Clinical trials: Insulin Resistance, Diabetes
Dyslipidemia, Diabetes
Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors
Fructose-containing sugars have been implicated in the epidemics of obesity, diabetes and related cardiometabolic disorders. This view is supported by lower quality evidence from ecological observations, animal models, and select…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT02716870
- Testing
- Fructose-containing Sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetes Mellitus, HIV/AIDS
Diabetes Mellitus and HIV Study in Mwanza
Emerging evidence from high-income countries suggests that diabetes mellitus is become a major health problem among HIV-infected patients.
- Trial name
- CICADA (NCT03106480)
- Where
- Tanzania
- Volunteers
- 1,947 people
- Sponsor
- National Institute for Medical Research, Tanzania
Type 2 Diabetes, Overweight
Effects of Replacing Diet Beverages With Water on Weight Maintenance of Type 2 Diabetic Obese Women: 18 Months Follow up
the present study aimed to follow up our participants in order to consider the changes in weight and anthropometric measurements after the 12-month weight maintenance as well as the total of 18 months, consisting of the…
- Conditions
- Type 2 Diabetes, Overweight, Obese
- Trial name
- NCT03726762
- Testing
- DBs at the end of the main meal + weight control program, Water at the end of the main meal+ weight control program
- Where
- Iran
- Volunteers
- 81 people
- Sponsor
- Novindiet Clinic
Metabolic Syndrome, Type 2 Diabetes
Dairy Lipids, Proteins, and the Metabolic Syndrome - "DairyHealth"
Dairy food contains a large amount of long-chain saturated fat, which traditionally has been linked to increased risk of cardiovascular disease (CVD). However, recent data indicates a more neutral role.
- Conditions
- Metabolic Syndrome, Type 2 Diabetes, Cardiovascular Disease, Abdominal Obesity
- Trial name
- NCT01472666
- Testing
- High content of MC-SFA, Whey, Low content of MC-SFA
- Where
- Denmark
- Volunteers
- 63 people
- Sponsor
- University of Aarhus
Type 2 Diabetes
Dog-rose, Cranberry Leaves, Cranberry Berries, Alfalfa, Fenugreek, Lemon Beebrush, Urtica and Sumac in Diabetes Mellitus
This study investigates the safety and combined effect of Cranberry leaves, Cranberry Berries, Alfalfa, Fenugreek, Lemon Beebrush, Urtica, Dog-rose, and Sumac on improving the glycemic profile of patients with type 2 diabetes…
- Trial name
- NCT05700513
- Testing
- Capsules containing the combination products
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Tabriz University of Medical Sciences
Pregnancy Complications
Metformin Versus Insulin in Pregnant Women With Type 2 Diabetes
Pregnant women with type 2 diabetes mellitus (T2DM) are at increased risk for miscarriages, birth defects, large infants, and stillbirths. Maintaining blood sugars in the normal range decreases these pregnancy complications.
- Trial name
- NCT00678080
- Testing
- Metformin, Insulin (NPH and Regular)
- Where
- 3 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Type 1 Diabetes, Children
Think-Find-Solve Activities for Insulin Self-Management in Type 1 Diabetes
Children with type 1 diabetes require lifelong insulin therapy. However, improper management of insulin therapy may lead to serious, potentially life-threatening complications.
- Conditions
- Type 1 Diabetes, Children, Activity, Insulin
- Trial name
- NCT07670572
- Testing
- Insulin Self-Management Know-Find-Solve Activity Book, Routine education
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Marmara University
Type 1 Diabetes, Diabetic Kidney Disease
MANATEE-T1D: Metformin ANd AutomaTEd Insulin Delivery System Effects on Renal Vascular Resistance, Insulin Sensitivity, and Cardiometabolic Function in Youth With Type 1 Diabetes
Diabetic kidney disease and cardiovascular disease remain the leading causes of morbidity and mortality in people with type 1 diabetes and are exacerbated with longer duration of diabetes and time outside goal glycemic range.
- Conditions
- Type 1 Diabetes, Diabetic Kidney Disease, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- MANATEE-T1D (NCT05065372)
- Testing
- Metformin Hcl 1000Mg Tab, Aminohippurate Sodium 20 % Injection, Iohexol 300 Mg/mL Injectable Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kalie Tommerdahl
Metabolic Syndrome, Type 2 Diabetes Mellitus
Effects of Sodium-glucose Co-transporter-2( SGLT-2 ) Inhibition on Sympathetic Nervous System Activity in Humans
This study is designed to investigate whether the sodium-glucose co-transporter-2 (SGLT-2) inhibitor Empagliflozin reduces sympathetic nervous system (SNS) activity in humans.
- Conditions
- Metabolic Syndrome, Type 2 Diabetes Mellitus, Obesity
- Trial name
- EMPA-SNS (NCT03912909)
- Testing
- Empagliflozin Oral Tablet [Jardiance]
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Royal Perth Hospital
Obesity, Diabetes Mellitus
Activating Brown Adipose Tissue Through Exercise
The energy burning capacity of brown adipose tissue makes it an attractive target for anti-obesity therapies. Sympathetic nervous system (SNS) is the classical regulator of brown adipose tissue; however, recent findings show a…
- Conditions
- Obesity, Diabetes Mellitus, Metabolic Syndrome X
- Trial name
- ACTIBATE (NCT02365129)
- Testing
- Exercise training based on recommendations for adults (WHO)
- Where
- Spain
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Obesity, Metabolic Syndrome
Effects of Leptin Replacement in Children
To assess the endocrine and immune effects of leptin replacement in leptin-deficient children, from a consanguineous family. The hypothesis is that leptin replacement will have significant effects on endocrine function.
- Conditions
- Obesity, Metabolic Syndrome, Diabetes
- Trial name
- NCT00659828
- Testing
- Recombinant methionyl human leptin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Miami
Metabolic Syndrome, Diabetes Mellitus, Type 2
Assessing Inherited Markers of Metabolic Syndrome in the Young
The AIMM Young study is a collaboration between Children's National Medical Center (CNMC) and colleges/universities nationwide--currently including Howard University (HU), East Carolina University (ECU), and University of…
- Conditions
- Metabolic Syndrome, Diabetes Mellitus, Type 2, Obesity
- Trial name
- AIMMY (NCT00966407)
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Eric Hoffman
Type 1 Diabetes Mellitus
MEnstrual Cycle pHase ANd dIabeteS Management
This study evaluates the impact of menstrual cycle phases on insulin sensitivity, glycaemic control, and insulin requirements in women with type 1 diabetes (T1D).
- Trial name
- MECHANISM (NCT07004504)
- Where
- Switzerland
- Volunteers
- 77 people
- Sponsor
- DCB Research AG
Metabolic Syndrome, Type 2 Diabetes
Bed Rest, Alternate Daily Fasting and Incretin Effect
Bed rest produces insulin resistance in healthy volunteers. In this study the investigators aim to investigate the effect of 8 days bed rest on the incretin effect and how alternate daily fasting affects cognitive function and…
- Conditions
- Metabolic Syndrome, Type 2 Diabetes, Critical Illness
- Trial name
- NCT02134860
- Testing
- Bed rest, OGTT, IVGTT
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obesity, Type 2 Diabetes
PREMIER: PREvention of Metabolic Illness Through prEcision nutRition
Dietary intake is a major driving force behind the escalating obesity and type 2 diabetes epidemics. Large, high-quality clinical trials have shown that close adherence to healthy dietary recommendations significantly reduce the…
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome, Diet Habit
- Trial name
- PREMIER (NCT04148482)
- Testing
- Dietary intervention
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Metabolic Syndrome, Obesity
Reduction of the Metabolic Syndrome in Navarra-Spain
The purpose of this study is to determine whether a dietary pattern based on crononutrition and dietary training, together with dietary and psychological control, can reduce the body weight, improve the oxidative and inflammatory…
- Conditions
- Metabolic Syndrome, Obesity, Diabetes, Cardiovascular Disease
- Trial name
- RESMENA-S (NCT01087086)
- Testing
- Crononutrition, American Heart Association
- Where
- Spain
- Volunteers
- 109 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Diabetes Mellitus, Type 1
Flexible, Intensive Insulin Therapy in Patients With Type 1 Diabetes
To prospectively evaluate the long term metabolic and psychological effects of flexible intensive insulin therapy (FIT) courses in an unselected population of type 1 diabetic patients at the University of Basel Hospital.
- Trial name
- NCT00595569
- Testing
- Flexible insulin therapy (FIT)
- Where
- Switzerland
- Volunteers
- 45 people
- Sponsor
- University of Lausanne Hospitals
Prediabetic State, Cardiovascular Diseases
Role of Aging and Individual Variation in Exercise Training Responsiveness
The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15…
- Conditions
- Prediabetic State, Cardiovascular Diseases, Insulin Resistance, Obesity
- Trial name
- STRRIDE IV (NCT06471569)
- Testing
- Low/Mod, High/Mod, High/Vig
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Diabetes, Gestational, Insulin Sensitivity
Glucose Monitoring During Threatening Preterm Birth in Patients With and Without Gestational Diabetes Mellitus
This study aims to show whether the hyperglycaemic phases following a treatment with glucocorticoids, as well as blood measurements correlated to high blood glucose levels and insulin resistance, vary significantly between…
- Conditions
- Diabetes, Gestational, Insulin Sensitivity, PreTerm Birth, Glucose Intolerance During Pregnancy
- Trial name
- NCT03007186
- Where
- Austria
- Volunteers
- 36 people
- Sponsor
- Medical University of Vienna
Insulin Resistance, Diabetes Mellitus, Type 2
Identification of New Biomarkers of Insulin Resistance
Diabetes is a chronic metabolic disease affecting 415 million people worldwide, 90% of cases are type 2 which is frequently associated with obesity and a sedentary lifestyle.
- Conditions
- Insulin Resistance, Diabetes Mellitus, Type 2, Inflammation, Gastrointestinal Microbiome
- Trial name
- NCT03362554
- Testing
- Controlled diet and exercise.
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
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