paediatric Type 1 diabetics on insulin pump therapy.
- Trial name
- INDIGO 2 (NCT01429467)
- Testing
- Continuous Glucose Monitor (CGM) and Telemedicine (Enlite Guardian real-time system Medtronic®)
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- University of Dundee
Diabetes Mellitus, Type 1
Assessment of an Automatic Closed-loop Insulin Delivery System
The overall aim of this research proposal is to determine the safety, feasibility and efficacy of an automatic closed-loop insulin delivery system.
- Trial name
- NCT02366767
- Testing
- Automatic closed-loop insulin delivery, Control
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Stanford University
Type 1 Diabetes
Role of Exenatide in Type 1 Diabetes
The purpose of this study is to see if giving exenatide and insulin before a meal would lower blood sugars after the meal. This study may help in developing new treatments to help control high blood sugars after meals.
- Trial name
- NCT00456300
- Testing
- Exenatide, Insulin
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Montefiore Medical Center
Type 1 Diabetes, Type 2 Diabetes
Comparison of Noninvasive Blood Glucose Concentrations Relative to Finger Capillary Blood Glucose References
The purpose of the study is to prospectively evaluate a noninvasive, near-infrared based method for measuring glucose concentration relative to invasive blood reference measurements.
- Conditions
- Type 1 Diabetes, Type 2 Diabetes, Gestational Diabetes
- Trial name
- NCT01415544
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- InLight Solutions
Type 1 Diabetes
Effect of Different Fixed Pramlintide:Insulin Dose Ratios on Postprandial Glucose in T1DM
To examine the effects of different fixed pramlintide:insulin dose ratios in subjects with type 1 diabetes on postprandial plasma glucose concentrations
- Trial name
- NCT01708044
- Testing
- Pramlintide acetate
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Type I, Hypoglycemia
Carnitine Levels and Carnitine Supplementation in Type I Diabetes
The purpose of this study is to determine whether type I diabetics with carnitine deficiency exhibit increased numbers of hypoglycemic (low blood sugars) events and if unrecognized hypoglycemia occurs during continuous 72-hour…
- Trial name
- NCT00351234
- Testing
- Carnitine (drug)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 1
A Research Study to See How a Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine, Both in Combination With Insulin Aspart, in Adults With Type 1 Diabetes
This study compares insulin icodec, an insulin taken once a week to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 1 diabetes.
- Trial name
- ONWARDS 11 (NCT07076199)
- Testing
- Insulin icodec, Insulin glargine, Insulin aspart
- Where
- 182 sites in United States, Australia and 6 more
- Volunteers
- 877 people
- Sponsor
- Novo Nordisk A/S
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