Clinical trials: Insulin Resistance Syndrome X
Metabolic Syndrome X
Effects of Dietary Proteins on Hepatic Lipid Metabolism
Individuals submitted to a high-fat or a high-fructose/sucrose diet develop, over a 6 day-period, several features of the metabolic syndrome, including increased plasma triglycerides, increased intrahepatic lipids, and decreased…
- Trial name
- NCT00558740
- Testing
- high protein intake
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Insulin Resistance, Metabolic Syndrome X
Side Effects of Antipsychotic Medications
Medications like olanzapine have been associated with the development of weight gain and diabetes in some patients. It is not known if the increased risk of developing diabetes is a direct effect on insulin or simply related to…
- Conditions
- Insulin Resistance, Metabolic Syndrome X, Schizophrenia and Disorders With Psychotic Features, Mood Disorders
- Trial name
- NCT00363181
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Stanford University
Cardiovascular Diseases, Heart Diseases
Behavioral Factors in Coronary Heart Disease
To elucidate the role of biobehavioral factors in the etiology, pathogenesis and course of coronary heart disease (CHD) and to use this knowledge to devise more effective prevention, treatment and rehabilitation approaches.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Metabolic Syndrome X
- Trial name
- NCT00005314
- Volunteers
- 694 people, healthy volunteers welcome
- Sponsor
- Duke University
Depressive Disorder, Major, Metabolic Syndrome X
Pioglitazone for the Treatment of Major Depressive Disorder Comorbid With Metabolic Syndrome
The goal of this study is to begin to test whether or not pioglitazone, an FDA approved medication used to treat high blood sugar, may be safe and effective in treating Major Depressive Disorder (MDD) in patients with comorbid…
- Trial name
- NCT00671515
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Joseph Calabrese, MD
Hyperlipidemia, Diabetes Mellitus
Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders
The purpose of the present study is to conduct a thorough and relevant physiology study of carriers and non-carriers of the gene variant X in order to determine the effect of the genetic variant on various metabolic parameters.
- Conditions
- Hyperlipidemia, Diabetes Mellitus, Metabolic Syndrome, Arterial Hypertension
- Trial name
- NCT01571609
- Testing
- first phase insulin secretion (FPIR), Hyperinsulinemic euglycemic clamp (HEC), glucose tracer, and palmitate tracer
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Hypertension, Blood Pressure Monitoring, Home
Home Blood Pressure Variability and Its Link to Arteriosclerosis and Metabolic Dysfunction in Hypertensive Patients
This observational study investigates the correlation between home blood pressure variability (BPV) and arteriosclerosis, alongside metabolic indicators, in hypertensive patients over a three-year period.
- Conditions
- Hypertension, Blood Pressure Monitoring, Home, Arteriosclerosis, Metabolic Syndrome X
- Trial name
- NCT06394934
- Testing
- Healthscan App
- Where
- 2 sites in South Korea
- Volunteers
- 4,188 people
- Sponsor
- Korea University Anam Hospital
Angina Pectoris, Metabolic Syndrome X
Rosiglitazone Versus Placebo in Chronic Stable Angina
We wish to see if the drug rosiglitazone, currently used in the treatment of type 2 diabetes, could be used as a new treatment for angina when compared with placebo in overweight subjects who do not have overt diabetes.
- Trial name
- NCT00225355
- Testing
- Rosiglitazone
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- University of Glasgow
Hyperlipidemia, Metabolic Syndrome X
Low Fat Plant-Based Supplemented Diet Effects on Risk Factors for Chronic Non-communicable Diseases
The effect of a diet free from animal-sourced nutrients on a variety of risk factors for chronic non-communicable diseases in weight reduction programs is not well established.
- Trial name
- LFPBDS2 (NCT02905448)
- Testing
- Low fat plant-based nutrition
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Barbara Jakše s.p.
Cardiovascular Diseases, Heart Diseases
Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I)
To investigate the separate effects of the amount of exercise and exercise intensity on cardiovascular risk factors in overweight men and women with mild to moderate dyslipidemia.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Hyperlipidemia
- Trial name
- NCT00200993
- Testing
- physical activity
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Lipid Disorder, Dyslipidemias
Causal Mechanisms in Adolescent Arterial Stiffness
Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear.
- Conditions
- Lipid Disorder, Dyslipidemias, Aortic Stiffness, Insulin Resistance Syndrome
- Trial name
- NCT04128969
- Testing
- CS+, CS-
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Metabolic Syndrome X, Schizophrenia
Metabolic Syndrome in Patients With First-episode Schizophrenia
The metabolic syndrome (MetS) is highly prevalent in patients with schizophrenia and is a major risk factor of type-2 diabetes, cardiovascular disease and early death.
- Trial name
- NCT00957294
- Where
- Denmark
- Volunteers
- 203 people
- Sponsor
- Aarhus University Hospital
Schizophrenia, Metabolic Syndrome X
Ziprasidone for Improving Insulin Sensitivity in People With Schizophrenia Who Are at Risk for Diabetes
This study will evaluate the effectiveness of ziprasidone treatment versus treatment with a standard atypical antipsychotic drug in improving insulin sensitivity and reducing excess abdominal fat storage in people with…
- Conditions
- Schizophrenia, Metabolic Syndrome X, Insulin Resistance
- Trial name
- NCT00338949
- Testing
- Switch, Control
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Veterans Medical Research Foundation
Metabolic Syndrome X, Cardiovascular Problems in Elderly
Effect of Blood Flow Restriction on Cardiovascular Function in Elderly with Metabolic Syndrome X
The purpose of the study is to investigate the effect of aerobic exercise with Blood flow restriction training (BFR) on cardiovascular function and quality of life in hypertensive elderly patients.
- Trial name
- NCT06877130
- Testing
- Aerobic exercise with BFR, Aerobic training
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Pancreatic Steatosis, Metabolic Syndrome X
Study for the Identification of a Score to Assess Intrapancreatic Fat Through Eco-Elastography and Its Correlation With Metabolic Syndrome and Insulin-Secreting Cells.
Brief Summary of the SPES Clinical Study The SPES clinical study aims to evaluate the relationship between pancreatic fat accumulation (pancreatic steatosis) and metabolic health.
- Conditions
- Pancreatic Steatosis, Metabolic Syndrome X, Diabetes Mellitus
- Trial name
- SPES (NCT06801769)
- Testing
- C-peptide
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Catholic University of the Sacred Heart
Psoriatic Arthritis, Osteoarthitis
CARTIZ Registry: Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts - A Four-Institute Mexican Observational Registry
CARTIZ is a prospective observational clinical registry of adults in Mexico receiving tirzepatide (a dual GLP-1/GIP receptor agonist) under an independent clinical indication - typically type 2 diabetes, insulin resistance…
- Conditions
- Psoriatic Arthritis, Osteoarthitis, Knee, Diabetes (DM)
- Trial name
- CARTIZ (NCT07567378)
- Testing
- Tirzepatide
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- JULIO GRANADOS MONTIEL
Metabolic Syndrome X
Effect of a Low Glycemic Index on Metabolic Syndrome
Metabolic Syndrome (MetS) is a cluster of multiple risk factors of metabolic origin associated with an increased risk of cardiovascular disease, type 2 diabetes mellitus and other diseases, including some cancers.
- Trial name
- NCT02356952
- Testing
- Mediterranean Diet, Low Glycemic Index Diet, Low Glycemic Index Mediterranean Diet
- Where
- Italy
- Volunteers
- 163 people
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Metabolic Syndrome x
Therapeutic Efficacy of Phytosterols on Metabolic Syndrome
The objective is to evaluate therapeutic efficacy of 2 grams nano-phytosterols daily supplemention on diagnosis criteria of metabolic syndrome.
- Trial name
- FESIME (NCT02969720)
- Testing
- Phytosterols, Titanium Dioxide
- Where
- Chile
- Volunteers
- 220 people
- Sponsor
- Universidad de los Andes, Chile
Insulin Resistance Syndrome, Cardio Vascular Disease
Prevalenza Della Insulino Resistenza e Correlate Malattie Cardiovascolari Nella città di Napoli
This is an observational retrospective study to verify the prevalence of insulin resistance (IR) in the municipality of Naples and ita association with cardiovascular diseases. Primary outcome measure 1: The prevalence of IR.
- Conditions
- Insulin Resistance Syndrome, Cardio Vascular Disease, Prevalence
- Trial name
- NCT07785518
- Testing
- No Intervention: Observational Cohort
- Where
- Italy
- Volunteers
- 123,752 people
- Sponsor
- Comune di Napoli
Obesity, Metabolic Syndrome X
The Potential Role for Adenosine in the Haemodynamic Effects of Free Fatty Acids
The metabolic syndrome is associated with hyperdynamic circulation and sympathetic activation. Recently, Bakker et al. (Atherosclerosis 2002) described the hypothesis that free fatty acids are responsible for this association.
- Trial name
- NCT00184899
- Testing
- Intravenous infusion of Intralipid/heparin, Intravenous infusion of Glycerol/heparin
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Small for Gestational Age
Study of Growth-promoting and Metabolic Effects of Growth Hormone (rhGH)
Recombinant growth hormone (rhGH) treatment is widely used in France to normalize height during childhood and final height in children born small for gestational age (SGA).
- Trial name
- SGA (NCT00597480)
- Testing
- rhGH (Norditropine SimpleXx®), rhGH norditropine simple Xx
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris