Clinical trials: Insulin Resistance, Diabetes
Obesity, Type 2 Diabetes
Evaluation of Intra-Abdominal Fat in Patients With Type 2 Diabetes Using a Non-Invasive Method
The main aim of this study is to compare 2 different measurements of visceral fat that can be easily used in clinical practice (waist circumference versus bioelectric impedance) in relation to known risk factors of coronary…
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01283113
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia
Maximising Time With a Normal Blood Glucose to Restore the Glucagon Response in Type 1 Diabetes
Almost all people who have had type 1 diabetes for 5 years have a defect in secretion of the hormone Glucagon. This hormone is involved in the body's response to low blood glucose (hypoglycaemia).
- Conditions
- Type 1 Diabetes, Type 1 Diabetes Mellitus With Hypoglycemia, Hypoglycemia, Hypoglycemia Unawareness
- Trial name
- NCT04614168
- Testing
- Stepped hyperinsulinaemic-hypoglycaemic clamp study, Insulin pump, Continuous glucose monitor
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus, Type 2, Insulin Resistance
Study of Improving Insulin Sensitivity by Electroacupuncture Therapy
The aim of this study is to find out whether the hypoglycemic and improving insulin resistance effect will appear or not, when EA applying on specific acupoints of NIDDM patients.
- Trial name
- NCT00379379
- Testing
- electroacupuncture
- Where
- Taiwan
- Volunteers
- 26 people
- Sponsor
- China Medical University Hospital
Prediabetic State, Impaired Glucose Tolerance
Effect of Linagliptin + Metformin on Patients Who do Not Achieve Normoglucemia With Metformine
The goal of this protocol is to evaluate the effect of addhing linagliptin to patients with prediabetes who do not reverse to normoglycemia after 12 months of treatment with metformin alone.
- Conditions
- Prediabetic State, Impaired Glucose Tolerance, Insulin Resistance
- Trial name
- RESCATHEME (NCT04088461)
- Testing
- Linagliptin / Metformin Oral Tablet, Metformin
- Where
- Mexico
- Volunteers
- 31 people
- Sponsor
- Universidad de Guanajuato
Type 2 Diabetes Mellitus, Hypertension
Vitamin D and Omega-3 Inhibit Metabolic Syndrome
The study will test the hypothesis that supplementing the diet of subjects with Metabolic Syndrome with 2000 IU vitamin D and 1.8 g omega-3 fatty acids (EPA + DHA) per day, will facilitate weight loss, improve body composition…
- Conditions
- Type 2 Diabetes Mellitus, Hypertension, Hyperlipidemia, Obesity
- Trial name
- NCT01326442
- Testing
- low glycemic diet, vitamin D omega-3
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Guelph
Type 1 Diabetes Mellitus, Type 1 Diabetes
PROCHYMAL® (Human Adult Stem Cells) for the Treatment of Recently Diagnosed Type 1 Diabetes Mellitus (T1DM)
The purpose of this study is to establish the safety and efficacy of multiple administrations of PROCHYMAL® in participants recently diagnosed with type 1 diabetes mellitus.
- Conditions
- Type 1 Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Insulin-Dependent, Juvenile Diabetes
- Trial name
- NCT00690066
- Testing
- PROCHYMAL®
- Where
- 20 sites in United States
- Volunteers
- 63 people
- Sponsor
- Mesoblast, Inc.
Type2 Diabetes Mellitus
Effects of Vitamin D Supplementation on SOD,IL-6 and Insulin Resistance in Type 2 Diabetes Mellitus (DM)
The aim of this intervention clinical study are: evaluation the effect of vitamin D supplementation on anti-oxidant status, inflammation, insulin resistance in patients type 2 diabetes mellitus.
- Trial name
- DM (NCT05596383)
- Testing
- Vitamin D 5000 IU
- Where
- Indonesia
- Volunteers
- 112 people
- Sponsor
- Trisakti University
Obesity, Diabetes
Role of Dietary Fatty Acids in Fatty Liver and Insulin Resistance
The purpose of this study is to investigate whether substituting saturated fats with polyunsaturated fats reduces fatty liver and improves insulin action and other metabolic variables in abdominally obese subjects
- Conditions
- Obesity, Diabetes, Insulin Resistance, Fatty Liver
- Trial name
- HEPFAT (NCT01038102)
- Testing
- PUFA Diet, SFA diet
- Where
- Sweden
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Type 2 Diabetes Mellitus (T2DM)
A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM
To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-KHK and to evaluate the safety, tolerability, efficacy, PK and PD of multiple doses of KHK.
- Trial name
- NCT05761301
- Testing
- ALN-KHK
- Where
- 15 sites in United States, Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Type 1 Diabetes, Dawn Phenomenon
Comparison of Lantus and Neutral Protamine Hagedorn (NPH) Insulin in the Dawn Phenomenon
1. To investigate the effect of insulin glargine (Lantus™) vs NPH insulin regarding glycemic control during the early AM (dawn phenomenon) in individuals with type 1 diabetes. 2.
- Trial name
- DAWN (NCT00694122)
- Testing
- Lantus (glargine)
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus Type 2, Mild Cognitive Impairment
The Early Warning System for the Diabetic Encephalopathy
Diabetes( mainly type II diabetes )lead to the central nervous system (CNS) function impairment, especially the mild cognitive impairment that increased the risk of progression to dementia.The primary objectives are defined…
- Conditions
- Diabetes Mellitus Type 2, Mild Cognitive Impairment, Metabolic Syndrome X
- Trial name
- NCT02420470
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
Diabetes Mellitus, Type 2, Gestational Diabetes
Hormonal and Inflammatory Changes During Pregnancy in Women With Glucose Metabolic Disorders.
The first aim of this study is to describe maternal hormonal and inflammatory changes during pregnancy in women that differ metabolically (limited to women with type 2 diabetes, gestational diabetes and/or overweight).
- Conditions
- Diabetes Mellitus, Type 2, Gestational Diabetes, Overweight and Obesity, Pregnancy in Diabetic
- Trial name
- HI-MET (NCT04617405)
- Testing
- No interventions
- Where
- 3 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- University of Aarhus
Insulin Resistance, Insulin Sensitivity
Fructose: Substrate, Stimulus, or Both?
This objective of this study is to use sensitive methodology under controlled conditions to investigate the mechanisms by which fructose consumption contributes to excess fatty acid synthesis and elevations in blood glucose…
- Conditions
- Insulin Resistance, Insulin Sensitivity, Pre Diabetes
- Trial name
- NCT04168372
- Testing
- High fructose, fructose labeled meal, High fructose, pyruvate labeled meal, Low fructose, fructose labeled meal
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Touro University, California
Obesity, Insulin Sensitivity/Resistance
Energy -Sensing Metabolites in Caloric Restriction
General integrated goal of the coordinated project: To elucidate the role of succinate and other metabolites derived from the intestinal microbiota such as Short Chain Fatty Acids (SCFAs), as energy sensing metabolites in the…
- Conditions
- Obesity, Insulin Sensitivity/Resistance, Diabetes Type 2
- Trial name
- NCT05031572
- Testing
- dietary intervention
- Where
- Spain
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Type1diabetes, Metabolic Syndrome
The Effect of Exercise on Metabolic Parameters, Anthropometric Measurement Values and Quality of Life
This study was planned as a randomized controlled experimental study to determine the effect of exercise with Augmented Reality Glasses (AR) on metabolic parameters, anthropometric measurement values and quality of life in…
- Conditions
- Type1diabetes, Metabolic Syndrome, Nursing Caries
- Trial name
- NCT05737654
- Testing
- Exercise with augmented reality glasses
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- TC Erciyes University
Diabetes, Gestational, Obesity
Maternal GDM in Hispanic Youth: Risk for Obesity
Our studies are aimed at examining effects of intrauterine exposure to GDM on metabolic risks in Hispanic children. Our primary hypothesis predicts that intrauterine exposure to GDM will be associated with one or more of three…
- Conditions
- Diabetes, Gestational, Obesity, Insulin Resistance, Insulin Secretion
- Trial name
- NCT02668601
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Hypercholesterolemia, Hypertension
Effectiveness of Nigella Sativa (Kalonji) Seed in Dyslipidemia
This is a pilot study. The aim of the investigators' study is to evaluate the effectiveness of nigella sativa seed in the treatment of dyslipidemia.
- Conditions
- Hypercholesterolemia, Hypertension, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- NCT00327054
- Testing
- Nigella sativa seed
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Type 2 Diabetes, Ageing
Effects of Nitrate on Liver Perfusion and Sugar Control
Rationale: Mediterranean style diets and diets rich in green leafy vegetables protect against the risk of developing type 2 diabetes and a wide range of cardiovascular disease. These diets are rich in nitrate.
- Trial name
- DiMPLe (NCT02195856)
- Testing
- Beetroot juice
- Where
- 2 sites in United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Blood Pressure, Diabetes
Mitigating the Pro-inflammatory Phenotype of Obesity
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell…
- Conditions
- Blood Pressure, Diabetes, Obesity, Insulin Resistance
- Trial name
- MAPLE (NCT04934228)
- Testing
- Hydrochlorothiazide 12.5Mg Tab, Clonidine Pill
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kansas Medical Center
Type 2 Diabetes Mellitus
Comparison of Neutral Protamine Hagedorn (NPH) and Lantus Based Insulin Regimen in the Management of Hypoglycemia in the Hospitalized Patients in Noncritical Care Setting
The goal of the current study is to determine difference in glycemic control between traditional split mix regimen with Neutral Protamine Hagedorn (NPH) and regular insulin vs basal bolus regimen with glargine and humalog in a…
- Trial name
- NCT02189395
- Testing
- NPH and regular insulin, glargine and humalog
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Riverside University Health System Medical Center
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