Clinical trials: Insulin Homeostasis
Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose
Lactose, Sucrose & Corn Syrup Tolerance
Lactose, one of the key nutrients in human milk may be critically important to infants for more reasons than being a source of energy.
- Trial name
- NCT01789307
- Testing
- corn syrup solids, sucrose
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Physiology, Gastroenterology
GIP and GLP-1 on Gastric Emptying, Appetite and Insulin-glucose
Academic phase 1 study which investigates the effects of the two incretin hormones glucose-insulinotropic peptide (GIP) and glucagon-like peptide-1 (GLP-1) on gastric emptying, appetite, insulin release and glucose disposal in…
- Conditions
- Physiology, Gastroenterology, Endocrinology
- Trial name
- GIP-GLP-gas (NCT01079624)
- Testing
- Glucose-insulinotropic peptide, Glucagon-like peptide-1
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Diabetes, Prediabetic
Sleep Effectiveness and Insulin and Glucose Homeostasis
The purpose of this study is to examine the influence of sleep effectiveness on glucose and insulin metabolism in health and disease (prediabetes and type two diabetes).
- Conditions
- Diabetes, Prediabetic, Prediabetes, Glucose Intolerance
- Trial name
- NCT01887691
- Testing
- eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Morbid Obesity, Metabolic Syndrome
FMT in Obesity: RYGB vs. LEAN vs. Autologous FMT
This double-blinded proof-of-concept study is proposed to explore the effects of fecal microbiota transfer (FMT) in human subjects.
- Conditions
- Morbid Obesity, Metabolic Syndrome, Diabetes, PreDiabetes
- Trial name
- DACH (NCT06268990)
- Testing
- Fecal microbiota transplantation
- Where
- Austria
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Wiebke Kristin Fenske
Healthy, Insulin Resistance
Effects of Hepatic Ultrasound on Metabolic Homeostasis
The purpose of this study is to define the effect of ultrasound exposure of the liver in the region of the porta hepatis on glucose homeostasis and insulin resistance in healthy subjects.
- Trial name
- NCT04622683
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Postprandial Insulin Secretion and Appetite Regulation After Moderate Alcohol Consumption
A body of epidemiologic studies show that moderate alcohol consumption is associated with a protective effect against type 2 diabetes.
- Trial name
- NCT00524550
- Testing
- moderate alcohol consumption
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- TNO
Obesity, Insulin Resistance
Systemic Cross-talk Between Brain, Gut, and Peripheral Tissues in Glucose Homeostasis: Effects of Exercise Training
Obesity and insulin resistance are worldwide epidemic and taking a major public health toll. Obesity also increases the risk for cognitive impairment which is also an increasing medical, societal, and economic challenge.
- Conditions
- Obesity, Insulin Resistance, Type2 Diabetes, Exercise Training
- Trial name
- CROSSYS (NCT03730610)
- Testing
- Exercise training
- Where
- Finland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Turku
Obesity
Effect of Fibre Products on Appetite and Weight
This study explores the nutritional effects of fibre. Short chain fatty acid(SCFA), such as propionate, are produced through the fermentation of fibre in the bowel.
- Trial name
- NCT00750438
- Testing
- Propionate ester, Inulin, Cellulose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Protein, Healthy
Dietary Protein Restriction and Health
The incidence of type 2 diabetes worldwide has increased significantly over the past decades, which is associated with changing dietary habits and physical inactivity.
- Conditions
- Protein, Healthy, Diet
- Trial name
- LOWPRO (NCT06267235)
- Testing
- Dietary protein restriction
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Insulin Resistance
Effects of Insulin Resistance in Non-diabetic Acute Coronary Syndrome Patients
Effects of insulin resistance in non-diabetic acute coronary syndrome patients by the homeostasis model assessment index (HOMA2-IR)
- Trial name
- NCT06163768
- Testing
- Insulin resistance
- Where
- Vietnam
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Insulin Resistance
Vitamin D Supplementation and Glycemic Outcomes
The investigators examined the effect of vitamin D supplementation on glucose homeostasis and metabolic markers in healthy normal weight and overweight young subjects and healthy normal-weight and overweight elderly subjects…
- Trial name
- NCT02942732
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Université d'Auvergne
Deficiency, Vitamin D, Insulin Resistance
Vitamin D Supplementation and and Glycemic Indexes
Age affect insulin sensitivity and the metabolism, and vitamin D status was shown to have a correlation with markers of insulin resistance.
- Trial name
- NCT03478475
- Testing
- cholecalciferol (Euro-Pharm International, Canada)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Université d'Auvergne
Postprandial Hyperglycemia, Metabolic Syndrome
Effects of a Carbonated Water Enriched With Amino Acids and Chromium Picolinate (Good Idea®) on Glucose Homeostasis.
It has previously been shown in healthy subjects, that a carbonated water containing a mix of amino acids and chromium picolinate can decrease postprandial blood glucose.
- Conditions
- Postprandial Hyperglycemia, Metabolic Syndrome, Type 2 Diabetes Mellitus
- Trial name
- NCT03552315
- Testing
- Carbonated water with amino acids and chromium
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- DoubleGood AB
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Glucose Homeostasis
Comparison of the Effects of a 12-Week Consumption of Two Carbonated Beverages on Insulin Sensitivity
The purpose of this study is to determine whether consumption of carbonated drinks containing sweeteners affect insulin sensitivity.
- Trial name
- SEDULC (NCT02031497)
- Testing
- Drink with sweeteners, Drink without sweeteners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute For European Expertise in Physiology
Pre Diabetes
Abscisic Acid Effects on Glucose Homeostasis and Insulin Sensitivity
The purpose of this study is to determine the effects of oral abscisic acid (ABA) on glucose metabolism in subjects with defined prediabetes.
- Trial name
- ABA (NCT04722354)
- Testing
- Hyperinsulemic euglycemic clamp, Muscle Biopsy, Oral abscisic acid (ABA)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Obesity & Overweight, Insulin Resistance Syndrome
SENSILINS: Impact of Cephalic Phase Insulin Release Induced by an Environmental Food Odor Stimulus on Glucose Homeostasis According to Insulin Sensitivity Level
This single-center, randomized, single-blind, 2-period crossover interventional study will evaluate whether exposure to a pleasant food odor 10 minutes before a 75 g oral glucose tolerance test (OGTT) modifies glucose homeostasis…
- Trial name
- SENSILNS (NCT07638111)
- Testing
- Pleasant Food Odor Stimulation, Control Environmental Condition
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Healthy
Acute Effects of Spices on Pathways Associated With Glucose Homeostasis and Inflammation on PBMCs of Healthy Subjects
This study aims to investigate the effect of spices on gene expression of pathways associated with glucose homeostasis, oxidative stress and inflammation, in the postprandial phase in healthy human subjects.
- Trial name
- NCT02479334
- Testing
- Fat challenge breakfast, Fat challenge breakfast+spices, Carbohydrate challenge breakfast
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Lund University
Type 2 Diabetes Mellitus
The Effects of Bethanechol on Glucose Homeostasis
Xenin-25 and glucose-dependent insulinotropic polypeptide (GIP) are hormones produced in the intestine that are released into the blood immediately after ingestion of a meal.
- Trial name
- NCT01434901
- Testing
- Bethanechol (25 mg), Bethanechol (50 mg), Bethanechol (100 mg)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Overweight
Sumatriptan and Glucose
The purpose of this study is to establish the proof of concept for a brain serotonin pathway controlling blood glucose control in humans.
- Trial name
- NCT04690270
- Testing
- Sumatriptan 100 mg
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust