Clinical trials: Interaction
Healthy Male Volunteers
The Study of Pharmacokinetic Interactions Between HL237 and Tacrolimus
This study aims to evaluate the pharmacokinetic interaction between HL237 and tacrolimus in healthy male subjects.
- Trial name
- NCT04633733
- Testing
- HL237 tablet, tacrolimus capsule
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hanlim Pharm. Co., Ltd.
Infertility, Eclampsia Preeclampsia
Modelization of Early Endometrial-trophoblast Molecular Interaction
Despite significant advances in assisted reproductive technology, only 25% of in vitro fertilization (IVF) embryo transfers result in pregnancy, largely due to implantation failure.
- Trial name
- MEETMI (NCT07825649)
- Testing
- Diagnostic hysteroscopy with endometrial biopsy
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Intercommunal Creteil
Acute Coronary Syndrome
Potential Drug Interactions With Bisoprolol in Egyptian Patients With ACS
Acute coronary syndrome (ACS) is any group of clinical symptoms compatible with acute myocardial ischemia and includes unstable angina (UA), non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation…
- Trial name
- NCT05536284
- Testing
- Bisoprolol Fumarate Tablets
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- Damanhour University
ADHD
A Trial to Assess How Centanafadine Interacts With Stimulants in the Body
This study will look at how centanafadine works when taken together with stimulant medicines in healthy adults, and whether combining them affects how the body responds.
- Trial name
- NCT07314333
- Testing
- Centanafadine, Methylphenidate, Lisdexamfetamine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bacterial Infection, Infections, Bacterial
Evaluation of the Safety, Tolerability and Pharmacokinetics of Repeat Oral Doses of GSK580416
This study will evaluate the safety, tolerability and exposure of repeat escalating oral doses, a loading dose/maintenance dose regimen of GSK580416 and when co administered with ketoconazole, a PGP/CYP3A4 inhibitor.
- Trial name
- NCT00680485
- Testing
- GSK580416 oral tablets (250 mg) Ketoconazole oral tablets (200 mg)
- Where
- Australia
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pulmonary Arterial Hypertension
Effect Of Rifampin On Pharmacokinetics Of Sitaxsentan
This study will assess how rifampin will affect the blood levels of sitaxsentan. Safety of sitaxsentan given alone and with rifampin will also be assessed.
- Trial name
- NCT01251835
- Testing
- Sitaxsentan alone, Sitaxsentan, Rifampin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pfizer
QT-prolongation
QT-prolongation in Psychiatric Hospitals
Observational study in 6 psychiatric hospitals in Flanders. Patients are included when a QT-prolonging drug is added to a medication profile that already contains a potential QT-prolonging drug.
- Trial name
- NCT02043925
- Testing
- drugs linked with QT-prolongation
- Where
- Belgium
- Volunteers
- 152 people
- Sponsor
- KU Leuven
Type2 Diabetes Mellitus
Interaction of Bexagliflozin With Metformin, Glimepiride and Sitagliptin
The purpose of this study is to examine the drug-drug interaction in your body when given the study drug, bexagliflozin, with three commonly used ant-diabetic medications, metformin, glimepiride or sitagliptin.
- Trial name
- NCT02956044
- Testing
- Bexagliflozin, Metformin, Glimepiride
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Theracos
Cocaine Addiction
Vigabatrin Ph 1 Cocaine Interaction Study
This is a Phase 1 safety/tolerably study to determine if there are clinically significant interactions between oral vigabatrin (gamma vinyl-gamma-amino butyric acid; VGB) concurrent with intravenous (IV) cocaine infusions.
- Trial name
- NCT00626834
- Testing
- Vigabatrin
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Healthy Male Subjects
Drug Interaction Between SHR4640 Tablets and Furosemide Tablets in Healthy Volunteers (Single Center, Single Arm, Open, Self-control)
The purpose of this study was to evaluate the effect of SHR4640 tablets on the pharmacokinetics of furosemide tablets in healthy male volunteers, using a single-center, single-arm, open, self-control design.
- Trial name
- NCT04850638
- Testing
- SHR4640 tablets and furosemide tablets
- Where
- China
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Mechanical Ventilation Complication, Neurological Disorder
The Cerebral-Respiratory Interaction in Controlled Mechanically Ventilated Neurosurgical Patients. (The CeRes-CMV Study)
The impact of mechanical ventilation on intracranial perfusion is still not completely clarified. It is often assumed that raising airway pressure will invariably elevate the intracranial pressure, but this is not always the…
- Conditions
- Mechanical Ventilation Complication, Neurological Disorder, Lung Injury
- Trial name
- CeRes-CMV (NCT05363085)
- Testing
- Mechanically ventilated neurosurgical patients
- Volunteers
- 30 people
- Sponsor
- Uppsala University
Type 2 Diabetes Mellitus
Drug-drug Interaction Study(CKD-501, Amlodipine)
The purpose of this study is to assess the pharmacokinetic drug interaction between CKD-501 and amlodipine after oral administration in healthy male volunteers.
- Trial name
- NCT01341392
- Testing
- CKD-501, amlodiopine, CKD-501 amlodipine
- Where
- South Korea
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Amblyopia, Strabismus
The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years
Around one child in fifty has a lazy eye (termed amblyopia) where the eye is structurally normal but the vision fails to develop correctly.
- Trial name
- I-BiT Plus (NCT02810847)
- Testing
- I-Bit plus
- Volunteers
- 182 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Healthy
Drug Interaction and Safety Between Pitavastatin and Valsartan (CWP-PTV-101)
This study is designed to evaluate a pharmacokinetic drug interaction and safety between Pitavastatin and Valsartan in healthy male subjects
- Trial name
- NCT01232049
- Testing
- Multiple Oral Dose of
- Where
- South Korea
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Alzheimer Disease
Drug-Drug Interaction Study With Aricept® (Donepezil)
The purpose of this study is to find out if the plasma concentration of donepezil is changed when BMS-708163 is administered at the same time
- Trial name
- NCT01042314
- Testing
- Donepezil, BMS-708163
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Bristol-Myers Squibb
Autism, Autism Spectrum Disorder
Evaluating the Feasibility of Collecting User Interaction Data at the Emory Autism Center Using MapHabit Software
The purpose of this study is to evaluate the impact of the MapHabit System on autistic transition-age youth (ages 18-24) as they navigate key life transitions including graduating from high school, entering adult services…
- Trial name
- NCT07859306
- Testing
- MapHabit System (MHS)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Emory University
Drug Interaction Potentiation
Open-label, Single Center, Non-randomized, Fixed Sequence Phase 1 Drug-drug Interaction Study With LEO 32731 and Midazolam
This is a single center, non-randomized, open-label, fixed sequence study to investigate the effect of multiple oral dosing of LEO 32731 (up-titrated), on CYP3A activity in healthy male subjects using midazolam as a probe CYP3A…
- Trial name
- NCT03126578
- Testing
- LEO 32731, Midazolam
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Parent-Child Relations
ATTACH™ Program: Promoting Vulnerable Children's Health at Scale
ATTACH™ is a psycho-educational parenting program, designed with community agencies serving families of preschoolers affected by toxic stress (e.g.
- Trial name
- ATTACH™ (NCT04853888)
- Testing
- ATTACH™ Parenting Program
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Stroke
Interaction Between the Brain Hemispheres - Key to Motor Recovery After Stroke
Rationale: Acute stroke leaves many patients with functional deficits, of which upper extremity motor impairment is one of the most disabling.
- Trial name
- InterAct (NCT06381388)
- Testing
- cTBS
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jord Vink
Drug Drug Interaction
AV-101 Alone and in Combination With Probenecid in Healthy Subjects
This is an open-label, two period, fixed-sequence, drug-drug interaction study to compare the PK and PD of orally administered AV-101 alone and in combination with probenecid in healthy subjects.
- Trial name
- NCT05280054
- Testing
- AV-101, Probenecid
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- VistaGen Therapeutics, Inc.
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