Clinical trials: Interaction
Alzheimer Disease
Digital Reminiscence Therapy for Alzheimer's in Institutionalized People
Digital reminiscence therapy (DRT) is an innovative intervention designed to enhance the psychological health of institutionalized seniors with Alzheimer's disease.
- Trial name
- NCT06666075
- Testing
- Digital and Interactive Reminiscence
- Where
- Spain
- Volunteers
- 72 people
- Sponsor
- University of Jaén
Musculoskeletal Pain
A Phase 1 Clinical Trial DHP2306R1 and DHP2306R2 in Healthy Adult Volunteers
This phase 1 study is to evaluate the safety and pharmacokinetic drug interactions of DHP2306R1 and DHP2306R2 when administered alone and in combination in healthy conditions.
- Trial name
- NCT06395155
- Testing
- DHP2306R1, DHP2306R2
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Daehwa Pharmaceutical Co., Ltd.
Teaching Innovation, Medical Education
Effectiveness of Teacher-Student Interactive Immersive Mixed Reality Technology on Anatomy Education
Background: Novice surgeons often struggle to translate anatomical knowledge into clinical practice, primarily due to a lack of resources, significant variability in anatomical structures, and limited hands-on experience.
- Conditions
- Teaching Innovation, Medical Education, Anatomy Education
- Trial name
- NCT06739590
- Testing
- Learning with CT scans, Learning with 3D visualization models, Learning with 3D-MR visualization models
- Where
- China
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zhujiang Hospital
Type 2 Diabetes Mellitus, Diabetes Mellitus, Type 2
A Study of the Effects of Ketoconazole Taken Orally Has on the PK Profiles of a Dose of GSK189075 in Healthy Volunteers
The purpose of this research study is to evaluate the effect of several daily doses of ketoconazole (a medication used to treat fungal infections like athlete's foot) on a single dose of GSK189075 (an experimental diabetes drug)…
- Trial name
- NCT00501397
- Testing
- ketoconazole, GSK189075
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
HIV Infections
Antiviral Activity of and Resistance to Lamivudine in Combination With Zidovudine, Stavudine, or Didanosine
To evaluate the efficacy, safety, and pharmacokinetics of lamivudine (3TC) combined with zidovudine (AZT), stavudine (d4T), or didanosine (ddI) in comparison with d4T or ddI monotherapy in HIV-infected patients with no prior…
- Trial name
- NCT00000838
- Testing
- Lamivudine, Stavudine, Zidovudine
- Where
- 32 sites in United States, Puerto Rico
- Volunteers
- 256 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
Pharmacokinetics & Tolerability Study of MAP0004 Co-administered With Ketoconazole
Compare the DHE pharmacokinetic profiles observed following administration of: 1. MAP0004 (oral inhalation DHE) 2. MAP0004 co-administered with oral Ketoconazole 3.
- Trial name
- NCT01468558
- Testing
- MAP0004, IV DHE, Ketoconazole
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Allergan
Kidney Transplant Recipient, Heart Transplant Recipient
Pharmacokinetics of Mmf and Valganciclovir
The primary objective of this study is to determine whether a clinically significant PK drug interaction ( a 30% difference in the AUC of MPA) exists between mycophenolate mofetil (under steady state conditions) and VGCV in renal…
- Trial name
- NCT00189150
- Testing
- Mycophenolate mofetil, Valganciclovir
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Michigan
Self-hypnosis, Functional Bowel Disorder
Hypnotherapy With Audiofiles for Children and Adolescents With Disorders of Gut-brain Interactions in Sweden -a Feasibility Study
This study aims at testing the effect and feasibility of a new treatment strategy - hypnotherapy mediated with audio files - for children and adolescents with disorders of gut-brain-interaction (DGBI) in Sweden.
- Conditions
- Self-hypnosis, Functional Bowel Disorder, Functional Abdominal Pain Syndrome
- Trial name
- NCT06493097
- Testing
- Gut-directed hypnotherapy via audio files
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Karolinska Institutet
Drug Interactions
Open-Label, Multiple-Dose, Non-Randomized Study to Assess Drug-Drug Interactions of Proellex® in Female Subjects
This study will assess possible drug-drug interactions with specific isoenzymes over a total study duration of 6-8 weeks. Blood samples collected pre and post-dose, and urine samples collected post dose will be analyzed.
- Trial name
- NCT00741468
- Testing
- Proellex, CYP1A2 probe, CYP2C9 probe
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Repros Therapeutics Inc.
Healthy Volunteers
A Pharmacokinetic Drug Interaction and Tolerance Study of Paracetamol and Nefopam
Pain remains the leading cause of consultation. Despite a wide therapeutic arsenal, a significant percentage of patients disclaim little or no pain relief with common analgesics, specific or not their type of pain.
- Trial name
- PARA-NEF (NCT02174068)
- Testing
- paracetamol 1000 mg per os, nefopam 60mg per os, paracetamol 1000 mg + nefopam 60 mg per os
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
HIV Infections, Hepatitis C
Zidovudine Levels in HIV Infected Patients Being Treated for HCV
This study will test the amount of anti-HIV drugs in the blood cells of HIV-infected patients who are also being treated for hepatitis C virus (HCV) infection.
- Trial name
- NCT00059358
- Testing
- Ribavirin plus interferon alfa-2b, Ribavirin, Peginterferon alfa-2b
- Where
- Puerto Rico
- Volunteers
- 16 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Obesity
Trial of Provider-to-Patient Interactive Voice Response (IVR) Calls to Improve Weight Management in Community Health Centers (CHCs)
This study will test the effect of provider to patient interactive voice response (IVR) calls in local Community Health Centers within a weight management program.
- Trial name
- IVR (NCT01131143)
- Testing
- Provider Voice, Generic Voice
- Where
- United States
- Volunteers
- 1,228 people, healthy volunteers welcome
- Sponsor
- Indiana University
Healthy
Drug-Drug Interaction Study of Esomeprazole (D961H) Capsule and Loxoprofen Tablet After Repeated Oral Administration in Japanese Males
The purpose of this study is to evaluate the pharmacokinetic profile of Esomeprazole (D961H) during repeated oral administration with and without co-administration of loxoprofen and the pharmacokinetic profile of loxoprofen…
- Trial name
- NCT00676117
- Testing
- Esomeprazole (D961H), Loxoprofen
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
An Interaction Study to Assess Drug Levels in Healthy Adult Subjects
To date, no study has investigated whether there is a drug interaction between the protease inhibitor fosamprenavir and the integrase inhibitor raltegravir.
- Trial name
- NCT00614991
- Testing
- Raltegravir, Fosamprenavir, Ritonavir
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Garden State Infectious Disease Associates, PA
Healthy
Aripiprazole and Lexapro Drug Interaction Study
The purpose of this clinical research study is to learn whether aripiprazole has effect on the steady-state pharmacokinetics of escitalopram in healthy subjects.
- Trial name
- NCT00361790
- Testing
- Escitalopram on days -7 to day 14; Aripiprazole dosed starting Day 1 to day 14: 3 days at 10 mg, 4 days at 15 mg and 7 days at 20 mg
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Type 2 Diabetes
The DDI Study of SP2086 and Simvastatin
The purpose of the study is to investigate the potential interaction between multiple oral doses of SP2086 and a single oral dose of Simvastatin in healthy adult volunteers.
- Trial name
- NCT02817243
- Testing
- SP2086, Simvastatin
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Amphetamine-Related Disorders
Assessment of Potential Interactions Between Methamphetamine and Bupropion - 1
The purpose of this study is to assess potential interactions between intravenous (IV) methamphetamine and oral bupropion.
- Trial name
- NCT00040040
- Testing
- Bupropion
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Premature Birth
Effects of Early Intervention for Preterm Children at School Age
Despite the remarkable achievements in neonatal survival of preterm infants with very low birth weight (VLBW, birth weight < 1,500 g) over the past three decades, improvements have produced little change in their prevalence of…
- Trial name
- NCT01952093
- Testing
- Home-based intervention program, Clinic-based intervention program
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
COPD
Drug-drug Interaction Study of CHF5993 With Cimetidine
The purpose of this study is to evaluate the pharmacokinetic interaction when CHF5993 (pressurized metered-dose inhaler (pMDI) is administered with Cimetidine (probe inhibitor of the organic cation transport in the kidneys), by…
- Trial name
- NCT02287272
- Testing
- CHF 5993 pMDI, Cimetidine plus CHF5993 pMDI
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chiesi Farmaceutici S.p.A.
Tourette Syndrome in Adolescence, Social Adjustment
Board Game Project for Adolescents with Tourette Syndrome
The study aims to investigate the effectiveness of using a board game to improve adolescents' tics, mental health, and interpersonal interactions.
- Conditions
- Tourette Syndrome in Adolescence, Social Adjustment, Psychosocial Functioning
- Trial name
- NCT05566236
- Testing
- board game
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
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