Clinical trials: Interaction
HIV Infections
A Study on Possible Interactions Between Protease Inhibitors (Anti-HIV Drugs) and Drugs Which Lower the Level of Fat in Your Blood
The purpose of this study is to find out whether taking protease inhibitors (anti-HIV drugs) together with lipid-lowering drugs (drugs which lower the amount of fat in the blood) has an effect on the level of drugs found in the…
- Trial name
- NCT00000941
- Testing
- Pravastatin sodium, Simvastatin, Atorvastatin calcium
- Where
- 13 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Picky Eaters, Feeding Interaction, Good Enough Parenting, Family Meals, Emotional Eating Prevention
"Improved Mother Infant Feeding Interaction (MI-FI) at 12 Months With Very Early Parent Training"
Rise in childhood obesity and poor eating habits and eating problems is apparent over the last decades. Parents are at lose what the correct way to tackle these problems may be.
- Trial name
- MI-FI (NCT03086811)
- Testing
- Mother Infant Feeding Interaction very early training
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Cardiomyopathy, Dilated
Electrical Interactions in Heart Disease
This study will evaluate the relationship of markers of cardiac activation and their determinants. The hypothesis is that these markers will be interrelated.
- Trial name
- NCT01508871
- Testing
- Observational study, no intervention
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Type 2 Diabetes, Depression
Interaction Between St John's Wort and Metformin?
The goal of the study is to examine the difference of the pharmacokinetics of metformin with and without a 3 weeks pretreatment of St John's Wort.
- Trial name
- NCT01726764
- Testing
- St John's Wort, Metformin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Southern Denmark
Unrecognized Condition
Interaction of Genetic and Environmental Factors for Body Fat Mass Control
Although the effect of interaction between genetic and environmental factors on body fat mass (BFM) has been proposed, how lifestyle changes affect body weight with regard to the genetic composition needs to be verified.
- Trial name
- NCT04299698
- Testing
- lifestyle
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Experiences, Lived Experiences
Research-patientS and Clinical researcH Nurses: Exploring Their Experiences of tAking paRt in Clinical resEarch in the NHS
This PhD explores the views of clinical research nurses (CRNs) and research-patients as they take part in clinical research within their respective roles, i.e., as a specialised staff member and as a patient volunteer.
- Conditions
- Experiences, Lived Experiences, Research Participation, Research Subjects
- Trial name
- SHARE (NCT07663058)
- Testing
- Interviews, Non-participant observations
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
DDI (Drug-Drug Interaction)
Drug-Drug Interaction Study of Befotertinib Capsules in Healthy Participants.
This study adopts a single-center, open-label, same-subject sequential crossover clinical trial design, aiming to evaluate the effects of oral administration of rifampicin or itraconazole on the pharmacokinetic profiles of…
- Trial name
- NCT07809815
- Testing
- Befotertinib and rifampicin, Befotertinib and itraconazole
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Betta Pharmaceuticals Co., Ltd.
Overweight or Obesity, Healthy
Berries, Inflammation, and Gut Microbiome
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations…
- Trial name
- NCT04100200
- Testing
- Mixed berries, FOS, Control
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Solid Tumours
A Study in Healthy Male Subjects to Understand How Savolitinib Behaves Inside the Body (Pharmacokinetics) When Administered Alone and in Combination With Famotidine
This will be an open-label, randomised, 2 part (Part A and Part B), 2 treatment (savolitinib alone or in combination with famotidine), crossover study in healthy, non Japanese, male subjects, performed at a single study centre.
- Trial name
- NCT04179071
- Testing
- Savolitinib, Famotidine
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Parkinson's Disease
A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin
The purpose of this study is to evaluate the influence of repeated oral doses of KW-6356 on the pharmacokinetics of index substrates for CYP3A4/5, CYP1A2 and BCRP.
- Trial name
- NCT03970798
- Testing
- Midazolam, Caffeine, Rosuvastatin
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Hypertension
A Clinical Trial to Evaluate Pharmacokinetic Interactions and Safety Between Fimasartan and Linagliptin in Healthy Male Volunteers
The purpose of this study is to evaluate pharmacokinetic interactions and safety between fimasartan and linagliptin in healthy male volunteers.
- Trial name
- NCT03250052
- Testing
- (fimasartan or linagliptin) x 7days, (fimasartan and linagliptin) x 7days
- Where
- South Korea
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Healthy Volunteer
A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants
This is a Phase 1 study to investigate safety and pharmacokinetics of ABBV-722 and Upadacitinib following multiple oral doses in healthy adult participants.
- Trial name
- NCT07425899
- Testing
- ABBV-722, Upadacitinib
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- AbbVie
Cardiovascular Diseases, Heart Diseases
Antihypertensive Drug/Gene Interactions and CV Events
To investigate drug-gene interactions on the incidence of non-fatal myocardial infarction and stroke for hypertensive patients.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Myocardial Infarction, Hypertension
- Trial name
- NCT00005332
- Sponsor
- University of Washington
Healthy Subjects
Clinical Study to Investigate Safety and Effects on Heart Rate, Blood Pressure, and Pharmacokinetic Interactions of ACT-334441
The aim of the study is to investigate the safety of the concomitant administration of ACT-334441 with cardiovascular drugs.
- Trial name
- NCT02479204
- Testing
- ACT-334441 2 mg, ACT-334441 4 mg, Atenolol
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Viatris Innovation GmbH
Alcohol Drinking, Coping Skills
Coping Skills for Alcohol Use
A total of 120 young adults who drink to cope with negative affect will be randomized to a 4-week, web-based intervention with interactive modules on cognitive-behavioral skills (n=60) or an assessment only control (n=60).
- Trial name
- NCT05356533
- Testing
- Drinking to Cope CBT skills
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Washington
Cytochrome P450 Interaction
A Study To Test The Effect Of Apatinib On P450 Enzymes
Apatinib, an oral inhibitor of vascular endothelial growth factor receptor 2（VEGFR-2）, inhibits multiple cytochrome P450 (CYP450) enzymes in vitro.
- Trial name
- NCT03245307
- Testing
- Apatinib, Nifedipine GTIS, Warfarin Potassium
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Healthy Participants
A Drug-Drug Interaction Study to Evaluate the Effect of Itraconazole on the Pharmacokinetic Profile of Etrumadenant in Healthy Adult Participants
This study will evaluate the effect of multiple oral doses of itraconazole, on the pharmacokinetics of etrumadenant when etrumadenant is administered as a single dose in healthy adult participants.
- Trial name
- NCT05154136
- Testing
- Etrumadenant, Itraconazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Arcus Biosciences, Inc.
Parkinson Disease
Video Game-based Exercise for Persons With Parkinson's Disease
This study assessed the effects of interactive video game-based exercise (IVGB) on balance in persons with Parkinson's disease . Twenty-four patients were randomly allocated to two groups (12 participants per group).
- Trial name
- NCT03689764
- Testing
- interactive video game-based exercise, no intervention
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Taipei Medical University Hospital
Breast Neoplasms, Metastases, Neoplasm
Safety, Efficacy and Pharmacokinetic Between Capecitabine and Exisulind in Metastatic Breast Cancer Patients
The primary objective of the phase I study is to determine a safe dose for combination therapy with capecitabine and exisulind. A secondary objective is to assess pharmacokinetic interactions between the two drugs and assess the…
- Trial name
- NCT00037609
- Testing
- Capecitabine, Exisulind
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- M.D. Anderson Cancer Center
Healthy
Interaction Between Paracetamol and Lamotrigine: A Clinical Interaction Study
The investigators will study the effect of paracetamol on the steady state metabolism of lamotrigine in 12 healthy male volunteers. Subjects will receive lamotrigine, slowly titrated from 25 mg daily to 100 mg daily over 28 days.
- Trial name
- NCT02303106
- Testing
- Lamotrigine
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Per Damkier
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