Clinical trials: Insulin Homeostasis
Appetite and General Nutritional Disorders
The Effects of Whey, Rice and Potato pRotein isOlates on appeTite rEgulatIoN in Healthy Men
INTRODUCTION: Global protein consumption has been increasing for decades due to changes in socio-economic demographics and consumer trends towards higher protein intake, which may be related to their health benefits in…
- Trial name
- PROTEIN (NCT04876495)
- Testing
- Whey protein isolate, Potato protein isolate, Rice protein isolate
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Obesity, Insulin Resistance
Correction of Vitamin D Levels and Its Effect on Insulin Resistance and Weight Gain in Obese Youth
Vitamin D deficiency is extremely common in obese youth. In our obese population followed in the Endocrinology clinic at Children's Medical Center Dallas, vitamin D levels were inversely correlated with a measure of insulin…
- Conditions
- Obesity, Insulin Resistance, Vitamin D Deficiency
- Trial name
- NCT02168660
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Perrin C White, MD
Hepatitis C, Chronic, Insulin Resistance
Study of Response in Chronic Hepatitis C (CHC) Participants Genotype 1 With Insulin Resistance and Prolonged Treatment Duration in Late Responders (P04823/MK-4031-303)
This is a Phase 3b/4, prospective, open-label, randomized, multicenter study of peginterferon alfa-2b plus ribavirin in participants with chronic hepatitis C, genotype 1.
- Trial name
- NCT00493805
- Testing
- Combination of pegylated interferon alfa-2b and ribavirin
- Volunteers
- 59 people
- Sponsor
- Merck Sharp & Dohme LLC
Insulin Sensitivity, Oxidative Stress
Racial Differences in Vagal Control of Glucose Homeostasis, Chronic Study
Investigators will test the hypothesis that chronic restoration of vagal nerve activity with a central acetylcholinesterase inhibitor improves insulin sensitivity and reduces adipose tissue oxidation in obese African American…
- Trial name
- RDVCGH (NCT03014323)
- Testing
- Galantamine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Morbid Obesity
A Longitudinal Study on Short-term Effects of Gastric Bypass on Glucose Homeostasis in Obesity
The purpose of this study is to quantify the relative contribution of improved insulin sensitivity and improved insulin secretion to the glycaemic effect of bariatric surgery.
- Trial name
- NCT01063127
- Testing
- Study on insulin sensitivity after diet or bariatric surgery, gastric bypass
- Where
- Italy
- Volunteers
- 23 people
- Sponsor
- Catholic University of the Sacred Heart
Diabetes Mellitus, Type 2, Acupuncture
Effects of Acupuncture as Adjunctive Therapy in Patients With Type 2 Diabetes Mellitus
This study aims to determine the effect of acupuncture as an adjunctive therapy on homeostasis model assessment-insulin resistance (HOMA-IR) and health-related quality of life (HRQoL) in patients with type 2 diabetes mellitus.
- Trial name
- NCT04829045
- Testing
- SEIRIN PYONEX Acupuncture Needles
- Where
- Malaysia
- Volunteers
- 46 people
- Sponsor
- Universiti Putra Malaysia
Glucose Homeostasis
Comparison of the Effects of a 12-Week Consumption of Two Carbonated Beverages on Insulin Sensitivity
The purpose of this study is to determine whether consumption of carbonated drinks containing sweeteners affect insulin sensitivity.
- Trial name
- SEDULC (NCT02031497)
- Testing
- Drink with sweeteners, Drink without sweeteners
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute For European Expertise in Physiology
Obesity
Effect of Fibre Products on Appetite and Weight
This study explores the nutritional effects of fibre. Short chain fatty acid(SCFA), such as propionate, are produced through the fermentation of fibre in the bowel.
- Trial name
- NCT00750438
- Testing
- Propionate ester, Inulin, Cellulose
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Type 2 Diabetes, Cardiometabolic Syndrome
PDE3B in Metabolic Regulation
Phosphodiesterase 3B (PDE3B), an enzyme responsible for the degradation of cyclic AMP and GMP (two important second messengers used for intracellular signal transduction), has been associated with cardiometabolic outcomes.
- Conditions
- Type 2 Diabetes, Cardiometabolic Syndrome, Cardiovascular Diseases
- Trial name
- NCT06533007
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Insulin Sensitivity, 24-hour Glucose Control
Ultra-processed Food Consumption, Gut Microbiota, and Glucose Homeostasis
Advancing age is associated with gut dysbiosis, low-grade chronic inflammation, progressive insulin resistance, and increased risk of type 2 diabetes (T2D).
- Trial name
- NCT05358171
- Testing
- HIgh UPF controlled diet, No UPF controlled diet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Glucose Intolerance, Type 2 Diabetes Mellitus
Vitamin D and Calcium Homeostasis for Prevention of Type 2 Diabetes
The purpose of the randomized trial is to quantify the effect of vitamin D and calcium supplementation on beta-cell function, insulin sensitivity, glucose tolerance and systemic inflammation and other cardiometabolic outcomes in…
- Conditions
- Glucose Intolerance, Type 2 Diabetes Mellitus, Metabolic Syndrome
- Trial name
- CaDDM (NCT00436475)
- Testing
- Vitamin D3 2,000 IU orally once daily, Calcium Carbonate 400 mg orally twice daily
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Tufts Medical Center
MODY-2 Diabetes
The Effect of ß-cell Specific Glucokinase Mutation on Glucose Homeostasis and Insulin Secretion in a MODY-2 Family
Type 2 diabetes mellitus patients exhibit many glucose homeostasis abnormalities in different tissues and organs. Among the more important defects are disturbed hepatic glucose metabolism and defective pancreatic β-cell function.
- Trial name
- NCT01960231
- Testing
- OGTT
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Diabetes Mellitus, Type 2
Association Between Insulin Resistance and Beta Cell Function With HbA1C in Diabetics
Progression of T2DM is widely accepted to be contributed by two main components: beta cell function deterioration where insulin secretion is impaired and insulin resistance where insulin physiological response is reduced.
- Trial name
- InsuReB (NCT03196154)
- Testing
- Fasting insulin level, Plasma drug level
- Where
- Malaysia
- Volunteers
- 255 people
- Sponsor
- Clinical Research Centre, Malaysia
Surgery--Complications, Acute Illness
Perioperative Metabolic and Hormonal Aspects in Major Emergency Surgery
Emergency laparotomies, which most often is performed due to high risk disease (bowel obstruction, ischemia, perforation, etc.), make up 11 % of surgical procedures in emergency surgical departments, however, give rise to 80 % of…
- Conditions
- Surgery--Complications, Acute Illness, Gastrointestinal Disease, Stress
- Trial name
- PHASE (NCT03482830)
- Testing
- Major emergency gastrointestinal surgery
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Zealand University Hospital
Healthy, Metabolic Syndrome
Study of Metabolic Homeostasis in Chinese
In this open-label, acute intervention study, we will recruit 120 sex-matched participants aged 20-70 years (100 normal or overweight/obese subjects and 20 Mets subjects).
- Trial name
- NCT04173728
- Testing
- Standard mixed macronutrients tolerance test
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Type 1 Diabetes, Bariatric Surgery Candidate
Role of the Liver in Glucose Homeostasis Using Metabolic Imaging
The primary objective of this study is to assess hepatic glucose uptake using non-invasive metabolic imaging in three different populations that differ in terms of insulin and glucose kinetics.
- Trial name
- LEMON (NCT04352738)
- Testing
- Multiparametric, multinuclear MR (DMI/ 13C-MRS/ GlycoCEST/GlycoNOE)
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Metabolic Syndrome
Effect of Elliptical Training on Metabolic Homeostasis in Metabolic Syndrome
The growing prevalence of metabolic syndrome (MetS) in the worldwide is becoming a serious health problem and economic burden. MetS has become a crucial risk factor for the development of type 2 diabetes mellitus (T2DM) and…
- Trial name
- NCT04635202
- Testing
- exercise training on elliptical device, group B (control group)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Bone Mineral Density, Body Fat Distribution
The Bone-Fat-Pancreas Axis in Children
The overarching hypothesis of this proposal is that obesity and positive energy balance in children promote both low bone mass accrual and risk for diabetes through events that are mechanistically associated and that involve bone…
- Conditions
- Bone Mineral Density, Body Fat Distribution, Insulin Homeostasis
- Trial name
- NCT01041898
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes Mellitus
Effect of Exenatide on Glucose Homeostasis Determinants in Type 2 Diabetes
The purpose of this study is to determine in type 2 diabetic patients in secondary failure to combined oral therapy whether, besides improvement in glycemic control, addition of exenatide, a new drug introduced to treat diabetes…
- Trial name
- NCT00948168
- Testing
- exenatide (Byetta)
- Where
- Belgium
- Volunteers
- 34 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Overweight
Sumatriptan and Glucose
The purpose of this study is to establish the proof of concept for a brain serotonin pathway controlling blood glucose control in humans.
- Trial name
- NCT04690270
- Testing
- Sumatriptan 100 mg
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust