Clinical trials: Insulin Sensitivity
Type 2 Diabetes, Insulin Resistance
Dietary Advanced Glycation End-products and Insulin Resistance in Overweight and Obese Humans
We hypothesize that reduction in dietary advance glycation endproducts (AGE) intake will increase insulin sensitivity and normalise insulin secretion in overweight and obese individuals through reduction of chronic low grade…
- Conditions
- Type 2 Diabetes, Insulin Resistance, Obesity
- Trial name
- NCT00422253
- Testing
- dietary intervention
- Where
- Australia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Bayside Health
Healthy Women
Exercise Intensity, Metabolic Rate and Insulin Sensitivity
The primary goal is to test the hypothesis high interval exercise increases energy expenditure and Insulin sensitivity more than 2 days of rest or moderate intensity exercise cumulatively over 23 hours during and following the…
- Trial name
- NCT01879891
- Testing
- Aerobic
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Healthy
Two-day Bed Rest, Insulin Sensitivity and Muscle Protein Synthesis
The impact of two days bed rest versus two days of habitual activity on insulin sensitivity and cumulative muscle protein synthesis will be investigated in healthy young males
- Trial name
- 2d-BR (NCT03877822)
- Testing
- Habitual activity, Bed rest
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Exeter
Healthy
Peripheral Effects of Endotoxin on Insulin Resistance
The aim of the study is to isolate the direct effects of endotoxin on glucose, lipid and protein metabolism. Eight healthy volunteers are enrolled.
- Trial name
- NCT00929136
- Testing
- USP endotoxin
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Dysglycemia, Type 2 Diabetes Mellitus
Alkaline Diet for Insulin Sensitivity
The purpose of this study is to test the effect of increasing the body pH acutely with an alkaline medication (sodium bicarbonate, NaHCO3, sodibic) on glucose metabolism post meal in non diabetic subjects with normal renal…
- Trial name
- ADIS (NCT02501343)
- Testing
- Sodium Bicarbonate Oral Capsule
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Garvan Institute of Medical Research
Obesity, Type 2 Diabetes Mellitus
Changes in Insulin Sensitivity After Weight Loss
This study is designed to compare the changes in insulin sensitivity as well as gastrointestinal hormone levels in diabetic and non-diabetic obese individuals who are undergoing weight loss procedures.
- Conditions
- Obesity, Type 2 Diabetes Mellitus, Insulin Resistance
- Trial name
- NCT00627484
- Testing
- Gastric bypass, Gastric banding, Sleeve gastrectomy
- Where
- United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Columbia University
Overweight and Obesity, Metabolic Syndrome
Testing the Adipose Expandability Hypothesis In Vivo During Overfeeding
Adipose, or fat, tissue is a plastic organ that retains the ability to expand and store excess calories during positive energy balance in humans.
- Trial name
- EAT 2 (NCT04583514)
- Testing
- Control, Overfeeding
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Type 2 Diabetes Mellitus
GOS and Insulin Sensitivity
Based on our hypothesis that orally administered GOS will be fermented into a SCFA pattern high in acetate and that this will lead to beneficial effects on human substrate and energy metabolism, we aim to address the following…
- Trial name
- NCT02271776
- Testing
- Galactooligosaccharide, maltodextrin
- Where
- Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity
Progressive Metabolic Adaptations to Low Intensity Exercise Training and Weight Loss
the investigators first aim is to determine the effect of low intensity exercise (without weight loss) on insulin sensitivity, muscle lipid metabolism, and factors regulating these processes in skeletal muscle after 1 day, 2 wks…
- Trial name
- NCT01452074
- Testing
- Exercise Training, Weight Loss with continued Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity, Insulin Sensitivity
Effect of Weight Loss on Intermuscular Adipose Tissue (IMAT) Signaling
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity.
- Conditions
- Obesity, Insulin Sensitivity, Muscle Weakness, Adiposity
- Trial name
- NCT06129110
- Testing
- Diet Weight Loss
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Adiposity, Insulin Sensitivity
The Sweet Kids Study (Stevia on Weight and Energy Effect Over Time)
This is an 8 to14-week three-arm randomized controlled in children 8 to 12 years old. The main purpose of the study is to evaluate if stevia has benefits for weight control and metabolic function relative to caloric sweeteners…
- Conditions
- Adiposity, Insulin Sensitivity, Weight Gain, Blood Pressure
- Trial name
- NCT05992688
- Testing
- Sucrose sweetened beverage, Stevia sweetened beverages, Calorie free flavored water beverage
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Muscle Protein Synthesis, Muscle Atrophy
Exogenous Ketosis During Bed Rest in Older Adults
The goal of this randomized, double-blind, parallel group interventional study is to evaluate the effect of ketone bodies on healthy older adults (65-85 y) during 5 days of bed rest.
- Conditions
- Muscle Protein Synthesis, Muscle Atrophy, Insulin Sensitivity, Mitochondrial Function
- Trial name
- KBR (NCT05679596)
- Testing
- ketone monoester (R)-3-hydroxybutyl (R)-3- hydroxybutyrate
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- McGill University
Morbid Obesity, Type2 Diabetes
Elucidating the Mechanism of Remission of Type 2 Diabetes in Morbid Obese Patients After Bariatric Surgery
The main aim of this study is to elucidate the mechanism of the remission of type 2 diabetes in the morbid obese patients after laparoscopic sleeve gastrectomy.
- Trial name
- NCT03038373
- Testing
- Laparoscopic Sleeve Gastrectomy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Dasman Diabetes Institute
Adiposity, Insulin Sensitivity/Resistance
The Influence of Obesity and Insulin Sensitivity on Reward Processing and Decision Making
Reward learning and decision-making processes, which operate largely outside of conscious control, shape food choices and eating behaviors.
- Conditions
- Adiposity, Insulin Sensitivity/Resistance, Decision-Making, Reward Learning
- Trial name
- No acronym (NCT07638059)
- Testing
- Beverage: Conditioned Stimulus -, Beverage: Conditioned Stimulus +
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Insulin Sensitivity, Obstructive Sleep Apnea
Obesity, Sleep Apnea, and Insulin Resistance
Obstructive sleep apnea (OSA) and type 2 diabetes confer increasing economic, social, and public health burdens in the United States.
- Trial name
- NCT02192684
- Testing
- Pioglitazone
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Stanford University
Obesity, Energy Balance
Activity, Adiposity, and Appetite in Adolescents 2 Intervention
The objective of the study is to quantify the relationship between physical activity, metabolic function, and appetite in adolescents.
- Conditions
- Obesity, Energy Balance, Appetite, Metabolism
- Trial name
- AAAA2INT (NCT05443347)
- Testing
- Aerobic exercise, Newsletter
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Diabetes Mellitus, Type 2, Insulin Resistance
Interleukin-1 Receptor Antagonist and Insulin Sensitivity
Obesity is characterized by continuous low-grade inflammation. This is an important link between obesity and insulin resistance.
- Trial name
- NCT00928876
- Testing
- Anakinra (Kineret)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Glucose Intolerance
Carnitine Infusion and Insulin Resistance
Insulin resistant subjects and type 2 diabetic patients are characterized by a decreased metabolic flexibility: a reduced capability to switch from fat oxidation in the basal state to carbohydrate oxidation in the…
- Trial name
- NCT02722902
- Testing
- Carnitor, IntraLipid
- Where
- Netherlands
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Diabetes Mellitus, Type 2, Diabetes
Normal-weight Diabetes: Adipocyte-directed Therapy With Pioglitazone or Tirzepatide
This study is to investigate how adipocyte (fat cell) function and fat distribution differ between individuals with normal-weight type 2 diabetes (NWD), those with overweight type 2 diabetes (OWD), and normal-weight controls…
- Conditions
- Diabetes Mellitus, Type 2, Diabetes, Type 2 Diabetes, Pre Diabetes
- Trial name
- NCT06657209
- Testing
- Insulin resistance testing, OGTT, Fat biopsy
- Where
- 2 sites in United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Stanford University
Fatty Liver, Insulin Resistance
Effects of Weight Loss on Hepatic and Muscle Lipid Content and on Insulin Sensitivity on Obese Adolescents With NAFLD
To assess whether reversal of fatty liver by moderate weight loss (8% of body weight) will lead to improvements in insulin sensitivity, which will be associated with changes in both glucose status and lipid profiles, in obese…
- Trial name
- NCT00585299
- Testing
- Low-fat diet, Traditional diet
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Yale University