Clinical trials: Interleukin
Periodontitis
A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis
The study will follow a parallel arm, randomised, double blinded, placebo controlled design. There will be two groups Group 1 = receiving 1% curcumin chips after routine scaling and root planing (n=20) Group 2 = receiving placebo…
- Trial name
- NCT03790605
- Testing
- 1 % curcumin chip, Scaling and root planing
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Inflammation, Cancer
Ashwagandha: Effects on Stress, Inflammation and Immune Cell Activation
Ayurvedic medicine has been practiced in for more than 2,500 years. Ashwagandha is one of the most widely utilized herbs in the system. It is thought to affect the endocrine, immune, nervous, and cardiopulmonary systems.
- Conditions
- Inflammation, Cancer, Autoimmune Diseases
- Trial name
- NCT00817752
- Testing
- Ashwagandha
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National University of Natural Medicine
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Interleukin 6
Assessment of Licorice Extract as an Adjunctive Therapy to Mechanical Debridement in Stage II Periodontitis
To assess the clinical effectiveness of the locally delivered licorice extract as an adjunctive therapy to mechanical debridement in stage II periodontitis patients.
- Trial name
- NCT07422883
- Testing
- Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local application of licorice gel., Mechanical Debridement
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Multiple Sclerosis, Relapsing-Remitting
Polymorphisms of Interleukins, Glypican, and Human Leukocyte Antigen Genes and Treatment Response in Multiple Sclerosis.
HLA-DRB1 * Gene and some genes involved in inflammation and immunity (IL-7R, GPC5, CTSS) have been linked to risk of MS and the response to treatment with immunomodulators.
- Trial name
- WESTEMDRB1 (NCT02769767)
- Testing
- Polymorphism of Interleukins, Glypican, and Human Leukocyte Antigen Genes.
- Where
- Mexico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Instituto Jalisciense de Cancerologia
Treatment of Leg Ulcer, Sharp Debridement
Treatment of Chronic Leg Ulcer in Outpatient's Department and i Primary Care - Wound Size and Inflammation
The purpose of this study is to investigate the rate of wound healing using sharp debridement using curette and to compare between such intensive treatment at hospital and treatment in primary care.
- Conditions
- Treatment of Leg Ulcer, Sharp Debridement, Proinflammatory Cytokines
- Trial name
- NCT01249495
- Testing
- Sharp debridement
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Ankylosing Spondylitis
Ankylosing Spondylitis
The goal of this observational study is to measure the serum level of cytokines IL-17, IL-38,IL-41, and gene expression of HLA-B27 gene in ankylosing spondylitis patients and healthy control group.
- Trial name
- Interleukins (NCT07396194)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sohag University
Acute Lymphoblastic Leukemia, B-Cell
The Role of Serum Cytokines IL_17 A and IL_10 in Disease Activity of Acute B Lymphoblastic Leukemia in South Egypt
Study aimsTo measure the serum levels of IL-17 A and IL-10 in newly diagnosed patients with B-cell acute lymphoblastic leukemia (B-ALL).
- Trial name
- NCT07509385
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Inflammatory Bowel Diseases, Microbiota
Microbiome Alterations in IL10RA-deficient Patients After HSCT
To elucidate the longitudinal development of intestinal microbiota in patients with IL10RA deficiency after hematopoietic stem cell transplantation (HSCT).
- Trial name
- NCT03752372
- Testing
- hematopoietic stem cell transplantation
- Where
- China
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Fudan University
Atopic Dermatitis, AD
An Open-label, Single-arm Longitudinal Study With Dupilumab for Patients With Atopic Dermatitis
24-week, open-label, single-arm longitudinal study of patients with AD, including a comparison between baseline values for adult patients with moderate-to-severe AD and untreated normal control patients.
- Conditions
- Atopic Dermatitis, AD, Eczema
- Trial name
- NCT04520308
- Testing
- Dupilumab Only Product
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Eric Simpson
Healthy
Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels
In this study, the investigators address the research question of whether palm olein will have a positive influence on plasma total homocysteine levels in human volunteers provided with high-protein diets formulated from common…
- Trial name
- NCT00941837
- Testing
- Olive Oil, Palm Olein Oil, Coconut Oil
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Malaysia Palm Oil Board
Periapical Periodontitis
Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
Comparing the effect of Simvastatin versus calcium hydroxide used as an intracanal medicament on Post-operative Pain and Total amount of IL-6 and IL-8 in Periapical Fluids of lower premolars in patients with Symptomatic Apical…
- Trial name
- NCT05525013
- Testing
- Simvastatin Powder, Calcium Hydroxide
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Chronic Periodontitis, Aggressive Periodontitis
IL-34 Levels in Various Types of Periodontitis
The objective of this study is to 1) identification of the impact of IL-34 on the pathogenesis of periodontal disease and determine whether any relationship among the existing levels of Gingival crevicular fluid (GCF) Interleukin…
- Trial name
- NCT04223869
- Testing
- non-surgical periodontal treatment
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Asthma
The Effect of Anti-IL17 on Airway Hyperresponsiveness and Resistance
This observational longitudinal cohort study aims to assess the effect of monoclonal antibodies targeting interleukin 17 (anti-IL-17) on airway hyperreactivity and airway resistance.
- Trial name
- NCT06224634
- Where
- Denmark
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Healthy Subjects and Atopic Dermatitis Subjects
A Two-Part, Phase 1, Single-Dose Study of IL-31 mAb (Anti-Interleukin 31 Monoclonal Antibody); in Healthy Subjects and Adults With Atopic Dermatitis
The purpose of the study is to determine safety and tolerability of IL-31 mAB
- Trial name
- NCT01614756
- Testing
- BMS-981164
- Where
- 4 sites in United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Periodontitis, Gingivitis
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression
T Regulatory cells which suppressor subset of T cells and related cytokines remain in blood and infiltrates into the tissue under need.
- Trial name
- NCT06135116
- Testing
- Flow Cytometric Detection of Regulatory T Cells and Cytokines analysis by ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Subjective Cognitive Decline
Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline.
Subjective cognitive decline (SCD) is receiving increasing attention as a risk factor for incident dementia due to AD. SCD manifests prior to the onset of clinical impairment, and as such could serve as a potential target…
- Trial name
- NCT04744922
- Testing
- Extracts of citrus peels standardized in AUR and NAR (phytocomplex).
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Covid19
Cytokine Status of Covid-19 Patients
COVID-19, spreading rapidly all over the world, causes serious morbidity and mortality. In severe COVID-19 infections, after pulmonary inflammation, cardiovascular organ failure, cytokine storm, hemophagocytosis, septic shock…
- Trial name
- NCT04531345
- Testing
- Flow cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Crowding, Tooth
The Effects of Ibuprofen and Laser on Orthodontic Pain
Early orthodontic pain is usually caused by the insertion of elastomeric separators to the mesial and distal of the tooth to be banded in order to create adequate space for proper placement.
- Trial name
- NCT04070001
- Testing
- 400 Mg Ibuprofen, laser application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeşim KAYA