Clinical trials: Insulin Resistance, Diabetes
Insulin Resistance
Nutritional Intervention of Type II Diabetes Mellitus by Vitamin D in Qatar
There is an association between elevated Type II Diabetes Mellitus (T2DM) risk and low serum levels of vitamin D. It is important to examine whether Vitamin D can enhance oral glucose tolerance in individuals at risk for…
- Trial name
- NCT02098980
- Testing
- Vitamin D
- Where
- Qatar
- Volunteers
- 200 people
- Sponsor
- Supreme Council Of Health, Qatar
Type2 Diabetes, Glucose, High Blood
The TCF7L2 Gene: Dietary Prevention of T2DM
Nutrients and chemicals in food are able to regulate expression of genetic elements. Gene-nutrient interaction in response specific diets can increase an individual's risk, shifting the individual from health toward the…
- Trial name
- NCT03458494
- Testing
- Mediterranean Diet, Low-fat diet
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Tufts University
Diabetes, Prediabetes
Meta-analyses of the Effect of Dietary Pulses on Acute Postprandial Metabolic Control
Dietary pulses (beans, peas, chickpeas, and lentils), more commonly known as "legumes", are generally recognized as healthy components of the diet.
- Conditions
- Diabetes, Prediabetes, Dysglycemia, Overweight
- Trial name
- NCT01605422
- Testing
- Dietary pulses
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- John Sievenpiper
Diabetes Mellitus, Type 2, Skeletal Muscle Insulin Sensitivity
Effects of 5 Weeks Treatment With Dapagliflozin in Type 2 Diabetes Patients on How the Hormone Insulin Acts on Sugar Uptake in Muscles.
The purpose of this study is to investigate the effects of 5 weeks treatment with dapagliflozin in type 2 diabetes patients on how the hormone insulin acts on sugar uptake in muscles.
- Trial name
- DAPAMAAST (NCT03338855)
- Testing
- Dapagliflozin
- Where
- Netherlands
- Volunteers
- 26 people
- Sponsor
- AstraZeneca
Pre-diabetes
Effects of a Dietary Supplement Containing L-Arabinose and Trivalent Patented Food-source of Chromium on Blood Glucose and Insulin
This study was designed to examine changes in capillary blood glucose and venous insulin levels after a 70 gram oral sucrose challenge with and without simultaneous consumption of a dietary supplement containing L-Arabinose and a…
- Trial name
- L-Arabinose (NCT01107431)
- Testing
- L-Arabinose and Chromium, Sucrose without dietary Supplement
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
Obesity, Physical Inactivity
Age and Insulin Resistance
Insulin resistance is a crucial factor for the development of type 2 diabetes and a major health problem for older adults. It is the principal mechanism by which obesity is considered to increase the risk for type 2 diabetes and…
- Conditions
- Obesity, Physical Inactivity, Aging
- Trial name
- AGIR (NCT01224886)
- Testing
- Physical activity
- Where
- 2 sites in Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Healthy, Metabolic Syndrome X
Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)
The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance.
- Conditions
- Healthy, Metabolic Syndrome X, Hyperlipidemia, Hypertension
- Trial name
- NCT00408824
- Where
- Japan
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Normoglycemia, T2DM (Type 2 Diabetes Mellitus)
To Study the Effects of Mango Ingestion in T2DM and Non-diabetic Subjects.
T2DM patient will be recruited from endocrine OPD 1. Clinical History and Examination: 1. General Physical Examination: Height (cm) weight (kg) BMI (kg/m2) Blood Pressure (mmHg) 2.
- Trial name
- NCT06055582
- Testing
- Bread, Mango
- Where
- India
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
Diabete Type 1
Eating Disturbances in Patients With Type 1 Diabetes Initiating Insulin Therapy
The prevalence of eating disorders is particularly high among people with type 1 diabetes (T1D). These abnormalities, such as "diabulimia," are frequently responsible for poor insulin therapy management and, consequently, chronic…
- Trial name
- CALI-BF (NCT07151924)
- Testing
- Questionnaires answers, Biological assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse
Postprandial Glycemia, Postprandial Insulinemia
A Human Clinical Trial Evaluating the Effect of MealShape™ on Blood Glucose Level Following Consumption of Standard Meal
The purpose of the study is to evaluate the effect of MealShape, a Ceylon cinnamon extract (Cinnamomum zeylanicum) on blood glucose and insulin response after consumption of a standard meal composed of white bread, in healthy…
- Trial name
- NCT02074423
- Testing
- MealShape cinnamon extract
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Dialpha
Diabetic Nephropathies
Nitric Oxide (NO) Activity and Diabetic Nephropathy
Experimental data suggest that oxidative stress and endothelial dysfunction are key players in the pathogenesis of diabetic nephropathy.
- Trial name
- NCT00136188
- Testing
- Folic Acid
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Obesity, PreDiabetes
Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
This study intends to assess the role of inflammation in insulin resistant conditions (i.e., obesity and pre-diabetes) and the subsequent development of disease, such as type 2 diabetes (T2D) and cardiovascular disease (CVD), in…
- Conditions
- Obesity, PreDiabetes, Adolescent Obesity, Inflammation
- Trial name
- MI4D (NCT04031222)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
Pre-diabetes
Long-term Resveratrol and Metabolism
The main objective of the study is to investigate if 6 months resveratrol supplementation can improve glucose tolerance in overweight/obese individuals.
- Trial name
- NCT02565979
- Testing
- resveratrol
- Where
- Netherlands
- Volunteers
- 42 people
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Non-Insulin-Dependent
A Study to Evaluate the Effect of Vitamin D Supplementation on Insulin Sensitivity and Secretion
The purpose of the study is to evaluate the change in insulin sensitivity and secretion indices (early markers for development of diabetes) after 4 weeks of a megadose of Vitamin D.
- Trial name
- NCT00320853
- Testing
- Vitamin D
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sitaram Bhartia Institute of Science and Research
Incretin Effect, Insulin Resistance
Incretin Effect in Lean and Obese Subjects
The incretin effect is markedly reduced in patients with type 2 diabetes. Data support the notion that this deficiency is a consequence of the diabetic state.
- Conditions
- Incretin Effect, Insulin Resistance, Type 2 Diabetes
- Trial name
- BMI-INK (NCT00803296)
- Testing
- Oral glucose tolerance test (OGTT), Isoglycemic intravenous glucose infusion
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Diabetes Mellitus, Type 2
Evaluation of the Integrated Radio Frequency Denervation System to Improve Glycemic Control in Type 2 Diabetic Subjects
The objective of this early feasibility study is to evaluate the safety and performance of intravascular hepatic denervation using the Metavention Integrated Radio Frequency Denervation System (iRF System) to improve glycemic…
- Trial name
- DeLIVER (NCT04285554)
- Testing
- iRF System Hepatic Denervation
- Where
- 8 sites in United States
- Volunteers
- 15 people
- Sponsor
- Metavention
Diabetes Mellitus, Type 2, Acupuncture
Effects of Acupuncture as Adjunctive Therapy in Patients With Type 2 Diabetes Mellitus
This study aims to determine the effect of acupuncture as an adjunctive therapy on homeostasis model assessment-insulin resistance (HOMA-IR) and health-related quality of life (HRQoL) in patients with type 2 diabetes mellitus.
- Trial name
- NCT04829045
- Testing
- SEIRIN PYONEX Acupuncture Needles
- Where
- Malaysia
- Volunteers
- 46 people
- Sponsor
- Universiti Putra Malaysia
Healthy Volunteers, Insulin Resistance
Polyphenols and Insulin Resistance
Diet and nutrition play an essential role in the development and the clinical expression of the most common health problems. Overeating and obesity induce oxidative stress, which has been proposed to be a pathogenic mechanism…
- Conditions
- Healthy Volunteers, Insulin Resistance, Type 2 Diabetes (T2D)
- Trial name
- POLYOXRESIST (NCT01478841)
- Testing
- polyphenol
- Where
- France
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Type 2 Diabetes
The Effects of Two Education Strategies About Insulin on Patient Preferences and Perceptions About Insulin Therapy
This study compared the impact of two educational strategies (an education program versus a pamphlet) on participants preferences for insulin and their perceptions about insulin and injections after attending an educational…
- Trial name
- NCT00149331
- Testing
- Structured education program
- Where
- Canada
- Volunteers
- 86 people
- Sponsor
- Hamilton Health Sciences Corporation
Metabolic Syndrome, Insulin Resistance
Continuous Tart Cherry Juice Supplementation With Metabolic Syndrome Participants
The present study examined the effect of Montmorency tart cherry juice on functional and blood-based cardio-metabolic markers in humans with Metabolic Syndrome.
- Conditions
- Metabolic Syndrome, Insulin Resistance, Hypertension
- Trial name
- NCT03619941
- Testing
- Montmorency Tart Cherry Juice
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Hertfordshire
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