Clinical trials: Interaction
Parent-child Interaction
A Primary Prevention Trial to Strengthen Child Attachment in a Native Community
The purpose of this study is to to conduct a randomized controlled trial comparing an intervention group and a control group to evaluate the feasibility of the Promoting First Relationships method in an American Indian community…
- Trial name
- FPT PFR (NCT02139332)
- Testing
- PFR Group, Resource & Referral Group
- Where
- United States
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- University of Washington
Neonatal Intensive Care Unit, Medication Errors
Drug-Related Problems in Neonatal Patients
Drug-related problems in newborn babies have been reported with a rate of 4-30%. It is estimated that the higher rates of these problems in hospitalized children under the age of two are related to the variety of drugs used and…
- Conditions
- Neonatal Intensive Care Unit, Medication Errors, Drug-Related Problems, Adverse Drug Event
- Trial name
- NCT04899960
- Testing
- Clinical Pharmacist Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 512 people
- Sponsor
- Hacettepe University
Drug-drug Interaction
Pharmacokinetic Interaction Between DWP14012 and DWC202005 in Healthy Volunteers
An open-label, multiple-dose clinical trial to evaluate the safety/tolerability and pharmacokinetic interaction between DWP14012 and DWC202005 in healthy volunteers
- Trial name
- NCT04328766
- Testing
- DWC202005, alone, DWP14012 + DWC202005, DWP14012 + DWC202005, after multiple doses of DWP14012
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Anemia, Herbal Interaction
Development of PHY606 as Adjunct Therapy for Anemia Patients
Many reasons can cause anemia, decreased RBC production or increased destruction of circulation RBC. The investigators investigate the Danggui Buxue Tang (PHY606) composed of Angelicae Sinensis Radix and Astragali Radix in the…
- Trial name
- NCT04974073
- Testing
- PHY606
- Where
- Taiwan
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Sheng-Teng Huang
Ranitidine Adverse Reaction, Pharmacokinetics
Clinical Study to Investigate the Urinary Excretion of N-nitrosodimethylamine (NDMA) After Ranitidine Administration
Ranitidine is an over-the-counter and prescription drug, which decreases the amount of acid secreted by the stomach. Some ranitidine medicines contain an impurity called N-nitrosodimethylamine (NDMA) at low levels.
- Conditions
- Ranitidine Adverse Reaction, Pharmacokinetics, Food-drug Interaction
- Trial name
- NCT04397445
- Testing
- Ranitidine, Low nitrite/NDMA meals, High nitrite/NDMA meals
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Food and Drug Administration (FDA)
Drug Interaction
Drug-Drug Interaction Study to Evaluate the Effect of Inhibition of UGTs on the PK of Ecopipam and Its Active Metabolite
This is a single center, open-label, fixed sequence, drug-drug interaction (DDI) study in healthy subjects.
- Trial name
- NCT04902105
- Testing
- ecopipam HCL, Mefenamic acid, Divalproex Sodium ER
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Emalex Biosciences Inc.
Healthy Subjects, Drug-drug Interaction
A Study of the Effect of Quizartinib on the Pharmacokinetics of the P-gp Substrate Dabigatran Etexilate in Healthy Participants
The purpose of this study is to investigate the one-way drug-drug interaction potential of quizartinib on dabigatran etexilate in healthy adult participants.
- Conditions
- Healthy Subjects, Drug-drug Interaction, Pharmacokinetics, Quizartinib
- Trial name
- NCT04459585
- Testing
- Dabigatran Etexilate Mesylate, Quizartinib
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo Co., Ltd.
Drug Drug Interaction
Fruquintinib CYP3A Inhibitor and Inducer Study
A study to assess the effect of itraconazole, a strong CYP3A inhibitor, and the effect of rifampin, a strong CYP3A inducer, on the pharmacokinetics of fruquintinib in healthy subjects.
- Trial name
- NCT04557397
- Testing
- Fruquintinib, Itraconazole, Rifampin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hutchison Medipharma Limited
Drug Interaction, Food-drug Interaction
Fruquintinib Food Effect and Proton Pump Inhibitor Study
The purpose of this is to evaluate the effect of food and the effect of a proton pump inhibitor (rabeprazole) on the pharmacokinetics of fruquintinib.
- Trial name
- NCT04645940
- Testing
- fruquintinib with food/fruquintinib without food/fruquintinib with rabeprazole, fruquintinib without food/fruquintinib with food/fruquintinib with rabeprazole
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hutchison Medipharma Limited
Drug-Interactions
Drug-Drug Interaction Study to Evaluate the Effects of Ecopipam on the Pharmacokinetics of Multiple Substrates
This is a single center, open-label, fixed sequence Phase 1, drug-drug interaction (DDI) study in healthy subjects.
- Trial name
- NCT04764851
- Testing
- ecopipam HCl ~2mg/kg/day, Cohort 1 Probe Cocktail, Cohort 2 Probe Cocktail
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emalex Biosciences Inc.
Drug Interaction Potential
Effect of Pexidartinib on the Way the Body Processes CYP3A4 and CYP2C9 Substrates (Pharmacokinetics)
This study has two parts. Part 1 will evaluate how pexidartinib affects the way the body processes CYP3A4 and CYP2C9 substrates using midazolam and tolbutamide, respectively, as probe agents.
- Trial name
- NCT03291288
- Testing
- Tolbutamide, Midazolam, Pexidartinib
- Where
- 11 sites in United States, Netherlands and 2 more
- Volunteers
- 32 people
- Sponsor
- Daiichi Sankyo
Food-drug Interaction
Red Clover Botanical Dietary Supplements - Metabolism and Safety in Women
Human safety studies were carried out to test whether red clover botanical dietary supplements used by peri- and post-menopausal women are safe to use with Food and Drug Administration (FDA)-approved drugs.
- Trial name
- NCT03205787
- Testing
- Trifolium pratense
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Gene and Diet Interaction
Diet Quality and Genetic Association With Body Mass Index: Results From Three Observational Studies
Background In the most recent genome-wide association study (GWAS), of the 97 body mass index (BMI)-associated single nucleotide polymorphisms (SNPs) identified, more than half of the SNPs were highly enriched for expression in…
- Trial name
- NCT03577639
- Volunteers
- 11,700 people
- Sponsor
- Harvard School of Public Health (HSPH)
Drug Drug Interaction
Drug-Drug Interaction Study of Intravenous Administration of SyB V-1901 and Cyclosporine in Japanese Healthy Subjects
To evaluate the effect of coadministered cyclosporine on the pharmacokinetics of brincidofovir following simultaneous administration of SyB V-1901 with cyclosporine, or coadministration of cyclosporine at 2 hours after the…
- Trial name
- NCT04542252
- Testing
- SyB V-1901, Cyclosporine
- Where
- Japan
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- SymBio Pharmaceuticals
Autism Spectrum Disorder, Autism
Effects of Animal-assisted Therapy on the Physical Function and Communication of Adults With Autism
The aim is to evaluate the effects of a dog-assisted therapy program on physical function and communication in a sample comprised of 24 adults with autism spectrum disorder.
- Trial name
- NCT04859998
- Testing
- dog-assisted therapy
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Daniel Collado-Mateo
Healthy Subjects, Drug-drug Interaction, Pyrotinib
Drug-Drug Interaction of Pyrotinib With a Moderate CYP3A Inducer
This drug-drug interaction (DDI) study had been designed to investigate the effect of a moderate CYP 3A inducer efavirenz on the pharmacokinetics of maleate pyrotinib in Chinese healthy volunteers.
- Trial name
- NCT04680091
- Testing
- Pyrotinib Maleate, Efavirenz
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Food-drug Interaction
A Food-Effect Study of Hemay022 in Healthy Participants
The primary objective of this study is to determine the effect of food in healthy participants on the bioavailability of Hemay022 following single dose administration with and without a meal.
- Trial name
- NCT04673474
- Testing
- Hemay022
- Where
- China
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Tianjin Hemay Oncology Pharmaceutical Co., Ltd
Heart-lung Interaction, Right Ventricular Hypertrophy
Cardiopulmonary Effect of Mechanical Ventilation in Children With Right Ventricular Hypertrophy
Neurally adjusted ventilatory assist (NAVA) is a new mode of mechanical ventilation that delivers ventilatory assist in proportion to neural effort.
- Conditions
- Heart-lung Interaction, Right Ventricular Hypertrophy, Postoperative Care, Congenital Heart Disease
- Trial name
- NCT04825054
- Testing
- Mechanical ventilation with NAVA mode, Mechanical ventilation with PCV mode, Mechanical ventilation with PSV mode
- Where
- 2 sites in China
- Volunteers
- 30 people
- Sponsor
- Limin Zhu
Drug-drug Interaction
Drug-drug Interaction Study Between Edaravone and 2-Aminoethanesulfonic Acid in Compound Edaravone Injection
An experiment to evaluate the drug-drug interaction of formula edaravone and formula 2-aminoethanesulfonic acid in compound edaravone injection.
- Trial name
- NCT04218513
- Testing
- Compound Edaravone Injection, Edaravone Injection, 2-Aminoethanesulfonic Acid Injection
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Nanjing Yoko Biomedical Co., Ltd.
Drug Interactions
Study to Learn the Effect of Drug BAY1817080 on the Way the Body Absorbs, Distributes and Excretes Another Drug Rosuvastatin in Healthy Adult Participants
Researchers in this study want to learn how the study drug BAY1817080 interacts with another drug called rosuvastatin (brand name: Crestor) and affects the way the body absorbs, distributes and excretes rosuvastatin in healthy…
- Trial name
- NCT04252300
- Testing
- Rosuvastatin, Rosuvastatin + BAY1817080
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bayer