Clinical trials: Interaction
Probiotics, Gut Microbiota
Probiotic Effects on the Microbe-brain-gut Interaction and Brain Activity During Stress Tasks in Healthy Subjects
The aim of this study is to determine if and how the "Probiotic Product" affects functional brain responses in healthy subjects during an emotional- and arithmetic stress task, respectively and in terms of microbe-brain-gut…
- Conditions
- Probiotics, Gut Microbiota, Emotional Stress, Magnetic Resonance Imaging
- Trial name
- NCT03615651
- Testing
- Probiotic
- Where
- Sweden
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Mobility Limitation
Effects of Game-based Balance Exercise for Older Adults With Fall History
Due to the many problems associated with reduced balance and mobility, providing an effective and engaging rehabilitation regimen is essential to progress recovery from impairments and to help prevent further degradation of motor…
- Trial name
- NCT01381237
- Testing
- game-based balance exercises
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Amyotrophic Lateral Sclerosis, Healthy Volunteer
A Study to Assess the Effect of Erythromycin on the Test Medicine (SAR443820) When Given Orally as Tablets to Healthy Adult Male and Female Participants (Part A); and the Effect of Itraconazole on the Test Medicine (SAR443820) When Given Orally as Capsules to Healthy Adult Male Participants (Part B)
This is a Phase 1, cross-over, 2-part study for pharmacokinetic (PK) assessment of SAR443820 when co-administered with cytochrome P450 3A4 (CYP3A4) inhibitors (erythromycin ethyl succinate (EES) in Part A and possibly…
- Trial name
- NCT05797753
- Testing
- SAR443820, Erythromycin ethyl succinate, Itraconazole
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Sanofi
Drug-Drug Interaction, HIV Infection
Dihydroartemisinin-Piperaquine in the Context of Antiretroviral Therapy
Open-label prospective intensive pharmacokinetic study of dihydroartemisinin-piperaquine (DP) in HIV-infected children on efavirenz (EFV)-, lopinavir/ritonavir (LPV/r)-, or dolutegravir (DTG)-based antiretroviral therapy (ART)…
- Trial name
- DPART (NCT04487145)
- Testing
- Dihydroartemisinin-piperaquine
- Where
- 2 sites in Uganda
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy
A Crossover Study to Assess the Drug-drug Interaction of Acid Reducing Agent(s) on the Pharmacokinetics of a Single Oral Dose of Lumicitabine (JNJ-64041575) in Healthy Adult Participants
The main purpose of study is to evaluate the effect of multiple-dose administration of lansoprazole (and optional: time-separated single dose administration of ranitidine) on the pharmacokinetics (PK) of JNJ-63549109 after a…
- Trial name
- NCT03468777
- Testing
- Lumicitabine, Lansoprazole, Ranitidine
- Where
- Belgium
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Infection, Human Immunodeficiency Virus I
A Drug Interaction Study Evaluating Plasma GSK2248761 and GSK1349572 Pharmacokinetics in Healthy Adult Subjects.
This is a single-center, open-label, three-period, fixed-sequence cross over study in healthy adult subjects. A total of approximately 16 healthy subjects will be enrolled to provide data from 12 evaluable subjects.
- Trial name
- NCT01283100
- Testing
- GSK1349572, GSK2248761
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- ViiV Healthcare
Overweight, Obesity
Interactive Effects of an Isocaloric High-protein Diet and Resistance Exercise in Untrained Overweight Young Men
Background: The interactive effects of resistance training and dietary protein on hormonal responses in overweight or obese adults are not clear and remain controversial.
- Trial name
- NCT01714700
- Testing
- High protein diet, Resistance exercise, Standard diet, Resistance exercise
- Where
- South Korea
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Fungal Infection
Safety, Pharmacokinetics, Bioavailability, Food Effect, Drug-Drug Interaction Study of APX001 Administered Orally
This is a Phase l double-blind, placebo-controlled, randomized study to investigate the safety, tolerability, pharmacokinetics, bioavailability and food effect of single doses of APX001 administered intravenously and orally…
- Trial name
- NCT02957929
- Testing
- APX001 single IV dose, APX001 single oral dose 1, APX001 single oral dose 2
- Where
- 2 sites in Netherlands
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Acute Respiratory Failure
Brain-lung Interaction During Acute Respiratory Failure
Acute hypoxemic de novo respiratory failure (AHRF) is a common cause of admission to the intensive care unit (ICU). Its main cause is community-acquired pneumonia.
- Trial name
- BrainFlow (NCT07279831)
- Testing
- EEG/NIRS/EMG
- Where
- 2 sites in France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Anxiety Depression Disorder
Hemispheric Asymmetries in Emotion-Cognition Interactions
In this research, the investigators will recruit 2 groups of individuals: older adults (aged over 65) with anxiety and/or depression and older adults without mental health issues.
- Trial name
- NCT06406595
- Testing
- Observation
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Executive Function, Social Interaction
Study: Effects of a Collaborative Occupational Therapy Interactive Vaulting
Occupational therapy services will be integrated into an interactive vaulting program which is an equine assisted activity. Children with disabilities ages 5-17 will participate.
- Conditions
- Executive Function, Social Interaction, Disability, Developmental
- Trial name
- NCT04481334
- Testing
- Collaborative occupational therapy interactive vaulting group
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- East Carolina University
Overweight and Obesity
Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness
The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.
- Trial name
- NCT03367598
- Testing
- rs662799 (APOA5 -1131T>C)
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Oncology, Nausea and Vomiting Chemotherapy-Induced
The Effect of Using Interactive Mobile Application for the Management of Chemotherapy- Induced Nausea and Vomiting in Children
The aim of this study was to develop an interactive mobile application and to investigate the effect of this application on the management of nausea and vomiting symptoms by using it during chemotherapy treatment.
- Conditions
- Oncology, Nausea and Vomiting Chemotherapy-Induced, Pediatric Cancer, Mobile Application
- Trial name
- NCT04693832
- Testing
- 5inD
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Trakya University
Dental Anxiety
Improving Adolescent-dentist Interaction Through Digital Technology
The aim of the present study is to assess the impact of a digital tool on the interaction between the dentist and the adolescent patient, concerning the level of dental anxiety and communication.
- Trial name
- NCT03907514
- Testing
- "FALE" Application
- Where
- Brazil
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Organoid, Model Disease
Development of a Duodenal Organoid Model for Host-Intestinal Pathogen Interaction Studies
The goal of this clinical trial is to develop an in vitro model based on human duodenal organoids for the study of interactions between the human intestinal epithelium and enteric pathogens.
- Trial name
- DuoDenOrg (NCT07828665)
- Testing
- Donation of residual biological samples for the development of duodenal organoids.
- Where
- Italy
- Volunteers
- 6 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Engagement, Patient, Mood
SimpleC Wellness Platform With Social Robot Interaction
This implementation study will be conducted to test a Socially-Assistive Robot (SAR) system for residents in an Assisted Living environment. The goal of the SAR system is to enhance social engagement and connectedness.
- Conditions
- Engagement, Patient, Mood, Quality of Life, Aging
- Trial name
- NCT05296239
- Testing
- SimpleC Wellness Platform with Social Robot Interaction
- Where
- 2 sites in United States
- Volunteers
- 26 people
- Sponsor
- SimpleC, LLC
Healthy
A Study Evaluating Drug Drug Interaction Between Milvexian and Atorvastatin in Healthy Participants
The purpose of this study is to evaluate the potential pharmacokinetics (PK) interaction between milvexian and atorvastatin (and its metabolites) in healthy participants at steady state.
- Trial name
- NCT04388501
- Testing
- Milvexian, Atorvastatin
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Healthy
to Investigate the Pharmacokinetic Interactions and Safety Between Rosuvastatin and Ezetimibe in Healthy Male Volunteers
The purpose of this study is to compare the drug interaction of pharmacokinetics of rosuvastatin and ezetimibe.
- Trial name
- NVP-1205 (NCT02289430)
- Testing
- Crestor+Ezetrol, Ezetrol, Crestor
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- NVP Healthcare
Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein
Drug-Drug Interaction Study Between Colchicine and Diltiazem ER
Colchicine is a substrate for both cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp). Extended-release diltiazem (diltiazem ER) is a potent inhibitor of both CYP3A4 and P-gp.
- Trial name
- NCT00983372
- Testing
- Colchicine, Diltiazem ER
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Latent Tuberculosis, Human Immunodeficiency Virus
Doravirine, Rifapentine and Isoniazid Interaction
Drug therapy for persons living with human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) co-infected with latent tuberculosis infection (LTBI) is complex.
- Conditions
- Latent Tuberculosis, Human Immunodeficiency Virus, Rifamycins Causing Adverse Effects in Therapeutic Use, Drug Interaction Potentiation
- Trial name
- DORIIS (NCT03886701)
- Testing
- Doravirine (DOR), Rifapentine (RPT), Isoniazid (INH)
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Walter K. Kraft
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.