Clinical trials: Interaction
Drug Interaction Potentiation
Drug-Drug Interactions of Grazoprevir/Elbasvir in Taiwan
Co-morbid diseases often present in a substantial proportion of patients with chronic hepatitis C (CHC) and require drugs to treat and control. Grazoprevir/elbavir is metabolized by cytochrome P-450 enzyme of liver.
- Trial name
- NCT03706222
- Testing
- elbasvir/grazoprevir
- Where
- Taiwan
- Volunteers
- 400 people
- Sponsor
- National Cheng-Kung University Hospital
Transplantation, Immunosuppression
Influence of Pantoprazole on the Bioavailability of MMF and EC-MPS
The objective of this pharmacokinetic study is to examine a possible drug-drug interaction of Pantoprazole on the bioavailability mycophenolic acid.
- Conditions
- Transplantation, Immunosuppression, Drug Interaction
- Trial name
- NCT01801280
- Testing
- Mycophenolate sodium, Pantoprazole, Mycophenolate mofetil
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Klemens Budde
Social Skills, Social Interaction
Social Intelligence Training in Midlife
Childhood adversity leads to social difficulties, chronic illness, and early mortality for many, but not all adults: Some are resilient.
- Trial name
- NCT03824353
- Testing
- Social Intelligence Training, The Healthy Living Program
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Non-target Heterologous Effects of Vaccines, Vaccine Interactions
The Interaction Between Measles and DTP Vaccination
The purpose of this study is to investigate for the broad immunological effects of administering measles vaccine (MV) and diphtheria-tetanus-whole cell pertussis vaccine (DTP) to 9 month old Gambian infants, either alone or…
- Trial name
- NCT02710045
- Testing
- Measles Vaccine at 9 months of age, DTP Vaccine at 9 months of age, Measles Vaccine at 18 months of age
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Medical Research Council Unit, The Gambia
Drug Interaction
Phase 1 Study to Evaluate the Safety and Tolerability of DS-1040b IV Infusion With Clopidogrel in Healthy Subjects
This study is being conducted to test the hypothesis that coadministration of clopidogrel with DS-1040b will be safe and well tolerated.
- Trial name
- NCT02560688
- Testing
- DS-1040b, Clopidogrel
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Daiichi Sankyo
Psychosocial Stress
Biobehavioral Effects of Therapy Dog Visitation in Elderly Intensive Care Unit Patients: A Pilot and Feasibility Study
The purpose of this study is to assess the preliminary efficacy of a 10-minute therapy dog visitation (TDV) in reducing biobehavioral stress responses.
- Trial name
- NCT02997852
- Testing
- Therapy dog visitation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetes Mellitus, Type 2, Hepatitis C
Effect of Co-administration of Metformin and Daclatasvir on the Pharmacokinetis and Pharmacodynamics of Metformin
A Randomized,Two-period, Crossover Study to Determine the Possibility of Drug-drug Interaction After Co-administration of Metformin and Daclatasvir Where Twenty Eligible Adult Subjects Will be Randomized to Receive Either…
- Conditions
- Diabetes Mellitus, Type 2, Hepatitis C, Drug Interactions
- Trial name
- NCT03686722
- Testing
- Metformin, Daclatasvir
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mohamed Raslan
Health, Quality of Life
Effect of Art Museum Activity Program for the Elderly on Health: A Pilot Observational Study
Older adults, defined as 65 years or older, are increasing in number and representing a larger part of Canadian population. Assessing and addressing the needs of this growing number of individuals is essential.
- Conditions
- Health, Quality of Life, Social Interaction
- Trial name
- NCT03557723
- Testing
- Art activities program
- Where
- Canada
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Drug Interactions
A Drug Interaction Study of BIIB074 and an Oral Contraceptive Regimen
The primary objective of this study is to evaluate the effect of multiple doses of a uridine diphosphate glucuronosyltransferases (UGT)-inducing oral contraceptive (OC) regimen (ethinyl estradiol and levonorgestrel) on the PK of…
- Trial name
- NCT03324685
- Testing
- BIIB074, OC (ethinyl estradiol and levonorgestrel)
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Biogen
COPD, Lung Function
Lung Function Decline and Disease Risk From Young Adulthood to Middle Age
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, but markers that predict risk of developing disease outside of cigarette smoking have not been identified.
- Conditions
- COPD, Lung Function, Heart - Lung Interaction, Restrictive Lung Disease
- Trial name
- CARDIA Lung (NCT02245178)
- Testing
- Lung spirometry, CT scan analysis
- Volunteers
- 3,193 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Drug Interaction, Healthy Volunteer
A Study to Examine the Effects of Entinostat on Midazolam in Healthy Adult Subjects
The purpose of this study is to evaluate the effect of Entinostat on the bioavailability of Midazolam. The primary objective is to evaluate the effect of a single oral dose of entinostat on the pharmacokinetics (PK) of a single…
- Trial name
- NCT03187015
- Testing
- Entinostat, Midazolam
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Syndax Pharmaceuticals
Food-Drug Interactions
Coffee Interaction With the Antihypertensive Drug Felodipine
Coffee is a globally popular beverage. More than half of the United States population spends an estimated $ 40 billion on the purchase of coffee each year. Personal consumption habits can vary.
- Trial name
- NCT02232269
- Testing
- Black Coffee, Grapefruit Juice, Water
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Health Behavior, Social Interaction
Neuro-cognitive Bases of Joint Action
The ability to interact with conspecifics is crucial in life, yet there is no consensus on the underlying cognitive and neural mechanisms beyond those associated with imitative behaviors.
- Trial name
- NCT03369860
- Testing
- Interactivity of Experimental Condition
- Where
- Italy
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Drug-Drug Interaction
Drug Interaction Study of Fimasartan/Amlodipine/Hydrochlorothiazide in Healthy Male Subjects
The purpose of this study is to evaluate the Drug interaction and safety of Fimasartan/Amlodipine and Hydrochlorothiazide in Healthy Male volunteers.
- Trial name
- NCT03390465
- Testing
- Fimasartan/Amlodipine combination drug, Hydrochlorothiazide
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Coronary Artery Disease, Drug Interaction Potentiation
Ranitidin Versus Omeprazole in Patients Taking Clopidogrel
Previous reports have shown a possible drug interaction between clopidogrel and proton pump inhibitors (PPI´s), which could result in increased number of adverse cardiovascular events among patients on dual antiplatelet…
- Trial name
- NCT01896557
- Testing
- omeprazole, Ranitidine, Clopidogrel
- Volunteers
- 92 people
- Sponsor
- University of Sao Paulo General Hospital
Drug-Drug Interaction, Healthy Volunteers
The Effects of Multiple Dose Fluoxetine and Metabolites on CYP1A2, CYP2C19, CYP2D6 and CYP3A4 Activity
Inhibitory drug-drug interactions (DDIs) are a considerable concern as inhibition of drug's clearance can lead to increased plasma concentrations and subsequent adverse events and toxicities.
- Trial name
- FLUOXETINE (NCT01361217)
- Testing
- Fluoxetine, Lovastatin, Omeprazole, caffeine, midazolam, dextromethorphan
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Washington
Very Low Birthweight Infants, Mother Child Interaction
Delivery Room Skin-to-skin Study
The first hours after birth are a sensitive period for promotion of optimal mother-child-interaction and secure attachment. Maternal sensitivity and responsivness are high in the first hours after birth due to high oxytocin…
- Conditions
- Very Low Birthweight Infants, Mother Child Interaction, Preterm Infant
- Trial name
- deisy (NCT01959737)
- Testing
- skin-to.skin-contact
- Where
- Germany
- Volunteers
- 88 people
- Sponsor
- University of Cologne
Anxiety, Depression
Health Benefits of Gardening
The objective of the research is to test the hypothesis that participating in group-based gardening or group-based art activities may alter the mental health and cardiac physiological status of a wellness population of women ages…
- Conditions
- Anxiety, Depression, Healthy, Mood Disturbance
- Trial name
- NCT03266120
- Testing
- Art, Gardening
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Florida
Drug-Drug Interaction Healthy Volunteers
A Drug-Drug Interaction Study to Evaluate the Effect of Vapendavir on the Pharmacokinetics of Midazolam in Healthy Male and Female Volunteers
The primary aim of this Phase 1 study is to evaluate the effect of vapendavir daily doses of 528 mg daily (QD) and 264 mg twice daily (BID) on the pharmacokinetic (PK) profile of midazolam, a cytochrome (CYP) 3A4 substrate.
- Trial name
- NCT02204501
- Testing
- Midazolam 5mg Syrup, Vapendavir 264 mg BID, Vapendavir 528 mg QD
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Biota Scientific Management Pty Ltd
Healthy, Drug Interactions
Drug Interactions and Bioavailability of Cranberry
The purpose of this study is to evaluate the potential of cranberry juice to interact with conventional drugs. This study will also determine the the amount of cranberry flavonoids that appear in the blood and in the urine.
- Trial name
- NCT00200759
- Testing
- Cranberry juice and capsules
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina