Clinical trials: Insulin-Like Growth Factor I
Sleep
Acute Effects of Gabapentin in Sleep Parameters and Hormonal Release During Sleep in Older Men
The primary objective of this study is to evaluate the effects of gabapentin in sleep polysomnography parameters and in nocturnal secretion of endogenous hypothalamic-pituitary-adrenal (HPA), hypothalamic-pituitary-gonadal (HPG)…
- Trial name
- NCT02599701
- Testing
- Gabapentin
- Where
- Brazil
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Associação Fundo de Incentivo à Pesquisa
Bone Resorption, Osteoporosis
The Effect of Protein Supplementation on Bone Health in Healthy Older Men and Women
Women and men consuming a low protein diet may be at risk for bone loss. The purpose of this study is to determine whether a daily protein supplement will improve bone health among healthy older adults.
- Trial name
- NCT00421408
- Testing
- Whey protein supplement
- Where
- 2 sites in United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Yale University
IGF-1 Deficiency
IGF-1, IGFBP3, ALS Normative Ranges in Healthy Pediatric Spanish Population
To determine the normative ranges of the Insulin-like Growth Factor 1 (IGF-1), Insulin-like growth factor-binding protein 3 (IGFBP-3), Acid-Labile Subunit (ALS) according to age, sex and pubertal stage of a healthy paediatric…
- Trial name
- EDISON (NCT01676090)
- Where
- 9 sites in Spain
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Ipsen
Growth Retardation
The Effects of Time Points to Cease Parenteral Nutrition and IGF-1 on Very Low Birth Weight Infants
This study aims to estimate short-term and long-term effects of time points to cease parenteral nutrition on very preterm infants, such as growth; to estimate the role of insulin-like growth factor 1 in the growth.
- Trial name
- NCT06071403
- Testing
- (enteral feeding volume/ total fluid volume)*100%
- Where
- China
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Peking University
Acromegaly, Type 2 Diabetes Mellitus
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
Growth hormone (GH) and Insulin-like growth factor-I (IGF-I) secretion are altered in acromegaly and type 2 Diabetes Mellitis (DM).
- Trial name
- NCT00915954
- Testing
- Oral Glucose Tolerance Test, Subcutaneous administration of recombinant human IGF-1
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Interaction Between the GH/IGF-I System and the Immune-system
The Relationship Between the Growth Hormone (GH)- Insulin Like Growth Factor I (IGF-I) System and the Inflammatory System in Healthy Normal Persons
Observations in patients with growth hormone (GH)-disturbances have suggested that GH/IGF-I might have anti-inflammatory effects.
- Trial name
- NCT00969644
- Testing
- Somatropin, Pegvisomant
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Hepatocellular Carcinoma, Type 2 Diabetes
Role of LncRNA H19 in The Regulation of IGF-1R Expression
Hepatocellular carcinoma (HCC) is a common cancer that poses a heavy economic burden on the healthcare system. In Egypt, it is the most common cause of mortality and morbidity-related cancer.
- Conditions
- Hepatocellular Carcinoma, Type 2 Diabetes, Cancer
- Trial name
- NCT04767750
- Testing
- Blood sample collection
- Where
- 2 sites in Egypt
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Insulin-like Growth Factor I, Insulin-like Growth Factor II
Neurotrophic Factors in Cerebrospinal Fluid in Diabetic Patients With Polyneuropathy
Background: The pathogenetic factors underlying development of diabetic polyneuropathy (DP) remain unclear. Reduced neurotrophic stimulation has been proposed as a possible mechanism.
- Conditions
- Insulin-like Growth Factor I, Insulin-like Growth Factor II, Diabetes Complications, Polyneuropathies
- Trial name
- NCT01718015
- Where
- Denmark
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
UVB Phototherapy Burn, Insulin-like Growth Factor 1
Gene Expression Changes In Young and Geriatric Skin
This study does not involve any particular diagnosis. The goal of this research study is to explore the effects of artificial sunlight (ultraviolet B radiation; UVB) on the skin of young adults versus geriatric adults.
- Conditions
- UVB Phototherapy Burn, Insulin-like Growth Factor 1, Aging
- Trial name
- NCT03932162
- Testing
- Insulin-Like Growth Factor 1, No Insulin-Lie Growth Factor 1
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Wright State University
Dementia
A Study to Compare Genetic Variations of IGF-I and IGF-II
The purpose of this study is to determine if insulin-like growth factors (IGF) play a role in the development of dementia, specifically Alzheimer's disease (AD).
- Trial name
- NCT01329523
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Avera McKennan Hospital & University Health Center
HIV, Inflammation
Exercise for Healthy Aging: The Impact of HIV and Aging on Physical Function and the Somatopause
The primary objective of this proposal is to compare a moderate or high intensity exercise intervention to improve physical function in persons aging with Human Immunodeficiency Virus (HIV).
- Conditions
- HIV, Inflammation, Obesity, Aging, Biological
- Trial name
- NCT02404792
- Testing
- High-intensity cardiovascular and resistance exercise, Moderate-intensity cardiovascular and resistance exercise
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Schizophrenia
Clinical Symptoms of Schizophrenia and Physical Exercise
Schizophrenia is a severe mental illness, of psychosis being the most prevalent in society, affecting 1% of the population. The treatment of schizophrenia is basically done with antipsychotic drugs, although other…
- Trial name
- NCT01674543
- Testing
- Resistance Training, Concurrent Training, Control
- Where
- Brazil
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Smoking, Tobacco, Placenta Diseases
Effects of Smoking on Placenta and Lactation
Maternal smoking during pregnancy although it is known to be associated with fetal growth restriction, it's effect on postpartum breastfeeding is not yet clear.
- Conditions
- Smoking, Tobacco, Placenta Diseases, Breastfeeding, Fetal Conditions
- Trial name
- NCT06456645
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Insulin Growth Factor I Deficiency, IGF1 Deficiency
Effect of a HIIT Program on Quality of Life, Executive Functions, and IGF-1 Response in Sedentary Young University Women
Sedentary lifestyle, understood as an activity that requires minimal body movement (Tremblay et al., 2017), is one of the main factors responsible for chronic diseases in Young adults.
- Conditions
- Insulin Growth Factor I Deficiency, IGF1 Deficiency, Executive Function Disorder
- Trial name
- NCT05642169
- Testing
- HIIT, HIIT+PA, CON
- Where
- Spain
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Seville
Chronic Low Back Pain (Non-specific, Uncomplicated), Chronic Low Back Pain (CLBP)
Chronic Low Back Pain Comorbidities: Unravelling Impaired Glucose Metabolism
Chronic low back pain (CLBP) is a global health problem. The first step for developing effective treatments is a better understanding of underlying mechanisms, including its comorbidities.
- Trial name
- GLOW (NCT07734714)
- Testing
- Glucose beverage, Isomaltulose beverage, Standardized breakfast
- Where
- Belgium
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Growth Acceleration, Growth; Stunting, Nutritional
The Effect of Milk Protein vs Blends of Milk and Plant Protein on Growth Markers in 7-8 Year Old Healthy Danish Children
The purpose of PROGRO is to determine which combinations of milk and plant proteins are optimal to promote growth factors in children
- Trial name
- PROGRO (NCT03384719)
- Testing
- 35 g protein (30% milk + 70% rapeseed), 35 g protein (54% milk + 46% rapeseed), 35 g protein (100% milk)
- Where
- Denmark
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Skin Cancer
Chemical Peels and Fractional Laser on IGF-1 Levels in Skin
The purpose of this study is to evaluate the impact of fractional laser versus chemical peels on IGF-1 levels in skin.
- Trial name
- NCT03775031
- Testing
- Fractional Laser and Chemical Peel
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Rheumatoid Arthritis, Healthy
The Role of Cytokines on Growth Hormone Suppression in Premenopausal Women With Rheumatoid Arthritis and the Effect of Treatment With Etanercept
This study has two phases. Phase 1 will examine the role of inflammatory mediators called cytokines on growth hormone levels in women with rheumatoid arthritis (RA).
- Trial name
- NCT00034060
- Testing
- Etanercept
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Growth Hormone Deficiency, Growth Hormone Treatment
Effects of Growth Hormone and IGF-1 on Anabolic Signals and Stem Cell Recruitment in Human Skeletal Muscle
12 adult hypopituitary patients with newly diagnosed Growth hormone (GH)-deficiency will be studied two times. The first examinations will be performed shortly after time of diagnose before initiation of exogenous GH treatment…
- Trial name
- NCT03878992
- Testing
- Genotropin miniquick 0.5 mg, injection
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Population
Establishment of Reference Values for Insulin-like Growth Factor 1 (IGF1) in the General Population
Various assays can be used for IGF-I measurement in French laboratories. Unfortunately, each assay gives a very different result for the same sample.
- Trial name
- VARIETE (NCT01831648)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 924 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris