Clinical trials: Intensive Care Unit (ICU)
Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients
Virtual Reality to Reduce Anxiety, Agitation and Delirium in Critically Ill Patients
This is a pilot feasibility study examining the use of immersive virtual reality (VR) in adult intensive care unit (ICU) patients.
- Conditions
- Delirium in the Intensive Care Unit, Sleep Quality in Adult ICU Patients, Agitation Associated With Critical Illness, Anxiety Acute
- Trial name
- NCT07649876
- Testing
- Virtual reality (VR) therapy
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Sleep, Circadian Dysregulation
reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit
The goal of this pilot clinical trial is to learn whether a program to support sleep and the body's daily rhythms can be delivered safely and consistently to critically ill adults in intensive care units (ICUs).
- Conditions
- Sleep, Circadian Dysregulation, ICU, Delirium in Intensive Care Unit
- Trial name
- ALIGN ICU (NCT07886567)
- Testing
- Sleep chronobundle, Control
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Alberta
Pupillometry, Behavioral Pain Scale
Pupillometry vs. BPS (Behavioral Pain Scale) for Analgesia Management in Inpatient Intensive Care Unit Patients on Invasive Mechanical Ventilation
Patients admitted to the intensive care unit (ICU) and receiving invasive mechanical ventilation (IMV) frequently require sedation and analgesia to ensure their comfort, prevent pain associated with invasive procedures, and…
- Conditions
- Pupillometry, Behavioral Pain Scale, Analgesia Assessment, Intensive Care Unit (ICU)
- Trial name
- GOLDEN EYE (NCT07867678)
- Testing
- PPI Measurement (Pupillary Pain Index), BPS Measurement (Behavioral Pain Scale)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cognitive Rehabilitation, ICU Survivorship
Returning to Everyday Tasks Utilizing Rehabilitation Networks-III (RETURN-III)
Millions of patients survive care in medical and surgical Intensive Care Units (ICUs) every year, only to suffer from a new or accelerated dementia-like process, called post-ICU long-term cognitive impairment (ICU-LTCI).
- Conditions
- Cognitive Rehabilitation, ICU Survivorship, Intensive Care Unit, ICU
- Trial name
- RETURN-III (NCT04353804)
- Testing
- Treatment Arm: Computerized Cognitive Rehabilitation, Active Control computer games
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD
Controlled Versus Standard Oxygen Therapy in ICU Patients With Acute Exacerbation of COPD
Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality worldwide. Acute exacerbations frequently require intensive care unit (ICU) admission.
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD), Acute Exacerbation of COPD, Intensive Care Unit (ICU), Controlled Oxygen Therapy
- Trial name
- OXYCOPD-ICU (NCT07842510)
- Testing
- Controlled oxygen therapy, Standard oxygen therapy
- Where
- 2 sites in Tunisia
- Volunteers
- 240 people
- Sponsor
- Hôpital Universitaire Taher Sfar
Intensive Care Unit ICU, Vasopressor
Canadian Critical Care Comparative Effectiveness Platform
The Canadian Critical Care Comparative Effectiveness Platform(e) d'Évaluation Clinique Comparée en soins Critiques (CEPEC) is an international multi-centered randomized adaptive platform clinical trial.
- Conditions
- Intensive Care Unit ICU, Vasopressor, Platelet, Nutrition
- Trial name
- CEPEC (NCT06605144)
- Testing
- 1- Vasopressor - Mean arterial pressure 56-60, 2- Vasopressor - Mean arterial pressure 61-65, 3- Vasopressor - Mean arterial pressure 66-70
- Where
- 11 sites in Canada, New Zealand and 1 more
- Volunteers
- 5,500 people
- Sponsor
- Université de Sherbrooke
Hypokalemia, Intensive Care Unit (ICU)
Management of Hypokalemia in Intensive Care Patients
Hypokalemia is a common electrolyte disorder in critically ill patients and may contribute to substantial morbidity and mortality if inadequately managed.
- Conditions
- Hypokalemia, Intensive Care Unit (ICU), Intensive Care Unit (ICU) Patients
- Trial name
- NCT07833722
- Testing
- Implementation of hypokalemia treatment algorithm
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Anadolu University
Intensive Care Unit (ICU), Sleep Disruption
Impact on Prognosis of Increased Sleep Quality Obtained by Personalized Night-time Nursing Care in Critically Ill Patients
Sleep disturbances are common among intensive care unit (ICU) patients and have been associated with difficult weaning from invasive mechanical ventilation, with an increased risk of endotracheal intubation.
- Conditions
- Intensive Care Unit (ICU), Sleep Disruption, Sleep Monitoring
- Trial name
- MEDICOSLEEP (NCT07606495)
- Testing
- Sleepscan device, Sleep-guided nursing care
- Where
- 7 sites in France
- Volunteers
- 460 people
- Sponsor
- Poitiers University Hospital
Hospitalized Patients, ICU Hospitalization
Virtual Reality in Intensive Care Unit: Patient Satisfaction, Clinical and Functional Outcomes, Feasibility
Background: Virtual reality is recognized as a progressive technology with the potential to enhance the rehabilitation process. Immersive virtual reality-based treatments can improve motor outcomes in physical rehabilitation…
- Conditions
- Hospitalized Patients, ICU Hospitalization, Intensive Care Unit-acquired Weakness
- Trial name
- NCT07089134
- Testing
- reabilitação fisioterapêutica tradicional, fisioterapia utilizando realidade virtual imersiva
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Hospital Sirio-Libanes
Glucose, Metabolism
Tracing Of Real-time glu13Cose Metabolism in Human Immune Cells - Intensive Care Unit
The purpose of this study is to understand how cells of the immune system use the common sugar glucose during critical illness. Investigators will intravenously infuse a non-radioactive carbon-13 glucose tracer into adult…
- Conditions
- Glucose, Metabolism, Isotope Labeling, Immune System and Related Disorders
- Trial name
- TORCH-ICU (NCT07811180)
- Testing
- 13C6-Glucose
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Intensive Care (ICU), Intensive Care Unit (ICU) Admission
Supply Induced Demand in Intensive Care Unit: a Retrospective Trial
Intensive Care Unit (ICU) represents a high-level healthcare and expensive resource in hospitals. The causes of hospitalization in critical care are therefore multiple, and over the years numerous prognostic scores have been…
- Conditions
- Intensive Care (ICU), Intensive Care Unit (ICU) Admission, Intensive Care Unit Survivors, SID
- Trial name
- NCT07768410
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Saint Camillus International University of Health Sciences
Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission
Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study
The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU…
- Conditions
- Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission, Return of Spontaneous Circulation, Comatose
- Trial name
- CINEFIL (NCT07760636)
- Testing
- Value of neurofilament light chain (NFL) at different time points
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Patients in ICU, Delirium in the Intensive Care Unit
A Prospective Observational Study Using the FAM-CAM
The goal of this observational study is to learn whether family members can help identify signs of delirium in adult patients who are staying in the intensive care unit.
- Conditions
- Patients in ICU, Delirium in the Intensive Care Unit, Family
- Trial name
- NCT07694687
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Delirium in the Intensive Care Unit, Burnout, Healthcare Workers
A Study of Silent Alarm Delivery Versus Standard Audible Alarm Delivery in Intensive Care and High Dependency Units
The goal of the trial is to learn if a strategy to eliminate audible alarm noise in intensive care and high dependency units can reduce overall noise levels, patient delirium, staff alarm fatigue, and staff burnout.
- Conditions
- Delirium in the Intensive Care Unit, Burnout, Healthcare Workers, Noise in the ICU, Alarm Fatigue
- Trial name
- DECIBEL (NCT07364097)
- Testing
- Silent alarm strategy
- Where
- India
- Volunteers
- 311 people
- Sponsor
- MindWave Medical Inc
Intensive Care Unit ICU, Intubation
The Effects of Endotracheal Suctioning on Pain and Serum Markers
The goal of this experimental study is to understand if endotracheal tube (ETT) suctioning increases pain and causes stress on the body in intubated adult ICU patients.
- Conditions
- Intensive Care Unit ICU, Intubation, Critical Illness, Mechanical Ventilation
- Trial name
- NCT06692400
- Testing
- endotracheal tube suctioning
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Loma Linda University
Critical Illness, Frailty
CALLY Index, Frailty and SOFA-2 for Mortality Prediction in Geriatric ICU Patients
This study aims to evaluate the prognostic value of the C-reactive protein-albumin-lymphocyte (CALLY) index, Clinical Frailty Scale (CFS), and SOFA-2 score in predicting mortality among geriatric intensive care unit (ICU)…
- Conditions
- Critical Illness, Frailty, Intensive Care Unit (ICU)
- Trial name
- CALLY-FS (NCT07579728)
- Testing
- observational study
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul University - Cerrahpasa
Pressure Injury, Intensive Care Unit (ICU)
Arterial Blood Gas Levels, Oxygen Saturation, and Pressure Injury Risk in ICU Patients
The purpose of this study is to examine the relationship between arterial blood gas (ABG) parameters and oxygen saturation (SpO₂) levels and the risk of pressure injury development in patients hospitalized in intensive care…
- Trial name
- NCT07691710
- Where
- Turkey (Türkiye)
- Volunteers
- 122 people
- Sponsor
- Istanbul University
ICU Acquired Weakness, Post Intensive Care Unit Syndrome
Muscle Recovery After Critical Illness
The overarching goal of the proposed study is to determine the trajectories of physical recovery and cellular markers involved with the underlying failure to recover muscle after critical illness, while exploring which…
- Conditions
- ICU Acquired Weakness, Post Intensive Care Unit Syndrome, Muscle Weakness, Critical Illness
- Trial name
- TRACER (NCT05537298)
- Where
- 3 sites in United States
- Volunteers
- 209 people
- Sponsor
- Esther Dupont-Versteegden
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Pulmonary Function, Colectomy
Effect of Arm Cycling Exercise on Pulmonary Functions After Colectomy In Elderly
This study will be done to investigate the effect of arm cycling on exercise and functional capacity, arterial blood gases, pulmonary functions, diaphragmatic excursion, time to peak inspiratory amplitude, physical function…
- Conditions
- Pulmonary Function, Colectomy, Colorectal Cancer, Post-operative Rehabilitation
- Trial name
- NCT06876961
- Testing
- Arm cycling exercise, The traditional physical therapy program
- Where
- Bahrain
- Volunteers
- 60 people
- Sponsor
- Cairo University