Clinical trials: Insulin Resistance, Diabetes
Diabetes Mellitus, Type 2
To Compare the Effects of Non-nutritive Sweeteners Intake in Subjects With T2DM
ABSTRACT Introduction: There is no current data about the effects of non-nutritive sweeteners (NNS) about important factors, such as the energy intake, appetite and its relationship in people with diabetes when tasting sweet.
- Trial name
- NCT03680482
- Testing
- Intervention ingest a 48 mg of sucralose, Intervention ingest a 96 mg of stevia
- Volunteers
- 17 people
- Sponsor
- University of Chile
Type2 Diabetes, Cardiometabolic Syndrome
Effects of White Potato Consumption on Measures of Cardiometabolic Health in Individuals With Type 2 Diabetes Mellitus
The investigators are examining the effects of potato consumption on indices of glycemic control and cardiovascular health in overweight and obese individuals with type two diabetes mellitus (T2D) to provide feasible and…
- Conditions
- Type2 Diabetes, Cardiometabolic Syndrome, Arterial Stiffness, Overweight and Obesity
- Trial name
- NCT04511325
- Testing
- Potato Regimen, Refined Grain Regimen
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Florida State University
Obesity, Diabetes Mellitus Type-2
Synbiotics and Low Grade Inflammation in Obese Subjects
The purpose of this study is to determine whether the daily administration of a synbiotic (oligofructose and Bifidobacterium animalis subsp.
- Conditions
- Obesity, Diabetes Mellitus Type-2, Insulin Resistance, Metabolic Syndrome
- Trial name
- NCT01235026
- Testing
- Synbiotic
- Where
- Chile
- Volunteers
- 44 people
- Sponsor
- University of Chile
Type 2 Diabetes
Effects of PDE-5 Inhibition on Postprandial Hyperglycemia in Type 2 Diabetes
An increase of blood flow and capillary permeability decrease the impact of an endothelial barrier for glucose and insulin allowing them to reach their target cells in peripheral insulin sensitive organ in the human body.
- Trial name
- NCT01238224
- Testing
- Tadalafil
- Where
- Sweden
- Volunteers
- 22 people
- Sponsor
- Vastra Gotaland Region
Heart Failure, Diabetes
DANHEART (H-HeFT and Met-HeFT)
The present study is testing in a combined design to types of drugs in patients with chronic heart failure: 1) Hydralazine in combination with isosorbide dinitrate (BiDil) and 2) Metformin hydrochloride.
- Trial name
- DANHEART (NCT03514108)
- Testing
- Hydralazine Isosorbide Dinitrate, Metformin Hydrochloride
- Where
- 26 sites in Denmark
- Volunteers
- 1,100 people
- Sponsor
- Henrik Wiggers
Severe Acute Respiratory Syndrome Coronavirus 2, Metabolic Syndrome
Metformin Glycinate in Patients With MS or DM2 , Hospitalized With COVID-19 and SARS Secondary to SARS-CoV-2
The purpose of this study is to evaluate the efficacy and safety of metformin glycinate at dose of 620 mg twice per day plus standard treatment comparing to standard treatment alone (we will use placebo) of patients who have…
- Conditions
- Severe Acute Respiratory Syndrome Coronavirus 2, Metabolic Syndrome, Type 2 Diabetes
- Trial name
- DMMETCOV19 (NCT04626089)
- Testing
- metformin glycinate
- Where
- Mexico
- Sponsor
- Laboratorios Silanes S.A. de C.V.
DIABETES
Effects of Heating Massaging Vibrating Vicinity of the Insulin Delivery Site
The aim of this experiment is to test the pharmacodynamics and pharmacokinetics of insulin analogs and their dependence on external and physiological alterations.
- Trial name
- NCT01307514
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Insulin Sensitivity, Type 2 Diabetes
Milk Fat Intake and Metabolic Health Markers
This study investigates the effects of bioactive fatty acids in full fat dairy (whole yogurt), on insulin action, calorie needs, blood lipids, immune function, and body composition in normal and overweight male and female…
- Trial name
- DMFMHM (NCT02659748)
- Testing
- Milk Fat, Control Fat
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Vermont Medical Center
Diabetes Mellitus, Metabolic Syndrome
Effect of Implantable Contraception on Type-2 DM and Metabolic Syndrome in Women With History of Gestational DM
The purpose of this study is to determine the effect of implantable contraception on the incidence of diabetes mellitus in women with history of gestational diabetes mellitus comparing with those using nonhormonal contraceptives.
- Trial name
- NCT02114476
- Testing
- progestin implant
- Where
- Thailand
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk Adults
The purpose of this clinical trial is to find out whether one type of fish oil works better than another at improving metabolic health in people who are at high risk of developing type 2 diabetes.
- Conditions
- Type 2 Diabetes, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Prediabetes / Type 2 Diabetes, Obesity & Overweight
- Trial name
- END-T2D (NCT07575438)
- Testing
- Fish Oil, Corn oil control
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- May Faraj, PDt, PhD
Postpartum Women, Diabetes, Gestational
Circadian Clocks and Eating Patterns (Cohort)
For women of reproductive age, the overall postpartum weight retention (weight gain between pregnancies) plays a significant role in long-term obesity.
- Trial name
- NCT04642534
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Diabetes Mellitus, Type 2, Glucose, High Blood
Use of Functional MRI to Assess Functional Hypothalamic Activation in Response to Diazoxide
The goal of this study is to determine whether metabolic control centers in the brain can be activated in patients with type 2 diabetes (T2D) as compared to non-diabetic individuals.
- Conditions
- Diabetes Mellitus, Type 2, Glucose, High Blood, Glucose Metabolism Disorders (Including Diabetes Mellitus)
- Trial name
- NCT03566511
- Testing
- Diazoxide
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Meredith Hawkins
Metabolic Syndrome
Mechanisms of Ramipril Reduction in the Onset of Type 2 Diabetes
The study will be focused on determining the integrated in-vivo mechanisms responsible for Ramipril's effects on delaying type 2 diabetes and restoring normal (blood sugar levels) glycemia in patients with impaired glucose…
- Trial name
- NCT00574834
- Testing
- Ramipril, HCTZ-hydrochlorothiazide, Ramipril+HCTZ
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Obesity, Diabetes Type 2
Pharmacogenetics of Response to GLP1R Agonists
Overweight/obese otherwise healthy volunteers will be recruited from the Old Order Amish population in Lancaster County, PA. Lancaster County, PA.
- Trial name
- PORT (NCT05071898)
- Testing
- Semaglutide Pen Injector [Ozempic]
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Type 2 Diabetes Mellitus
A Study to Characterize Regimens of Basal Insulin Intensified With Either Symlin® or Rapid Acting Insulin in Patients With Type 2 Diabetes
This will be a randomized, open label, parallel group, multicenter study. There will be two phases in the study. Phase 1 (Baseline to Week 24) will compare the efficacy and safety of regimens of basal insulin intensified with…
- Trial name
- NCT00467649
- Testing
- pramlintide acetate (Symlin), rapid acting insulin (Humalog® [insulin lispro], Novolog® [insulin aspart], or Apidra® [insulin glulisine]), basal insulin (Lantus® [insulin glargine], or Levemir® [insulin detemir])
- Where
- 37 sites in United States
- Volunteers
- 112 people
- Sponsor
- AstraZeneca
Overactive Bladder, Insulin Resistance
Genomics and Epigenomics for New Insights in fEmale OAB (GENIE) Study
Millions of women suffer from overactive bladder, and the changes in bladder function affect their quality of life. The study team believes that it needs to be better understand why women get overactive bladder in the first place…
- Trial name
- GENIE (NCT03057158)
- Where
- United States
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- Duke University
Type 2 Diabetes Mellitus
Effect of Pistachio Intake on Insulin Resistance and Type 2 Diabetes Mellitus
Hypothesis: Chronic intake of pistachios improves glucose metabolism and insulin resistance status thus contributing to decrease the risk of type 2 diabetes mellitus and its associated abnormalities.
- Trial name
- EPIRDEM (NCT01441921)
- Testing
- Pistachios, control diet
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Diabetes Mellitus, Type 2
Formulas for Diabetes With Sucromalt & Isomaltulose on Glycemic Index, Hormones & Subjective Appetite in Type 2 Diabetes
Consumption of nutritional supplements with low glycemic carbohydrates induce favorable glycemic responses in subjects with type 2 diabetes.
- Trial name
- NCT03829800
- Testing
- Ensure® Abbott Nutrition, Glucerna® Abbott Nutrition, Diasip® Nutricia Advanced
- Volunteers
- 23 people
- Sponsor
- Universidad del Zulia
Diabetes Mellitus, Type 2, Insulin Resistance
Characterization of the Incretinpathy in Type 2 Diabetes Initiated After Sixty Years Old
Type 2 diabetes (T2DM) is characterized by hyperglycemia, insulin resistance, absolute or relative insulin deficiency, hyperglucagonemia, increased hepatic glucose production, frequently accelerated gastric emptying and obesity.
- Trial name
- NCT00843232
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Campinas, Brazil
Obesity, Insulin Resistance
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
Background: About 40 percent of adults and 20 percent of adolescents in the U.S. have a body mass index over 30 kg/m2. Being overweight may lead to a state of low-level inflammation. This may cause health problems.
- Conditions
- Obesity, Insulin Resistance, Inflammation
- Trial name
- NCT05017571
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
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