Clinical trials: Intensive Care Units
Cardiopulmonary Bypass Surgery
HPI (Hypotension Prediction Index) Care Trial
A prospective single-center randomized controlled trial to determine if guided hemodynamic management with the Acumen HPI technology in the OR and ICU can reduce the mean duration of hypotension in cardiac surgery patients…
- Trial name
- NCT05083403
- Testing
- AcumenTM HPI Software Feature, Non-protocolized Standard of Care
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Edwards Lifesciences
Pressure Incidence Prevention
Pressure Injury Prevention in the ICU With Multi-Layer Foam Dressings
A Multi-Centre, Open, Non-controlled, Clinical Investigation to Evaluate the User Friendliness and Wear Time of Multi-layer Foam Dressings With Safetac® for Pressure Injury Prevention in the Intensive Care Unit
- Trial name
- PUP16_01 (NCT02962882)
- Testing
- Mepilex Border
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Molnlycke Health Care AB
Communication
Improving Communication in the PICU: The Navigate Study
The project seeks to study the use of an navigator-based intervention called "PICU Supports." The study will test the impact of PICU Supports during and after PICU discharge on parent outcomes (satisfaction with decision making…
- Trial name
- NCT02333396
- Testing
- PICU Supports, Educational Brochure
- Where
- 2 sites in United States
- Volunteers
- 442 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Agitation
Acupuncture to Improve Comfort of Children on a Ventilator in the Intensive Care Unit
The purpose of this study is to determine whether acupuncture is effective at improving comfort in children on a ventilator in the intensive care unit.
- Trial name
- NCT01848158
- Testing
- acupuncture
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Seattle Children's Hospital
Acute Respiratory Failure, Shock
Impact of Early Enteral vs. Parenteral Nutrition on Mortality in Patients Requiring Mechanical Ventilation and Catecholamines
The purpose of this study is to assess the hypothesis that, as compared to early intravenous feeding, early nutrition via the enteral route is associated with reduced Day 28-mortality in critically ill patients treated with…
- Trial name
- NUTRIREA2 (NCT01802099)
- Testing
- Enteral nutrition, Parenteral nutrition
- Where
- 41 sites in France
- Volunteers
- 2,410 people
- Sponsor
- Centre Hospitalier Departemental Vendee
Weaning Failure, Complication of Respirator [Ventilator]
Evaluation of a Systematic Approach to Weaning From Mechanical Ventilation
Prolongation of mechanical ventilation poses serious personal and financial threats to healthcare consumers. The investigators objectives are create and implement an multidisciplinary evidenced-based ventilator-weaning protocol…
- Trial name
- NCT01482429
- Testing
- Multidisciplinary weaning-ventilator protocol
- Where
- Brazil
- Volunteers
- 235 people
- Sponsor
- Federal University of Uberlandia
Critical Illness
Exploration of Investigating ICU Mobilisation With Vasoactive Drugs
There is a need to know more about the safety of mobilizing intensive care unit (ICU) patients who are receiving vasoactive drugs that support the heart and blood pressure.
- Trial name
- NCT03869541
- Testing
- Mobilization
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Critical Illness
European Mortality & Length Of Intensive Care Unit (ICU) Stay Evaluation (ELOISE)
The starting point of ELOISE is the significant number of Intensive Care Unit (ICU) survivors who die after the transfer to ward.
- Trial name
- ELOISE (NCT01422070)
- Where
- Italy
- Volunteers
- 6,433 people
- Sponsor
- Università degli Studi di Ferrara
Anemia
Age of Blood in Children in Pediatric Intensive Care Units
ABC PICU is a randomized clinical trial that will compare the clinical consequences of RBC storage duration in 1538 critically ill children.
- Trial name
- ABC-PICU (NCT01977547)
- Testing
- Short storage RBC age
- Where
- 37 sites in United States, Canada and 3 more
- Volunteers
- 1,538 people
- Sponsor
- Washington University School of Medicine
Pulmonary Infections
Dornase Alfa Therapy for Ventilator Associated Lung Infections in the Neonatal Intensive Care Unit (NICU)
To evaluate the effect of Dornase alfa on preterm and late preterm neonates with ventilator associated pulmonary infections. Dornase alfa has been effective in the treatment of pulmonary infections in patients with cystic…
- Trial name
- PVAIN (NCT01356147)
- Testing
- Dornase alfa
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Georgetown University
Gastrointestinal Bleeding, Stress Ulcers
Stress Ulcer Prophylaxis in the Intensive Care Unit
Stress ulcer prophylaxis (SUP) is standard of care in the intensive care unit (ICU), however the quantity and quality of evidence is low and potential harm has been reported.
- Trial name
- SUP-ICU (NCT02467621)
- Testing
- Pantoprazole, Saline (0.9%)
- Where
- 33 sites in Denmark, Finland and 4 more
- Volunteers
- 3,350 people
- Sponsor
- Dr. Morten Hylander Møller
Atelectasis, Bronchoscopy
Evaluation of BAL Procedure With Ambu aScope 3 Large in Patients in an ICU Setting
An Investigation to determine the single-use scope's ability to suction secretion from the lungs to resolve the collapse of the lung.
- Trial name
- NCT03581474
- Testing
- Bronchoscopic procedure
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ambu A/S
Infection
Optimal Feeding Tube Dwell Time in VLBW Infants to Reduce Feeding Tube Contamination
The study team will determine whether a decreased feeding tube dwell time will reduce feeding tube contamination
- Trial name
- NCT03728608
- Testing
- Feeding tube dwell time of 48 hours, Feeding tube dwell time of 7 day
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of Florida
Bed-ridden Patient, Solid Organ Transplant
Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study
1. Study Title: Use of an Off-the-Shelf Exergame as an In-Bed Gamified Rehabilitation Intervention for Severely Deconditioned Inpatients: A Feasibility Study 2.
- Conditions
- Bed-ridden Patient, Solid Organ Transplant, Post Critical Care
- Trial name
- NCT06937463
- Testing
- Rehabilitation
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Asan Medical Center
Acute Brain Injuries
Building Resiliency in Patients Admitted to the Neuroscience Intensive Care Unit and Their Caregivers
The investigators will compare a dyadic intervention (Recovering Together) with an attention placebo educational control in dyads of patients with acute neurological illnesses and their caregivers at risk for chronic emotional…
- Trial name
- NCT03694678
- Testing
- Recovering Together
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Massachusetts General Hospital
Critical Illness, Acute Respiratory Failure
Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill Patients (TOP-UP)
The specific aim of the proposed study is to conduct a pilot study involving 160 critically-ill lean and obese patients enrolled at 11 sites in Canada, the United States of America, Belgium and France in order to: Specific Aims…
- Trial name
- TOP-UP (NCT01206166)
- Testing
- Olimel (5.7%E / N9E)
- Where
- 12 sites in United States, Belgium and 2 more
- Volunteers
- 125 people
- Sponsor
- Clinical Evaluation Research Unit at Kingston General Hospital
Cross Infection, Pneumonia, Ventilator-associated
Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
This prospective, randomized, controlled trial will compare the incidence of nosocomial infections (composite of primary bloodstream infections, catheter-associated urinary tract infections, ventilator-associated pneumonia, and…
- Conditions
- Cross Infection, Pneumonia, Ventilator-associated, Catheter-related Infections, Infection Due to Indwelling Urinary Catheter
- Trial name
- NCT01640925
- Testing
- Chlorhexidine gluconate, Standard bathing
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Joshua Swan
Prematurity
A Clinical Trial of A Pacifier-Activated Music Player
Neonatal intensive care unit infants are at high risk for oromotor difficulties including poor coordination of sucking swallowing and breathing.
- Trial name
- NCT01600586
- Testing
- Pacifier-Activated-Lullaby system (PAL).
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Vanderbilt University Medical Center
Muscle Atrophy, Muscle Weakness
Neuromodulation for Prevention of Intensive Care Unit Acquired Weakness and Post Intensive Care Syndrome
Post-intensive care syndrome (PICS) encompasses persistent physical, cognitive, and psychiatric symptoms following ICU discharge, commonly triggered by serious conditions such as respiratory failure, sepsis, and mechanical…
- Conditions
- Muscle Atrophy, Muscle Weakness, Blood Flow
- Trial name
- NCT06238609
- Testing
- Intervention Group, Control Group
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Bijan Najafi, PhD
Critical Illness
Daily Checklists and Outcome in the Intensive Care Unit
Medical errors account for tens of thousands of deaths and tens of billions of dollars in healthcare costs in the United States every year.
- Trial name
- NCT01396044
- Testing
- Electronic checklist, Verbal prompting
- Where
- 2 sites in United States
- Volunteers
- 451 people
- Sponsor
- Northwestern University