Clinical trials: Insulin Resistance
Insulin Sensitivity, Healthy Adult
Diaplex and Glycemic Control
The goal of this 16-week double-blind, placebo-controlled pilot study is to determine whether daily Diaplex supplementation improves insulin sensitivity and glycemic control in adults with elevated blood glucose levels, while…
- Trial name
- NCT07711587
- Testing
- Diaplex
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Standard Process Inc.
HIV
Switching From Protease Inhibitor/Ritonavir to Generic Single Tablet Regimen of Tenofovir Alafenamide/Emtricitibine/Dolutegravir
This is a phase III, multicenter, open-label, single-arm study of 190 virologically suppressed HIV-infected adults
- Trial name
- NCT03727152
- Testing
- generic single tablet TAF/FTC/DTG
- Where
- 2 sites in Thailand
- Volunteers
- 170 people
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Obesity, Diabetes Mellitus, Type 2
Efficacy, Safety, and Tolerability of Tirzepatide in Real-World Conditions in Paraguay.
This is a prospective cohort study evaluating the efficacy, safety, and tolerability of tirzepatide under real-world conditions in the Paraguayan population.
- Trial name
- REAL-TIRZEPY (NCT07588438)
- Testing
- Tirzepatide (LIPOLESS de Laboratorio de Productos Eticos C.E.I.S.A.)
- Where
- Paraguay
- Volunteers
- 160 people
- Sponsor
- Las Rías Medical Center
Fatty Liver, Liver Dysfunction
The Effect of Helicobacter Pylori Eradication on Liver Fat Content in Non-alcoholic Fatty Liver Disease
The role of Helicobacter pylori(HP)in the pathogenesis of non-alcoholic fatty liver disease (NAFLD) is controversial.
- Conditions
- Fatty Liver, Liver Dysfunction, Insulin Resistance
- Trial name
- NCT01876108
- Testing
- H.pylori eradication (Omeprazole, Amoxicillin, Bismuth subcitrate, Azithromycin)
- Where
- Iran
- Volunteers
- 100 people
- Sponsor
- Tehran University of Medical Sciences
Cardiovascular Diseases, Heart Diseases
Partnership Programs to Reduce Ethnic Differences in the Risk of Cardiovascular Disease
The purpose of this study is to improve cardiovascular disease (CVD) outcomes in racial and ethnic minorities. Specifically, the study seeks to systematically characterize potential ethnic differences in obesity-related CVD by…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Metabolic Syndrome X
- Trial name
- META-HEALTH (NCT00101517)
- Where
- 2 sites in United States
- Volunteers
- 4,024 people, healthy volunteers welcome
- Sponsor
- Emory University
Diabetes
Urine pH as a Predictor of Diabetes
Urine pH has been lately linked to insulin resistance. The early phase of Diabetes Mellitus involves insulin resistance. Thus, the investigators want to check if a simple cheap study like a urine analysis that can predict…
- Trial name
- NCT01017848
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Northwell Health
Metabolic Syndrome
Comparison of Two Programs for Weight Loss and Impact on Metabolic Syndrome
The purpose of this study is to learn the impact stress may have on weight management and emotional eating.
- Trial name
- NCT02023515
- Testing
- Emotional brain training, Behavioral weight loss
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Kelly Webber
Obesity, Hypertension
A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients
The main purposes of this study are to find out if the study drug losartan (Cozaar) or placebo ("sugar pill") has an effect on insulin sensitivity (how your body responds to insulin) and to measure the effect of the study drug…
- Conditions
- Obesity, Hypertension, Hyperglycemia
- Trial name
- NCT00675987
- Testing
- losartan
- Where
- 9 sites in United States
- Volunteers
- 53 people
- Sponsor
- Brigham and Women's Hospital
Morbid Obesity, Metabolic Syndrome X
Randomized Comparison of Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity
Bariatric surgery is the most effective treatment for morbid obesity. Roux-en-Y gastric bypass (RYGB) is a bariatric procedure with known safety and effectiveness.
- Conditions
- Morbid Obesity, Metabolic Syndrome X, Diabetes Mellitus, Dyslipidemia
- Trial name
- NCT01806506
- Testing
- Laparoscopic sleeve gastrectomy, Roux-en-Y Gastric Bypass
- Where
- Poland
- Volunteers
- 72 people
- Sponsor
- Medical University of Warsaw
Whole Body Catabolisme Induced by Glucocorticoids
Glucocorticoid Induced Whole Body Catabolisme
The main purpose of the trial is to advance our knowledge on the possible mechanism underlying the catabolic effects of long-term treatment with glucocorticoid.
- Trial name
- NCT01762540
- Testing
- Glucocorticoids, Calcium Supplement
- Where
- Denmark
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Polycystic Ovary Syndrome
Effect of Ramadan Fasting on Ovulation and Insuline Resistance in Patients With PCOS
Polycystic ovary syndrome (PCOS) has a heterogeneous clinical presentation comprising reproductive (hyperandrogenism, menstrual irregularity, anovulation, infertility, pregnancy complications), metabolic [insulin resistance (IR)…
- Trial name
- NCT02499289
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Metabolic Cardiovascular Syndrome
Fermented Plant-based Portfolio Diet 4 Metabolic Health
The primary objective of this study is to evaluate the metabolic effects of a high-fiber portfolio diet based on fermented plant-based foods compared to a corresponding non-fermented plant-based diet and a control diet (habitual…
- Trial name
- FermDiHealth (NCT06587958)
- Testing
- Fermented plant-based foods, Non-fermented plant-based foods, Habitual diet
- Where
- Sweden
- Volunteers
- 89 people
- Sponsor
- Chalmers University of Technology
Liver Transplant; Complications, Renal Insufficiency
Extended-Release Tacrolimus Following Liver Transplantation
Medications used after transplant to prevent rejection are associated with many side effects. Tacrolimus side effects include kidney dysfunction; tremor, headaches, difficulty sleeping, change in sensation (legs), seizure, or…
- Conditions
- Liver Transplant; Complications, Renal Insufficiency, Immunosuppressant Adverse Reaction, Metabolic Syndrome
- Trial name
- NCT05242315
- Testing
- Envarsus Oral Product, Prograf (SOC)
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- University of Alberta
Metabolic Syndrome
Food Supplement for Individuals with Metabolic Syndrome
In metabolic syndrome, blood levels of apolipoprotein B (Apo B) reveal the presence of quantitative and qualitative alterations of atherogenic lipoproteins and therefore represent an indicator of the risk of developing…
- Trial name
- META-TREAT (NCT06647108)
- Testing
- Food Supplement
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- ESI
Insulin Sensitivity, Obesity
Comparative the Effect of Metformin and Acupuncture on Weight Loss and Insulin Sensitivity
The investigators designed this randomized double blind (patients/ assessor) clinical trial to compare the therapeutic effects of Metformin monotherapy with Metformin and acupuncture combined therapy on weight loss and insulin…
- Trial name
- NCT02438540
- Testing
- metformin, acupuncture
- Volunteers
- 43 people
- Sponsor
- Amir Firouzjaei
Metabolic Syndrome
Effects of Xanthohumol on Metabolic Syndrome Progression
A huge body of scientific evidence has suggested that xanthohumol (XAN) consumption, a polyphenol present in beer, has a positive effect on energy metabolism.
- Trial name
- XAN4Health (NCT03561116)
- Testing
- XAN
- Where
- Portugal
- Volunteers
- 76 people
- Sponsor
- Universidade do Porto
Loss of Control of Diabetes
Metformin Therapy in Type 1 Diabetes Mellitus.
The use of exogenous insulin and incorrect nutritional habits are conducive to obesity and excess weight. This leads to the development of insulin resistance, even in patients with type 1 diabetes mellitus.
- Trial name
- NCT01889706
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Poznan University of Medical Sciences
Dyslipidemia
Efficacy of Fluvastatin and Fenofibrate in Comparison to Simvastatin and Ezetimibe in Patients With Metabolic Syndrome
This study will investigate the effects of the combination of fluvastatin and fenofibrate on dyslipidemia in comparison to the combination of simvastatin and ezetimibe.
- Trial name
- NCT00385658
- Testing
- Fluvastatin extended release, fenofibrate, Fixed combination simvastatin/ezetimibe
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 75 people
- Sponsor
- Novartis
Insulin Resistance, Obesity
Potato Research for Enhancing Metabolic Outcomes
The potato is a nutritious food that comprises approximately 30% of total vegetable intake in the United States (US). Consumption of pulses in the US is low but its contribution to health is frequently promoted.
- Trial name
- PREMO (NCT04203238)
- Testing
- Reduced Meat High Potato Diet, Reduced Meat High Pulses Diet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Pennington Biomedical Research Center
Healthy, Insulin Resistance
A Comparison of Neuromuscular Recruitment in Trained and Untrained Adults
The objective of the study is to use neurological techniques to obtain quantitative measurements of nervous system control of skeletal muscle activity in adults aged 60-85 who are either long-term resistance exercisers or who are…
- Trial name
- NCT06820658
- Testing
- Neuromuscular Test, DEXA, Mixed Meal Tolerance Test
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic