Clinical trials: Insulin Resistance, Diabetes
Obesity, Metabolic Syndrome
Diet, Obesity and Genes (DiOGenes)
Study Title: Diogenes, A randomised controlled trial comparing the effect of reduced-fat diets varying in glycaemic index (high vs. low) and protein content (high vs.
- Conditions
- Obesity, Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- DIOGENES (NCT00390637)
- Testing
- High or low Glycemic Index and high or low Protein Diet
- Where
- Denmark
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Pre-diabetes, Overweight
Genetic Counseling and Lifestyle Change for Diabetes Prevention
This study will examine the impact diabetes genetic counseling on patient motivation and disease prevention behaviors among subjects with pre-diabetes.
- Conditions
- Pre-diabetes, Overweight, Metabolic Syndrome
- Trial name
- GC/LC (NCT01034319)
- Testing
- Diabetes Genetic Counseling, No genetic counseling
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Insulin Resistance, Chronic Heart Failure
The Role of Insulin Resistance in Patients With Heart Failure and Type 2 Diabetes
The purpose of this cross-sectional comparative 2x2 trial study is to compare the degree of insulin resistance, myocardial function and selected metabolic parameters and to explore the pathophysiological mechanisms by which…
- Trial name
- CARMET2 (NCT02559128)
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Aging, Diabetes Mellitus, Type 2
Effect of GLP1 Receptor Agonists on Physical Function, Body Composition, and Markers of Aging in Older Adults
Semaglutide is a medication approved by the US Food and Drug Administration (FDA) as an antihyperglycemic (a drug that reduces glucoses in those with diabetes) and for weight management.
- Conditions
- Aging, Diabetes Mellitus, Type 2, PreDiabetes, Overweight and Obesity
- Trial name
- NCT05786521
- Testing
- Semaglutide Injectable Product, Lifestyle Counseling
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Obesity, Insulin Resistance
Effect of Probiotic Co-administration With Omega-3 Fatty Acids on Obesity Parameters and Insulin Resistance
Probiotics are defined as live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. Omega-3 fatty acids belong to the family of polyunsaturated fatty acids.
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Type2 Diabetes
- Trial name
- ENDO-5 (NCT04201938)
- Testing
- Symbiter-Omega
- Where
- Ukraine
- Volunteers
- 56 people
- Sponsor
- Bogomolets National Medical University
Type 2 Diabetes Mellitus
Orthogonal Polarisation Study in Young, Elderly and Type 2 Diabetics
Aging is accompanied by a progressive loss of skeletal muscle mass and strength, leading to the loss of functional capacity and an increased risk of developing chronic metabolic disease.
- Trial name
- NCT01476384
- Testing
- Glucose
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Insulin Resistance
Mitochondrial Function in Pediatric Obesity
The prevalence of pediatric obesity is increasing at an unprecedented rate. Obese children are at risk for the development of insulin resistance, relative insulin deficiency and type 2 diabetes mellitus.
- Trial name
- NCT00577174
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes (DM)
Studies of Insulin and Glucagon Action in the Liver
This study examines how glucagon works to regulate glucose metabolism, based on new findings that suggest glucagon signaling in the liver has more than one role, and that these multiple roles can be opposing in nature.
- Trial name
- SIGNAL (NCT07300982)
- Testing
- Glucagon
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Duke University
Insulin Resistance, Hyperglycemia
A Cold Physical Treatment to Manage Insulin Resistance
Insulin resistant volunteers will choose to undergo an 8-week cold treatment, 2 hours per day, to selective regions of the body enriched with brown fat including neck, supraclavicular and interscapular regions) in combination…
- Conditions
- Insulin Resistance, Hyperglycemia, Hyperinsulinemia, Diabetes
- Trial name
- CTPMIR (NCT02852759)
- Testing
- Selective Cold, Electroacupuncture
- Where
- China
- Volunteers
- 33 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Prediabetes, Type 2 Diabetes
Effects of Dried Whole Fruits on Metabolism in Diabetes
Diabetes becomes epidemic in worldwide countries. Diabetes Canada indicated that 30% of adults in Manitoba are diabetes or prediabetes. Nine out of ten diabetic patients are type 2 diabetes (T2D).
- Trial name
- NCT07354386
- Testing
- Freeze dried whole Saskatoon berry, Freeze dried apple slice bulk
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- University of Manitoba
Kidney Transplantation, Insulin Resistance
Effect of Pioglitazone on Insulin Resistance and Atherosclerosis in Renal Allograft Recipients Without Diabetes
The aim of this study was to evaluate the effect of pioglitazone treatment on insulin secretion, insulin resistance, and progression of atherosclerosis in renal allograft recipients without preoperative history of diabetes.
- Conditions
- Kidney Transplantation, Insulin Resistance, Atherosclerosis
- Trial name
- NCT00598013
- Testing
- Pioglitazone
- Where
- South Korea
- Volunteers
- 83 people
- Sponsor
- Yonsei University
Metabolic Cardiovascular Syndrome
Health Improvement After Pregnancy (HIP) Program Randomized Control Trial
Recent Canadian studies, public opinion polls and the Canadian Heart Health Strategy and Action Plan state that women's heart health is a key national priority; it should be addressed through improving heart health awareness and…
- Trial name
- HIP (NCT02077179)
- Testing
- HIP Program
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Queen's University
Type 1 Diabetes
Atorvastatin in New Onset Type 1 Diabetes Mellitus (T1DM)
The goal of this application is to evaluate the safety and efficacy of atorvastatin as a potential treatment to preserve beta cell function in children and young adults with newly diagnosed type 1 diabetes (T1DM).
- Trial name
- TIDM (NCT00529191)
- Testing
- Atorvastatin
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital of Philadelphia
Type 2 Diabetes Mellitus
Switch From U-100 Insulin Analog to U-500 Regular Insulin in Pumps for Type 2 Diabetes
The aim of the study was to perform a 3-year retrospective analysis from a cohort of patients with type 2 diabetes that were treated by a pump device and were uncontrolled despite high U-100 insulin requirements.
- Trial name
- NCT04371497
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Obesity
Bariatric Surgery: Microbiome & Diabetes
This study is a prospective cohort study, following 80 morbidly obese patients undergoing bariatric surgery, specifically Roux-en-Y gastric bypass (RYGB).
- Trial name
- NCT03723486
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Type 1 Diabetes
Sensor-Augmented Insulin Delivery: Insulin Plus Glucagon Versus Insulin Alone
This study aims to test an insulin and glucagon delivery algorithm designed to be used in conjunction with a continuous glucose monitoring system.
- Trial name
- NCT00797823
- Testing
- Insulin, Asp(B28)-, Glucagon
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Legacy Health System
Insulin Resistance
Nutritional Intervention of Type II Diabetes Mellitus by Vitamin D in Qatar
There is an association between elevated Type II Diabetes Mellitus (T2DM) risk and low serum levels of vitamin D. It is important to examine whether Vitamin D can enhance oral glucose tolerance in individuals at risk for…
- Trial name
- NCT02098980
- Testing
- Vitamin D
- Where
- Qatar
- Volunteers
- 200 people
- Sponsor
- Supreme Council Of Health, Qatar
Diabetes Mellitus
Effect of Fenugreek on Blood Sugar and Insulin in Diabetic Humans
The purpose of this study is to determine if bread containing fenugreek reduces blood sugar and insulin compared to identical bread without fenugreek.
- Trial name
- Fenugreek (NCT00597350)
- Testing
- Trigonella foenum-graecum (fenugreek)
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Insulin Resistance, Hyperinsulinemia
Effect of Alpelisib in Healthy Volunteers
The goal of this clinical trial is to test a single dose of the phosphoinositide-3-kinase (PI3K) inhibitor alpelisib versus placebo in healthy volunteers.
- Conditions
- Insulin Resistance, Hyperinsulinemia, Dyslipidemias
- Trial name
- NCT05733455
- Testing
- Alpelisib 150 mg [Piqray], 2 overencapsulated tablets (total: 300 mg), FreeStyle Libre Pro, Oral glucose tolerance test (OGTT) with Trutol glucose beverage
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Columbia University
Cystic Fibrosis-related Diabetes
β-cell Function and Insulin Sensitivity in Patients With Cystic Fibrosis
Cystic fibrosis is a genetic disorder caused by mutations in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene, leading to pulmonary infections, sinus disease, pancreatic insufficiency, hepatobiliary disease and…
- Trial name
- NCT04379726
- Testing
- therapeutic optimization
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
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