Clinical trials: Insulin Response
Type 2 Diabetes Mellitus (T2D), Obesity (BMI>30)
Impact of Endoscopic Sleeve Gastroplasty (ESG) in Obese Adults With Type 2 Diabetes (T2D)
The goal of this clinical trial is to determine whether Endoscopic Sleeve Gastroplasty (ESG)-induced weight loss can improve glycemic outcomes and alter the trajectory toward insulin dependence in adults with obesity and…
- Trial name
- MEASURE (NCT07639684)
- Testing
- ESG with OverStitch
- Volunteers
- 50 people
- Sponsor
- Boston Scientific Corporation
Obesity, Diabetes
The Effects of Carbohydrate Source on Food Intake, Blood Glucose and Gut Hormone Response in Healthy Children
This study will compare the effects of commonly consumed carbohydrate sources such as potatoes, pasta and rice along with a fixed portion of meat on blood glucose, satiety and insulin levels among healthy body weight children.
- Trial name
- NCT02499107
- Testing
- Rice treatment, Pasta treatment, Boiled and mashed potato treatment
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Hyperuricemia, Healthy
The Relationship Among, Serum Uric Acid, Left Ventricular Hypertrophy and Metabolic Syndrome
Hyperuricemia is associated with the prevalence of metabolic syndrome and cardiovascular risks in diverse of the population. Whether the dose-response effects on the prevalence of metabolic syndrome and cardiometabolic risks is…
- Trial name
- NCT03473951
- Testing
- Hyperuricemia
- Where
- Taiwan
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Type 1 Diabetes Mellitus, Glycemic Variability
Impact of Dietary Fat and Menstrual Cycle Phases in Type 1 Diabetes
This clinical trial aims to evaluate how variations in dietary fat content and hormonal status influence postprandial glycemic response in individuals with type 1 diabetes (T1D), with a special focus on women.
- Conditions
- Type 1 Diabetes Mellitus, Glycemic Variability, Sex Characteristics, Menstrual Cycle
- Trial name
- DIABETEXX/3 (NCT07278063)
- Testing
- Low Fat Mixed Meal, High Fat Mixed Meal
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Sedentary Behavior, Insulin Sensitivity
The Effect of Sitting and Moderate Exercise on Plasma Insulin and Glucose Responses to an Oral Glucose Tolerance Test
The investigators hypothesize that cycling for 1 hour of exercise at 65% peak oxygen consumption (VO2peak) after sitting >13 hr/day (SIT+EX) will not be different in postprandial plasma insulin responses compared to the control…
- Conditions
- Sedentary Behavior, Insulin Sensitivity, Sedentary Lifestyle
- Trial name
- NCT04195165
- Testing
- SIT, ACTIVE, EX
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Metabolic Syndrome, Prediabetes
Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
- Trial name
- BITE (NCT07620886)
- Testing
- Postprandial walking, Brief resistance exercise snacks
- Volunteers
- 25 people
- Sponsor
- Seoul National University
Diabetes Prevention, Obesity Prevention
PERFECT Project - Part 2 - Study 2
The objectives are to test the acute effects of different cereals containing pulse ingredients on: 1) aerobic endurance and substrate oxidation during exercise 2) response of blood glucose, insulin and appetite to an aerobic…
- Trial name
- NCT02370927
- Testing
- Control, Pea protein, Pea Starch
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Chronic Hepatitis b
The Effect of Metabolic Syndrome on Antiviral Response in People With Chronic Hepatitis B
Chronic hepatitis B (CHB) affects an estimated 292 million people, and causes approximately 800,000 people deaths per year from liver-related complications including cirrhosis and hepatocellular carcinoma, remaining a major…
- Trial name
- NCT05705141
- Volunteers
- 1,000 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Glucose Intolerance, Glucose and Insulin Response
Sucralose and Glucose Metabolism in Young Healthy Adults
This study aimed to investigate the effects of a three-week consumption of sucralose-sweetened beverages (low-calorie sweetener) on postprandial glycemic responses in healthy adults, compared with sugar-sweetened beverages under…
- Conditions
- Glucose Intolerance, Glucose and Insulin Response, Glucose Homeostasis, Low-grade Inflammation
- Trial name
- NARELO (NCT07194772)
- Testing
- Low-calorie sweeteners (LCS), Refined sugars (SSB), Natural sugars (FJ)
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Diabetes
Glycemic Response to Oral Nutrition Supplements
This will be a randomized, cross-over study of two oral nutrition supplements in individuals with Type 2 Diabetes.
- Trial name
- NCT02612675
- Testing
- ONS
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Société des Produits Nestlé (SPN)
Dysglycemia
A Study to Investigate the Effect of MCE on Glucose and Insulin Responses in Healthy Males
Maize Cob Extract (MCE) is intended to be used as a bulking agent in food. The purpose of this study is to determine the glycaemic and insulinemic response of MCE consumed in isolation compared to glucose; the glycaemic and…
- Trial name
- NCT04296045
- Testing
- MCE, Glucose
- Where
- Ireland
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cambridge Glycoscience
Cardiovascular Diseases
Effects of the Mediterranean Diet on Cardiovascular Risk Profile in Men and Women
The purpose of this study is to document differences between men and women in changes in metabolic variables associated with cardiovascular risk in response to a 4 weeks isocaloric controlled nutritional intervention based on the…
- Trial name
- ALIMED (NCT01293344)
- Testing
- Controlled nutritional intervention based on the Mediterranean diet
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Laval University
Energy Expenditure, Metabolic Health
Effects of NMES on Energy Expenditure, Glycaemia and Hormonal Responses to Glucose Ingestion
The purpose of this study is to investigate whether self-selected neuromuscular stimulation (NMES) affects energy expenditure, glycaemia and hormonal responses in healthy men and women
- Trial name
- NCT04389736
- Testing
- Sitting, Standing, Self-selected maximal intensity of neuromuscular electrical stimulation
- Where
- Taiwan
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- National Taiwan Normal University
Appetite, Satiety
Effect of Sourdough Bread Consumption on Postprandial Responses, Appetite Regulation and Energy Intake
During this project the effect of yeast bread and sourdough breads consumption on satiety, energy intake at subsequent meal and postprandial metabolic responses, will be investigated.
- Conditions
- Appetite, Satiety, Energy Intake, Glucose Response
- Trial name
- SPAR (NCT06015867)
- Testing
- Dietary Intervention with Wholemeal Bread with Yeast, Dietary Intervention with Wholemeal Sourdough Bread
- Where
- 2 sites in Belgium
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Diabetes, Diabetes Mellitus, Type 1
A Trial Investigating the Within-subject Variability of NN1250 in Subjects With Type 1 Diabetes
This trial is conducted in Europe. The aim of this clinical trial is to evaluate the variability in the blood glucose-lowering effect of NN1250 (insulin degludec) in subjects with type 1 diabetes.
- Trial name
- NCT00961324
- Testing
- insulin degludec, insulin glargine
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- Novo Nordisk A/S
Study Focus 1:Glycaemic Index, Study Focus 2:Glycaemic Response
Blood Glucose and Insulin Responses to Snack Food Products
The purpose of this study is to assess the effects of added food ingredients, when baked into a snack food product, on glycaemic index of the product and glycaemic and insulinemic responses to the product in healthy adults.
- Conditions
- Study Focus 1:Glycaemic Index, Study Focus 2:Glycaemic Response, Study Focus 3:Insulinemic Response
- Trial name
- NCT01341769
- Testing
- Dietary Intervention
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Sepsis, Respiratory Failure
The Effect of Intensive Insulin Therapy in the Surgical Critical Care Unit
We sought to determine if there is a benefit to using an insulin drip to control hyperglycemia in the surgical critical care unit for patients who undergo general and vascular surgery.
- Conditions
- Sepsis, Respiratory Failure, Renal Failure, Surgical Site Infection
- Trial name
- NCT00282594
- Testing
- Novolin R (human recombinant Insulin)
- Where
- United States
- Volunteers
- 317 people
- Sponsor
- Genesys
Human Memory, Intranasal Insulin
fMRI Study of Effects of Nasal Insulin on Memory
Recent research has suggested insulin may be involved in how human's form and recall memories. This study is designed to look at how nasal insulin is used in the brain.
- Trial name
- NCT02758691
- Testing
- Intranasal Insulin, Intranasal Saline
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Postprandial Blood Glucose
Effect of an Arabinogalactan Product
Dietary fiber is an important nutrient that supports gastrointestinal function as well as blood glucose and cholesterol maintenance.
- Trial name
- NCT04005924
- Testing
- arabinogalactan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Biofortis, Merieux NutriSciences
Sedentary Behavior
Effects of Physical Inactivity on Insulin Sensitivity, Appetite, Energy Balance, and Cardiovascular Responses in Humans.
Physical inactivity is a significant predictor of major non-communicable diseases such as type 2 diabetes (7%), cardiovascular disease (6%), musculoskeletal disorders and some cancers, and has been proposed to be the 4th leading…
- Trial name
- NCT04172090
- Testing
- Control, SIT+E, SIT=E
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Nottingham