Clinical trials: Interleukin
Inflammation Biomarkers, Quality of Recovery (QoR-15)
Comparison of Inflammatory Factors, Pain Scale, and Postoperative Recovery Quality (QOR - 15) in Patients Undergoing Colorectal Cancer Surgery with Conventional General Anesthesia Techniques Compared to General Anesthesia Combined with Epidural Anesthesia At Prof. Ngoerah Hospital
Surgery can increase IL-6 cytokines, triggering inflammation and metastasis. The combination of general and epidural anesthesia has the potential to suppress IL-6, improve the tumor microenvironment, provide analgesia, and…
- Conditions
- Inflammation Biomarkers, Quality of Recovery (QoR-15), Visual Analog Pain Scale
- Trial name
- NCT06784258
- Testing
- General Anesthesia (control group), General Anesthesia combined with epidural anesthesia
- Where
- Indonesia
- Volunteers
- 44 people
- Sponsor
- Udayana University
Asthma
A Study to Establish the Efficacy of QBX258 in Patients With Moderate to Severe Asthma
This study is designed to investigate the efficacy and safety of QBX258 in subjects with moderate to severe asthma.
- Trial name
- NCT01479595
- Testing
- QBX258
- Where
- 20 sites in United States, Germany and 1 more
- Volunteers
- 65 people
- Sponsor
- Novartis Pharmaceuticals
Lymphoma, Carcinoma
Continuous Infusion of rhIL-15 for Adults With Advanced Cancer
Background: People with cancer can have a weak immune system as a result of the cancer itself, or from prior treatments. Still, treatments that stimulate the immune system have been shown to be effective against a number of…
- Trial name
- NCT01572493
- Testing
- rh IL-15 (10 DAYS), rh IL-15 (5 DAYS)
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- National Cancer Institute (NCI)
Symptomatic Periapical Periodontitis
Influence of Intra-Canal Cryotherapy on Post-Endodontic Pain and Interleukin-6 Expression Using Different Irrigation Protocols: A Randomized Clinical Trial
the study was to evaluate the effect of intra-canal cryotherapy on post-endodontic pain and interleukin-6 expression in teeth with symptomatic apical periodontitis using different irrigation protocols.
- Trial name
- NCT04324398
- Testing
- Cryotherapy
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Infantile Colic
Lactobacillus Reuteri Versus Placebo in the Treatment and Prevention of Infantile Colic
The purpose of this study is: to study the intestinal microflora of colicky infants before and after L. reuteri or placebo administration, evaluating the effect of Lactobacillus reuteri on the growth of the main intestinal…
- Trial name
- NCT00893711
- Testing
- Lactobacillus reuteri DSM 17938, L.reuteri + Vit D
- Where
- 3 sites in Italy
- Volunteers
- 155 people
- Sponsor
- Azienda Ospedaliera Ospedale Infantile Regina Margherita Sant'Anna
Cancer of Colon, Interleukins
Immunologic Changes and Recovery-related Factors in Elderly Colon Cancer Patients
Colorectal cancer is one of the most frequent malignancies, with a rising proportion of elderly patients in an aging society. In this study, the investigators attempted to find out the relationship between immunologic factors and…
- Conditions
- Cancer of Colon, Interleukins, Aged
- Trial name
- NCT06454071
- Testing
- Blood test
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Soonchunhyang University Hospital
Menstrual Cycle-Associated Gingivitis
The Effect of Menstrual Cycle On IL-6, TNF-α And Periodontal Status
Aim: Women's menstrual cycle is controlled by the secretion of sex hormones. Sex steroid hormones are thought to be affect to periodontal tissues, wound healing, periodontal disease progression and bone turn over.
- Trial name
- NCT03281109
- Testing
- diagnosis
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people
- Sponsor
- Yuzuncu Yil University
Colitis, Ulcerative
A Study of LY3471851 in Adult Participants With Moderately to Severely Active Ulcerative Colitis (UC)
The reason for this study is to determine if the study drug LY3471851 is safe and effective in adult participants with active ulcerative colitis (UC). The study treatment will last about 52 weeks.
- Trial name
- INSTRUCT-UC (NCT04677179)
- Testing
- LY3471851
- Where
- 116 sites in United States, Argentina and 20 more
- Volunteers
- 81 people
- Sponsor
- Nektar Therapeutics
Lipodystrophy, Obesity
Adipocyte, Insulin-resistance and Immunity : Evaluation of Interleukin-7 in Lipodystrophy, Diabetes and Obesity
White adipose tissue-related diseases spread from excess (obesity) to lack (lipoatrophies) through aberrant distribution (lipodystrophies), these 3 different disorders being paradoxically able to induce a metabolic insulin…
- Conditions
- Lipodystrophy, Obesity, Type 2 Diabetes
- Trial name
- IL-7norm (NCT01784289)
- Where
- 5 sites in France
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University Hospital, Lille
Nephrotic Syndrome Steroid-Dependent, Interleukin 2
Treatment of Steroid Dependent Idiopathic Nephrotic Syndrome in Children With Low Doses of Interleukin 2: a Pilot Study
NIL-2 is a clinical trial designed to evaluate the efficacy and safety of low doses of Interleukin2 in the treatment of recently diagnosed, steroid dependent idiopathic nephrotic syndrome in children.
- Trial name
- NIL-2 pilote (NCT02997150)
- Testing
- IL-2 Low dose
- Sponsor
- University Hospital, Limoges
Metastatic Melanoma
Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patients
The purpose of this study is to see if the combination of the two cancer drugs, Dacarbazine (DTIC) and a low-dose of Proleukin (IL2), would provide a less toxic and more effective treatment for melanoma than currently available…
- Trial name
- DTIC (NCT00553618)
- Testing
- Proleukin and Dacarbazine
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Louisville
Oral Squamous Cell Carcinoma (OSCC)
Salivary IL-6 and Interleukin Gene Polymorphisms in Oral Squamous Cell Carcinoma
This observational study will evaluate whether salivary interleukin-6 levels and selected interleukin gene polymorphisms are associated with regional lymph node involvement in patients with oral squamous cell carcinoma.
- Trial name
- IL6-OSCC (NCT07692360)
- Testing
- Saliva Collection and Biomarker Analysis
- Where
- 2 sites in Italy
- Volunteers
- 38 people
- Sponsor
- University of Pavia
Overweight and Obesity
Polymorphism C677T MTHFR and Folate Intake in Inflammatory Biomarkers
The C677T polymorphism of the MTHFR gene is associated to several biochemicals imbalances, as changes in folic acid serum levels and some inflammatory markers, elevating the oxidative stress and increasing the risk of developing…
- Trial name
- NCT03186196
- Testing
- Diet containing Folate
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Healthy Participants
An Accessorised Prefilled Syringe to an Autoinjector Pharmacokinetic Bridging Study of Tozorakimab
The purpose of this study is to compare the pharmacokinetic (PK) exposures of a single subcutaneous (SC) dose of tozorakimab administered using AI or APFS in healthy participants.
- Trial name
- NCT06908577
- Testing
- Tozorakimab, Autoinjector (AI) Device, Accessorised Prefilled Syringe (APFS) Device
- Where
- 4 sites in United States, Germany and 1 more
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hepatitis C, Chronic
Study of PEG-rIL-29 (or PEG-IFN Lambda) in Subjects With Chronic Hepatitis C Virus Infection
Interleukin 29 (IL-29) is a substance that is produced in the body to help fight viral infections. The purpose of this study is to test the safety and antiviral effects of PEG-rIL-29 (a man-made form of IL-29) when it is given…
- Trial name
- NCT00565539
- Testing
- PEGylated recombinant interleukin 29 (PEG-rIL-29)
- Where
- 11 sites in United States, Canada
- Volunteers
- 56 people
- Sponsor
- ZymoGenetics
Glaucoma
Tear Interleukin Biomarkers After Glaucoma Treatment
This prospective study aims to evaluate inflammatory biomarkers in tear fluid in patients with glaucoma undergoing micropulse transscleral cyclophotocoagulation (MP-CPC), continuous-wave cyclophotocoagulation (CPC), and…
- Trial name
- TIGT (NCT07592988)
- Testing
- MicroPulse Transscleral Cyclophotocoagulation, Conventional Transscleral Cyclophotocoagulation, Antiglaucoma Surgery
- Where
- Kazakhstan
- Volunteers
- 24 people
- Sponsor
- Kazakh Eye Research Institute
General Anxiety Disorders, Systemic Inflammation
Effects of Mulberry Juice on Inflammatory Status and Clinical Symptoms in Patients With General Anxiety Disorder
Anxiety and depression are normally associated with inflammation reactions and interleukin (IL) related pathways are most evidently involved.
- Conditions
- General Anxiety Disorders, Systemic Inflammation, Interleukin
- Trial name
- NCT03935061
- Testing
- Mulberry juice
- Where
- Taiwan
- Volunteers
- 104 people
- Sponsor
- Taipei Medical University
Cancer, Diabetes Mellitus, Type 2
SGLT2 Inhibitors and Reducing the Risk of Cancers Among Diabetics , an Observational Study
Since the discovery of SGLT2 inhibitors, there is a great shift in diabetic treatment, so this drug is magic, this drug can reduce the blood sugar level by blocking the reabsorption of glucose in the kidney and increasing glucose…
- Conditions
- Cancer, Diabetes Mellitus, Type 2, Interleukin 6, SGLT2 Inhibitors
- Trial name
- NCT05612269
- Testing
- interleukin 6
- Where
- Saudi Arabia
- Volunteers
- 200 people
- Sponsor
- Ministry of Health, Saudi Arabia
Cryopyrin-Associated Periodic Syndromes, Amyloidosis
Repeat PET/CT Imaging in People With CAPS and Anakinra-Induced Amyloidosis Using an Amyloid-Reactive Peptide to Measure Changes in Organ-Specific Amyloid Load
Background: Anakinra is a drug used to treat people with certain diseases that affect their immune systems. Sometimes anakinra can cause proteins under the skin to clump together.
- Trial name
- NCT06974877
- Testing
- 124I AT-01
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
COVID-19, COVID-19 Respiratory Infection
Use of Low-frequency Magnetic Fields in the Hybrid Treatment of COVID-19 Patients
The purpose of this study was to evaluate the efficacy of low-frequency magnetic field in the hybrid treatment of COVID-19 patients, i.e., including magnetostimulation in the standard treatment.
- Conditions
- COVID-19, COVID-19 Respiratory Infection, COVID-19 Pneumonia
- Trial name
- NCT05163613
- Testing
- magnetostimulation, standard therapy
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Medical University of Lodz