Clinical trials: Interleukin 1-beta
Diabetes Mellitus, Type 2, Insulin Resistance
Interleukin-1 Receptor Antagonist and Insulin Sensitivity
Obesity is characterized by continuous low-grade inflammation. This is an important link between obesity and insulin resistance.
- Trial name
- NCT00928876
- Testing
- Anakinra (Kineret)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Peri-implantitis
Relationship Between Metrnl Expression, IL-1β, and TNF-α in Patients With Peri-Implantitis
Peri-implantitis is an inflammatory disease affecting the tissues around dental implants and may lead to progressive bone loss and implant failure.
- Trial name
- NCT07697729
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Periodontitis (Stage 3), Gremlin-1
Comparative Analysis of Gremlin-1, Syndecan-4 and IL-1 Beta Levels in Gingival Crevicular Fluid Among İndividuals With Periodontal Health and Stage III Periodontitis, Considering Both Smokers and Non-Smokers, Before and After Non-Surgical Periodontal Therapy
eriodontitis is a complex disease characterized by the inflammation and destruction of the tissues supporting the teeth, and smoking can adversely affect the pathophysiological changes in this process.
- Conditions
- Periodontitis (Stage 3), Gremlin-1, Syndecan 4, Interleukin 1-beta
- Trial name
- NCT06687005
- Testing
- non-surgical periodontal therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Tugba Aydin
Periodontal Disease
Efficacy of Laser Therapy for Periodontitis
The aim of this study is to evaluate the efficacy of diode laser in addition to periodontal treatment in periodontitis patients and to investigate their effects on gingival crevicular fluid (GCF) cytokine levels before and after…
- Trial name
- NCT07013162
- Testing
- High power diode laser + SRT, Low diode diode laser + SRT, Curettage (SRT) only
- Where
- 2 sites in Yemen
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Science and Technology, Yemen
Covid Patients
Beta Endorphins,Interleukin 1 and Interleukin 38 in Covid Patients Associated With Neuropsychological Manifestations.
Measurement of Beta endorphins,interleukin 1 and interleukin 38 in covid patients associated with neuropsychological manifestations.
- Trial name
- NCT05198388
- Testing
- βeta endorphins, interleukin 6 and interleukin 38
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Peri-implant Soft Tissue Healing
Soft Tissue Response and IL-1β Levels Around CAD/CAM-Milled vs 3D-Printed PMMA Healing Abutments
This study looked at how the gums and tissues around dental implants heal when using two different types of temporary healing caps made of PMMA (a common dental material).
- Trial name
- NCT07287722
- Testing
- CAD/CAM-Milled PMMA Healing Abutment, 3D-Printed PMMA Healing Abutment
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ali Hassan Eid Toto
Periodontitis, Gingivitis
Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis
This study investigates the impact of smoking on pyroptosis and inflammatory signaling pathways in systemically healthy individuals with various periodontal conditions.
- Conditions
- Periodontitis, Gingivitis, Periodontal Diseases, Smoking ( Cigarette)
- Trial name
- NCT07563192
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Gingival Inflammation, Oral Bacterial Infection
Gingival Inflammatory Response,Bacterial Adhesion and Patient Satisfaction of Ceramo-metallic vs Zirconia Crowns
Ceramo metallic restoration has proved high success rate over past years as considered to be the gold standard while Monolithic zirconia as fixed dental prostheses have gained attention because of their good fracture strength…
- Trial name
- CairoU (NCT04077606)
- Testing
- ceramo-metallic crown prepartion, full anatomical monolithic zirconia crown
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Suicide, Attempted, Suicidal Ideation
Biomarkers as Predictors of Suicidal Risk in Adolescents
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk.
- Conditions
- Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
- Trial name
- NCT03014518
- Testing
- Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
One-Piece Dental Implant, Bone-Level Implant
Inflammatory Biomarkers, Microbial Findings, and Clinical Characteristics Before and After Treatment of Peri-Implant Mucositis Around One-Piece and Two-Piece Dental Implants
The goal of this clinical study was to learn whether the design of a dental implant affects how the gums around it respond to treatment of peri-implant mucositis, an early and reversible inflammation of the soft tissue around a…
- Conditions
- One-Piece Dental Implant, Bone-Level Implant, Two-Piece Dental Implant, Nonsurgical Mechanical Debridement
- Trial name
- 1PvsBL (NCT07892313)
- Testing
- Nonsurgical Mechanical Debridement With 1% Chlorhexidine Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cuneyt Asim Aral
Sphingosine 1-phosphate, Interleukin 1-beta
IL-1β and S1P Levels After Periodontal Therapy: A Split-Mouth Study
This randomized split-mouth clinical trial aimed to evaluate the changes in interleukin-1 beta (IL-1β) and sphingosine-1-phosphate (S1P) levels in gingival crevicular fluid (GCF) following non-surgical periodontal therapy (NSPT)…
- Conditions
- Sphingosine 1-phosphate, Interleukin 1-beta, Gingival Crevicular Fluid, Non-surgical Periodontal Therapy
- Trial name
- NCT06930430
- Testing
- Non-Surgical Periodontal Therapy (NSPT)
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periodontal Diseases, Smoking Cessation
Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy
The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease.
- Trial name
- NCT06145685
- Testing
- Minimally invasive non-surgical periodontal therapy, Conventional non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Inflammation, Interleukin-1beta
Effect on Cytokines IL-1ß, TNF-α, IL-4, and Total Bacterial Load of a Composition Comprising Olive Oil, Trimethylglycine and Xylitol Delivered as a Toothpaste
The goal of this clinical trial is to learn if a novel composition comprising olive oil, trimethylglycine and xylitol, affects salivary levels of IL-1ß, TNF-α and IL-4 in a group of periodontally healthy, normal and…
- Conditions
- Inflammation, Interleukin-1beta, TNF-α, Cytokine Levels
- Trial name
- NCT06786910
- Testing
- Toothpaste with olive oil, trimethylglycine and xylitol, Toothpaste without olive oil, trimethylglycine nor xylitol
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mucosa Innovations, S.L.
Healthy
Pharmacokinetics and Pharmacodynamics of RPH-104 in Healthy Subjects
The purpose of this first in human study is to evaluate the safety and tolerability of RPH-104 in humans.
- Trial name
- NCT02667639
- Testing
- RPH-104, Sodium chloride Sterile Injection 0.9% w/v
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- R-Pharm
Post Operative Inflammatory Marker Levels
The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital
. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect on the levels of IL-6 \& IL-1β pro inflammatory…
- Trial name
- NCT01339065
- Testing
- Ketamine
- Where
- Uganda
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Makerere University
Periodontitis, Periodontal Inflammation
GCF Galectin-3 and Interleukin-1beta Levels in Periodontitis.
This study aims to evaluate gingival crevicular fluid Galectin-3 and Interleukin-1beta levels in different grades (B and C) of stage 3 periodontitis, concurrently, and also to investigate their discriminative efficiencies in…
- Trial name
- NCT05449093
- Testing
- Periodontal clinical measurements and gingival crevicular fluid sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Periodontitis
GCF Levels of IL-1Beta, MIP-1 Alfa and G-CSF in Gingivitis and Stage I-II-III-IV Periodontitis Patients
Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response.
- Trial name
- NCT04629313
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uşak University
Non-steroidal Anti-inflammatory Poisoning
Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic…
- Trial name
- NCT02658799
- Testing
- cataflam (diclofenac potassium)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Baskent University
Obesity &Amp; Overweight, Peri Implantitis
The Role of Obesity in Peri-Implant Health(ROPIPH)
This clinical study aims to evaluate the influence of obesity on peri-implant health. Both clinical parameters and biochemical markers in peri-implant crevicular fluid(PICF) will be assessed.
- Conditions
- Obesity &Amp; Overweight, Peri Implantitis, Dental Implant
- Trial name
- ROPIPH (NCT07183163)
- Testing
- Clinical and biochemical assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mine Keskin