Clinical trials: Insulin Resistance, Diabetes
Diabetes Mellitus, Type 2
Hypoglycemic Efficacy of Greenyn Momordica Charantia Extracts in Diabetic Subjects
This is a randomized, double-blind, placebo-controlled, add-on clinical trial to evaluate the efficacy and safety of Momordica Charantia extracts taken orally for 3 months by subjects with type 2 diabetes.
- Trial name
- NCT03151837
- Testing
- Greenyn Momordica charantia extracts
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chung Shan Medical University
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Type 2 Diabetes Mellitus
Dietary Fatty Acids As Complementary Therapy in Type 2 Diabetes Mellitus
The purpose of the study is to see how a dietary oil called conjugated linoleic acid, or CLA, might be useful in combination with diabetes medication. Some studies show that CLA can modestly reduce body weight and body fat.
- Trial name
- FACT (NCT00607945)
- Testing
- Rosiglitazone (Avandia) OR other diabetes medication currently prescribed to participant, conjugated linoleic acid (CLA)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Ohio State University
Type 2 Diabetes Mellitus, Cardiovascular Diseases
Physical Activity, Insulin Resistance and Function of Fat Tissue in the Offspring of Patients With Type 2 Diabetes
Offspring of patients with type 2 diabetes have increased risk of developing diabetes and are typically more insulin resistant than their peers with no diabetes family history.
- Trial name
- NCT00268541
- Testing
- Physical activity
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Pre-diabetes
The Insulin Sensitivity Using Aerobic Interval Conditioning
The Insulin Sensitivity using Aerobic Interval Conditioning (ISAIC) trial will compare traditional aerobic training (AER) to interval training (INT) in sedentary, overweight/obese men at risk for pre-diabetes.
- Trial name
- ISAIC (NCT01286922)
- Testing
- Behavioral: exercise
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Prediabetic State, Insulin Resistance
Effect of Linagliptin + Metformin vs Metformin Alone in Patients With Prediabetes
Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this clinical trial is to evaluate the effect of linagliptin + metformin vs metformin alone on…
- Trial name
- PRELLIM (NCT03004612)
- Testing
- Linagliptin + metformin, Metformin
- Where
- Mexico
- Volunteers
- 144 people
- Sponsor
- Universidad de Guanajuato
Malaria, Diabetes Mellitus
Diabetes, Metabolic Syndrome and Risk of Malaria in Cameroon
Non-communicable diseases (NCDs) such as diabetes are increasing in countries where malaria transmission is common. This study aims to investigate the relationship between NCDs and parasitic infections in Cameroon.
- Conditions
- Malaria, Diabetes Mellitus, Metabolic Syndrome, Endemic
- Trial name
- NCT06278181
- Where
- Cameroon
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Insulin
Regimen Switch After Intensive Insulin Therapy
Insulin intensive therapy have traditionally been considered a sequential therapy in type 2 diabetes last choice, a number of guidelines and consensus recommendations insulin intensive therapy can be as obvious hyperglycemia in…
- Trial name
- NCT04833413
- Testing
- Continuous intensive insulin therapy
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Shanghai Zhongshan Hospital
Hyperinsulinemia, Insulin Resistance
Glycemic Effect of Diazoxide in NAFLD
The goal of this clinical trial is to compare a two-week course of diazoxide (at two different doses) and placebo in people with overweight/obesity and insulin resistance (IR) with, or at high risk for, non-alcoholic fatty liver…
- Conditions
- Hyperinsulinemia, Insulin Resistance, Non-Alcoholic Fatty Liver Disease, Prediabetic State
- Trial name
- NCT05729282
- Testing
- Diazoxide oral suspension, 1 mg per kg per dose, Diazoxide oral suspension, 2 mg per kg per dose, FreeStyle Libre Pro
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Columbia University
Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM)
MRI Assessment of Pancreatic Fat Changes and Islet Function Recovery After Bariatric Surgery in Obese Patients
This study evaluates changes in pancreatic fat and recovery of pancreatic function in obese patients undergoing laparoscopic sleeve gastrectomy (LSG), a weight-loss surgery.
- Conditions
- Obesity & Overweight, Type 2 Diabetes Mellitus (T2DM), Pancreatic Steatosis, Insulin Resistance
- Trial name
- PANFAT-BS (NCT07464223)
- Testing
- Laparoscopic Sleeve Gastrectomy (LSG)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- yu li，MD
Insulin Resistance, Prediabetes
Metformin and Longevity Genes in Prediabetes
Pre-diabetes, a condition characterized by hyperglycaemia, is associated with increased cardiovascular risk and reduced life expectancy, as compared to the general population.
- Conditions
- Insulin Resistance, Prediabetes, Aging, Inflammation
- Trial name
- NCT01765946
- Testing
- Metformin
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Padova
Type 2 Diabetes
Short-Term Intensive Insulin Therapy Induction of Long-term Glycemic Control
We designed this prospective, randomized control study to compare the benefits between the insulin therapy and OADs after correction of the glucose toxicity with a short period of intensive insulin therapy.
- Trial name
- NCT00506194
- Testing
- Insulin, OAD
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Hyperglycemia, Diabetes
Basal Bolus Versus Human Insulin in Hospitalized Patients With Diabetes in Paraguay
Few randomized studies have focused on the optimal management of non-ICU patients with type 2 diabetes in Latin America. Objective: Compare safety and efficacy of a basal bolus regimen with analogs and human insulins in general…
- Trial name
- NCT02278913
- Testing
- Basal Bolus (Glargine and Glulisine), Human Insulin
- Where
- Paraguay
- Volunteers
- 134 people
- Sponsor
- Universidad Nacional de Asunción
Diabetes Mellitus, Type 2
Skin and Retina Microvascular Endothelial Function in Healthy, Insulin Resistant and Type 2 Diabetic Subjects
The purpose of this study is to investigate microvascular endothelial function in the retina of lean, obese, and type 2 diabetic subjects and to compare microvascular endothelial function in the retina with several other…
- Trial name
- NCT01241370
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ELAB-Logistics
Metabolic Syndrome, Diabetes
Personalized Medicine for Diabetes Prediction and Prevention of Complications
The metabolic syndrome is a collection of related risk factors that predispose to the development of type 2 diabetes Mellitus and cardiovascular disease.
- Trial name
- NCT01268813
- Testing
- Breath analysis and blood analysis
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Diabetes Mellitus
Effect of Adiponectin Genetic Polymorphism on Rosiglitazone Response
The aims of the present study were to investigate the association between adiponectin gene polymorphisms and the response to rosiglitazone monotherapy in T2D patients.
- Trial name
- NCT00501488
- Testing
- rosiglitazone
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Central South University
Prostate Cancer, Insulin Resistance
Pioglitazone and Insulin Resistance in ADT
This study is being done to establish the mechanisms underlying insulin resistance (reduced insulin action that can lead to high blood sugar and maybe diabetes) in patients undergoing androgen deprivation therapy (ADT) for…
- Conditions
- Prostate Cancer, Insulin Resistance, Diabetes Mellitus, Type 2, Androgen Deficiency
- Trial name
- NCT05098327
- Testing
- Pioglitazone 30 mg
- Where
- United States
- Sponsor
- State University of New York at Buffalo
Diabetes Mellitus, Type 2
Insulin Start Therapy Application With Resources and Training
The purpose of the I-START study is to evaluate an educational phone application (app) designed to support patients with type 2 diabetes (T2DM) by reinforcing the necessary skills needed for insulin administration as part of…
- Trial name
- I-START (NCT03999268)
- Testing
- I-START, Standard Insulin Administration Education
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Pittsburgh
Abdominal Obesity
Physical Activity in Youth: Implications for Reversing Risk Factors for Type 2 Diabetes
In this randomized controlled trial, we will examine the effect of a 3-month exercise training (aerobic exercise versus resistance exercise) without calorie restriction on total and regional adiposity, and risk of type 2 diabetes…
- Trial name
- NCT00739180
- Testing
- Control, Resistance Exercise, Aerobic exercise
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Insulin Resistance, Type 2 Diabetes
Fish Gelatin Supplement and Omega-3 Supplement in Obese or Overweight Subjects With Insulin Resistance
The present study was conducted to test whether a fish gelatin supplement combined with an omega-3 polyunsaturated fatty acid supplement can exert beneficial and sex-specific effects on insulin sensitivity, glucose tolerance…
- Trial name
- NCT01215903
- Testing
- Fish gelatin and omega-3 polyunsaturated fatty acid, Omega-3 polyunsaturated fatty acid
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Laval University
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