Clinical trials: Insulin Resistance, Diabetes
Type 2 Diabetes
Efficacy and Safety Study of MP-513 in Patients With Type 2 Diabetes
The purpose of this study is to evaluate the efficacy and safety and to determine the appropriate dose for phase 3 confirmatory trial, of MP-513 (Teneligliptin) in patients with type 2 Diabetes based on the change of HbA1c and…
- Trial name
- NCT00628212
- Testing
- Teneligliptin 10mg, Teneligliptin 20 mg, Teneligliptin 40 mg
- Where
- Japan
- Volunteers
- 324 people
- Sponsor
- Tanabe Pharma Corporation
Insulin Resistance, Type 2 Diabetes
Dietary Fish Protein in Subjects With Insulin Resistance
The objective of our research project is to determine the effects of fish protein, present in fish, on insulin sensitivity in insulin-resistant human individuals, and its mechanism of action on glucose metabolism.
- Trial name
- NCT00400036
- Testing
- Cod protein NCEP-diet
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Laval University
Diabetes
A Phase III Clinical Study to Assess the Efficacy and Safety of GZR4 in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin
This study will be conducted to compare the efficacy, safety and patient-reported outcome of once-weekly GZR4 and once-daily Insulin Degludec with or without Non-Insulin Antidiabetic Agents in subjects with Type 2 Diabetes…
- Trial name
- NCT06767748
- Testing
- GZR4, insulin degludec
- Where
- China
- Volunteers
- 620 people
- Sponsor
- Gan & Lee Pharmaceuticals.
Depression, Major Depressive Disorder
eIMPACT-DM Pilot Trial: Depression Treatment to Reduce Diabetes Risk
This pilot randomized controlled trial seeks: (1) to determine the preliminary efficacy of our modernized collaborative care intervention for depression in improving the diabetes risk markers of hemoglobin A1c and insulin…
- Conditions
- Depression, Major Depressive Disorder, Dysthymic Disorder, Depressive Symptoms
- Trial name
- NCT04437485
- Testing
- Good Days Ahead (GDA), Problem Solving Treatment in Primary Care (PST-PC), Antidepressant Medications
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Indiana University
Hyperglycemia, Diabetes
Conversion of Hyperglycemic Patients Being Treated With Intravenous Insulin Infusions to Lantus Insulin
The primary objective of this study is to determine the optimal dose of glargine insulin when converting from intravenous short-acting continuous insulin infusions in surgical and intensive care unit patients using a prospective…
- Trial name
- NCT00338104
- Testing
- insulin glargine
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Northwestern University
Obesity, Diabetes
Semaglutide 2.4 mg in Patients With Poor Weight-loss
A double-blinded, randomised, placebo-controlled trial of semaglutide 3.0 mg/ml in patients with poor weight-loss following bariatric surgery.
- Conditions
- Obesity, Diabetes, Metabolic Syndrome
- Trial name
- BARI-STEP (NCT05073835)
- Testing
- Semaglutide 3 mg
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- University College, London
Metabolic Syndrome, Diabetes
Metabolic Profile and Anthropometric Changes in Schizophrenia
"No clinical differences will be found between the three antipsychotics under study - olanzapine, risperidone and haloperidol - on the patients' metabolic profile and weight. "
- Conditions
- Metabolic Syndrome, Diabetes, Obesity
- Trial name
- MetS (NCT00534183)
- Testing
- Olanzapine, Risperidone, Haloperidol
- Where
- India
- Volunteers
- 2,006 people
- Sponsor
- Central Institute of Psychiatry, Ranchi, India
Type 2 Diabetes, Endothelial Dysfunction
Endothelial Effects of Basal Insulin: Detemir Versus Glargine
Endothelial progenitor cell (EPC) level represents a surrogate marker of cardiovascular risk and an indicator of the ongoing vascular damage.
- Conditions
- Type 2 Diabetes, Endothelial Dysfunction, Cardiovascular Disease
- Trial name
- NCT00699686
- Testing
- Glargine, Detemir
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Type1 Diabetes Mellitus
The Insulin-Only Bionic Pancreas Bridging Study- Pediatric Transitional Study
The iLet is a closed-loop delivery system that can be used in insulin-only, bihormonal, or glucagon-only configurations. Previous studies have utilized a phone-based bionic pancreas.
- Trial name
- NCT04112069
- Testing
- iLet Bionic Pancreas insulin-only configuration with Humalog or Novolog, Usual Care
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Pre-Diabetes, Major Lung or Abdominal Surgery
Attenuating The Post-Operative Insulin Resistance And Promoting Protein Anabolism
Major surgery results in a stress- induced catabolic response, marked by post-operative insulin resistance, hyperglycemia and loss of body protein, which is associated with increased morbidity, mortality and adverse outcomes.
- Conditions
- Pre-Diabetes, Major Lung or Abdominal Surgery, Insulin Resistance
- Trial name
- NCT02393573
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type2 Diabetes, Insulin Sensitivity
Effects of Empagliflozin on Cardiac Microvasculature and Insulin Sensitivity in Subjects With Type 2 Diabetes
The aim is to test in T2DM patients, whether, compared to placebo, 12 weeks of SGLT-2 inhibitor improves post-absorptive, post-insulin infusion or postprandial insulin action to enhance Cardiac Muscle vascular function and…
- Trial name
- EJB051 (NCT04203927)
- Testing
- Empagliflozin 25 MG
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Virginia
Chronic Periodontitis, Type 2 Diabetes Mellitus
Glycemic Control in T2DM Through Non-Surgical Periodontal Therapy
It is submitted that incident and prevalent chronic periodontal infection, known as chronic periodontitis (CP) possibly has a causal relationship with diabetes mellitus (DM) having effects on HbA1c, fasting plasma/ blood glucose…
- Trial name
- NCT03343366
- Testing
- Metronidazole, Scaling Root Planing, Oral Hygiene Instructions
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Dow University of Health Sciences
Vitamin D Deficiency
Vitamin D Deficiency, Insulin Resistance and FGF-23
The purpose of this project is to determine if treating vitamin D deficiency decreases insulin resistance and improves insulin secretion in healthy volunteers.
- Trial name
- NCT00491322
- Testing
- Ergocalciferol
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus, Type 2, Obesity
Influence of a Liquid Oat Bran Product on Blood Glucose in Patients With Poorly Controlled Type 2 Diabetes
This study evaluates the effects of an ad libitum addition of a high fiber product to the regular diet of type 2 diabetes patients on body weight and blood sugar control.
- Conditions
- Diabetes Mellitus, Type 2, Obesity, Overweight, Metabolic Syndrome
- Trial name
- NCT03805802
- Testing
- active product, reference product
- Where
- Germany
- Volunteers
- 34 people
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Metabolic Syndrome, Abdominal Obesity
Copenhagen Obesity Risk Assessment Study
The aim of the present study is to assess the effect of a high intake of industrially produced trans fatty acids for 16 weeks on abdominal obesity and risk markers of type 2 diabetes and heart disease in healthy, moderately…
- Conditions
- Metabolic Syndrome, Abdominal Obesity, Heart Disease, Type 2 Diabetes
- Trial name
- COBRA (NCT00655902)
- Testing
- Trans fat (soy bean oil), Control fat (sunflower oil)
- Where
- Denmark
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
PreDiabetes, Metabolic Syndrome
Women's Lifestyle Balance Study
This pilot study aims to determine whether adding a sleep extension and sleep hygiene intervention to an existing lifestyle improvement program improves its efficacy for weight loss in those at risk for diabetes and…
- Conditions
- PreDiabetes, Metabolic Syndrome, Overweight
- Trial name
- LB (NCT03184337)
- Testing
- CDC's PreventT2 Program, CDC's PreventT2 Program with Added Sleep Content
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Type 2 Diabetes, Metabolic Syndrome
Effect of VeSTAL Device in Type 2 Diabetes Mellitus
The aim of this study is to evaluate the efficacy of non-invasive electrical vestibular nerve stimulation (VeNS), together with a lifestyle modification program, as a method of reducing HbA1c, as compared to a sham control with…
- Trial name
- NCT04149951
- Testing
- Vestal Device
- Where
- Ireland
- Volunteers
- 50 people
- Sponsor
- Neurovalens Ltd.
Topical, Insulin
Topical Insulin Dressing on Management of Diabetic Foot Ulcers
This study aimed to find out the advantages of topical insulin in the management of diabetic foot ulcers over the conventional wound saline dressing.
- Conditions
- Topical, Insulin, Dressing, Diabetic Foot Ulcers
- Trial name
- NCT07432581
- Testing
- Insulin, Normal saline
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Cairo University
Cardiovascular Risk Factor, Type2 Diabetes Mellitus
Orange Juice And Sugar Intervention Study
The objectives of this proposal are to address the gaps in knowledge regarding the metabolic effects of consuming orange juice, the most frequently consumed fruit juice in this country, compared to sugar-sweetened beverage.
- Conditions
- Cardiovascular Risk Factor, Type2 Diabetes Mellitus, Insulin Sensitivity, Metabolic Syndrome
- Trial name
- OASIS (NCT03527277)
- Testing
- Naturally-sweetened orange juice, Sugar-sweetened beverage
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Diabetes Mellitus, Type 2
ADAM17 and Vascular Function in Diabetes
The objective of this project is to determine the extent to which administration of the dietary supplement phosphatidylserine (PS), a competitive inhibitor of ADAM17 sheddase activity, effects vascular function and…
- Trial name
- ADAM17 (NCT04557228)
- Testing
- Phosphatidylserine
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Missouri-Columbia
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