Clinical trials: Interleukin 1-beta
Sphingosine 1-phosphate, Interleukin 1-beta
IL-1β and S1P Levels After Periodontal Therapy: A Split-Mouth Study
This randomized split-mouth clinical trial aimed to evaluate the changes in interleukin-1 beta (IL-1β) and sphingosine-1-phosphate (S1P) levels in gingival crevicular fluid (GCF) following non-surgical periodontal therapy (NSPT)…
- Conditions
- Sphingosine 1-phosphate, Interleukin 1-beta, Gingival Crevicular Fluid, Non-surgical Periodontal Therapy
- Trial name
- NCT06930430
- Testing
- Non-Surgical Periodontal Therapy (NSPT)
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Periodontal Diseases, Smoking Cessation
Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy
The aim of this study is to evaluate the effect of smoking cessation on inflammatory markers following non-surgical treatment of periodontal disease.
- Trial name
- NCT06145685
- Testing
- Minimally invasive non-surgical periodontal therapy, Conventional non-surgical periodontal therapy
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- October 6 University
Gingivitis
Probiotic Yoghurt Effect on Experimental Gingivitis
The aim of this study was to evaluate the effects of probiotic yoghurt on the development of gingival inflammation. Fifty-one periodontally healthy individuals were given standard oral hygiene instructions and randomly divided…
- Trial name
- NCT02546206
- Testing
- Probiotic Yoghurt, Natural Yoghurt
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Marmara University
Post Prandial Inflammation Markers
Study to Investigate the Efficacy of Digestive Enzymes on Inflammation After a Meal
The primary objective of the study is to assess the efficacy of Digestive Enzyme Blend #2, a digestive enzyme dietary supplement product, on markers indicative of inflammation after a meal.
- Trial name
- NCT01729793
- Testing
- Digestive Enzyme #2
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Enzyme Company
Periodontitis, Gingivitis
Activin-A and Interleukin-1β Levels in Periodontitis
Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06110221
- Testing
- Periodontal clinical measurements, GCF and saliva sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Aggressive Periodontitis
Evaluation of Efficacy of Full-mouth Disinfection in Generalized Aggressive Periodontitis Patients
The purpose of this study is to determine whether full-mouth disinfection is effective in the initial periodontal treatment of generalized aggressive periodontitis on clinical parameters, gingival crevicular fluid interleukin-1β…
- Trial name
- NCT02466646
- Testing
- Klorhex® Gel, rinse and spray, Conventional IPT, Full-mouth IPT
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Marmara University
Healthy
Pharmacokinetics, Safety and Immunogenicity of RPH-104 at a New Dosage and Different Doses Via Single Subcutaneous and Intravenous Administration in Healthy Volunteers
The purpose of this study is to evaluate the safety, immunogenicity and pharmacokinetics of RPH-104 after single intravenous and subcutaneous administration to healthy volunteers at different doses
- Trial name
- NCT07206043
- Testing
- RPH-104 80 mg, RPH-104 160 mg, RPH-104 320 mg
- Where
- Russia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- R-Pharm International, LLC
Non-steroidal Anti-inflammatory Poisoning
Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic…
- Trial name
- NCT02658799
- Testing
- cataflam (diclofenac potassium)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Baskent University
Periodontitis, Gingival Crevicular Fluid
Gingival Crevicular Fluid (GCF) Bactericidal Permeability Protein (BPI) and Interleukin (IL)-1 Beta
Objective: The aim of this study is to determine the amounts of BPI (Bactericidal permeability protein) and interleukin-1beta (IL-1β) in gingival fluid samples obtained from individuals with periodontally healthy and periodontal…
- Conditions
- Periodontitis, Gingival Crevicular Fluid, Interleukin 1-beta, Bactericidal Permeability Protein
- Trial name
- NCT06295666
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Cytokine Storm, Cytokines
The Effect of Omega-3 on Selected Cytokines Involved in Cytokine Storm
The trial was designed to assess the effect of daily dose of 300 mg omega-3 supplements for 2 months on the selected interleukins levels in uninfected people with Covid-19.
- Trial name
- NCT04483271
- Testing
- 300 mg of omega3-FA
- Where
- Jordan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University
Obesity
Biomarkers of Metabolic Obesity.
The main aims of the work: Analysis of the concentration of selected pro-inflammatory parameters in blood serum and saliva of people with different distribution of subcutaneous and visceral adipose tissue.
- Trial name
- NCT05604196
- Where
- Poland
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Periodontitis, Gingivitis
Evaluation of the Effect of Smoking on Pyroptosis in Periodontal Pathogenesis
This study investigates the impact of smoking on pyroptosis and inflammatory signaling pathways in systemically healthy individuals with various periodontal conditions.
- Conditions
- Periodontitis, Gingivitis, Periodontal Diseases, Smoking ( Cigarette)
- Trial name
- NCT07563192
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Peri-implantitis
Relationship Between Metrnl Expression, IL-1β, and TNF-α in Patients With Peri-Implantitis
Peri-implantitis is an inflammatory disease affecting the tissues around dental implants and may lead to progressive bone loss and implant failure.
- Trial name
- NCT07697729
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Gingivitis, Circadian Rhythm Disruption
Circadian Clock Proteins in Gingival Crevicular Fluid of Individuals With and Without Circadian Rhythm Disruption
This prospective cross-sectional clinical study aims to investigate the relationship between circadian rhythm disruption and periodontal inflammation by evaluating circadian clock protein levels, inflammatory (IL-1beta) and…
- Conditions
- Gingivitis, Circadian Rhythm Disruption, Periodontal Inflammation, Circadian Rhythm Sleep Disorder, Shift Work Type
- Trial name
- Nursma-CIRC-HG (NCT07592052)
- Testing
- Standard Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Inonu University
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Healthy
Pharmacokinetics and Pharmacodynamics of RPH-104 in Healthy Subjects
The purpose of this first in human study is to evaluate the safety and tolerability of RPH-104 in humans.
- Trial name
- NCT02667639
- Testing
- RPH-104, Sodium chloride Sterile Injection 0.9% w/v
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- R-Pharm
Periodontitis
GCF Levels of IL-1Beta, MIP-1 Alfa and G-CSF in Gingivitis and Stage I-II-III-IV Periodontitis Patients
Periodontal diseases are chronic diseases that occur as a result of a violation of the balance between microbial dental plaque and the host response.
- Trial name
- NCT04629313
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Uşak University
Inflammation, Interleukin-1beta
Effect on Cytokines IL-1ß, TNF-α, IL-4, and Total Bacterial Load of a Composition Comprising Olive Oil, Trimethylglycine and Xylitol Delivered as a Toothpaste
The goal of this clinical trial is to learn if a novel composition comprising olive oil, trimethylglycine and xylitol, affects salivary levels of IL-1ß, TNF-α and IL-4 in a group of periodontally healthy, normal and…
- Conditions
- Inflammation, Interleukin-1beta, TNF-α, Cytokine Levels
- Trial name
- NCT06786910
- Testing
- Toothpaste with olive oil, trimethylglycine and xylitol, Toothpaste without olive oil, trimethylglycine nor xylitol
- Where
- Spain
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Mucosa Innovations, S.L.
Obesity &Amp; Overweight, Peri Implantitis
The Role of Obesity in Peri-Implant Health(ROPIPH)
This clinical study aims to evaluate the influence of obesity on peri-implant health. Both clinical parameters and biochemical markers in peri-implant crevicular fluid(PICF) will be assessed.
- Conditions
- Obesity &Amp; Overweight, Peri Implantitis, Dental Implant
- Trial name
- ROPIPH (NCT07183163)
- Testing
- Clinical and biochemical assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mine Keskin
Post Operative Inflammatory Marker Levels
The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital
. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect on the levels of IL-6 \& IL-1β pro inflammatory…
- Trial name
- NCT01339065
- Testing
- Ketamine
- Where
- Uganda
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Makerere University