Clinical trials: Interaction
Metastatic/Recurrent Breast Cancer
Pharmacokinetic Study of Tesmilifene (YMB1002) Plus Epirubicin and Cyclophosphamide in Metastatic Breast Cancer
This is a Phase I, multi-centre, open-label, cross-over pharmacokinetic study designed to investigate whether the co-administration of a fixed dose of tesmilifene alters the plasma pharmacokinetics of a standard regimen of…
- Trial name
- NCT00364754
- Testing
- Tesmilifene (YMB 1002)
- Where
- 10 sites in Georgia, Russia and 1 more
- Volunteers
- 28 people
- Sponsor
- YM BioSciences
RSV Infection
Drug-Drug Interaction Study Between Fluconazole and EDP-938 in Healthy Subjects
A Non-Randomized, Open-Label, Drug-Drug Interaction Study to Evaluate the Effects of Fluconazole on the Pharmacokinetics and Safety of EDP-938 in Healthy Subjects
- Trial name
- NCT04871724
- Testing
- EDP-938, Fluconazole
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Enanta Pharmaceuticals, Inc
Aging, Primary Hypothyroidism
Evaluation of Evening Versus Morning Levothyroxine Intake in Elderly
A study designed to compare evening versus morning levothyroxine intake in the elderly.
- Conditions
- Aging, Primary Hypothyroidism, Interaction Drug Food
- Trial name
- MONIALE (NCT03614988)
- Testing
- Evening Levothyroxine Administration, Morning Levothyroxine Administration
- Where
- Brazil
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Intracerebral Infarcts, Ischemic Stroke
Discharge Educational Strategies for Reduction of Vascular Events
DESERVE is a discharge education study using health workers to enroll and randomly assign 800 subjects diagnosed with TIA, or mild stroke to either risk factor education or usual care.
- Conditions
- Intracerebral Infarcts, Ischemic Stroke, Hemorrhagic Strokes, TIA's
- Trial name
- DESERVE (NCT01836354)
- Testing
- DESERVE education
- Where
- 3 sites in United States
- Volunteers
- 552 people
- Sponsor
- NYU Langone Health
Violence by Teachers
Preventing Violence by Teachers Against Children in Sub-Saharan Africa
Violence has severe and long-lasting negative consequences for children's and adolescents' well-being and psychosocial functioning, thereby also hampering communities' and societies' economic growth.
- Trial name
- EVIDENCE (NCT04948580)
- Testing
- Interaction Competencies with Children - for Teachers (ICC-T)
- Where
- 3 sites in Ghana, Tanzania and 1 more
- Volunteers
- 3,264 people
- Sponsor
- Bielefeld University
Healthy
Effects of Kava on the Body's Elimination of Caffeine and Dextromethorphan
This study will examine how kava-a widely used herbal remedy-may affect the body's elimination of other medicines. Many people take kava to reduce anxiety or cause sedation.
- Trial name
- NCT00009542
- Testing
- kava (Piper methysticum)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
HIV Infections, Sexual Behavior
Keeping it LITE: Exploring HIV Risk in Vulnerable Youth With Limited Interaction and Digital Health Intervention
Despite advances in HIV diagnostics, care and prevention strategies, infection rates among adolescent and young adult sexual and gender minorities (SGM) continue to rise in the United States (US).
- Trial name
- LITE-2 (NCT05848570)
- Testing
- Keeping it LITE
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Hektoen Institute for Medical Research
Drug-Interactions
Effect of Fluvastatin on Top of Clopidogrel and Aspirin in Patients After DES Implantation on Platelet Aggregation
The purpose of the study was to determine the influence of fluvastatin and atorvastatin on platelet aggregation in patients treated with aspirin and plavix after coronary stenting.
- Trial name
- EFA-1 (NCT00465322)
- Testing
- fluvastatin
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Insulin Resistance
Substudy of Change in Cardiometabolic Disease (CMD) Risk Factors During an Interactive Fitness Program
Substudy examining cardiovascular and metabolic risk factor change in children at high risk for future atherosclerosis who are enrolled in a pilot intervention using novel gaming and exercise activities to increase physical…
- Trial name
- EXCEL (NCT01080339)
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Tuberculosis
Pharmacokinetic Interaction Study in Indonesian Tuberculosis Patients Indonesia
Pharmacokinetic study in TB patients to determine the effect of rifampicin on the pharmacokinetic profile of moxifloxacin.
- Trial name
- NCT00306319
- Testing
- moxifloxacin
- Where
- Indonesia
- Volunteers
- 23 people
- Sponsor
- Radboud University Medical Center
HIV Infections
Older HIV-infected Adults and Drug Interactions: French Cross-sectional Study
Drug interactions between antiretroviral drugs and concomitants drugs and between antiretroviral need to be studied HIV-population is ageing. The referential of interactions is the Liverpool base.
- Trial name
- POPVIH65 (NCT03416881)
- Volunteers
- 13,225 people
- Sponsor
- University Hospital, Caen
Healthy
Crossover Drug-Drug Interaction Study to Determine Effects of Cytochrome P450 3A on Exposure to Mifepristone and Its Metabolites
This is a Phase 1, single center, fixed sequence, open label, drug-drug interaction study of the effect of multiple doses of rifampin 600 mg daily, a strong CYP3A inducer, on the exposure of mifepristone at 2 dose levels.
- Trial name
- NCT03258372
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Glanzmann Thrombasthenia
The Genetics and Functional Basis of Inherited Platelet, White Blood Cell, Red Blood Cell, and Blood Clotting Disorders.
Blood contains red blood cells, white blood cells, and platelets, as well as a fluid portion termed plasma. We primarily study blood platelets, but sometimes we also analyze the blood of patients with red blood cell disorders…
- Trial name
- NCT00230165
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Amphetamine-Related Disorders
Assessment of Potential Interactions Between Methamphetamine and Selegiline - 1
The purpose of this study is to assess the potential interactions between intravenous methamphetamine and oral selegiline.
- Trial name
- NCT00033072
- Testing
- Selegiline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Juvenile Idiopathic Arthritis, Diabetes type1
Host-microbiota-environment Interactions
Two types of inflammatory and autoimmune diseases (excluding monogenic diseases) can be distinguished in children: those similar to adult diseases but with an early onset (type 1 diabetes, inflammatory diseases of the…
- Conditions
- Juvenile Idiopathic Arthritis, Diabetes type1, Inflammatory Bowel Diseases
- Trial name
- MIP-1 (NCT05176795)
- Testing
- Stool sample
- Where
- France
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
HIV
Polypharmacy and Clinically Significant Drug Interactions Among HIV-Infected Patients Receiving Antiretroviral Therapy
This will be a cross-sectional population-based study carried out in the region of Madrid (6,468,322 inhabitants according to current census) to quantify the number of Co-meds in HIV-infected individuals on ART in the region of…
- Trial name
- PODIUM (NCT03123575)
- Volunteers
- 1,000 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Mechanical Ventilation Complication
Automated Detection of Patient Ventilator Asynchrony Using Pes Signal
Rationale: Patient-ventilator asynchrony (PVA) in mechanical ventilation is associated with adverse patient outcome such as a prolonged stay in the ICU and even mortality.
- Trial name
- NCT06186557
- Testing
- No intervention
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Leiden University Medical Center
Smoking
HIV-1 and Brain Interaction on Smoking Comorbidity
People living with HIV-1 have high rates of cigarette smoking, which may be related to nicotinic interaction with HIV-1 infection and brain function levels.
- Trial name
- NCT03308331
- Testing
- Tobacco smoking and nicotine patch
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hypertension Self-management, Hypertension
Adaptive Intervention Model for Hypertension Self-Management in Rural Areas: A Doctor-Patient Interaction Approach
The aim of this project is to develop and validate an adaptive intervention model to improve self-management behavior in rural hypertensive patients.
- Trial name
- NCT06869031
- Testing
- Standard Interactive Intervention for Hypertension Management, Intensified Interactive Intervention for Hypertension Management
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Yuju Wu
SARS-CoV-2 Infection, Hematologic Malignancy
Mechanism and Immune Function Analysis of SARS-CoV-2 Infection in Hematologic Tumors
The goal of this observational study is to compare the immune function and infection mechanism of patients with hematologic tumors and those people without underlying diseases after infection with SARS-CoV-2.
- Trial name
- NCT05683353
- Testing
- None intervention
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
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