Clinical trials: Interaction
Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More)
Prevalence of Inappropriate Prescriptions and Omitted Therapies in Hospitalized Elderly: STOPP/START Criteria Analysis
Evaluate the prevalence of potentially inappropriate prescriptions (PIPs) and potential omitted prescriptions (PPOs) in elderly patient upon admission to the acute geriatric department, based on adherence or non-adherence to the…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More), Deprescribing, Hospitalization
- Trial name
- SPIna (NCT07202962)
- Testing
- medication review and deprescribing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Aging, Foot Muscle Dysfunction
Effects of Rehabilitative Exergame Training on Foot Muscle Activity, Balance, and Mobility in Older Adults
This study is designed as a randomized controlled trial. A total of 40 healthy older adults residing in private and public nursing homes and rehabilitation centers in Mersin will be enrolled.
- Conditions
- Aging, Foot Muscle Dysfunction, Sarcopenia, Age-Related Muscle Weakness
- Trial name
- EXG-FOOT (NCT07357662)
- Testing
- Exergame-based Balance and Foot Muscle Training, Conventional Functional Balance Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Tarsus University
Alzheimer's Disease
GSK2647544 RD, DDI in Healthy Young and Elderly Volunteers
GSK2647544 is an orally available, selective inhibitor of Lp PLA2 that is being developed for the treatment of Alzheimer's disease.
- Trial name
- NCT01978327
- Testing
- GSK2647544, drug-drug interaction
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Cocaine-Related Disorders, Drug Administration Schedule
Evaluation of Modafinil as a Cocaine Treatment Medication and Interactions With Cocaine - 1
The purpose of this study is to evaluate modafinil, a cocaine treatment medication, and its interactions with intravenous (IV) cocaine.
- Conditions
- Cocaine-Related Disorders, Drug Administration Schedule, Infusions, Intravenous
- Trial name
- NCT00033046
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Neoplasms
Drug-Drug Interaction Study of Rucaparib, Rosuvastatin and Oral Contraceptives
This study will investigate the drug-drug interactions (DDIs) between rucaparib and oral rosuvastatin (Arm A), and between rucaparib and oral ethinylestradiol and levonorgestrel (Arm B), with rucaparib as a perpetrator.
- Trial name
- NCT03954366
- Testing
- Rucaparib, Rosuvastatin, Oral Contraceptives
- Where
- 7 sites in Hungary, Poland and 1 more
- Volunteers
- 36 people
- Sponsor
- pharmaand GmbH
Anesthesia, Sedation
A Study Evaluating Drug-Drug Interaction (DDI) Between HSK3486 Injectable Emulsion and Voriconazole Tablets
This is a single-center, open-label, randomized, two-stage, two-way crossover study evaluating the effect of voriconazole on the PK, PD, and safety of HSK3486 in healthy subjects.
- Trial name
- NCT04145583
- Testing
- HSK3486, voriconazole +HSK3486
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Imagery (Psychotherapy), Postural Control
The Effect of Motor Image Training on Balance Performance in Geriatric Individuals
The goal of this study [type of study: clinical trial] is to was planned to investigate the effect of motor imagery training given to geriatric individuals with action observation on their balance performance and to compare these…
- Conditions
- Imagery (Psychotherapy), Postural Control, Postural Balance, Virtual Reality Therapy
- Trial name
- NCT06056180
- Testing
- Balance Training, Motor İmagery Training, Action Observation Training
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Muğla Sıtkı Koçman University
Cocaine Dependence, Cocaine Addiction
Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study
The main purpose of this study is to determine if it is safe to use the study drug, clavulanic acid, in combination with cocaine.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
- Trial name
- NCT02563769
- Testing
- Clavulanic acid, Intravenous cocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Temple University
Post-Traumatic Headache
Interactive CBT for Headache And Relaxation Training
This mixed-methods pilot study aims to evaluate the feasibility, acceptability, and preliminary effectiveness of iCHART (Interactive CBT for Headache And Relaxation Training), an interactive voice response (IVR) based delivery of…
- Trial name
- iCHART (NCT05093556)
- Testing
- iCHART - Interactive CBT for Headache And Relaxation Training
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- VA Connecticut Healthcare System
Acute Stroke
The Bern Heart and Brain Interaction Study - Interaction Between Brain and Heart in Acute Ischemic Stroke
Acute ischemic stroke is caused by blockage of blood vessels in the brain. Blood vessels can be obstructed by several different mechanisms and identification of this cause is essential to minimize the risk of recurrence.
- Trial name
- BEHABIS (NCT03720522)
- Testing
- Short cardiovascular MRI (CMR), Adenosine-perfusion cardiovascular MRI (CMR), Blood draw
- Where
- Switzerland
- Volunteers
- 220 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hepatitis C
Drug Interaction Study With BI 201335 and Methadone or Buprenorphine/Naloxone
Otherwise healthy subjects who are currently bein maintained on either methadone or buprenorphine/naloxone for opioid maintenance therapy who have been on a stable dose for at least 30 days will be administered BI 201335 daily to…
- Trial name
- NCT01637922
- Testing
- BI 201335
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- Boehringer Ingelheim
Multiple Sclerosis
GSK239512 DDI Study
The study will determine the effect of 400 mg once daily of ketoconazole at steady state on the pharmacokinetics of a single oral dose of GSK239512 in young healthy volunteers.
- Trial name
- NCT01802931
- Testing
- GSK239512, ketoconazole
- Where
- Australia
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stroke
Virtual Environment Rehabilitation for Chronic Stroke
More than half of individuals post-stroke have residual movement disabilities, including reduced mobility, balance, and increased risk of falling.
- Trial name
- VEHAB (NCT01414686)
- Testing
- Commercially-Available Interactive Video Games
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of South Carolina
Herb-drug Interactions
Use of Herbal Medicine in Internal Medicine Wards
Herbs are physiologically active substances which can significantly affect the outcome of medical treatment, either by inhibiting or promoting drug disposition or through additive and synergistic effects when used in conjunction…
- Trial name
- NCT00564473
- Testing
- questionnaire
- Where
- 2 sites in Israel
- Volunteers
- 200 people
- Sponsor
- Shaare Zedek Medical Center
Healthy
Pharmacokinetics and Drug Interaction Study Between Rosuvastatin and CS-866 in Healthy Male Volunteers
The purpose of this study is to evaluate the pharmacokinetics profile and drug-drug interaction between rosuvastatin and CS-866 in healthy male volunteers.
- Trial name
- NCT01415466
- Testing
- Cresto, Olmetec, Cresto, Olmetec
- Where
- South Korea
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Reproductive Behavior, Contraception
eKISS: Electronic KIOSK Intervention for Safer-Sex
This study is a randomized controlled trial to test acceptability, feasibility and preliminary efficacy of an interactive computer-based intervention with individualized feedback to promote sexual health in adolescents and young…
- Conditions
- Reproductive Behavior, Contraception, Sexually Transmitted Diseases
- Trial name
- eKISS (NCT03027531)
- Testing
- eKISS: electronic KIOSK for Safer-Sex
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- University of Washington
Thromboembolic Diseases
Pharmacogenetics of Acenocoumarol
The use of oral anticoagulation is marked by an elevated risk of adverse drug events (ADE) due to a narrow therapeutic window leading to important medical and economical consequences.
- Trial name
- NCT01492777
- Where
- Switzerland
- Volunteers
- 115 people
- Sponsor
- University Hospital, Geneva
Breast Cancer
De-convoluting Interactions Between Genes, the Cancer Environment, and the Immune System to Develop Therapies That Work for You
This is a live biobank study for breast cancer (BC) patients where samples will be collected at inflection points in the course of the disease.
- Trial name
- DIGNITY (NCT05134779)
- Testing
- Live Biobank
- Where
- 2 sites in United States
- Volunteers
- 400 people
- Sponsor
- Weill Medical College of Cornell University
Children, Healthy
Interaction Between Dairy and Gut Hormone Response on Cognitive Performance in Children.
The purpose of this study is to investigate the short-term effects of milk and yogurt of varying fat and protein content on cognitive performance in healthy children aged 9 - 14 years; and to provide insight into mechanisms by…
- Trial name
- NCT07231146
- Testing
- Fat-Free Milk, Low-Fat Milk, Full-fat Milk
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Healthy Volunteers
A Study to Assess Potential Drug-Drug Interactions of E2086 in Healthy Participants
The primary purpose of this study is to assess potential drug-drug interactions of E2086 when coadministered orally with Itraconazole, Carbamazepine, Midazolam, Dextromethorphan, Bupropion, or Combined Oral Contraceptives in…
- Trial name
- NCT07766369
- Testing
- E2086
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
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