Clinical trials: Intensive Care Medicine, active
Sepsis, Acute Kidney Injury Due to Sepsis
Microbiome and Enteric Signatures in Sepsis-associated Hepatorenal Injury
Sepsis is a major cause of morbidity and mortality in intensive care units. Sepsis-associated liver injury (SALI) and sepsis-associated acute kidney injury (S-AKI) are common complications associated with adverse clinical…
- Conditions
- Sepsis, Acute Kidney Injury Due to Sepsis, Gastrointestinal Microbiome, Sepsis-Associated Liver Injury
- Trial name
- MESH (NCT07735182)
- Where
- 6 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Intensive Care Medicine, Acute Care Medical
Functional Incremental Stepping in Place Test (F-IST) Validation
The purpose of this multi-site prospective study is to assess validity of a new step test called Functional-Incremental Stepping-in-place- Test (F-IST) compared to gold-standard cardiopulmonary exercise testing (CPET) and to…
- Trial name
- F-IST (NCT06853236)
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kirby Mayer
Critical Illness, Intensive Care Medicine
VoiceLove: An App-Based COMMunication Tool Designed to Address DeliriUm and Improve Family ENgagement and PatIent/Family SatisfaCtion in CriticAlly Ill PaTiEnts (COMMUNICATE)
VoiceLove is a phone application allowing family and patients to share information in a secure platform. This project will compare the VoiceLove app to usual care to learn about whether VoiceLove improves patient-family…
- Trial name
- COMMUNICATE (NCT06923462)
- Testing
- Communication Application
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
All-cause Mortality, Quality of Life
PRophylaxis Against Early VENTilator-associated Infections in Acute Brain Injury
This research is about whether treatment with a commonly used antibiotic can prevent infections in airway and lungs and improves the chance of surviving, if it is given soon after patients commence mechanical ventilation when…
- Conditions
- All-cause Mortality, Quality of Life, Disability, Intellectual, Neurological Disorder
- Trial name
- PREVENT-NEURO (NCT06819592)
- Testing
- Ceftriaxone 2g diluted in >200ml 0.9%sodium chloride
- Where
- 29 sites in Australia, Canada and 1 more
- Volunteers
- 3,300 people
- Sponsor
- The George Institute
Education, Training
Simulation-based Training in the Anaesthesia Residency Curriculum
This study aims to describe the current implementation and structure of simulation-based education and training in anaesthesiology and intensive care residency programmes across countries affiliated with the World Federation of…
- Conditions
- Education, Training, Simulation Based Medical Education, Anesthesia
- Trial name
- NCT07771569
- Where
- Czechia
- Volunteers
- 150 people
- Sponsor
- Brno University Hospital
Mechanical Ventilation, Intensive Care Medicine
Intelligent Lung Support in the Intensive Care Unit
The aim of this observational study is to test the IntelliLung decision support system based on artificial intelligence. This system is intended to help to set the ventilator.
- Trial name
- IntelliLung (NCT06595602)
- Testing
- Artificial intelligence based decision support system (AI-DSS); software
- Where
- 5 sites in Germany, Italy and 2 more
- Volunteers
- 530 people
- Sponsor
- Technische Universität Dresden
Cardiac Surgery, Peri Operative Medicine
Risk Factors of Atrial Fibrillation After Cardiac Surgery
Supraventricular arrhythmias complicate more than 40% of cardiac surgeries and are associated with an increased risk of bleeding, stroke, heart failure, and death.
- Conditions
- Cardiac Surgery, Peri Operative Medicine, Thoracic Surgery, Cardiopulmonary Bypass
- Trial name
- PFAS (NCT07625033)
- Where
- France
- Volunteers
- 918 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Critically Ill, Intensive Care (ICU)
Factor Associated With Mortality in the ICU
ICU mortality indicates the severity of disease, healthcare quality, and the efficacy of interventions. The severity scores are tools to predict the risk of mortality in the ICU, and the APACHE II score is frequently used for…
- Conditions
- Critically Ill, Intensive Care (ICU), Intensive Care Medicine, Mortality
- Trial name
- ICUMortal (NCT07249749)
- Testing
- Exposure factors
- Where
- Colombia
- Volunteers
- 1,000 people
- Sponsor
- Hospital Departamental de Villavicencio
Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome)
RECOMMEND Platform Trial
The goal of this platform trial is to determine the efficacy, safety and cost-effectiveness of various interventions in patients with acute cardiorespiratory failure requiring extracorporeal membrane oxygenation (ECMO) The main…
- Conditions
- Extracorporeal Membrane Oxygenation Complication, ARDS (Acute Respiratory Distress Syndrome), Intensive Care Medicine, Cardiac Arrest (CA)
- Trial name
- RECOMMEND (NCT06526533)
- Testing
- Liberal RBC Transfusion, Restrictive RBC Transfusion
- Where
- 3 sites in Australia
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Intensive Care Medicine, Respiratory Distress Syndrome (RDS)
Improving Sedation Practice in Critically Ill Adult Patients Using a Co-designed Sedation Protocol
Sedation (painkillers and sedative drugs) treats pain, reduces suffering, and helps patients in the intensive care unit (ICU) receiving extracorporeal membrane oxygenation (ECMO) remain comfortable.
- Conditions
- Intensive Care Medicine, Respiratory Distress Syndrome (RDS), Sedation and Analgesia, ExtraCorporeal Membrane Oxygenation (ECMO)
- Trial name
- ECMO-SED (NCT07032987)
- Testing
- Not an intervention study
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Critical Illness, Recovery Outcomes
UP STUDY - Decipher Persistent Critical Illness Through in Deep Clinical Phenotyping.
Persistent Critical Illness (PCI) is a condition that affects some patients who remain in the Intensive Care Unit (ICU) for a long time, usually more than 10-14 days. It is estimated to occur in 5-20% of critically ill patients.
- Conditions
- Critical Illness, Recovery Outcomes, Critical Care, Intensive Care, Critical Care
- Trial name
- UPSt_UCI (NCT07510776)
- Where
- 7 sites in Portugal
- Volunteers
- 7,000 people
- Sponsor
- Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa
Liver Cirrhosis, Viral Pneumonia
Liver Cirrhosis Patients With Invasive Pulmonary Aspergillosis: in Depth Understanding Clinical Host Risk Factors
Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection of the respiratory system, caused by a specific fungus called Aspergillus species.
- Conditions
- Liver Cirrhosis, Viral Pneumonia, Fungal Infection, Invasive Pulmonary Aspergillosis
- Trial name
- LIVERIPA (NCT07238114)
- Where
- Belgium
- Volunteers
- 450 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Palliative Care, Withdrawal of Life Support
End-of-life Care in Mechanically Ventilated Patients: Impact of a Comprehensive Palliative Care Protocol in the Intensive Care Setting
The ARREVE-3 trial will evaluate whether a structured palliative care protocol can improve end-of-life management for mechanically ventilated ICU patients in whom a decision to withdraw life-sustaining therapies has been made.
- Conditions
- Palliative Care, Withdrawal of Life Support, Intensive Care Medicine, Sedation
- Trial name
- ARREVE-3 (NCT07368010)
- Testing
- Protocol for palliative care and life-support withdrawal
- Where
- France
- Volunteers
- 720 people
- Sponsor
- Nantes University Hospital
Arterial Catheterization, Intensive Care Medicine
Non-inferiority of Nurse-performed Versus Interventional Cardiologist-Performed Radial Catheterization in Elective Coronary Angiography: a Single-center, Open-label Randomized Trial.
Coronary angiography (or coronary arteriography) is a heart examination performed with contrast media to detect and treat coronary stenosis.
- Conditions
- Arterial Catheterization, Intensive Care Medicine, Nurse
- Trial name
- CATHE (NCT07176884)
- Testing
- nurse-performed coronary catheterization, interventional cardiologist-performed coronary catheterization
- Where
- France
- Volunteers
- 1,602 people
- Sponsor
- Centre Hospitalier Intercommunal de Compiègne-Noyon
Cirrhosis, Intensive Care Medicine
Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study
Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess…
- Conditions
- Cirrhosis, Intensive Care Medicine, Acute on Chronic Liver Failure(ACLF)
- Trial name
- REACIRRHOSE (NCT06948565)
- Testing
- observational study
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Respiratory Insufficiency, Pressure Injury
Effectiveness of Platform-Based Lateralization Therapy in Reducing Interface Pressure Between The Patient And The Support Surface
Pressure injury (PI) is characterized as damage to the skin and/or underlying tissues resulting from sustained pressure or a combination of pressure and shear forces between the patient and the support surface.
- Conditions
- Respiratory Insufficiency, Pressure Injury, Intensive Care Medicine, ARDS
- Trial name
- PREVENT-ICU (NCT06819943)
- Testing
- Automated Lateral Rotation Therapy
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo General Hospital
Venous Thromboembolism (VTE), Intensive Care Medicine
Pulsed Electromagnetic Field Therapy or Pneumatic Compression VTE Prophylaxis
Venous thromboembolism (VTE) is frequent in patients in the intensive care unit (ICU). Pharmacologic prophylaxis is sometimes contraindicated, and mechanical prophylaxis is used.
- Conditions
- Venous Thromboembolism (VTE), Intensive Care Medicine, Venous Thromboembolism
- Trial name
- SOPHIE (NCT06958588)
- Testing
- Experimental: Hyperslim, Active Comparator #1
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Science Valley Research Institute
Transportation of Patients, PET / CT
To Evaluate Transport Safety Between Different Scanning Methods for Patients in the Intensive Care Unit (ICU)
The goal of this study is to assess how safe it is for critically ill patients in the Intensive Care Unit (ICU) to undergo a PET scan. A PET scan is a type of medical imaging used to help determine why a patient is sick.
- Conditions
- Transportation of Patients, PET / CT, Intensive Care Medicine
- Trial name
- CASA (NCT06912464)
- Where
- Netherlands
- Volunteers
- 208 people
- Sponsor
- University Medical Center Groningen
Anesthesia, Intensive Care Medicine
Optimization of Morphinomimetic Administration Intraoperatively: Evaluation of the Impact of the NOL Index on the Occurrence of Postoperative Adverse Events Related to Morphinomimetics
Reducing the quantity of morphinomimetics during the operative period reduces the prevalence and intensity of adverse effects. However, morphinomimetics are indispensable during surgery, as they limit the autonomic nervous…
- Trial name
- NOL-Impact (NCT06861634)
- Testing
- Nol index
- Where
- 6 sites in France
- Volunteers
- 332 people
- Sponsor
- University Hospital, Tours
Intensive Care Medicine, Critical Care
Evaluating the Use of Artificial Intelligence to Improve Family Conversations for Intensive Care Patients and Their Families
This study looks at how artificial intelligence (AI), like generative pre-trained transformer (GPT-4), can help doctors in the intensive care unit (ICU) save time and improve communication with families.
- Trial name
- NCT06756542
- Where
- 2 sites in Netherlands
- Volunteers
- 40 people
- Sponsor
- Davy van de Sande