Clinical trials: Intensive Care Unit Days
Ventilator-associated Pneumonia
Impact of Direct Antimicrobial Susceptibility Testing on Respiratory Sample of Intensive Care Patient With Suspected VAP
Inappropriate antibiotic therapy in ventilator-associated pneumonia (VAP) is associated with increased mortality. The international guidelines recommend using broad spectrum antimicrobials especially in patients who received…
- Trial name
- AB-DIRECT2 (NCT02897466)
- Testing
- Direct Antimicrobial Susceptibility Testing
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Conscious Sedation
Dexmedetomidine for Continuous Sedation
The study aims to demonstrate that dexmedetomidine is non-inferior to current best practice sedation with propofol/midazolam and daily sedation stops, in maintaining a target depth of sedation in long-stay intensive care unit…
- Trial name
- NCT00226785
- Testing
- Dexmedetomidine
- Where
- 4 sites in Finland, Switzerland
- Volunteers
- 900 people
- Sponsor
- Orion Corporation, Orion Pharma
Acute Renal Failure
Augmented Vs. Normal Renal Replacement Therapy in Severe Acute Renal Failure (ARF).
This study seeks to determine if increasing the dose of continuous renal replacement therapy (CRRT) reduces 90-day all cause mortality in Intensive Care Unit (ICU) patients with severe acute renal failure (ARF).
- Trial name
- NCT00221013
- Testing
- "augmented" CRRT regimen
- Where
- Australia
- Volunteers
- 1,508 people
- Sponsor
- The George Institute
Anemia, Critical Illness
Hepcidine and Iron Deficiency in Critically Ill Patients
Anaemia is very frequent among critically ill patients, concerning more than 60 % of them at admission and more than 80% at intensive care unit discharge.
- Conditions
- Anemia, Critical Illness, Hospitalized for 5 Days or More
- Trial name
- HEPCIDANE (NCT02276690)
- Testing
- hepcidin, ferritin and transferrin saturation
- Where
- France
- Volunteers
- 408 people
- Sponsor
- University Hospital, Montpellier
Cancer, Frailty
Association of ICU Admission Time, Age Stratification, and Clinical Frailty Scale With 30-Day Mortality in Geriatric Oncology Patients
Geriatric oncology patients frequently require intensive care admission and are at increased risk of adverse outcomes due to advanced age, frailty, and critical illness.
- Conditions
- Cancer, Frailty, Mortality
- Trial name
- NCT07825090
- Testing
- Observation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Ventilator-free Days, Quality of Breathing
Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation
INTELLiVENT-Adaptive Support Ventilation (ASV) is a fully automated closed-loop mode of mechanical ventilation available on commercial ventilators.
- Trial name
- ACTiVE (NCT04593810)
- Testing
- INTELLiVENT-ASV, CONVENTIONAL VENTILATION
- Where
- 10 sites in Italy, Netherlands
- Volunteers
- 1,201 people
- Sponsor
- Prof. Dr. Marcus J. Schultz
Early Ventilator Associated Pneumonia
Duration of Antibiotic Treatment for Early VAP (DATE) Trial
Hypothesis: 4 days of antibiotic therapy, as compared to 8 days, is equally effective and results in decreased antibiotic exposure among surgical ICU patients with early VAP.
- Trial name
- DATE (NCT01994980)
- Testing
- Default 4 days antibiotic therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Denver Health and Hospital Authority
Mechanically Ventilated Patients
Mechanical Ventilation Practices in Uganda's Intensive Care Units
A prospective cohort study carried out in four ICUs in Uganda. All patients, 18 years and above initiated on mechanical ventilation will be recruited.
- Trial name
- NCT03800849
- Where
- Uganda
- Volunteers
- 214 people
- Sponsor
- Makerere University
COVID-19, Critical Illness
Characteristics and Outcomes of Patients Admitted to Swedish Intensive Care Units for COVID-19
This is a registry-based cohort study of all adult patients (≥18 years) admitted to Swedish Intensive Care Units with confirmed SARS-CoV-2 infection and COVID-19 disease during the first 2 months of the 2020 pandemic.
- Trial name
- NCT04462393
- Testing
- Admission to ICU for COVID-19
- Where
- Sweden
- Volunteers
- 7,500 people
- Sponsor
- Linkoeping University
Coronary Artery Diseases, Heart Valve Diseases
The Effect of Digital Window on Day and Night Perception Status and Sleep Quality in Intensive Care Patients
The research will be carried out in the Cardio Vascular Surgery (CVS) Intensive Care Unit (ICU) of Ankara Training and Research Hospital (TRH) . Patients will be divided into two Experimental (n=24) and control (n=24) groups.
- Trial name
- NCT05486780
- Testing
- Digital Window
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ankara Yildirim Beyazıt University
Sepsis, Critical Illness
Peripheral Perfusion Index Trajectory to Predict 28-Day Mortality in Patients With Sepsis in the Intensive Care Unit
Sepsis is a life-threatening condition caused by the body's overwhelming response to infection, and it remains a leading cause of death in intensive care units.
- Trial name
- PERFUSE-ICU (NCT07740304)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 400 people
- Sponsor
- Trakya University
Central Line-associated Bloodstream Infection (CLABSI)
The Association Between Chlorhexidine Bathing and Central Line-Associated Infections in Medical Intensive Care Units
We conducted a retrospective observational cohort study assessing the relationship between regular bathing using 2% CHG wipes every other day and the occurrence of central line-associated infections (CLABSI) in patients within…
- Trial name
- NCT05919966
- Testing
- Chlorhexidine bathing
- Where
- Taiwan
- Volunteers
- 6,930 people
- Sponsor
- National Taiwan University Hospital
Pneumonia
Effect of High Dose Intravenous Vitamin C in Severe Pneumonia
This trial is a multicenter, randomized, double-blind, two-arm, parallel-group, placebo-controlled trial to investigate the effect of high dose intravenous (IV) Vitamin C as an adjunct to the standard of care for patients with…
- Trial name
- VICSEP (NCT05842382)
- Testing
- Active Ingredient
- Where
- 3 sites in Malaysia
- Volunteers
- 484 people
- Sponsor
- Clinical Research Centre, Malaysia
Critical Care, Critical Illness
Early Multimodal Therapy and Mechanical Ventilation
To assess the association between early multimodal therapy and the duration of invasive mechanical ventilation in the Intensive Care Unit at Fundación Santa Fe de Bogotá.
- Trial name
- NCT06133504
- Testing
- Early Multimodal Therapy, Late Multimodal Therapy
- Volunteers
- 74 people
- Sponsor
- Fundación Santa Fe de Bogota
Intensive Care Unit Syndrome, Mechanical Ventilation Complication
Ketamine Infusion as Sedative Analgesic in Severe ARDS
To evaluate whether ketamine is a safe sedative-analgesic agent to be used in an intensive care unit (ICU) setting as compared to traditionally used agents such as propofol, opioids, and midazolam
- Conditions
- Intensive Care Unit Syndrome, Mechanical Ventilation Complication, Sedatives and Hypnotics Causing Adverse Effects in Therapeutic Use, Delirium
- Trial name
- KISS (NCT04818827)
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Interfaith Medical Center
Emergency Medical Services, Response
Response Times in Danish Emergency Medical Services
The overall aim of this retrospective observational study is to investigate the association of emergency medical services response time with patient survival and treatment outcomes.
- Conditions
- Emergency Medical Services, Response, Triage, Survival Outcomes
- Trial name
- AHRTEMIS (NCT06666647)
- Testing
- Treatment by ambulance or helicopter services with response times
- Where
- Denmark
- Volunteers
- 2,500,000 people
- Sponsor
- Peter Martin Hansen
Intensive Care Unit Acquired Weakness
Efficacy and Safety of Administration of High Levels of Protein to Critically Ill Patients.
Critically ill patients are known to develop serious nutritional deterioration during the course of their disease. They develop, from the beginning, a multifactorial protein malnutrition that relates to a poor clinical course and…
- Trial name
- FISIO (NCT05918757)
- Testing
- Protein dose 1.5 g/kg/day, Protein dose 1.0 g/kg/day
- Where
- 18 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Spanish Society of Critical Care Medicine and Coronary Units
Acute Respiratory Failure, Critical Illness
Lactate/Albumin Ratio and Mortality in Respiratory Failure
This retrospective observational study aims to evaluate the association between the lactate-to-albumin ratio (LAR) measured at ICU admission and 28-day mortality in adult patients admitted to the intensive care unit with acute…
- Conditions
- Acute Respiratory Failure, Critical Illness, Mortality, Mortality Prediction
- Trial name
- NCT07909226
- Testing
- Assessment of Admission Serum Lactate-to-Albumin Ratio (LAR)
- Where
- Turkey (Türkiye)
- Volunteers
- 1,250 people
- Sponsor
- Kocaeli City Hospital
Traumatic Brain Injuries, Brain Injuries,Traumatic
Doppler Ultrasonography Parameters and Mortality in Traumatic Brain Injury
The purpose of this study is to find out whether blood flow measurements of the brain and neck arteries, obtained with bedside Doppler ultrasonography are associated with neurological outcome and survival in adult patients with…
- Trial name
- NCT07890259
- Testing
- Transcranial and Carotid Doppler Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Inonu University
Oxidative Stress, Inflammation
Effect of Alpha-lipoic Acid on Biochemical Markers and Important Outcomes in Patients Admitted to Intensive Care Units
Increasing Reactive oxygen and nitrogen production occurred simultaneously with decreasing serum and intracellular level of antioxidants and enzymes in critical ill patients, which result in increasing ventilator dependency and…
- Conditions
- Oxidative Stress, Inflammation, Malnutrition
- Trial name
- NCT01888861
- Testing
- alpha-lipoic acid
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- najmeh hejazi