Clinical trials: Interleukin
Interleukin 6
Assessment of Licorice Extract as an Adjunctive Therapy to Mechanical Debridement in Stage II Periodontitis
To assess the clinical effectiveness of the locally delivered licorice extract as an adjunctive therapy to mechanical debridement in stage II periodontitis patients.
- Trial name
- NCT07422883
- Testing
- Mechanical debridement will be performed for 20 stage II periodontitis patients followed by local application of licorice gel., Mechanical Debridement
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Lumbar Disc Degeneration, Low Back Pain
Interleukin-1β (rs 1143627 T/C) Gene Polymorphism May Increase the Risk of Developing LDD in Turkish Population
This study aims to show the association between the Interleukin-1β (rs 1143627 T/C) gene polymorphism and the patient's pain level, radiological features, functional disability, and spinal flexibility.
- Conditions
- Lumbar Disc Degeneration, Low Back Pain, Inflammation
- Trial name
- NCT05601739
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yeditepe University
Migraine, Tension-Type Headache
Salivary Inflammatory Markers in Tension Type Headache and Migraine
Data role of salivary inflammatory markers in migraine and Tension Type headache (TTH) are lacking. Τhe investigators studied whether headache attacks are associated with changes in C reactive protein (CRP), Interleukin -1β and…
- Trial name
- SalHead (NCT03727672)
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Covid19
Cytokine Status of Covid-19 Patients
COVID-19, spreading rapidly all over the world, causes serious morbidity and mortality. In severe COVID-19 infections, after pulmonary inflammation, cardiovascular organ failure, cytokine storm, hemophagocytosis, septic shock…
- Trial name
- NCT04531345
- Testing
- Flow cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Periodontitis, Adult, Smoking
Impact of Smoking on Salivary Interleukin (IL)-39, IL-41, IL-1β, TNF-α Levels in Periodontal Disease
The goal of this observational study is to evaluate if the measurement of salivary Interleukin (IL)-39, IL-41, IL-1Beta(β), and Tumor necrosis factor-alpha (TNF-α) levels can aid in the early diagnosis of periodontitis in…
- Conditions
- Periodontitis, Adult, Smoking, Periodontal Diseases
- Trial name
- NCT06528522
- Testing
- Clinical Measurements and Saliva Sample Collection
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Symptomatic Irreversible Pulpitis
Effect of Diclofenac Potassium Versus Prednisolone on Post-endodontic Pain and Pulpal IL-8 Expression
To assess the effect of using diclofenac potassium versus prednisolone as a pre-medication compared to placebo on: Intensity of post-endodontic pain in patients with symptomatic irreversible pulpitis. Pulpal IL-8 expression.
- Trial name
- NCT04608981
- Testing
- Prednisolone 30 mg, Diclofenac Potassium 50mg Tab
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Psoriasis Vulgaris, UVB Phototherapy Burn
Effect Narrow-Band UVB Radiations
Narrow-band UVR affects Interleukin 17 which has a major role in the pathogenesis of psoriasis Vulgaris. the aim of this study to evaluate the serum levels of Interleukin 17 in psoriatic patients and compare with the levels in…
- Trial name
- UVB (NCT05647187)
- Testing
- Serum Interleukin 17 levels, NB-UVB
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- South Valley University
Acute Myeloid Leukemia, Vitamin D Deficiency
Vitamin D Effect on A Disintegrin-like And Metalloprotease Thrombospondin1 Motif 13& Interleukin 6 in Leukemia
A Disintegrin-like And Metalloprotease with Thrombospondin type 1 motif 13 (ADAMTS13) deficiency was incriminated in poor prognosis, high probability of serious complications and mortality in acute myeloid leukemia (AML)…
- Conditions
- Acute Myeloid Leukemia, Vitamin D Deficiency, ADAMTS13, Interleukin 6
- Trial name
- NCT05149339
- Testing
- Cholecalciferol 2800 I.U. ml oral drops
- Where
- Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Low Back Pain
Effects of Spinal Manipulative Treatment on Inflammatory Markers in Low Back Pain Patients
It is expected that mechanical low back pain (LBP) is associated with inflammatory changes localized to the affected tissues. Could such changes be detected in cells involved in the inflammatory process in an in vitro model? The…
- Trial name
- NCT01766141
- Testing
- Spinal manipulation
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Overweight and Obesity
Polymorphism C677T MTHFR and Folate Intake in Inflammatory Biomarkers
The C677T polymorphism of the MTHFR gene is associated to several biochemicals imbalances, as changes in folic acid serum levels and some inflammatory markers, elevating the oxidative stress and increasing the risk of developing…
- Trial name
- NCT03186196
- Testing
- Diet containing Folate
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Periodontitis Stage II
The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6
Sixty periodontally diseased patients will be enrolled in the study. After the patients are randomly divided into one of three treated groups, group 1 (n=20), SRP only; group 2 (n=20), SRP + i-PRF; and group 3 (n=20), P +…
- Trial name
- PRF & CIP-iPRF (NCT06968286)
- Testing
- SRP, SRP+Injectable platelet rich fibrin, SRP+ciprofloxacine loaded iPRF
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Periodontitis, Adult, Periodontal Pocket
Effect of Photodynamic Therapy on Gingival Crevicular Cytokines in Periodontitis Patients
Systemically healthy periodontitis patients were recruited in this single-blind, split-mouth, randomized controlled clinical trial. After SRP, PDT was applied at probing depth (PD) ≥ 4 mm at test quadrant.
- Conditions
- Periodontitis, Adult, Periodontal Pocket, Periodontitis, Periodontal Attachment Loss
- Trial name
- NCT03453476
- Testing
- SRP and Fotosan 630
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Periodontitis
A Clinical Trial to Study the Effect of a Drug, Curcumin in Patients With Periodontitis
The study will follow a parallel arm, randomised, double blinded, placebo controlled design. There will be two groups Group 1 = receiving 1% curcumin chips after routine scaling and root planing (n=20) Group 2 = receiving placebo…
- Trial name
- NCT03790605
- Testing
- 1 % curcumin chip, Scaling and root planing
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Postoperative Pain, Apical Periodontitis
Effect of Low-level Laser Therapy Versus Calcium Hydroxide Intracanal Medication on Postoperative Pain and Substance P Levels in Patients With Symptomatic Apical Periodontitis
a randomized clinical study to compare the effect of using low level laser therapy versus calcium hydroxide intra-canal medication on: Incidence and intensity of postoperative pain in patients with symptomatic apical…
- Trial name
- NCT04594317
- Testing
- low level laser therapy
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Cairo University
Analgesia, Surgical Procedure, Unspecified
TLIP Block Versus Modified TLIP Block for Posterior Decompression and Stabilization Surgery
This study aimed to compare the analgesia effectivity of TLIP and modified TLIP block in Posterior Lumbar Decompression and Stabilization Surgery Perioperatively.
- Trial name
- NCT05104203
- Testing
- Thoracolumbar Interfascial Plane block, Modified Thorcolumbar Interfascial Plane block
- Where
- Indonesia
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Periodontitis
Interleukin 20 and Periodontal Tisuue Destruction
Periodontitis is an inflammatory disease that causes destruction of periodontal tissues. IL-20, on the other hand, is known as a potent angiogenic, chemotactic, and pro-inflammatory cytokine associated with various chronic…
- Trial name
- NCT06091800
- Testing
- biochemical analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University
Shock, Septic
Mitochondrial Function of Immune Cells in Sepsis
Introduction: Evidence suggests that sepsis and septic shock severely impair mitochondria and that the resulting mitochondrial dysfunction is related to the severity and outcome of the resulting organ dysfunction.
- Trial name
- MitoSepsis (NCT01600989)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Melasma
Inflammation in Melasma: Study of Its Infiltrate and the Expression of Acute and Chronic Mediators
Melasma is an acquired hyperpigmentary disorder that commonly affects women from Asia and Latin-America.There is evidence of subclinical inflammation supported by diffuse spectrometry and by prominent inflammatory cells in…
- Trial name
- NCT01952379
- Where
- Mexico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí