Clinical trials: Insulin Secretion
Does the Vagus Nerve Mediate the Effects of Xenin-25
Effects of Xenin-25 on Insulin Secretion and Gastric Emptying in Humans With and Without a Complete Truncal Vagotomy
Glucose-dependent Insulinotropic Polypeptide (GIP) and xenin-25 are peptide hormones produced/released from your intestines and help regulate blood sugar levels after you eat.
- Trial name
- NCT01951716
- Testing
- Graded Glucose Infusion with GIP Alone, Graded Glucose Infusion with xenin-25 alone, Graded Glucose Infusion with GIP plus xenin-25
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Metabolic Syndrome X
Effect of Dapagliflozin Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion
The Metabolic Syndrome is a high prevalence disease worldwide. About a quarter of the adult population suffers the disease. Dapagliflozin is an inhibitor of the sodium-glucose co-transporter SGLT2 in the kidney and is a novel…
- Trial name
- NCT02113241
- Testing
- Dapagliflozin
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- University of Guadalajara
Dietary Nitrate Supplementation
Evaluating the Metabolic Effects of Dietary Nitrate Supplementation
Dietary nitrate is found to enhance muscle fatty acid oxidation/glucose uptake and increase mitochondrial biogenesis, which in turn, aid in the prevention and management of metabolic diseases.
- Trial name
- NIMMI (NCT05579262)
- Testing
- Beetroot juice
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Type 2 Diabetes
Dynamic Responsiveness of Insulin Secretory Parameters To Sitagliptin and Glimeperide Administration in Type 2 DM
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT02443922
- Testing
- Glimepiride, Sitagliptin, Metformin
- Volunteers
- 100 people
- Sponsor
- Foundation for the National Institutes of Health
Sleep, Insomnia
Treatment of Insomnia and Glucose Metabolism
Available data suggest that obtaining adequate sleep is associated with a better ability of the body to use carbohydrates as a source of energy and a lower risk of developing diabetes.
- Conditions
- Sleep, Insomnia, Insulin Resistance
- Trial name
- NCT00724282
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Gestational Diabetes, Diabetes, Gestational
Metabolic Analysis for Treatment Choice in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a significant clinical and public health burden, affecting over 400,000 pregnant women in the United States each year.
- Conditions
- Gestational Diabetes, Diabetes, Gestational, Pregnancy in Diabetes
- Trial name
- MATCh-GDM (NCT03029702)
- Testing
- Insulin, Glyburide, Metformin
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Maisa N. Feghali, MD
Type-1 Diabetes Mellitus
Effect of GLP-1 and GIP on Insulin Secretion in Type-1 Diabetes Mellitus
study hypothesis: treatment with GLP-1 and/or GIP is able to potentiate the maximal stimulated insulin secretion even in c-peptide negative type-1 diabetic patients classified as having no residual beta cell function left.
- Trial name
- NCT00603031
- Testing
- glucagon like peptide -1, NaCl, glucose dependent insulinotropic polypeptide
- Where
- Denmark
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Hvidovre University Hospital
Growth Hormone Deficiency
Comparative Validation of the Growth Hormone Releasing Hormone and Arginine Test for the Diagnosis of Adult Growth Hormone Deficiency
The aim of the study is to determine the specificity and sensitivity of the combined growth hormone releasing hormone (GHRH) + Arginine test in healthy volunteers, subjects with highly probable adult growth hormone deficiency…
- Trial name
- NCT01060488
- Testing
- GHRH+Arg, GHRH+Arg, ITT, ITT, ITT, GHRH+Arg.
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Merck KGaA, Darmstadt, Germany
Acromegaly, Excessive Growth Hormone Secretion
Substrate Metabolism and Insulin Sensitivity in Acromegalic Patients Before and After Treatment
The purpose of this study is to investigate the effects of chronic elevated growth hormone on metabolism and insulin sensitivity by studying acromegalic patients before and after treatment.
- Conditions
- Acromegaly, Excessive Growth Hormone Secretion, Insulin Resistance
- Trial name
- NCT00647179
- Testing
- Transsphenoidal adenomectomy
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Polycystic Ovary Syndrome, PCOS
Insulin Differences Between African-American and Caucasian Female Adolescents With Polycystic Ovary Syndrome (PCOS)
The purpose of this research study is to see if there are differences between African-American and Caucasian girls with Polycystic Ovary Syndrome (PCOS) in how their bodies respond to a type of sugar, called glucose, the body's…
- Trial name
- NCT02052479
- Testing
- Frequently Sampled Intravenous Glucose Tolerance Test (FSIVGTT)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Nationwide Children's Hospital
Spinal Cord Stimulation, Insulin Secretion
Effect of Spinal Cord Stimulation (SCS) on Insulin Secretion in Humans
This trial investigates the effect of BurstDR and tonic spinal cord stimulation (SCS) on glucose metabolism and heart rate variability in patients with neuropathic pain.
- Trial name
- NCT05794776
- Testing
- BurstDR stimulation, Tonic stimulation, No stimulation
- Where
- Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Type 2 Diabetes Mellitus
Effects of Short-term Intensive Insulin Therapy in Newly Diagnosed Type 2 Diabetes Patients
It is well known that Long-term hyperglycemia (also known as glucose toxicity) contribute to impairment in islet β-cell function and development of insulin resistance.
- Trial name
- NCT01588743
- Testing
- insulin aspart
- Volunteers
- 130 people
- Sponsor
- Li Guangwei
Diabetes
Nutrigenomics of Zinc Supplementation in Insulin Secretion and Diabetes
The purpose of this study is to evaluate the effect of zinc supplementation on insulin secretion by genotype of SLC30A8.
- Trial name
- NCT00981448
- Testing
- Zinc acetate
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Autonomic Function
Understanding Individual Variability in Neuronal Signal Transmission to Target Organs in Health and Disease
The goal of this clinical trial is to evaluate the influence of parasympathetic transmission from the brain to different metabolic organs. This transmission can be blocked with the muscarinic antagonist atropine.
- Trial name
- CPB_Atropine (NCT06912048)
- Testing
- Oral glucose tolerance test with double-tracer dilution and atropine infusion
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Chronic Renal Failure
Effects of Cyclosporine A on Pancreatic Insulin Secretion
Our primary aim is to investigate if cyclosporine A reduces insulin secretion.
- Trial name
- NCT00139035
- Testing
- cyclosporine A
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- University of Oslo School of Pharmacy
Obesity
Incretin Effect in People With Impaired Fasting Glucose
Regulation of endogenous glucose production (EGP) and insulin secretion are major actions of glucagon-like peptide-1 (GLP-1). Determining whether alterations in GLP-1 may contribute to abnormal EGP and insulin secretion in people…
- Trial name
- 1651 (NCT00795275)
- Testing
- Sitagliptin Phosphate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Obesity, Insulin Resistance
DIETFITS Study (Diet Intervention Examining the Factors Interacting With Treatment Success
Genomics research is advancing rapidly, and links between genes and obesity continue to be discovered and better defined. A growing number of single nucleotide polymorphisms (SNPs) in multiple genes have been shown to alter an…
- Trial name
- DIETFITS (NCT01826591)
- Testing
- Low-Carbohydrate Diet, Low-Fat Diet, Mobile App
- Where
- United States
- Volunteers
- 609 people, healthy volunteers welcome
- Sponsor
- Stanford University
Diabetes Mellitus, Type 2
Comprehensive Postpartum Screening Strategies for Women With Gestational Diabetes Mellitus (GDM)
Previous gestational diabetes (GDM) predisposes affected women to diabetes. Pregnancy, in essence, serves as a metabolic stress test and uncovers underlying insulin resistance and ß-cell dysfunction.
- Trial name
- COPSS-GDM (NCT00849849)
- Where
- United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Woman's
Gestational Diabetes, Gestational Diabetes Mellitus
Towards Precision Medicine for Diabetes in Pregnancy
Rationale: Gestational diabetes is currently treated by the one-size-fits-all-approach. Treatment efficacy is poorly defined and inconsiderate of patients clinical presentation Objective: To characterize the efficacy of…
- Trial name
- ToPMedDiP (NCT05932251)
- Testing
- Metformin
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Zuyderland Medisch Centrum
Diabetes
Regulation of Hepatic Insulin Extraction
This study is in the area of Type 2 diabetes and genetics Healthy Volunteers and those with mild type 2 diabetes may be eligible to participate This study is searching for genes that may affect the body's processing/digestion of…
- Trial name
- RHIE (NCT00811044)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine