Clinical trials: Interaction
Healthy Female Adults
A Study of Navlimetostat (BMS-986504) Drug Interactions and Food Effect in Healthy Participants
The purpose of this study is to assess the food effect and drug interactions on drug levels of Navlimetostat in health adult female participants
- Trial name
- NCT07800897
- Testing
- Navlimetostat, Itraconazole, Rifampin
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Psychosis, Food-drug Interaction
KF2022#3-trial: Effect of Tea and Cola Beverage on Absorption of Risperidone Oral Solution
Risperidone is widely used in the treatment of schizophrenia, bipolar disorder, and aggression associated with moderate or severe Alzheimer's dementia.
- Trial name
- KF2022#3 (NCT06218979)
- Testing
- Risperidone oral solution
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Infection, Human Immunodeficiency Virus
A Study to Evaluate the Effect of BMS-955176 on Pharmacokinetics of Dolutegravir and the Effect of Dolutegravir on the Pharmacokinetics of BMS-955176
The purpose of this study is to evaluate how BMS955176 affects pharmacokinetics (PK) of Dolutegravir (DTG) and also how DTG administration affects the PK of BMS955176
- Trial name
- NCT02715479
- Testing
- Dolutegravir, BMS955176
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Kidney Transplant, Immunosuppression
Evaluation of Interaction Between Immunosuppressive Drugs and Protein-bound Uremic Toxins in Renal Transplant Patients
The majority of studies conducted on uremic toxins involve patients before end stage renal failure or dialysis patients. Only a few studies have focused on transplant patients.
- Conditions
- Kidney Transplant, Immunosuppression, Uremic; Toxemia
- Trial name
- DRUGTOX (NCT04963673)
- Testing
- calcineurin inhibitor dosage
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Frailty, Emergency Department Visit
Association Between Geriatric Frailty and Medication Related Problems in the Emergency Department to Help Clinical Pharmacists Prioritise Patients
The healthcare systems are under increasing pressure due to a rise in emergency consultations, staff shortages, an ageing population and rising costs.
- Conditions
- Frailty, Emergency Department Visit, Elderly, Drug Drug Interaction
- Trial name
- DISARMED (NCT07282379)
- Testing
- Pharmaceutical analysis based on the Electronic Patient Record
- Where
- Switzerland
- Volunteers
- 300 people
- Sponsor
- Pharmacie des Hopitaux de l'Est Lemanique
Healthy Male Subjects
A Drug-drug Interaction Study With TS-172 in Healthy Adult Male Subjects
An open-label, single-center, single-sequence study to evaluate the drug-drud interaction between the CYP3A substrate triazolam and TS-172 (part A) and the potent CYP3A inhibitor itraconazole and TS-172 (part B) in healthy male…
- Trial name
- NCT06837142
- Testing
- Triazolam and TS-172, TS-172 and itraconazole
- Where
- Japan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Thyroid Cancer
The Effect of Thyroid Hormone on Drug Elimination in Cancer Patients
This study will examine whether and how levothyroxine (Synthroid, a synthetic thyroid hormone) affects the way the body handles other drugs.
- Trial name
- NCT00080574
- Testing
- Skin Biopsy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Solid Tumor, Cancer, Lung
Exploratory Drug Interaction Study Between SMIs and DOACs
The main objective of this study is to investigate the effect of small molecule inhibitors (SMIs), used in targeted therapy for tumours, on direct oral anticoagulants (DOACs).
- Trial name
- NCT05732350
- Where
- 2 sites in Netherlands
- Volunteers
- 37 people
- Sponsor
- Maastricht University Medical Center
HIV Infections
The Safety and Effectiveness of Interleukin-2 Plus Zidovudine in Patients With AIDS or AIDS Related Complex
To test the safety and tolerance of three different doses of recombinant human interleukin 2 (aldesleukin; IL-2), when it is given for five consecutive days to patients with AIDS or AIDS related complex (ARC), who have also…
- Trial name
- NCT00000986
- Testing
- Zidovudine, Aldesleukin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Tumor
A Drug-drug Interaction Study of Famitinib Malate With a Proton Pump Inhibitor in Healthy Adult Subjects
The primary objective is to evaluate the effect of omeprazole on the pharmacokinetics of famitinib malate in healthy adult subjects.
- Trial name
- NCT05041920
- Testing
- famitinib、omeprazole
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Venous Leg Ulcer, Venous Ulcer
Evaluation of the Efficacy of Multilayer Compression & UrgoStart Plus
Historically, venous leg ulcers have been very difficult to manage, with associated poor healing rates, and the likelihood of recurrence.
- Conditions
- Venous Leg Ulcer, Venous Ulcer, Venous Insufficiency of Leg, Leg Ulcer
- Trial name
- NCT06007703
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Gloucestershire Hospitals NHS Foundation Trust
Healthy
DDI Study to Investigate Interaction Between Amikacin and POL7080
Single-center, open-label, 2-sequence, 3-period crossover drug-drug interaction study. Repeated doses of POL7080 and repeated doses of amikacin will be administered alone or combined.
- Trial name
- NCT02897869
- Testing
- POL7080, Amikacin, POL7080 + Amikacin
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Polyphor Ltd.
Healthy Participant
Drug-Drug Interaction Study of Itraconazole With GST-HG171/Ritonavir in Healthy Participants
The purpose of this study is to estimate the effect of a strong inhibitor of CYP3A4 (itraconazole) on the pharmacokinetics (PK) of GST-HG171/ritonavir in healthy participants.
- Trial name
- NCT06087055
- Testing
- GST-HG171/Ritonavir, Itraconazole
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Fujian Akeylink Biotechnology Co., Ltd.
Upper Extremity Problem
Interactive Informed Consent and Decision Conflict
Informed consent for surgery can address the legal aspects while also being simple, informative, and empathic. It can help people confirm that the potential harms are acceptable in light of the potential benefits.
- Trial name
- NCT05980078
- Testing
- Interactive consent, Standard consent
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of Texas at Austin
HAART Non-Adherence, HIV
Cell Phone Reminders Intervention
This study will use a longitudinal, experimental design. Participants will be randomized to either the intervention or the control group.
- Conditions
- HAART Non-Adherence, HIV, HIV Infections
- Trial name
- NCT01049568
- Testing
- Cell Phone Intervention
- Where
- 5 sites in United States
- Volunteers
- 43 people
- Sponsor
- University of North Carolina, Chapel Hill
Knee Osteoarthritis
Live and Interactive Fitness Training Program (Vivo Knee OA)
Potential participants will be screened at clinic. Patients who meet eligibility criteria will be considered for study. After written informed consent is obtained, participants will complete baseline testing and participants who…
- Trial name
- LIFT-OA (NCT06462560)
- Testing
- Vivo Online Exercise Program, Medbridge Home program
- Where
- United States
- Volunteers
- 334 people
- Sponsor
- Intermountain Health Care, Inc.
Prosocial Behavior, Emotional Regulation
Comparison Between a Live Canine or Toy Dog on Prosocial Behavior and Emotional Regulation in Autistic Children
This study investigated the human-animal interaction (HAI) and bond (HAB) between a canine trained in therapy techniques or a canine plush toy and youth with autism spectrum disorder (ASD) during animal-assisted therapy (AAT)…
- Conditions
- Prosocial Behavior, Emotional Regulation, Human Animal Bonding, Human Animal Interaction
- Trial name
- NCT06915415
- Testing
- Animal-assisted therapy, Behavioral therapy
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Arkansas, Fayetteville
Heart Failure
MyoVasc Study on the Development and Progression of Heart Failure
The MyoVasc - Study is an observational, prospective cohort study. The study is investigating the development and progression of the heart failure syndrome, phenotypes of the heterogeneous syndrome, and the interactions of…
- Trial name
- NCT04064450
- Where
- Germany
- Volunteers
- 3,289 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Pharmacokinetics
Pharmacokinetics (PK) Drug Interaction Study of Milademetan and Itraconazole or Posaconazole in Healthy Participants
This will be an open-label, randomized, 3-treatment, 2-period, 2-sequence study in healthy subjects to evaluate the single-dose PK of milademetan when given as monotherapy and when administered with steady-state levels of the…
- Trial name
- NCT03614455
- Testing
- Milademetan, Itraconazole, Posaconazole
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Stroke, Hemiplegia
Robot-Assisted Stroke Rehabilitation Based on Patient-Therapist Interactions
Our study goal is to assess natural patient-therapist interactions in order to map such human-human activities to robot-human interactions.
- Conditions
- Stroke, Hemiplegia, Healthy
- Trial name
- Baxter (NCT02806843)
- Testing
- Rehab InterCap system and 3D Kinect
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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