Clinical trials: Insulin Resistance, Diabetes
NAFLD, Overweight and Obesity
The Acute Effects of Eucaloric and Hypocaloric Carbohydrate Restriction on Liver Fat Content and Metabolism in Obese Individuals
The primary aim of this study is to investigate the acute changes in liver fat content in response to a fixed carbohydrate restriction (i.e.
- Conditions
- NAFLD, Overweight and Obesity, Metabolic Syndrome, Diabetes
- Trial name
- FixedCarb (NCT05643521)
- Testing
- Dietary composition of macronutrients and calories
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Type2 Diabetes, Cardiometabolic Syndrome
Effects of White Potato Consumption on Measures of Cardiometabolic Health in Individuals With Type 2 Diabetes Mellitus
The investigators are examining the effects of potato consumption on indices of glycemic control and cardiovascular health in overweight and obese individuals with type two diabetes mellitus (T2D) to provide feasible and…
- Conditions
- Type2 Diabetes, Cardiometabolic Syndrome, Arterial Stiffness, Overweight and Obesity
- Trial name
- NCT04511325
- Testing
- Potato Regimen, Refined Grain Regimen
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Florida State University
Schizophrenia, Schizoaffective Disorder
Efficacy Study of Panax Ginseng to Boost Antipsychotics Effects in Schizophrenia
The objective of the study is to determine whether Panax Ginseng with multiple interactions with key components of brain signaling pathway, can augment the effects of antipsychotics in Schizophrenia.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Tardive Dyskinesia, Insulin Resistance
- Trial name
- NCT00401089
- Testing
- Panax Ginseng
- Where
- 4 sites in Canada, United Kingdom
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Type 2 Diabetes, Insulin Resistance
Nesfatin-1 Level in Patients With Type 2 Diabetes, Insulin Resistance and Obesity
This research was planned to determine the level of nesfatin-1, known as satiety hormone, in type 2 diabetes, insulin diabetes and obesity patients and to determine whether there is a relationship between patients' energy intake…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity, Nesfatin-1
- Trial name
- NCT04298515
- Testing
- Nesfatin-1
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Insulin Resistance, Low Birth Weight
Effects of 3 Months of Selective Serotonin Reuptake Inhibitor (SSRI)-Treatment on Metabolism and Hypothalamic-pituitary-adrenal (HPA)-Axis in Young Men Born With Low Birth Weight
Chronic stress has been proposed to be involved the development of western life-style diseases such as cardiovascular disease and type 2 diabetes (T2DM).
- Conditions
- Insulin Resistance, Low Birth Weight, Type 2 Diabetes, Cardiovascular Disease
- Trial name
- LBW-SSRI (NCT00971815)
- Testing
- Escitalopram
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Metabolic Disease, Insulin Sensitivity
Metabolic Effects of Melatonin Treatment
Modern living is associated with an epidemic of type 2 diabetes mellitus (T2DM). Sleep disturbances such as insomnia or frequent awakenings are strong risk factors for T2DM with several studies indicating a central role of…
- Conditions
- Metabolic Disease, Insulin Sensitivity, Glucose Metabolism Disorders (Including Diabetes Mellitus), Type 2 Diabetes Mellitus
- Trial name
- NCT03859934
- Testing
- Melatonin
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- University of Aarhus
Type 2 Diabetes Mellitus
Switch From U-100 Insulin Analog to U-500 Regular Insulin in Pumps for Type 2 Diabetes
The aim of the study was to perform a 3-year retrospective analysis from a cohort of patients with type 2 diabetes that were treated by a pump device and were uncontrolled despite high U-100 insulin requirements.
- Trial name
- NCT04371497
- Volunteers
- 65 people
- Sponsor
- University Hospital, Caen
Diabetes Mellitus, Type 2, Cardiomyopathy, Dilated
Cross-over Study on Effect of Lipid Lowering by Acipimox on Cardiac and Skeletal Muscle Mitochondrial Function
Accumulation of lipid in skeletal and cardiac muscle has been associated with insulin resistance and diabetic cardiomyopathy. In skeletal muscle, lipotoxic damage has been suggested to lead to dysfunction of mitochondria.
- Trial name
- ACP (NCT00943059)
- Testing
- Acipimox, Cellulosum Mycrocryst
- Where
- Netherlands
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Insulin Resistance
Exercise to Restore 24h Rhythms in Metabolism
This study will investigate the effect of exercise training on 24h rhythms in substrate metabolism in overweight subjects with impaired glucose tolerance. Subjects will perform exercise training for 12 weeks.
- Trial name
- RESTORE (NCT04565418)
- Testing
- High-intensity interval training
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Metabolic Syndrome
Effect of Genistein in Women With Metabolic Syndrome
The purpose of this study is to determine whether the phytoestrogen genistein is effective in improving bone condition in pre-menopausal and post-menopausal women suffering for osteopenia.
- Trial name
- NCT00541710
- Testing
- genistein
- Where
- 3 sites in Italy
- Volunteers
- 120 people
- Sponsor
- University of Messina
PreDiabetes
2-A-Day Study: Twice a Day Meals Study.
Caloric restriction increases lifespan and/or healthspan across multiple species. However implementation of long-term CR in humans is problematic and unacceptable to many individuals.
- Trial name
- NCT03809299
- Testing
- Ad libitum meal timing, Twice a day meals
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Gestatiaonl Diabetes Mellitus, Insulin Resistance
Impact of Gestational Diabetes on Childhood Obesity
In this study, we aimed to investigate the relationship between obesity, glucose intolerance (insulin resistance), dyslipidemia and diabetes in children aged 5-12 born to mothers with Gestational Diabetes Mellitus (GDM) in…
- Conditions
- Gestatiaonl Diabetes Mellitus, Insulin Resistance, Dyslipaemia, Obesity &Amp; Overweight
- Trial name
- NCT07069296
- Testing
- blood samples were collected from participants, blood samples
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Prediabetic State, Metabolic Syndrome
Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects
The aim of this prospective interventional study is to investigate the metabolic effects of consuming artificial and natural sweeteners in persons with prediabetes.
- Conditions
- Prediabetic State, Metabolic Syndrome, Insulin Resistance, Thrombosis
- Trial name
- Sweetheart (NCT07377097)
- Testing
- Saccharin, Sucralose, Erythritol
- Volunteers
- 80 people
- Sponsor
- Charite University, Berlin, Germany
Type2 Diabetes, Insulin Resistance
Effect of Probiotic on Insulin Resistance in Type 2 Diabetes Patients
Probiotics have beneficial effect on obesity related disorders in animal models. Despite a large number of animal data, randomized placebo-controlled trials (RCT) concluded that probiotics have a moderate effect on glycemic…
- Conditions
- Type2 Diabetes, Insulin Resistance, Probiotic
- Trial name
- NCT03434860
- Testing
- probiotic
- Volunteers
- 53 people
- Sponsor
- Bogomolets National Medical University
PreDiabetes, Obesity
Tolerability, Acceptance, and Utility of Intermittent CGM Use in Youth With Prediabetes
We are evaluating whether intermittent use of continuous glucose monitors (CGMs) in addition to standard nutritional counseling and physical activity counseling is associated with improved metabolic health for youth with…
- Conditions
- PreDiabetes, Obesity, Insulin Resistance
- Trial name
- NCT05505565
- Testing
- Abbott Freestyle Libre 2, Standard physical activity and nutritional counseling for prediabetes management
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Alabama at Birmingham
Generalized Lipodystrophy
A Study of the Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)
This study is researching an experimental drug called mibavademab. The study is focused on participants with GLD who have been on metreleptin treatment for at least 6 months with no change in dose for the last 3 months.
- Trial name
- NCT06548100
- Testing
- mibavademab
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Regeneron Pharmaceuticals
Diabetes
Efficacy and Safety of Frequently Modified Intensive Insulin
The purpose of this study is to evaluate the efficacy and safety of frequently modified intensive insulin therapy in patients with Type-2 and Type-1 diabetes mellitus.
- Trial name
- NCT01014832
- Testing
- Intensive insulin therapy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Hygieia, Inc
Diabetes Mellitus, Type 2, Insulin Resistance
Low Dose Fat-Induced Insulin Resistance
The primary goal of this study is to determine the dose of fatty acids that acutely induces mild insulin resistance in healthy volunteers.
- Conditions
- Diabetes Mellitus, Type 2, Insulin Resistance, Insulin Sensitivity
- Trial name
- BCAA (NCT03479671)
- Testing
- Intralipid, 20% Intravenous Emulsion
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Diabetes Mellitus, Type 2
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus
The aim of this study is to investigate the effect of GRK2 inhibitor paroxetine on insulin resistance in patients with type 2 diabetes mellitus.
- Trial name
- NCT06203275
- Testing
- Paroxetine
- Volunteers
- 44 people
- Sponsor
- aya ramadan ashmawy sarhan