Clinical trials: Interleukin
Metastatic Melanoma
Study Comparing TIL to Standard Ipilimumab in Patients With Metastatic Melanoma
In this randomized controlled phase III study the investigators will evaluate whether TIL infusion preceded by non-myeloablative chemotherapy and followed by high dose bolus interleukin-2 can result in an improved progression…
- Trial name
- TIL (NCT02278887)
- Testing
- Translational research, Cyclophosphamide, Fludarabine
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 168 people
- Sponsor
- The Netherlands Cancer Institute
Perianal Warts
Study of Leukocyte Interleukin, Injection for Treatment of Perianal Warts
Study is a dose escalation study. Fifteen patients will be enrolled in 2 treatment cohorts. Five participants (cohort A) will be treated with 200IU Multikine daily, 5 days/week for 2 weeks, off 2 weeks, then again 5 days/week for…
- Trial name
- PAW (NCT03038828)
- Testing
- Leukocyte Interleukin, Injection
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- CEL-SCI Corporation
Eosinophilia, Angioedema
Mepolizumab in Episodic Angioedema With Eosinophilia
Background: Gleich syndrome is also called episodic angioedema with eosinophilia (EAE). People with EAE have episodes of swelling. They may also have itching, hives, fever, and weight gain.
- Trial name
- NCT04128371
- Testing
- mepolizumab
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Iron Overload, Oxidative Stress
Safety of Various Mode of Delivery of Iron Supplement on Iron Toxicity Markers in Preschool Children
The purpose of study is to evaluate and compare the effect of iron supplementation when given as iron tablet or fortified biscuit or combined with zinc in the form of tablet on morbidity and iron toxicity markers among children…
- Trial name
- NCT00980421
- Testing
- Iron Supplementation
- Where
- India
- Volunteers
- 240 people
- Sponsor
- Annamalai University
Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation
Mepolizumab in Chronic Obstructive Pulmonary Diseases (COPD) With Eosinophilic Bronchitis
Some patients with chronic obstructive pulmonary diseases (COPD) have large number of specific white blood cells called eosinophils in their airways.
- Conditions
- Chronic Obstructive Pulmonary Diseases, Chronic Airways Limitation, Bronchitis
- Trial name
- NCT01463644
- Testing
- Mepolizumab
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- McMaster University
Inflammatory Bowel Disease
Study of the Role of Soluble Inhibitor of Interleukin 22, Interleukin 22 Binding Protein (IL-22BP), in Chronic Inflammatory Bowel Disease
IL-22 is an IL-10 family cytokine that plays major actions to increase intestinal epithelial barrier function and regeneration during experimental colitis.
- Trial name
- IL-22BP MICI (NCT02847052)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 52 people
- Sponsor
- Nantes University Hospital
Healthy Subjects and Atopic Dermatitis Subjects
A Two-Part, Phase 1, Single-Dose Study of IL-31 mAb (Anti-Interleukin 31 Monoclonal Antibody); in Healthy Subjects and Adults With Atopic Dermatitis
The purpose of the study is to determine safety and tolerability of IL-31 mAB
- Trial name
- NCT01614756
- Testing
- BMS-981164
- Where
- 4 sites in United Kingdom
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
DRESS Syndrome
Interest of a Targeted Therapy for the Treatment of a Severe Form of Hypersensitivity to Drug (DRESS Syndrome)
Drug Reaction with eosinophilia and Systemic Symptoms (DRESS) is a rare and severe multiorgan drug reaction whose pathophysiological mechanisms underlying remain unclear, but may involve the role of several immune cells like…
- Trial name
- BENRADRESS (NCT06734884)
- Testing
- Benralizumab 30 MG/ML [Fasenra]
- Where
- France
- Volunteers
- 96 people
- Sponsor
- University Hospital, Lille
Acute Gastroenteritis, Acute Diarrhea
Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis
Cytokines, such as IL-6 and IL-8 can be used as markers of acute infections, including acute gastroenteritis. This study aims to evaluate serum levels of interleukins 6 and 8 in children with acute gastroenteritis.
- Trial name
- NCT05213325
- Testing
- Evaluation of serum levels of IL-6 and IL-8
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Sohag University
Periodontitis, Gingivitis
Regulatory T Cell With Related Interleukins in Periodontal Disease Progression
T Regulatory cells which suppressor subset of T cells and related cytokines remain in blood and infiltrates into the tissue under need.
- Trial name
- NCT06135116
- Testing
- Flow Cytometric Detection of Regulatory T Cells and Cytokines analysis by ELISA
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Kidney Cancer
Sunitinib Malate in Treating Patients With Kidney Cancer
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00943839
- Testing
- sunitinib malate, laboratory biomarker analysis, pharmacological study
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Antoine Lacassagne
Crohn's Disease
An Analysis of the Relationship Between the Genetic Polymorphisms of Interleukin 12 Receptor Subunit Beta 1 and Crohn's Disease in Chinese Patients
From January 2018 to May 2025, diagnosed CD patients and gender- and age-matched normal controls were collected from Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.
- Trial name
- NCT07057856
- Testing
- Ustekinumab (UST)
- Where
- China
- Volunteers
- 866 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Acute Myeloid Leukemia
AML Cell Immunotherapy Using Chimeric Antigen Receptor T-cells
AML is one of the most aggressive forms of leukemia, where bone marrow transplantation remains the gold standard treatment, with its known associated toxicities and related mortality.
- Trial name
- CAR-LAM (NCT04169022)
- Testing
- Sample collection
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Diabetes Mellitus, Type 1
Probiotics Supplementation Effect on Glucose Homeostasis in Children With Type 1 Diabetes
Background: Probiotics influence immune homeostasis, through altering gut microbiota. The efficacy of probiotics in diabetes has been shown in preclinical settings as well as in human trials.
- Trial name
- NCT04579341
- Testing
- probiotics
- Where
- 2 sites in Egypt
- Volunteers
- 70 people
- Sponsor
- Ain Shams University
Subjective Cognitive Decline
Clinical and Biological Effects of Citrus-phytochemicals in Subjective Cognitive Decline.
Subjective cognitive decline (SCD) is receiving increasing attention as a risk factor for incident dementia due to AD. SCD manifests prior to the onset of clinical impairment, and as such could serve as a potential target…
- Trial name
- NCT04744922
- Testing
- Extracts of citrus peels standardized in AUR and NAR (phytocomplex).
- Where
- Italy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Covid19
Cytokine Status of Covid-19 Patients
COVID-19, spreading rapidly all over the world, causes serious morbidity and mortality. In severe COVID-19 infections, after pulmonary inflammation, cardiovascular organ failure, cytokine storm, hemophagocytosis, septic shock…
- Trial name
- NCT04531345
- Testing
- Flow cytometric analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Istanbul Training and Research Hospital
Crowding, Tooth
The Effects of Ibuprofen and Laser on Orthodontic Pain
Early orthodontic pain is usually caused by the insertion of elastomeric separators to the mesial and distal of the tooth to be banded in order to create adequate space for proper placement.
- Trial name
- NCT04070001
- Testing
- 400 Mg Ibuprofen, laser application
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yeşim KAYA
Type 1 Diabetes
Adaptive Study of IL-2 Dose Frequency on Regulatory T Cells in Type 1 Diabetes
Type 1 diabetes (T1D) is the most common severe autoimmune disease worldwide and is caused by the body's immune destruction of its own insulin producing pancreatic beta cells leading to insulin deficiency and development of…
- Trial name
- DILfrequency (NCT02265809)
- Testing
- Aldesleukin
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Melanoma
Tumor Infiltrating Lymphocytes Adjuvant Therapy of Melanoma
The objective of this multicentric Phase III study is to confirm the results of the phase I-II study (Dreno B \& Al. Cancer Immunol Immunother 2002; 51: 539-456) which demonstrated the preventive effect of a treatment by TIL…
- Trial name
- TIL (NCT00200577)
- Testing
- TIL + IL2
- Where
- 9 sites in France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
Shock, Septic
Mitochondrial Function of Immune Cells in Sepsis
Introduction: Evidence suggests that sepsis and septic shock severely impair mitochondria and that the resulting mitochondrial dysfunction is related to the severity and outcome of the resulting organ dysfunction.
- Trial name
- MitoSepsis (NCT01600989)
- Testing
- blood sampling
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern