Clinical trials: Insulin Resistance, open to volunteers
Shift-work Disorder
EMS Providers' Health Initiative Study
This study aims to explore dietary factors that influence glycemic control in night shift EMS providers and to test the feasibility of a dietary intervention among these providers.
- Trial name
- NCT05153759
- Testing
- Meal service
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Asthma, Atherosclerosis
Study of the Effect of Innate on the Inflammatory Response to Endotoxin
Background: Innate immunity is the process by which white blood cells and other parts of the immune system sense and respond to potential infections by causing an inflammation.
- Conditions
- Asthma, Atherosclerosis, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT01143480
- Where
- United States
- Volunteers
- 725 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Polycystic Ovary Syndrome, Glucose Profile
Glucose Profiles in Women With Polycystic Ovary Syndrome
Polycystic ovary syndrome is a very common condition that is associated with metabolic complications. Patients with polycystic ovary syndrome exhibit insulin resistance and are at greater risk to develop type 2 diabetes.
- Conditions
- Polycystic Ovary Syndrome, Glucose Profile, Insulin Resistance, Continuous Glucose Monitoring
- Trial name
- PROGLYSOPK (NCT07483723)
- Testing
- sensor, Age reader
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Recurrent C. Difficile (rCDI), Ulcerative Colitis (UC)
Multi-omics Dissection of Gut Microbiome Engraftment During FMT
The gut microbiota plays a key role in immunity and metabolism and contributes to diseases such as recurrent C. difficile infection (rCDI), ulcerative colitis (UC), and metabolic syndrome (MetS).
- Conditions
- Recurrent C. Difficile (rCDI), Ulcerative Colitis (UC), Metabolic Syndrome (MetS)
- Trial name
- DissEcT (NCT06992453)
- Testing
- Fecal microbiota transplantation (FMT)
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Catholic University of the Sacred Heart
Type II Diabetes Mellitus
cfMSC Therapy for Diabetes
The purpose of this study is to assess the feasibility, safety and clinical efficacy of the novel clonal fetal mesenchymal stem cell (cfMSC) therapy in patients with type II diabetes mellitus.
- Trial name
- NCT07495956
- Testing
- cfMSC therapy for diabetes
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Hypertension, Cardiovascular Diseases
Sympathetic-vascular Dysfunction in Obesity and Insulin Resistance (Vitamin C Study)
The main purpose of research is to examine and understanding the development of hypertension in obese adults with insulin resistance.
- Trial name
- NCT04715022
- Testing
- Ascorbic acid solution (American Regent Laboratories Inc.), Saline
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Kansas Medical Center
Blood Pressure, Diabetes
Mitigating the Pro-inflammatory Phenotype of Obesity
The purpose of this study is to examine the hypothesize that 4 weeks of sympathetic nerve activity (SNA) inhibition (oral clonidine) will cause a significant reduction in circulating blood concentrations and endothelial cell…
- Conditions
- Blood Pressure, Diabetes, Obesity, Insulin Resistance
- Trial name
- MAPLE (NCT04934228)
- Testing
- Hydrochlorothiazide 12.5Mg Tab, Clonidine Pill
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Kansas Medical Center
Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder
The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body…
- Conditions
- Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators, Cardiometabolic Risk Factors, Metabolic Syndrome
- Trial name
- ROACH (NCT07804680)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
Metabolic Syndrome, Behcet Disease
Efficacy of Physical Activity Program in Metabolic-syndrome Females With Behcet Disease
metabolci syndrom is highly prevalent in behcet disorder females. usually physical activity is recommended to solve this problem
- Trial name
- NCT07702123
- Testing
- treadmill walking
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
To Determine Whether Estrogen Influences the Effects of Training on Glycemic Control and Insulin Sensitivity
Does Estrogen Blunt the Effects of Exercise Training on Glycemic Control
Previous research has found that males and females respond differently to exercise training, particularly with respect to improvements in blood sugar control and immune system health.
- Trial name
- NCT07791394
- Testing
- EXERCISE TRAINING WITH OR WITHOUT MEDICATION
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Waterloo
Spinal Cord Injuries, Obesity
Spinal Cord Injury Model Systems (SCIMS) - Education Module
The purpose of this study is to find out if receiving education regarding increased risks of cardiometabolic disease helps subjects understand these risks and how these risks participants' health.
- Conditions
- Spinal Cord Injuries, Obesity, Cardiometabolic Syndrome
- Trial name
- NCT06003686
- Testing
- PVA Consumer Guide, WebMD
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- University of Miami
Obesity (BMI>30), Insulin Resistance
Peripheral Vascular Effects of Insulin in Obesity
Successful completion of this project will advance our understanding of the role sympathetic nervous system overactivity plays in driving skeletal muscle malperfusion during hyperinsulinemia and consequently impaired glucose…
- Trial name
- NCT07874945
- Testing
- human insulin
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Heavy Drinking, Metabolic Syndrome
Aerobic Exercise Addition to Cognitive Behavioural Treatment in Impotence Metabolic-syndrome Drinkers
Cognitive Behavioural Treatment is used as treatment for Heavy Drinking, Impotence, and Metabolic Syndrome. The efficacy of adding aerobic training to this treatment is not tested till now.
- Conditions
- Heavy Drinking, Metabolic Syndrome, Impotence
- Trial name
- NCT07277673
- Testing
- aerobci physical training and cognitive behavioural treatment, Cognitive behavioural treatment
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis
Investigating the Link Between Type 2 Immunity and NAFLD in Human Obesity
This study is being done to better understand the relationship between inflammation in adipose tissue (AT), abnormal deposition of fat around the liver and how this affects its appearance and function and ultimately insulin…
- Conditions
- Obesity, Morbid, NASH - Nonalcoholic Steatohepatitis, Chronic Inflammation
- Trial name
- NCT04232566
- Testing
- Bariatric surgery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Time Restricted Eating, Obstructive Sleep Apnea
Time Restricted Eating in Sleep Apnea
Obstructive sleep apnea (OSA) is a highly prevalent disorder that is associated with both cardiovascular and metabolic dysfunction, such as hypertension, increased blood glucose levels and diabetes, obesity, and nonalcoholic…
- Trial name
- TERESA (NCT06047496)
- Testing
- Time restricted eating
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
PCOS(Insulin Resistant)
Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin
Women with polycystic ovary syndrome with HOMA-IR >2.6 fulfilling inclusion and exclusion criteria will be randomly allocated into two groups:experimental group: A (Melatonin 3mg and Metformin 500mg) and control group: B…
- Trial name
- NCT07307677
- Testing
- Metformin 500mg, Melatonin 3mg
- Where
- Bangladesh
- Volunteers
- 60 people
- Sponsor
- Mst.Sumyara Khatun
Gestational Diabetes, Pregnancy Related
Studying Phenotypes of Gestational Diabetes Mellitus in an Asian Pregnant Cohort
Gestational diabetes mellitus (GDM) is a transient hyperglycemic condition identified during pregnancy in women without a history of chronic diabetes.
- Conditions
- Gestational Diabetes, Pregnancy Related, Pregnancy Complications, Birth Weight
- Trial name
- GDM-CARE (NCT06542718)
- Where
- Singapore
- Volunteers
- 800 people
- Sponsor
- National University Health System, Singapore
Polyendocrine Metabolic Ovarian Syndrome (PMOS)
Effect of Zinc Supplementation on Insulin Resistance and Clinical Features in Women With Polyendocrine Metabolic Ovarian Syndrome.
Polyendocrine Metabolic Ovarian Syndrome (PMOS) is the most common endocrinopathy in women of reproductive age, and is mechanistically anchored in insulin resistance (IR), and drives the downstream cascade of hyperandrogenism…
- Trial name
- NCT07801001
- Testing
- Tab. Elemental Zinc 50 mg, Elemental Zinc 50mg
- Where
- Bangladesh
- Volunteers
- 74 people
- Sponsor
- Bangladesh Medical University
Obsessive Compulsive Disorder (OCD), Lifestyle (Sedentary Behavior and Physical Activity)
A Lifestyle Intervention to Reduce Cardiometabolic Risk Factors in Individuals With Obsessive-compulsive Disorder
The overall aim of this study is to evaluate the efficacy and cost-effectiveness of a lifestyle intervention to improve lifestyle habits and reduce cardiometabolic risk factors in individuals with obsessive-compulsive disorder…
- Trial name
- LIFT (NCT07206212)
- Testing
- A group-based lifestyle intervention for individuals with OCD, Medical and lifestyle advice
- Where
- Sweden
- Volunteers
- 108 people
- Sponsor
- Karolinska Institutet